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The map label for this gene is groEL [H]

Identifier: 66047299

GI number: 66047299

Start: 4855526

End: 4857169

Strand: Reverse

Name: groEL [H]

Synonym: Psyr_4072

Alternate gene names: 66047299

Gene position: 4857169-4855526 (Counterclockwise)

Preceding gene: 66047300

Following gene: 66047297

Centisome position: 79.71

GC content: 57.48

Gene sequence:

>1644_bases
ATGGCTGCTAAAGAAGTTAAATTCGGCGATTCTGGCCGCAAAAAAATGCTCGCCGGTGTAAACGTCCTGGCTGACGCAGT
TAAAGCGACCCTGGGCCCTAAAGGCCGCAACGTTATCATCGAGAAAAGCTTTGGCGCTCCGCTGATCACCAAAGACGGTG
TTTCGGTTGCCAAGGAAATCGAGCTTAAAGACCGTTTCGAAAACATGGGCGCGCAGCTGGTCAAAGACGTTGCTTCCCGT
GCCAACGATGATGCAGGCGACGGTACCACTACCGCTACCGTTCTGGCTCAGGCCATCGTCAACGAAGGCCTGAAGGCTGT
CGCTGCCGGCATGAACCCGATGGACCTCAAGCGCGGCATCGACAAGGCGACCATCGCCATTGTTGCCGAGCTGAAGAAGC
TGTCCAAGCCATGCACCGACACCAAGGCAATCGCCCAGGTCGGCACCATCTCGGCCAACTCTGATCACTCCATCGGCGAC
ATCATTGCCGAAGCCATGGAAAAAGTGACCAAAGACGGCGTTATCACCGTTGAAGAAGGTTCGGGCCTGGAAAACGAGCT
GTCTGTTGTAGAAGGCATGCAGTTTGACCGTGGTTACCTGTCCCCGTACTTCATCAACAAGCCGGACACCATGGTTGCCG
AGCTGGACAGCCCGCTGCTGTTGCTGGTCGACAAGAAGATCTCCAACATTCGCGAAATGCTGCCGGTTCTGGAAGCAGTC
GCCAAGGCTGGCCGTCCTCTGCTGATCGTTGCCGAAGACGTTGAAGGCGAAGCGCTGGCGACTCTGGTAGTCAACAACAT
GCGCGGTATCGTGAAAGTTGCAGCCGTCAAGGCTCCAGGTTTCGGCGATCGTCGCAAGGCCATGCTGCAGGACATCGCTG
TTCTGACTGGCGGTACCGTTATCTCCGAAGAGATCGGCCTGAGCCTGGAAACCACTACCCTGGAACACCTGGGTAATGCC
AAGCGCGTCATCCTGAACAAGGAAAACACCACCATCATCGATGGTGCCGGCGTGAAAACCGATATCGACTCGCGTATCTC
CCAGATCCGTCAGCAAATCGGCGACACCAGCTCGGACTACGACAAGGAAAAACTGCAAGAGCGTCTGGCCAAGCTGTCTG
GCGGCGTTGCAGTGATCAAGGTCGGTGCCGGTTCCGAAGTCGAGATGAAAGAGAAGAAAGCCCGCGTTGAAGACGCCCTG
CACGCAACCCGCGCAGCCGTTGAAGAAGGCGTGGTACCTGGCGGTGGCGTGGCACTGGTTCGCTCGCTGCAGGCTATCGA
AGGTCTGAAAGGCGACAACGCTGATCAGGACGTCGGTATCGCTCTGCTGCGTCGTGCAGTCGAAGCGCCTCTGCGCCAGA
TCGTTGCCAACTCCGGTGACGAGCCAAGCGTTGTTGTCGACAAGGTCAAGCAGGGTTCGGGTAACTACGGTTACAACGCT
GCTTCCGGCGAATACGGCGACATGATCGAAATGGGTATCCTTGACCCGGCCAAAGTGACTCGCTCTGCTCTGCAGGCGGC
GTCCTCCATCGCCAGCTTGATGATCACCACCGAAGCGATGATCGCTGACGTGCCTGAAGACAAGCCAGCAGGCGGCGGCA
TGCCGGACATGGGCGGCATGGGTGGTATGGGCGGCATGATGTAA

