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The map label for this gene is degP [H]

Identifier: 66047182

GI number: 66047182

Start: 4702696

End: 4704141

Strand: Reverse

Name: degP [H]

Synonym: Psyr_3955

Alternate gene names: 66047182

Gene position: 4704141-4702696 (Counterclockwise)

Preceding gene: 66047183

Following gene: 66047181

Centisome position: 77.2

GC content: 60.58

Gene sequence:

>1446_bases
ATGTCGATACCACGCATGAAATCCTACTTTTCATTGATTGCCGCTGTGCTGATGCTCGGTCAGGTTGCTACGGCTCAGGC
CGAAAACCTGCCGGACTTCACCGGGCTGGTCGAGCAGGCATCGCCCGCAGTGGTGAATATCAGTACGCGCCAGAAGTTGC
CGGACCGTGCCGTCGCCAATCAGCAGATGCCTGATCTGGAAGGCCTGCCGCCGATGCTTCGCGAGTTTCTCGAGCGCAGC
ATGCCGCCAGGTTCGCGTCCGCCGGGCTCGGGTGCAGGCAAGGGTGATCGCCAGCGTGAGGCTCAGTCCCTCGGCTCGGG
CTTCATCATCTCCCCTGACGGCTACGTGCTGACCAACAATCATGTAATCGATGGTGCTGATGAGATTCTCGTACGCCTGT
CCGATCGCAGCGAGTTGAAGGCCAAACTGGTCGGTACCGATCCGCGTACCGACGTTGCCGTTCTGAAGATTGAGGGCAAG
GACCTGCCAACCGCCAAACTGGGCAATTCCAATACGCTCAAGGTCGGTGAATGGGTTCTGGCGATCGGCTCGCCGTTCGG
TTTCGATCACTCCGTGACCAAGGGTATCGTCAGTGCCAAGGGGCGCAGCCTGCCTAACGACACCTACGTGCCGTTCATTC
AGACCGACGTGGCCATCAACCCGGGTAACTCCGGTGGCCCGCTGTTCAACATGGCTGGCGAGGTCGTCGGGATCAACTCG
CAGATCTTCACGCGTTCCGGTGGTTTCATGGGCCTGTCGTTCGCGATTCCGATCGACGTCGCCATGGATGTGGCCAACCA
GCTCAAGGCCAACGGCAAAGTCAGCCGCGGCTGGCTGGGTGTGGTCATCCAGGAAGTGAACAAGGACCTTGCCGAGTCGT
TTGGTCTGGACAAGCCTGCCGGCGCGCTGGTTGCGCAAGTGCTTGAAGACGGCCCGGCTGCCAAGGGCGGTGTGCAGGTG
GGTGACGTGATTCTGAGCGCCAACGGCCAGCCCATCGTCATGTCGGCCGACCTGCCGCACCTGATCGGCAACCTCAAGGA
CGGCAGCAAGGCCGAACTTGAAGTGATTCGCGACGGCAAGCGTCAGAAGCTGACGGTCACCGTCGGCGCGCTGCCTGATG
AAGGTCAGGAAATGGGCGATGTTGGCGGTACGGGTGCCGAGCGCAGCAGTAATCGTCTGGGCGTATCGGTGATCGAGCTG
ACCGCCGAGCAGAAGAAATCCCTGGACCTCAAAGGTGGCGTTGCCATCAAGGAAGTCACCGGCGGCCCGGCTTCGCTGAT
CGGTCTGCAGGCGGGTGATGTGATCACTCACCTGAACAATCAGGCGATCACGTCCAGCAAGCAGTTCACCGAGGTGGCGA
AAAGCCTGCCCAAGGATCGCTCTGTCTCGATGCGTGTTCTGCGTCAGGGCCGTGCGACCTTCATCACCTTTAAGCTGTCC
GAGTAA

Upstream 100 bases:

>100_bases
AGGTCATGTCGCTGATCCAGAGATGAGCATCGTTGCTTGAGGTCTTTGAGTCGGTTGCTTCGGACTGCTTAATTTTTTCC
TCGTTACGAACGGGAGCCAT

Downstream 100 bases:

>100_bases
CCGGTCGGTTTAAGCGGAAAGGGTGGCCATGGCCACCCTTTTTTGTGCCCGTTTGTTTACCGTGCGCCGATCCGGGTGCC
TGTAAGCGTGACGCCTCTTG

Product: peptidase S1, chymotrypsin:PDZ/DHR/GLGF

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 481; Mature: 480

Protein sequence:

>481_residues
MSIPRMKSYFSLIAAVLMLGQVATAQAENLPDFTGLVEQASPAVVNISTRQKLPDRAVANQQMPDLEGLPPMLREFLERS
MPPGSRPPGSGAGKGDRQREAQSLGSGFIISPDGYVLTNNHVIDGADEILVRLSDRSELKAKLVGTDPRTDVAVLKIEGK
DLPTAKLGNSNTLKVGEWVLAIGSPFGFDHSVTKGIVSAKGRSLPNDTYVPFIQTDVAINPGNSGGPLFNMAGEVVGINS
QIFTRSGGFMGLSFAIPIDVAMDVANQLKANGKVSRGWLGVVIQEVNKDLAESFGLDKPAGALVAQVLEDGPAAKGGVQV
GDVILSANGQPIVMSADLPHLIGNLKDGSKAELEVIRDGKRQKLTVTVGALPDEGQEMGDVGGTGAERSSNRLGVSVIEL
TAEQKKSLDLKGGVAIKEVTGGPASLIGLQAGDVITHLNNQAITSSKQFTEVAKSLPKDRSVSMRVLRQGRATFITFKLS
E

Sequences:

>Translated_481_residues
MSIPRMKSYFSLIAAVLMLGQVATAQAENLPDFTGLVEQASPAVVNISTRQKLPDRAVANQQMPDLEGLPPMLREFLERS
MPPGSRPPGSGAGKGDRQREAQSLGSGFIISPDGYVLTNNHVIDGADEILVRLSDRSELKAKLVGTDPRTDVAVLKIEGK
DLPTAKLGNSNTLKVGEWVLAIGSPFGFDHSVTKGIVSAKGRSLPNDTYVPFIQTDVAINPGNSGGPLFNMAGEVVGINS
QIFTRSGGFMGLSFAIPIDVAMDVANQLKANGKVSRGWLGVVIQEVNKDLAESFGLDKPAGALVAQVLEDGPAAKGGVQV
GDVILSANGQPIVMSADLPHLIGNLKDGSKAELEVIRDGKRQKLTVTVGALPDEGQEMGDVGGTGAERSSNRLGVSVIEL
TAEQKKSLDLKGGVAIKEVTGGPASLIGLQAGDVITHLNNQAITSSKQFTEVAKSLPKDRSVSMRVLRQGRATFITFKLS
E
>Mature_480_residues
SIPRMKSYFSLIAAVLMLGQVATAQAENLPDFTGLVEQASPAVVNISTRQKLPDRAVANQQMPDLEGLPPMLREFLERSM
PPGSRPPGSGAGKGDRQREAQSLGSGFIISPDGYVLTNNHVIDGADEILVRLSDRSELKAKLVGTDPRTDVAVLKIEGKD
LPTAKLGNSNTLKVGEWVLAIGSPFGFDHSVTKGIVSAKGRSLPNDTYVPFIQTDVAINPGNSGGPLFNMAGEVVGINSQ
IFTRSGGFMGLSFAIPIDVAMDVANQLKANGKVSRGWLGVVIQEVNKDLAESFGLDKPAGALVAQVLEDGPAAKGGVQVG
DVILSANGQPIVMSADLPHLIGNLKDGSKAELEVIRDGKRQKLTVTVGALPDEGQEMGDVGGTGAERSSNRLGVSVIELT
AEQKKSLDLKGGVAIKEVTGGPASLIGLQAGDVITHLNNQAITSSKQFTEVAKSLPKDRSVSMRVLRQGRATFITFKLSE

Specific function: Serine Protease That Is Required At High Temperature. Involved In The Degradation Of Damaged Proteins. It Can Degrade Icia, Ada, Casein And Globin. Shared Specificity With Degq. [C]

COG id: COG0265

COG function: function code O; Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain

Gene ontology:

Cell location: Periplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 PDZ (DHR) domains [H]

Homologues:

Organism=Homo sapiens, GI4506141, Length=352, Percent_Identity=33.2386363636364, Blast_Score=155, Evalue=6e-38,
Organism=Homo sapiens, GI22129776, Length=257, Percent_Identity=37.3540856031128, Blast_Score=147, Evalue=2e-35,
Organism=Homo sapiens, GI24308541, Length=278, Percent_Identity=35.6115107913669, Blast_Score=146, Evalue=5e-35,
Organism=Homo sapiens, GI7019477, Length=289, Percent_Identity=33.9100346020761, Blast_Score=136, Evalue=4e-32,
Organism=Escherichia coli, GI1786356, Length=456, Percent_Identity=38.5964912280702, Blast_Score=254, Evalue=8e-69,
Organism=Escherichia coli, GI1789629, Length=479, Percent_Identity=34.6555323590814, Blast_Score=227, Evalue=1e-60,
Organism=Escherichia coli, GI1789630, Length=280, Percent_Identity=40, Blast_Score=189, Evalue=3e-49,
Organism=Saccharomyces cerevisiae, GI6324206, Length=394, Percent_Identity=23.8578680203046, Blast_Score=66, Evalue=1e-11,
Organism=Drosophila melanogaster, GI24646839, Length=289, Percent_Identity=35.2941176470588, Blast_Score=147, Evalue=2e-35,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001478
- InterPro:   IPR009003
- InterPro:   IPR011782
- InterPro:   IPR001254
- InterPro:   IPR001940 [H]

