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The map label for this gene is irlR [H]

Identifier: 66047297

GI number: 66047297

Start: 4853843

End: 4854526

Strand: Reverse

Name: irlR [H]

Synonym: Psyr_4070

Alternate gene names: 66047297

Gene position: 4854526-4853843 (Counterclockwise)

Preceding gene: 66047299

Following gene: 66047296

Centisome position: 79.66

GC content: 61.4

Gene sequence:

>684_bases
ATGCGAATTCTTCTGGTTGAAGACAACCGCGACATCCTGGCGAACATGGCCGATTACCTGGGCATGAAAGGCTATACCGT
CGATTGCGCCCAGGATGGCCTCTCAGGACTGCATCTGGCAGCCACCGAGCACTACGACCTGATCGTCCTCGACATCATGC
TGCCCGGTATCGACGGCTACACCTTGTGCAAGCGTCTGCGCGAAGATGCCCGGCGTGATACGCCGGTCATCATGCTGACC
GCCCGCGATCAACTGGACGACCGTCTGCAGGGTTTCCGCTCCGGTGCCGACGACTACCTGCTCAAGCCGTTTGCCCTGTC
TGAACTGGCCGCGCGGATCGAAGCGGTATTGCGTCGTGCCCAAGGCGGCGGGCGGCGTACCTTGCAGGTGGCCGATCTGG
TCTACGACCTCGACACCCTTGAAGTGACGCGTGAGGGGCGCATGCTCAAGCTCAACCCGGTCGGGCTCAAGCTGCTCGCC
GTACTGATGCAGAAAAGCCCGCATGTGCTGCGTCGCGAGATTCTCGAAGAAGCGCTGTGGGGCGATGACTGCCCGGACAG
TGACAGCCTGCGCAGCCATGTGCACCAGTTGCGTCAGGTGATCGACAAACCGTTTGGCAAACCGCTGTTGCAGACCGTGC
ATGGCGTGGGCTATCGCTTGGCCGAGGGCCGGGATGGAGTTTAA

Upstream 100 bases:

>100_bases
TGAATCATAGGTGAAAAAAACGTCATGCCATTTCGGCGCTGGCCCTCACGCCCACTTCGTCTTAAGCTGCGCCAGCCCAA
ACTGCATATGAGAGTGCTTT

Downstream 100 bases:

>100_bases
ACAGAGTCTTGCGCAACGGATCATCATTGCCTTCGCATTGATGAGTGCACTGGTCGCCGGGTCGTTCGCCATCGGGATCA
TCTCCACCGTCCACCTGGTC

Product: response regulator receiver:transcriptional regulatory protein, C-terminal

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 227; Mature: 227

Protein sequence:

>227_residues
MRILLVEDNRDILANMADYLGMKGYTVDCAQDGLSGLHLAATEHYDLIVLDIMLPGIDGYTLCKRLREDARRDTPVIMLT
ARDQLDDRLQGFRSGADDYLLKPFALSELAARIEAVLRRAQGGGRRTLQVADLVYDLDTLEVTREGRMLKLNPVGLKLLA
VLMQKSPHVLRREILEEALWGDDCPDSDSLRSHVHQLRQVIDKPFGKPLLQTVHGVGYRLAEGRDGV

Sequences:

>Translated_227_residues
MRILLVEDNRDILANMADYLGMKGYTVDCAQDGLSGLHLAATEHYDLIVLDIMLPGIDGYTLCKRLREDARRDTPVIMLT
ARDQLDDRLQGFRSGADDYLLKPFALSELAARIEAVLRRAQGGGRRTLQVADLVYDLDTLEVTREGRMLKLNPVGLKLLA
VLMQKSPHVLRREILEEALWGDDCPDSDSLRSHVHQLRQVIDKPFGKPLLQTVHGVGYRLAEGRDGV
>Mature_227_residues
MRILLVEDNRDILANMADYLGMKGYTVDCAQDGLSGLHLAATEHYDLIVLDIMLPGIDGYTLCKRLREDARRDTPVIMLT
ARDQLDDRLQGFRSGADDYLLKPFALSELAARIEAVLRRAQGGGRRTLQVADLVYDLDTLEVTREGRMLKLNPVGLKLLA
VLMQKSPHVLRREILEEALWGDDCPDSDSLRSHVHQLRQVIDKPFGKPLLQTVHGVGYRLAEGRDGV