Upstream 100 bases:

>100_bases
GACCTGCTGGTGATGAGCGAGAACGAGATTCTTGCTGTCGTCGAAGGCTGAGTGCTCCCGCTGACTTCCGTTACTACTAA
GTATTCAAGGAATAATGATC

Downstream 100 bases:

>100_bases
GTCAGCTTTACCCCCAGCGTTACACCCATAAAGAACCCCGCCTTGTGCGGGGTTTTTTATGGTCTTTGTGTGCCGGATCA
ATCAATGCGTCGGTTGTACC

Product: chaperonin GroEL

Products: NA

Alternate protein names: GroEL protein; Protein Cpn60 [H]

Number of amino acids: Translated: 547; Mature: 546

Protein sequence:

>547_residues
MAAKEVKFGDSGRKKMLAGVNVLADAVKATLGPKGRNVIIEKSFGAPLITKDGVSVAKEIELKDRFENMGAQLVKDVASR
ANDDAGDGTTTATVLAQAIVNEGLKAVAAGMNPMDLKRGIDKATIAIVAELKKLSKPCTDTKAIAQVGTISANSDHSIGD
IIAEAMEKVTKDGVITVEEGSGLENELSVVEGMQFDRGYLSPYFINKPDTMVAELDSPLLLLVDKKISNIREMLPVLEAV
AKAGRPLLIVAEDVEGEALATLVVNNMRGIVKVAAVKAPGFGDRRKAMLQDIAVLTGGTVISEEIGLSLETTTLEHLGNA
KRVILNKENTTIIDGAGVKTDIDSRISQIRQQIGDTSSDYDKEKLQERLAKLSGGVAVIKVGAGSEVEMKEKKARVEDAL
HATRAAVEEGVVPGGGVALVRSLQAIEGLKGDNADQDVGIALLRRAVEAPLRQIVANSGDEPSVVVDKVKQGSGNYGYNA
ASGEYGDMIEMGILDPAKVTRSALQAASSIASLMITTEAMIADVPEDKPAGGGMPDMGGMGGMGGMM

Sequences:

>Translated_547_residues
MAAKEVKFGDSGRKKMLAGVNVLADAVKATLGPKGRNVIIEKSFGAPLITKDGVSVAKEIELKDRFENMGAQLVKDVASR
ANDDAGDGTTTATVLAQAIVNEGLKAVAAGMNPMDLKRGIDKATIAIVAELKKLSKPCTDTKAIAQVGTISANSDHSIGD
IIAEAMEKVTKDGVITVEEGSGLENELSVVEGMQFDRGYLSPYFINKPDTMVAELDSPLLLLVDKKISNIREMLPVLEAV
AKAGRPLLIVAEDVEGEALATLVVNNMRGIVKVAAVKAPGFGDRRKAMLQDIAVLTGGTVISEEIGLSLETTTLEHLGNA
KRVILNKENTTIIDGAGVKTDIDSRISQIRQQIGDTSSDYDKEKLQERLAKLSGGVAVIKVGAGSEVEMKEKKARVEDAL
HATRAAVEEGVVPGGGVALVRSLQAIEGLKGDNADQDVGIALLRRAVEAPLRQIVANSGDEPSVVVDKVKQGSGNYGYNA
ASGEYGDMIEMGILDPAKVTRSALQAASSIASLMITTEAMIADVPEDKPAGGGMPDMGGMGGMGGMM
>Mature_546_residues
AAKEVKFGDSGRKKMLAGVNVLADAVKATLGPKGRNVIIEKSFGAPLITKDGVSVAKEIELKDRFENMGAQLVKDVASRA
NDDAGDGTTTATVLAQAIVNEGLKAVAAGMNPMDLKRGIDKATIAIVAELKKLSKPCTDTKAIAQVGTISANSDHSIGDI
IAEAMEKVTKDGVITVEEGSGLENELSVVEGMQFDRGYLSPYFINKPDTMVAELDSPLLLLVDKKISNIREMLPVLEAVA
KAGRPLLIVAEDVEGEALATLVVNNMRGIVKVAAVKAPGFGDRRKAMLQDIAVLTGGTVISEEIGLSLETTTLEHLGNAK
RVILNKENTTIIDGAGVKTDIDSRISQIRQQIGDTSSDYDKEKLQERLAKLSGGVAVIKVGAGSEVEMKEKKARVEDALH
ATRAAVEEGVVPGGGVALVRSLQAIEGLKGDNADQDVGIALLRRAVEAPLRQIVANSGDEPSVVVDKVKQGSGNYGYNAA
SGEYGDMIEMGILDPAKVTRSALQAASSIASLMITTEAMIADVPEDKPAGGGMPDMGGMGGMGGMM