Pfam domain/function: PF00595 PDZ; PF00089 Trypsin [H]

EC number: 3.4.21.-

Molecular weight: Translated: 50602; Mature: 50470

Theoretical pI: Translated: 6.56; Mature: 6.56

Prosite motif: PS50106 PDZ

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSIPRMKSYFSLIAAVLMLGQVATAQAENLPDFTGLVEQASPAVVNISTRQKLPDRAVAN
CCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCEEEEHHHHCCCCHHHHC
QQMPDLEGLPPMLREFLERSMPPGSRPPGSGAGKGDRQREAQSLGSGFIISPDGYVLTNN
CCCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHCCCEEECCCCEEEECC
HVIDGADEILVRLSDRSELKAKLVGTDPRTDVAVLKIEGKDLPTAKLGNSNTLKVGEWVL
EEECCHHHEEEEECCCCCCEEEEECCCCCCCEEEEEECCCCCCCEECCCCCCEECCEEEE
AIGSPFGFDHSVTKGIVSAKGRSLPNDTYVPFIQTDVAINPGNSGGPLFNMAGEVVGINS
EECCCCCCCHHHHHHHHHHCCCCCCCCCCCCEEEEEEEECCCCCCCCCEECCCCEEECCC
QIFTRSGGFMGLSFAIPIDVAMDVANQLKANGKVSRGWLGVVIQEVNKDLAESFGLDKPA
EEEECCCCEEEEEEECCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCH
GALVAQVLEDGPAAKGGVQVGDVILSANGQPIVMSADLPHLIGNLKDGSKAELEVIRDGK
HHHHHHHHHCCCCCCCCCEEEEEEEECCCCEEEEECCCHHHHCCCCCCCHHHHHHCCCCC
RQKLTVTVGALPDEGQEMGDVGGTGAERSSNRLGVSVIELTAEQKKSLDLKGGVAIKEVT
CEEEEEEEECCCCCCHHHCCCCCCCCCCCCCCCCEEEEEEEHHHHHCCCCCCCEEEEEEC
GGPASLIGLQAGDVITHLNNQAITSSKQFTEVAKSLPKDRSVSMRVLRQGRATFITFKLS
CCCCEEEEECCCHHHHHCCCCHHCCHHHHHHHHHHCCCCCCHHHHHHHCCCEEEEEEEEC
E
C
>Mature Secondary Structure 
SIPRMKSYFSLIAAVLMLGQVATAQAENLPDFTGLVEQASPAVVNISTRQKLPDRAVAN
CCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCEEEEHHHHCCCCHHHHC
QQMPDLEGLPPMLREFLERSMPPGSRPPGSGAGKGDRQREAQSLGSGFIISPDGYVLTNN
CCCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHCCCEEECCCCEEEECC
HVIDGADEILVRLSDRSELKAKLVGTDPRTDVAVLKIEGKDLPTAKLGNSNTLKVGEWVL
EEECCHHHEEEEECCCCCCEEEEECCCCCCCEEEEEECCCCCCCEECCCCCCEECCEEEE
AIGSPFGFDHSVTKGIVSAKGRSLPNDTYVPFIQTDVAINPGNSGGPLFNMAGEVVGINS
EECCCCCCCHHHHHHHHHHCCCCCCCCCCCCEEEEEEEECCCCCCCCCEECCCCEEECCC
QIFTRSGGFMGLSFAIPIDVAMDVANQLKANGKVSRGWLGVVIQEVNKDLAESFGLDKPA
EEEECCCCEEEEEEECCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCH
GALVAQVLEDGPAAKGGVQVGDVILSANGQPIVMSADLPHLIGNLKDGSKAELEVIRDGK
HHHHHHHHHCCCCCCCCCEEEEEEEECCCCEEEEECCCHHHHCCCCCCCHHHHHHCCCCC
RQKLTVTVGALPDEGQEMGDVGGTGAERSSNRLGVSVIELTAEQKKSLDLKGGVAIKEVT
CEEEEEEEECCCCCCHHHCCCCCCCCCCCCCCCCEEEEEEEHHHHHCCCCCCCEEEEEEC
GGPASLIGLQAGDVITHLNNQAITSSKQFTEVAKSLPKDRSVSMRVLRQGRATFITFKLS
CCCCEEEEECCCHHHHHCCCCHHCCHHHHHHHHHHCCCCCCHHHHHHHCCCEEEEEEEEC
E
C

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases) [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7861951 [H]