Specific function: Member of the two-component regulatory system irlR/irlS. May be involved in invasion of eukaryotic cells and heavy-metal resistance [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI87082012, Length=221, Percent_Identity=38.4615384615385, Blast_Score=157, Evalue=7e-40,
Organism=Escherichia coli, GI1789402, Length=223, Percent_Identity=40.3587443946188, Blast_Score=154, Evalue=5e-39,
Organism=Escherichia coli, GI1786784, Length=222, Percent_Identity=40.0900900900901, Blast_Score=153, Evalue=7e-39,
Organism=Escherichia coli, GI1790552, Length=227, Percent_Identity=37.4449339207048, Blast_Score=133, Evalue=8e-33,
Organism=Escherichia coli, GI1786599, Length=223, Percent_Identity=36.322869955157, Blast_Score=124, Evalue=5e-30,
Organism=Escherichia coli, GI1788394, Length=224, Percent_Identity=35.7142857142857, Blast_Score=118, Evalue=3e-28,
Organism=Escherichia coli, GI1786911, Length=222, Percent_Identity=34.6846846846847, Blast_Score=105, Evalue=2e-24,
Organism=Escherichia coli, GI2367329, Length=227, Percent_Identity=37.4449339207048, Blast_Score=105, Evalue=3e-24,
Organism=Escherichia coli, GI1789809, Length=226, Percent_Identity=32.7433628318584, Blast_Score=103, Evalue=7e-24,
Organism=Escherichia coli, GI1787375, Length=223, Percent_Identity=28.2511210762332, Blast_Score=98, Evalue=4e-22,
Organism=Escherichia coli, GI1790860, Length=223, Percent_Identity=30.0448430493274, Blast_Score=90, Evalue=1e-19,
Organism=Escherichia coli, GI1787229, Length=228, Percent_Identity=30.7017543859649, Blast_Score=85, Evalue=4e-18,
Organism=Escherichia coli, GI1788550, Length=108, Percent_Identity=37.037037037037, Blast_Score=84, Evalue=6e-18,
Organism=Escherichia coli, GI1790863, Length=230, Percent_Identity=26.9565217391304, Blast_Score=76, Evalue=2e-15,
Organism=Escherichia coli, GI1788713, Length=113, Percent_Identity=33.6283185840708, Blast_Score=72, Evalue=4e-14,
Organism=Escherichia coli, GI145693157, Length=109, Percent_Identity=36.697247706422, Blast_Score=64, Evalue=8e-12,
Organism=Escherichia coli, GI1790299, Length=119, Percent_Identity=31.0924369747899, Blast_Score=63, Evalue=2e-11,
Organism=Escherichia coli, GI145693140, Length=233, Percent_Identity=27.0386266094421, Blast_Score=61, Evalue=7e-11,

Paralogues:

None

Copy number: 10-20 Molecules/Cell [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR006291
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 25472; Mature: 25472

Theoretical pI: Translated: 5.96; Mature: 5.96

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRILLVEDNRDILANMADYLGMKGYTVDCAQDGLSGLHLAATEHYDLIVLDIMLPGIDGY
CEEEEEECCHHHHHHHHHHHCCCCCEEHHHHCCCCCEEEEECCCCCEEEEEEECCCCCHH
TLCKRLREDARRDTPVIMLTARDQLDDRLQGFRSGADDYLLKPFALSELAARIEAVLRRA
HHHHHHHHHHHCCCCEEEEECCHHHHHHHHHHHCCCCHHHCCHHHHHHHHHHHHHHHHHH
QGGGRRTLQVADLVYDLDTLEVTREGRMLKLNPVGLKLLAVLMQKSPHVLRREILEEALW
CCCCCCHHHHHHHHHHHHHHHHHCCCCEEEECHHHHHHHHHHHHCCCHHHHHHHHHHHHC
GDDCPDSDSLRSHVHQLRQVIDKPFGKPLLQTVHGVGYRLAEGRDGV
CCCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCEEECCCCCCC
>Mature Secondary Structure
MRILLVEDNRDILANMADYLGMKGYTVDCAQDGLSGLHLAATEHYDLIVLDIMLPGIDGY
CEEEEEECCHHHHHHHHHHHCCCCCEEHHHHCCCCCEEEEECCCCCEEEEEEECCCCCHH
TLCKRLREDARRDTPVIMLTARDQLDDRLQGFRSGADDYLLKPFALSELAARIEAVLRRA
HHHHHHHHHHHCCCCEEEEECCHHHHHHHHHHHCCCCHHHCCHHHHHHHHHHHHHHHHHH
QGGGRRTLQVADLVYDLDTLEVTREGRMLKLNPVGLKLLAVLMQKSPHVLRREILEEALW
CCCCCCHHHHHHHHHHHHHHHHHCCCCEEEECHHHHHHHHHHHHCCCHHHHHHHHHHHHC
GDDCPDSDSLRSHVHQLRQVIDKPFGKPLLQTVHGVGYRLAEGRDGV
CCCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9393784 [H]