Specific function: Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions [H]

COG id: COG0459

COG function: function code O; Chaperonin GroEL (HSP60 family)

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the chaperonin (HSP60) family [H]

Homologues:

Organism=Homo sapiens, GI41399285, Length=527, Percent_Identity=51.8026565464896, Blast_Score=537, Evalue=1e-152,
Organism=Homo sapiens, GI31542947, Length=527, Percent_Identity=51.8026565464896, Blast_Score=537, Evalue=1e-152,
Organism=Homo sapiens, GI63162572, Length=568, Percent_Identity=20.7746478873239, Blast_Score=67, Evalue=4e-11,
Organism=Escherichia coli, GI1790586, Length=530, Percent_Identity=76.6037735849057, Blast_Score=815, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17555558, Length=528, Percent_Identity=52.8409090909091, Blast_Score=556, Evalue=1e-159,
Organism=Caenorhabditis elegans, GI193210679, Length=210, Percent_Identity=52.3809523809524, Blast_Score=223, Evalue=2e-58,
Organism=Caenorhabditis elegans, GI17564182, Length=569, Percent_Identity=23.5500878734622, Blast_Score=78, Evalue=1e-14,
Organism=Saccharomyces cerevisiae, GI6323288, Length=526, Percent_Identity=55.7034220532319, Blast_Score=565, Evalue=1e-162,
Organism=Saccharomyces cerevisiae, GI6322524, Length=162, Percent_Identity=28.3950617283951, Blast_Score=69, Evalue=3e-12,
Organism=Drosophila melanogaster, GI24641193, Length=526, Percent_Identity=53.041825095057, Blast_Score=562, Evalue=1e-160,
Organism=Drosophila melanogaster, GI24641191, Length=526, Percent_Identity=53.041825095057, Blast_Score=562, Evalue=1e-160,
Organism=Drosophila melanogaster, GI45550936, Length=524, Percent_Identity=51.5267175572519, Blast_Score=538, Evalue=1e-153,
Organism=Drosophila melanogaster, GI45550132, Length=524, Percent_Identity=51.5267175572519, Blast_Score=538, Evalue=1e-153,
Organism=Drosophila melanogaster, GI45550935, Length=524, Percent_Identity=51.5267175572519, Blast_Score=538, Evalue=1e-153,
Organism=Drosophila melanogaster, GI17864606, Length=553, Percent_Identity=43.0379746835443, Blast_Score=444, Evalue=1e-125,
Organism=Drosophila melanogaster, GI24584129, Length=530, Percent_Identity=38.3018867924528, Blast_Score=345, Evalue=4e-95,
Organism=Drosophila melanogaster, GI19921262, Length=530, Percent_Identity=38.3018867924528, Blast_Score=345, Evalue=4e-95,

Paralogues:

None

Copy number: 2180 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 360 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 480 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 15012 Molecules/Cell In: Growth Phase,

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018370
- InterPro:   IPR001844
- InterPro:   IPR002423 [H]

Pfam domain/function: PF00118 Cpn60_TCP1 [H]

