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The map label for this gene is trpS [H]

Identifier: 66047350

GI number: 66047350

Start: 4912176

End: 4913525

Strand: Reverse

Name: trpS [H]

Synonym: Psyr_4123

Alternate gene names: 66047350

Gene position: 4913525-4912176 (Counterclockwise)

Preceding gene: 66047351

Following gene: 66047349

Centisome position: 80.63

GC content: 61.33

Gene sequence:

>1350_bases
ATGACCACTCGTATCCTGACCGGTATCACGACCACCGGCACTCCCCATCTGGGCAACTACGCGGGCGCCATTCGCCCGGC
CATTGTCGCCAGCCGTCAGAGCGATTTCGACTCGTTCTACTTTCTGGCCGACTACCACGCGCTGATCAAATGCGATGACC
CGCTGCGCATTCAGCGCTCGCGTCTGGAAATCGCCGCGACCTGGCTGGCAGCGGGGCTGGACGTTGATCGTGTGACCTTC
TATCGCCAGTCGGACATCCCTGAAATCCCGGAACTGACCTGGCTGCTCACCTGCGTCGCGGCCAAGGGCCTGCTCAATCG
CGCCCACGCCTACAAGGCGTCGGTAGACAAGAACGTGGAAGGTGGTGAAGACCCGGATGCAGGCATCACCATGGGGCTGT
ACAGCTACCCGGTGCTGATGGCTGCCGACATCCTGATGTTCAATGCGCATCAGGTTCCGGTAGGCCGCGATCAGATTCAG
CACGTTGAAATGGCACGCGACATCGGCCAGCGTTTCAATCACCTGTTCGGCAATGGCAAGGAATTCTTCGTCATGCCCGA
GGCGCTGATCGAAGAGAGCGTGGCGACGCTGCCCGGTCTGGACGGTCGCAAGATGTCCAAGAGCTACGACAACACCATCC
CGTTGTTCAGCGCTGCCAAGGACATGAAAGGCGCGATATCGCGCATCGTCACCGACTCACGTGCGCCGGGTGAAGCAAAA
GACCCGGACACCTCGCACCTGTTTACCCTGTATCAGGCCTTCTCGACCGCCGAGCAGTGCGCTGAATTCCGTTCCGACCT
GTTGCAGGGCCTGGGTTGGGGTGAAGCCAAGAATCGTCTGTTCACGTTGCTGGATGCGCAGCTTAGCGAGCCCCGTGAAA
AGTATCTGGGGCTGATCGAGCGTCCTGCCGATCTCGAAGACATCCTGCTCGCTGGCGCACAGAAAGCCCGACGTGTCGCC
ACCCCTTTCCTCGAAGAGTTGCGCGAGGCGGTGGGCCTGCGGTCGTTCCGTACCGTGGTGCAGAACGCCGACACCGGCAA
GAAGAAGGCCACTAAAGGCGCCCGTTTCGTCAGCTTCCGTGAAGACGACGGCAGCTTCCGTTTCCGTCTGCTGGCAGCCG
ATGGCGAGCAGTTGCTGTTGTCGCGCAATTTTGCCGATGGCAAGGCGGCTGGCGTGGTCAGCAAGCAGTTGCAGCAGGGC
GGTGAACTGGACCTGCGCAGCGAAGACGATCGCTTCACGCTGTGGCTGAACGGCGCCTGTGTGGCGGACAGTCCGGTATT
CGCCGACGCTGCCACGCGCGACAGTGCCATCGAAACGCTCAAGCTGGCGCTCGCTCCCCAACAGGACTGA

Upstream 100 bases:

>100_bases
CTTTTTTCACGGCAAGCTGACTGATCTGAAAGATCTGCTCCTGCCGCGACTTTCCAGCTGATTGCAGCCCGTATTGCATC
CTATTGATAAGCGACCTGCC

Downstream 100 bases:

>100_bases
TTGCCAATCCCCGGGGTCGTCGCTACAGTGACGACCCGTTTTTGTTGCCTTGCTAACGAATTATGACGCCCCTAGAACGA
TATCAAGCTGATCTGAAACG

Product: tryptophanyl-tRNA synthetase

Products: NA

Alternate protein names: Tryptophan--tRNA ligase; TrpRS [H]

