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The map label for this gene is dppA [H]

Identifier: 66047465

GI number: 66047465

Start: 5049950

End: 5051545

Strand: Direct

Name: dppA [H]

Synonym: Psyr_4238

Alternate gene names: 66047465

Gene position: 5049950-5051545 (Clockwise)

Preceding gene: 66047464

Following gene: 66047466

Centisome position: 82.87

GC content: 55.45

Gene sequence:

>1596_bases
TTGAAACTGCTATCGCTCCGCGCGTCGATTGCCATTGCGCTGCTTAGCGCCGCCGCAACCGTTTCGGCCAAACCGCTGGT
GGTCTGCACCGAAGCGAGCCCTGAAGGTTTCGATATCGTGCAGTACACGACCGCCGTCACGGCAGATGCCTCGGCCGAAA
CCATTCTTGAACGTCTGGTAGCGTTCACCCCAAGCACCACTGATACCGTACCGGGCCTGGCTGAAAGCTGGGACATCAGC
CCCGACGGTCTGACGTACACTTTCAAACTGCGAAAGGGCGTCAAATTCCAGACCACCGACTACTTCAAGCCCACCCGCGA
AATGAATGCCGATGACGTGGTCTGGAGCTTCAAGCGCCAGTTGGACCCCAAGCATCCGTGGCACGCACTTTCGCTGGTCG
GCTACCCCTATTTTGAAAGCATGGGCTTCCAGAACTTGCTCAAGGACGTCGAAAAAGTTGACGACTCCACCGTCAAGTTC
ACCCTTGCGCATCCCGAGTCGCCATTCCTGCGTGATCTGGCGATGCCGTTCACCTCGATCTATTCCGCCGAATACGCCGA
CCAGTTGCTCAAGAGCAACAAGACCGCCGAACTCAACAGCAAACCGATTGGCACCGGCCCGTTCATCCTGACTCGCTATG
CCAAGGATGCCCAAGTCCGCTATAAAGCCAACCCGAATTACTGGAAAGGCAAAGTGCCGAGTGAAGCACTGATCTTTGCC
ATCACTCTGGACAACAACACACGCCTGCAAAAGCTCAAGGCGAATGAATGTCAGGTTGCGCTTTACCCAAAACCTGACGA
TATTGCCAACATCAAGGCTGACCCCAATCTCAAGATCGACGAGATGGAGTCCATGATGACCAGCTACCTGGCCATGAACA
CCTCGCACAAATACCTGAGCGATGTGCGCGTGCGGCAGGCGATCAATCTGGCCTTCGACAAGAAATCGTACATCAGGGCA
CTGTTTGGCGAAGGCAAGGCCACTGAGGGTGTAGGCCCGTATCCACCGACCATGATGGGTTACGACACCGCTAGCAAGAG
CCCCGCATACGATCCTGACAAGGCCCGTGCGCTGCTCAAGGAAGCCGGCGTACCTGAGGGTCAGGTATTCACCCTGTTTG
CTCGAAATGGCGGCGCGGTGACCAACCCGAACCCGATGGTAGGCGCACAGATGCTTCAGTCGGACATGGCCAAGGTCGGG
ATCAAGATAGACATTCGCATCATGGAATGGGGCGAAATGCTCAAGCGCGCCAAAAATGGCGAACACGACATGGTTTTTGC
CGGATGGGCTGGCGACAATGGCGACCCGGATAACTTCCTCACGCCCAACCTGAGCTGTGACGCGGCCAAAAATGGCGAGA
ACTATGCCCGCTGGTGCAACAACGCGTTCGAGGACGCAATCACTCAAGCACGAAAAATAACCGAACCGGCGGAACGTGCC
GCCCTCTATAAGCAGGCTCAACAAGTGTTCAATCAAGAACAGCCCTGGATCAGCCTGGCTTACCCGAAACTTTTCGTTGC
AATGCGCAAAGATGTCGAAGGCTTTAAAATAAGCCCTTTGACCAATAACAACTTCGCCACTACCCAGGTGAAGTAG

Upstream 100 bases:

>100_bases
TCTGGTGACCACCGTTCCGTTCAACATTCTTTAAGCGGTCCCGTAGCCGTGGCTGACACAGGGTCAGTCACGGCTTCTTC
GATCAACAAGGAGGCTTCTA

Downstream 100 bases:

>100_bases
AAAAATAATCCGGCGAGCTCATAACCCGAGACTCGCCGGAGCACGCCTAACCGGCTGATGAGGTACACACCAAGATGTTT
AGTTTTATCGCCCGCCGAGT

Product: extracellular solute-binding protein

Products: ADP; phosphate; dipeptides [Cytoplasm] [C]

Alternate protein names: Dipeptide-binding protein; DBP [H]

Number of amino acids: Translated: 531; Mature: 531

Protein sequence:

>531_residues
MKLLSLRASIAIALLSAAATVSAKPLVVCTEASPEGFDIVQYTTAVTADASAETILERLVAFTPSTTDTVPGLAESWDIS
PDGLTYTFKLRKGVKFQTTDYFKPTREMNADDVVWSFKRQLDPKHPWHALSLVGYPYFESMGFQNLLKDVEKVDDSTVKF
TLAHPESPFLRDLAMPFTSIYSAEYADQLLKSNKTAELNSKPIGTGPFILTRYAKDAQVRYKANPNYWKGKVPSEALIFA
ITLDNNTRLQKLKANECQVALYPKPDDIANIKADPNLKIDEMESMMTSYLAMNTSHKYLSDVRVRQAINLAFDKKSYIRA
LFGEGKATEGVGPYPPTMMGYDTASKSPAYDPDKARALLKEAGVPEGQVFTLFARNGGAVTNPNPMVGAQMLQSDMAKVG
IKIDIRIMEWGEMLKRAKNGEHDMVFAGWAGDNGDPDNFLTPNLSCDAAKNGENYARWCNNAFEDAITQARKITEPAERA
ALYKQAQQVFNQEQPWISLAYPKLFVAMRKDVEGFKISPLTNNNFATTQVK

Sequences:

>Translated_531_residues
MKLLSLRASIAIALLSAAATVSAKPLVVCTEASPEGFDIVQYTTAVTADASAETILERLVAFTPSTTDTVPGLAESWDIS
PDGLTYTFKLRKGVKFQTTDYFKPTREMNADDVVWSFKRQLDPKHPWHALSLVGYPYFESMGFQNLLKDVEKVDDSTVKF
TLAHPESPFLRDLAMPFTSIYSAEYADQLLKSNKTAELNSKPIGTGPFILTRYAKDAQVRYKANPNYWKGKVPSEALIFA
ITLDNNTRLQKLKANECQVALYPKPDDIANIKADPNLKIDEMESMMTSYLAMNTSHKYLSDVRVRQAINLAFDKKSYIRA
LFGEGKATEGVGPYPPTMMGYDTASKSPAYDPDKARALLKEAGVPEGQVFTLFARNGGAVTNPNPMVGAQMLQSDMAKVG
IKIDIRIMEWGEMLKRAKNGEHDMVFAGWAGDNGDPDNFLTPNLSCDAAKNGENYARWCNNAFEDAITQARKITEPAERA
ALYKQAQQVFNQEQPWISLAYPKLFVAMRKDVEGFKISPLTNNNFATTQVK
>Mature_531_residues
MKLLSLRASIAIALLSAAATVSAKPLVVCTEASPEGFDIVQYTTAVTADASAETILERLVAFTPSTTDTVPGLAESWDIS
PDGLTYTFKLRKGVKFQTTDYFKPTREMNADDVVWSFKRQLDPKHPWHALSLVGYPYFESMGFQNLLKDVEKVDDSTVKF
TLAHPESPFLRDLAMPFTSIYSAEYADQLLKSNKTAELNSKPIGTGPFILTRYAKDAQVRYKANPNYWKGKVPSEALIFA
ITLDNNTRLQKLKANECQVALYPKPDDIANIKADPNLKIDEMESMMTSYLAMNTSHKYLSDVRVRQAINLAFDKKSYIRA
LFGEGKATEGVGPYPPTMMGYDTASKSPAYDPDKARALLKEAGVPEGQVFTLFARNGGAVTNPNPMVGAQMLQSDMAKVG
IKIDIRIMEWGEMLKRAKNGEHDMVFAGWAGDNGDPDNFLTPNLSCDAAKNGENYARWCNNAFEDAITQARKITEPAERA
ALYKQAQQVFNQEQPWISLAYPKLFVAMRKDVEGFKISPLTNNNFATTQVK

Specific function: Dipeptide-binding protein of a transport system that can be subject to osmotic shock. DppA is also required for peptide chemotaxis [H]

COG id: COG0747

COG function: function code E; ABC-type dipeptide transport system, periplasmic component

Gene ontology:

Cell location: Periplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the bacterial solute-binding protein 5 family [H]

Homologues:

Organism=Escherichia coli, GI1789966, Length=526, Percent_Identity=46.5779467680608, Blast_Score=495, Evalue=1e-141,
Organism=Escherichia coli, GI1787551, Length=508, Percent_Identity=34.4488188976378, Blast_Score=320, Evalue=1e-88,
Organism=Escherichia coli, GI1787052, Length=465, Percent_Identity=33.5483870967742, Blast_Score=209, Evalue=3e-55,
Organism=Escherichia coli, GI1787762, Length=536, Percent_Identity=25.9328358208955, Blast_Score=141, Evalue=1e-34,
Organism=Escherichia coli, GI1789887, Length=489, Percent_Identity=25.5623721881391, Blast_Score=134, Evalue=2e-32,
Organism=Escherichia coli, GI1789397, Length=478, Percent_Identity=26.5690376569038, Blast_Score=114, Evalue=2e-26,
Organism=Escherichia coli, GI1787495, Length=453, Percent_Identity=22.9580573951435, Blast_Score=107, Evalue=3e-24,
Organism=Escherichia coli, GI87081878, Length=452, Percent_Identity=22.5663716814159, Blast_Score=80, Evalue=4e-16,