EC number: NA

Molecular weight: Translated: 57227; Mature: 57095

Theoretical pI: Translated: 4.80; Mature: 4.80

Prosite motif: PS00296 CHAPERONINS_CPN60

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAAKEVKFGDSGRKKMLAGVNVLADAVKATLGPKGRNVIIEKSFGAPLITKDGVSVAKEI
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCEECCCHHHHHHH
ELKDRFENMGAQLVKDVASRANDDAGDGTTTATVLAQAIVNEGLKAVAAGMNPMDLKRGI
HHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHCC
DKATIAIVAELKKLSKPCTDTKAIAQVGTISANSDHSIGDIIAEAMEKVTKDGVITVEEG
CHHHHHHHHHHHHHCCCCCCHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHCCCEEEEECC
SGLENELSVVEGMQFDRGYLSPYFINKPDTMVAELDSPLLLLVDKKISNIREMLPVLEAV
CCCHHHHHHHHCCCCCCCCCCCEEECCCCHHHHHCCCCEEEEECHHHHHHHHHHHHHHHH
AKAGRPLLIVAEDVEGEALATLVVNNMRGIVKVAAVKAPGFGDRRKAMLQDIAVLTGGTV
HHCCCCEEEEEECCCCHHHHHHHHHHHHHHEEEEEEECCCCCHHHHHHHHHHHHHCCCEE
ISEEIGLSLETTTLEHLGNAKRVILNKENTTIIDGAGVKTDIDSRISQIRQQIGDTSSDY
EHHHHCCEEEHHHHHHCCCCEEEEEECCCCEEEECCCCCCCHHHHHHHHHHHHCCCCCCC
DKEKLQERLAKLSGGVAVIKVGAGSEVEMKEKKARVEDALHATRAAVEEGVVPGGGVALV
CHHHHHHHHHHHCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHH
RSLQAIEGLKGDNADQDVGIALLRRAVEAPLRQIVANSGDEPSVVVDKVKQGSGNYGYNA
HHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHCCCCCCCCCC
ASGEYGDMIEMGILDPAKVTRSALQAASSIASLMITTEAMIADVPEDKPAGGGMPDMGGM
CCCCCCCCHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCC
GGMGGMM
CCCCCCC
>Mature Secondary Structure 
AAKEVKFGDSGRKKMLAGVNVLADAVKATLGPKGRNVIIEKSFGAPLITKDGVSVAKEI
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCEECCCHHHHHHH
ELKDRFENMGAQLVKDVASRANDDAGDGTTTATVLAQAIVNEGLKAVAAGMNPMDLKRGI
HHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHCC
DKATIAIVAELKKLSKPCTDTKAIAQVGTISANSDHSIGDIIAEAMEKVTKDGVITVEEG
CHHHHHHHHHHHHHCCCCCCHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHCCCEEEEECC
SGLENELSVVEGMQFDRGYLSPYFINKPDTMVAELDSPLLLLVDKKISNIREMLPVLEAV
CCCHHHHHHHHCCCCCCCCCCCEEECCCCHHHHHCCCCEEEEECHHHHHHHHHHHHHHHH
AKAGRPLLIVAEDVEGEALATLVVNNMRGIVKVAAVKAPGFGDRRKAMLQDIAVLTGGTV
HHCCCCEEEEEECCCCHHHHHHHHHHHHHHEEEEEEECCCCCHHHHHHHHHHHHHCCCEE
ISEEIGLSLETTTLEHLGNAKRVILNKENTTIIDGAGVKTDIDSRISQIRQQIGDTSSDY
EHHHHCCEEEHHHHHHCCCCEEEEEECCCCEEEECCCCCCCHHHHHHHHHHHHCCCCCCC
DKEKLQERLAKLSGGVAVIKVGAGSEVEMKEKKARVEDALHATRAAVEEGVVPGGGVALV
CHHHHHHHHHHHCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHH
RSLQAIEGLKGDNADQDVGIALLRRAVEAPLRQIVANSGDEPSVVVDKVKQGSGNYGYNA
HHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHCCCCCCCCCC
ASGEYGDMIEMGILDPAKVTRSALQAASSIASLMITTEAMIADVPEDKPAGGGMPDMGGM
CCCCCCCCHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCC
GGMGGMM
CCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12928499 [H]