Number of amino acids: Translated: 449; Mature: 448

Protein sequence:

>449_residues
MTTRILTGITTTGTPHLGNYAGAIRPAIVASRQSDFDSFYFLADYHALIKCDDPLRIQRSRLEIAATWLAAGLDVDRVTF
YRQSDIPEIPELTWLLTCVAAKGLLNRAHAYKASVDKNVEGGEDPDAGITMGLYSYPVLMAADILMFNAHQVPVGRDQIQ
HVEMARDIGQRFNHLFGNGKEFFVMPEALIEESVATLPGLDGRKMSKSYDNTIPLFSAAKDMKGAISRIVTDSRAPGEAK
DPDTSHLFTLYQAFSTAEQCAEFRSDLLQGLGWGEAKNRLFTLLDAQLSEPREKYLGLIERPADLEDILLAGAQKARRVA
TPFLEELREAVGLRSFRTVVQNADTGKKKATKGARFVSFREDDGSFRFRLLAADGEQLLLSRNFADGKAAGVVSKQLQQG
GELDLRSEDDRFTLWLNGACVADSPVFADAATRDSAIETLKLALAPQQD

Sequences:

>Translated_449_residues
MTTRILTGITTTGTPHLGNYAGAIRPAIVASRQSDFDSFYFLADYHALIKCDDPLRIQRSRLEIAATWLAAGLDVDRVTF
YRQSDIPEIPELTWLLTCVAAKGLLNRAHAYKASVDKNVEGGEDPDAGITMGLYSYPVLMAADILMFNAHQVPVGRDQIQ
HVEMARDIGQRFNHLFGNGKEFFVMPEALIEESVATLPGLDGRKMSKSYDNTIPLFSAAKDMKGAISRIVTDSRAPGEAK
DPDTSHLFTLYQAFSTAEQCAEFRSDLLQGLGWGEAKNRLFTLLDAQLSEPREKYLGLIERPADLEDILLAGAQKARRVA
TPFLEELREAVGLRSFRTVVQNADTGKKKATKGARFVSFREDDGSFRFRLLAADGEQLLLSRNFADGKAAGVVSKQLQQG
GELDLRSEDDRFTLWLNGACVADSPVFADAATRDSAIETLKLALAPQQD
>Mature_448_residues
TTRILTGITTTGTPHLGNYAGAIRPAIVASRQSDFDSFYFLADYHALIKCDDPLRIQRSRLEIAATWLAAGLDVDRVTFY
RQSDIPEIPELTWLLTCVAAKGLLNRAHAYKASVDKNVEGGEDPDAGITMGLYSYPVLMAADILMFNAHQVPVGRDQIQH
VEMARDIGQRFNHLFGNGKEFFVMPEALIEESVATLPGLDGRKMSKSYDNTIPLFSAAKDMKGAISRIVTDSRAPGEAKD
PDTSHLFTLYQAFSTAEQCAEFRSDLLQGLGWGEAKNRLFTLLDAQLSEPREKYLGLIERPADLEDILLAGAQKARRVAT
PFLEELREAVGLRSFRTVVQNADTGKKKATKGARFVSFREDDGSFRFRLLAADGEQLLLSRNFADGKAAGVVSKQLQQGG
ELDLRSEDDRFTLWLNGACVADSPVFADAATRDSAIETLKLALAPQQD

Specific function: Unknown

COG id: COG0180

COG function: function code J; Tryptophanyl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I aminoacyl-tRNA synthetase family [H]

Homologues:

Organism=Homo sapiens, GI7710154, Length=339, Percent_Identity=30.3834808259587, Blast_Score=144, Evalue=1e-34,
Organism=Homo sapiens, GI41352700, Length=192, Percent_Identity=37.5, Blast_Score=140, Evalue=2e-33,
Organism=Escherichia coli, GI1789786, Length=339, Percent_Identity=34.2182890855457, Blast_Score=171, Evalue=8e-44,
Organism=Caenorhabditis elegans, GI71982800, Length=355, Percent_Identity=30.7042253521127, Blast_Score=131, Evalue=9e-31,
Organism=Caenorhabditis elegans, GI71982793, Length=355, Percent_Identity=30.7042253521127, Blast_Score=128, Evalue=6e-30,
Organism=Saccharomyces cerevisiae, GI6320474, Length=346, Percent_Identity=30.3468208092486, Blast_Score=147, Evalue=3e-36,
Organism=Drosophila melanogaster, GI24666151, Length=343, Percent_Identity=29.4460641399417, Blast_Score=123, Evalue=3e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002305
- InterPro:   IPR014729
- InterPro:   IPR002306 [H]

