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The map label for this gene is nhaA [H]

Identifier: 66047437

GI number: 66047437

Start: 5014645

End: 5015823

Strand: Reverse

Name: nhaA [H]

Synonym: Psyr_4210

Alternate gene names: 66047437

Gene position: 5015823-5014645 (Counterclockwise)

Preceding gene: 66047438

Following gene: 66047436

Centisome position: 82.31

GC content: 63.53

Gene sequence:

>1179_bases
ATGCACAAACCCACCCCTCGTACCGAATCCCCGAATGCACTGGCGTTCATCACGCGTTTCTTCGCTGCTGAATCCGCTGG
CGGGCTGGTGTTGATGGCAGCCGCGCTGGCGGCCCTGATCGTTGCCAACTCACCGCTGGGCGACAGCTACTTCGCCGCGC
TGCACGCAGTGTTCGCCGGTTTGTCGGTTTCGCACTGGATCAACGACGGTCTGATGGCGATCTTCTTCATGCTCGTCGGC
CTGGAGATCAAGCGCGAGGTGCTCGCCGGTCAGCTTGCCTCCTGGAGCCAGAGAGCCTTGCCGGGCTTTGCGGCGCTTGG
CGGCATGCTGGTTCCGGCGCTGATCTACGTGGCCTTCAACTGGGGGCGGCCAGACACCATCGGCGGCTGGGCCATTCCGG
CAGCGACCGATATCGCGTTCGCCCTGGGTGTGCTGTCACTGCTGGGCAAGCGCGTGCCGCTGTCGCTTAAGATCTTCCTG
TCGGCACTGGCGATTCTCGATGATCTCGGCGCGGTGCTGATCATCGCGTTGTTCTACACCAGCGATCTCTCCATTCCCAT
GCTGCTCGCAGCGCTGGGCTCCATCGCCATGCTCGTCGCGCTGAATCGTCTGGGTGTTAAAAAACTGCTGCCTTACCTCA
TCGTCGGCGCGCTGCTGTGGTTTTTCATGCTCCAGTCCGGCATCCACGCCACCCTCGCGGGCGTCGCGCTGGCGCTGTGC
ATCCCGTTGGGCAAACCCGATGAAGAGGCCCGCTCGCCGCTGCTGCACCTGGAAGAAAAGCTGCACCCATGGGTGGCGTT
TGCCGTCGTACCGATCTTTGGTTTTGCCAACGCTGGCGTGTCACTGTCGGGCATTACCGCCGACACGCTCGTGGACCCGG
TCCCGCTCGGCGTTGCGCTAGGACTGCTGGTCGGCAAACAGGTCGGCATATTCGCCATGGCCGCGCTGGCGATTCGCGCA
GGCCTGGCGCGCTTGCCGGATGGCAGCAACTGGGGCCAGCTTTATGGCGTTGCAGCCTTGTGTGGTATCGGCTTCACCAT
GAGCCTGTTCATTGGCGCACTGGCCTTCCCGGGCGCGCCGGAACTGGTCGATGAGGTCAAGGTGGGCGTGCTGATCGGTT
CGGTGTTGTCGGCTGTGCTGGGTGTGGTGGTGTTGCGCAGGTTTGCGCAGCGGGGGTGA

Upstream 100 bases:

>100_bases
GGGAAACGTTAATTTGTATCCTCAGGTTTACCAGGCCTTTGACAGGTTCTGCCGGTGGTAAAATTGCGACCTTTTTGCGC
TGTACCCCCGCGGAGCTGTC

Downstream 100 bases:

>100_bases
AGTTGCAGCAGTCCTTGGCACGACAGTTACAAGATTATCGTTCCTCACGCTCCAGCGTGGGAATGCCGTTCTGGACGCTC
CGCGTCCGGGTAGCGGAGTC

Product: pH-dependent sodium/proton antiporter

Products: Na (I) [Periplasm]; Proton [Cytoplasm] [C]

Alternate protein names: Sodium/proton antiporter nhaA 1 [H]

Number of amino acids: Translated: 392; Mature: 392

Protein sequence:

>392_residues
MHKPTPRTESPNALAFITRFFAAESAGGLVLMAAALAALIVANSPLGDSYFAALHAVFAGLSVSHWINDGLMAIFFMLVG
LEIKREVLAGQLASWSQRALPGFAALGGMLVPALIYVAFNWGRPDTIGGWAIPAATDIAFALGVLSLLGKRVPLSLKIFL
SALAILDDLGAVLIIALFYTSDLSIPMLLAALGSIAMLVALNRLGVKKLLPYLIVGALLWFFMLQSGIHATLAGVALALC
IPLGKPDEEARSPLLHLEEKLHPWVAFAVVPIFGFANAGVSLSGITADTLVDPVPLGVALGLLVGKQVGIFAMAALAIRA
GLARLPDGSNWGQLYGVAALCGIGFTMSLFIGALAFPGAPELVDEVKVGVLIGSVLSAVLGVVVLRRFAQRG

Sequences:

>Translated_392_residues
MHKPTPRTESPNALAFITRFFAAESAGGLVLMAAALAALIVANSPLGDSYFAALHAVFAGLSVSHWINDGLMAIFFMLVG
LEIKREVLAGQLASWSQRALPGFAALGGMLVPALIYVAFNWGRPDTIGGWAIPAATDIAFALGVLSLLGKRVPLSLKIFL
SALAILDDLGAVLIIALFYTSDLSIPMLLAALGSIAMLVALNRLGVKKLLPYLIVGALLWFFMLQSGIHATLAGVALALC
IPLGKPDEEARSPLLHLEEKLHPWVAFAVVPIFGFANAGVSLSGITADTLVDPVPLGVALGLLVGKQVGIFAMAALAIRA
GLARLPDGSNWGQLYGVAALCGIGFTMSLFIGALAFPGAPELVDEVKVGVLIGSVLSAVLGVVVLRRFAQRG
>Mature_392_residues
MHKPTPRTESPNALAFITRFFAAESAGGLVLMAAALAALIVANSPLGDSYFAALHAVFAGLSVSHWINDGLMAIFFMLVG
LEIKREVLAGQLASWSQRALPGFAALGGMLVPALIYVAFNWGRPDTIGGWAIPAATDIAFALGVLSLLGKRVPLSLKIFL
SALAILDDLGAVLIIALFYTSDLSIPMLLAALGSIAMLVALNRLGVKKLLPYLIVGALLWFFMLQSGIHATLAGVALALC
IPLGKPDEEARSPLLHLEEKLHPWVAFAVVPIFGFANAGVSLSGITADTLVDPVPLGVALGLLVGKQVGIFAMAALAIRA
GLARLPDGSNWGQLYGVAALCGIGFTMSLFIGALAFPGAPELVDEVKVGVLIGSVLSAVLGVVVLRRFAQRG

Specific function: Na(+)/H(+) antiporter that extrudes sodium in exchange for external protons [H]

COG id: COG3004

COG function: function code P; Na+/H+ antiporter

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the nhaA Na(+)/H(+) (TC 2.A.33) antiporter family [H]

Homologues:

Organism=Escherichia coli, GI1786201, Length=383, Percent_Identity=52.4804177545692, Blast_Score=340, Evalue=9e-95,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR023171
- InterPro:   IPR004670 [H]

Pfam domain/function: PF06965 Na_H_antiport_1 [H]

EC number: NA

Molecular weight: Translated: 40804; Mature: 40804

Theoretical pI: Translated: 8.24; Mature: 8.24

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHKPTPRTESPNALAFITRFFAAESAGGLVLMAAALAALIVANSPLGDSYFAALHAVFAG
CCCCCCCCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHH
LSVSHWINDGLMAIFFMLVGLEIKREVLAGQLASWSQRALPGFAALGGMLVPALIYVAFN
HHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHC
WGRPDTIGGWAIPAATDIAFALGVLSLLGKRVPLSLKIFLSALAILDDLGAVLIIALFYT
CCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
SDLSIPMLLAALGSIAMLVALNRLGVKKLLPYLIVGALLWFFMLQSGIHATLAGVALALC
CCCCHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHH
IPLGKPDEEARSPLLHLEEKLHPWVAFAVVPIFGFANAGVSLSGITADTLVDPVPLGVAL
HCCCCCCHHHHCHHHHHHHHHHHHHHHHHHHHHHHHCCCCEECCCCHHHHCCCHHHHHHH
GLLVGKQVGIFAMAALAIRAGLARLPDGSNWGQLYGVAALCGIGFTMSLFIGALAFPGAP
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCH
ELVDEVKVGVLIGSVLSAVLGVVVLRRFAQRG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MHKPTPRTESPNALAFITRFFAAESAGGLVLMAAALAALIVANSPLGDSYFAALHAVFAG
CCCCCCCCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHH
LSVSHWINDGLMAIFFMLVGLEIKREVLAGQLASWSQRALPGFAALGGMLVPALIYVAFN
HHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHC
WGRPDTIGGWAIPAATDIAFALGVLSLLGKRVPLSLKIFLSALAILDDLGAVLIIALFYT
CCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
SDLSIPMLLAALGSIAMLVALNRLGVKKLLPYLIVGALLWFFMLQSGIHATLAGVALALC
CCCCHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHH
IPLGKPDEEARSPLLHLEEKLHPWVAFAVVPIFGFANAGVSLSGITADTLVDPVPLGVAL
HCCCCCCHHHHCHHHHHHHHHHHHHHHHHHHHHHHHCCCCEECCCCHHHHCCCHHHHHHH
GLLVGKQVGIFAMAALAIRAGLARLPDGSNWGQLYGVAALCGIGFTMSLFIGALAFPGAP
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCH
ELVDEVKVGVLIGSVLSAVLGVVVLRRFAQRG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Na (I) [Cytoplasm]; Proton [Periplasm] [C]

Specific reaction: Na (I) [Cytoplasm] + 2 Proton [Periplasm] = Na (I) [Periplasm] + 2 Proton [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 12928499 [H]