Paralogues:

None

Copy number: 660 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 2980 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 40 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000914 [H]

Pfam domain/function: PF00496 SBP_bac_5 [H]

EC number: NA

Molecular weight: Translated: 58987; Mature: 58987

Theoretical pI: Translated: 7.04; Mature: 7.04

Prosite motif: PS01040 SBP_BACTERIAL_5

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLLSLRASIAIALLSAAATVSAKPLVVCTEASPEGFDIVQYTTAVTADASAETILERLV
CCHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCEEEEEEEEEECCCCHHHHHHHHH
AFTPSTTDTVPGLAESWDISPDGLTYTFKLRKGVKFQTTDYFKPTREMNADDVVWSFKRQ
HCCCCCCCCCCCCHHCCCCCCCCEEEEEEECCCCEEEECCCCCCHHCCCCHHHHHHHHHH
LDPKHPWHALSLVGYPYFESMGFQNLLKDVEKVDDSTVKFTLAHPESPFLRDLAMPFTSI
CCCCCCCEEEEEECCHHHHHCCHHHHHHHHHHCCCCEEEEEEECCCCHHHHHHHHHHHHH
YSAEYADQLLKSNKTAELNSKPIGTGPFILTRYAKDAQVRYKANPNYWKGKVPSEALIFA
HHHHHHHHHHHCCCCCCCCCCCCCCCCEEEEEECCCCEEEEECCCCCCCCCCCCCEEEEE
ITLDNNTRLQKLKANECQVALYPKPDDIANIKADPNLKIDEMESMMTSYLAMNTSHKYLS
EEECCCCHHHEEECCCCEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCHHHHH
DVRVRQAINLAFDKKSYIRALFGEGKATEGVGPYPPTMMGYDTASKSPAYDPDKARALLK
HHHHHHHHHHHHCHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHH
EAGVPEGQVFTLFARNGGAVTNPNPMVGAQMLQSDMAKVGIKIDIRIMEWGEMLKRAKNG
HCCCCCCCEEEEEECCCCCCCCCCCHHHHHHHHHHHHHCCEEEEEEEEHHHHHHHHHCCC
EHDMVFAGWAGDNGDPDNFLTPNLSCDAAKNGENYARWCNNAFEDAITQARKITEPAERA
CCCEEEEEECCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHH
ALYKQAQQVFNQEQPWISLAYPKLFVAMRKDVEGFKISPLTNNNFATTQVK
HHHHHHHHHHCCCCCEEEECHHHHHHHHHHCCCCEEEECCCCCCEEEEEEC
>Mature Secondary Structure
MKLLSLRASIAIALLSAAATVSAKPLVVCTEASPEGFDIVQYTTAVTADASAETILERLV
CCHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCEEEEEEEEEECCCCHHHHHHHHH
AFTPSTTDTVPGLAESWDISPDGLTYTFKLRKGVKFQTTDYFKPTREMNADDVVWSFKRQ
HCCCCCCCCCCCCHHCCCCCCCCEEEEEEECCCCEEEECCCCCCHHCCCCHHHHHHHHHH
LDPKHPWHALSLVGYPYFESMGFQNLLKDVEKVDDSTVKFTLAHPESPFLRDLAMPFTSI
CCCCCCCEEEEEECCHHHHHCCHHHHHHHHHHCCCCEEEEEEECCCCHHHHHHHHHHHHH
YSAEYADQLLKSNKTAELNSKPIGTGPFILTRYAKDAQVRYKANPNYWKGKVPSEALIFA
HHHHHHHHHHHCCCCCCCCCCCCCCCCEEEEEECCCCEEEEECCCCCCCCCCCCCEEEEE
ITLDNNTRLQKLKANECQVALYPKPDDIANIKADPNLKIDEMESMMTSYLAMNTSHKYLS
EEECCCCHHHEEECCCCEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCHHHHH
DVRVRQAINLAFDKKSYIRALFGEGKATEGVGPYPPTMMGYDTASKSPAYDPDKARALLK
HHHHHHHHHHHHCHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHH
EAGVPEGQVFTLFARNGGAVTNPNPMVGAQMLQSDMAKVGIKIDIRIMEWGEMLKRAKNG
HCCCCCCCEEEEEECCCCCCCCCCCHHHHHHHHHHHHHCCEEEEEEEEHHHHHHHHHCCC
EHDMVFAGWAGDNGDPDNFLTPNLSCDAAKNGENYARWCNNAFEDAITQARKITEPAERA
CCCEEEEEECCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHH
ALYKQAQQVFNQEQPWISLAYPKLFVAMRKDVEGFKISPLTNNNFATTQVK
HHHHHHHHHHCCCCCEEEECHHHHHHHHHHCCCCEEEECCCCCCEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; dipeptides [Periplasm]; H2O [C]

Specific reaction: ATP + dipeptides [Periplasm] + H2O = ADP + phosphate + dipeptides [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1702779; 1956284; 7536291; 8041620; 9278503; 9298646; 9600841; 8563629; 8527431 [H]