Pfam domain/function: PF00579 tRNA-synt_1b [H]

EC number: =6.1.1.2 [H]

Molecular weight: Translated: 49444; Mature: 49312

Theoretical pI: Translated: 5.24; Mature: 5.24

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTRILTGITTTGTPHLGNYAGAIRPAIVASRQSDFDSFYFLADYHALIKCDDPLRIQRS
CCCEEEECEECCCCCCCCCHHHHHHHHHHHCCCCCCCCEEHEEECEEEEECCCCHHHHHH
RLEIAATWLAAGLDVDRVTFYRQSDIPEIPELTWLLTCVAAKGLLNRAHAYKASVDKNVE
HHHHHHHHHHHCCCHHHEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
GGEDPDAGITMGLYSYPVLMAADILMFNAHQVPVGRDQIQHVEMARDIGQRFNHLFGNGK
CCCCCCCCEEEHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCC
EFFVMPEALIEESVATLPGLDGRKMSKSYDNTIPLFSAAKDMKGAISRIVTDSRAPGEAK
EEEEECHHHHHHHHHHCCCCCCCHHHCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCC
DPDTSHLFTLYQAFSTAEQCAEFRSDLLQGLGWGEAKNRLFTLLDAQLSEPREKYLGLIE
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCHHHHHHHHHC
RPADLEDILLAGAQKARRVATPFLEELREAVGLRSFRTVVQNADTGKKKATKGARFVSFR
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHCCCCCHHHHCCCCEEEEEE
EDDGSFRFRLLAADGEQLLLSRNFADGKAAGVVSKQLQQGGELDLRSEDDRFTLWLNGAC
CCCCCEEEEEEECCCCEEEEECCCCCCHHHHHHHHHHHCCCCCCCCCCCCEEEEEECCEE
VADSPVFADAATRDSAIETLKLALAPQQD
EECCCCCCCCCCHHHHHHHHHHCCCCCCC
>Mature Secondary Structure 
TTRILTGITTTGTPHLGNYAGAIRPAIVASRQSDFDSFYFLADYHALIKCDDPLRIQRS
CCEEEECEECCCCCCCCCHHHHHHHHHHHCCCCCCCCEEHEEECEEEEECCCCHHHHHH
RLEIAATWLAAGLDVDRVTFYRQSDIPEIPELTWLLTCVAAKGLLNRAHAYKASVDKNVE
HHHHHHHHHHHCCCHHHEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
GGEDPDAGITMGLYSYPVLMAADILMFNAHQVPVGRDQIQHVEMARDIGQRFNHLFGNGK
CCCCCCCCEEEHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCC
EFFVMPEALIEESVATLPGLDGRKMSKSYDNTIPLFSAAKDMKGAISRIVTDSRAPGEAK
EEEEECHHHHHHHHHHCCCCCCCHHHCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCC
DPDTSHLFTLYQAFSTAEQCAEFRSDLLQGLGWGEAKNRLFTLLDAQLSEPREKYLGLIE
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCHHHHHHHHHC
RPADLEDILLAGAQKARRVATPFLEELREAVGLRSFRTVVQNADTGKKKATKGARFVSFR
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHCCCCCHHHHCCCCEEEEEE
EDDGSFRFRLLAADGEQLLLSRNFADGKAAGVVSKQLQQGGELDLRSEDDRFTLWLNGAC
CCCCCEEEEEEECCCCEEEEECCCCCCHHHHHHHHHHHCCCCCCCCCCCCEEEEEECCEE
VADSPVFADAATRDSAIETLKLALAPQQD
EECCCCCCCCCCHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12928499 [H]