Click here to switch to the map view.

The map label for this gene is glpK [H]

Identifier: 66047132

GI number: 66047132

Start: 4645937

End: 4647442

Strand: Direct

Name: glpK [H]

Synonym: Psyr_3905

Alternate gene names: 66047132

Gene position: 4645937-4647442 (Clockwise)

Preceding gene: 66047131

Following gene: 66047133

Centisome position: 76.24

GC content: 60.69

Gene sequence:

>1506_bases
ATGACTGACACACAGAACAAGAACTACATCATTGCTCTTGACCAGGGCACCACCAGCTCGCGCGCCATCATCTTCGACCG
CGACGCCAACGTGGTGAGCACTGCCCAAAGCGAATTCGTTCAGCATTACCCGCAGGCAGGCTGGGTCGAACACGACCCGA
TGGAAATCTTCGCCACTCAGACCGCGTGCATGACCAAGGCGCTGGCGCAGGCCGATCTGCACCACAACCAGATCGCCGCG
ATCGGTATCACCAATCAGCGTGAAACCACCGTCATCTGGGAACGCGACACCGGCCGCCCGATCTACAACGCCATCGTCTG
GCAGTGCCGCCGCAGCACCGAGATCTGCCAGCAACTCAAGCGCGATGGCCTTGAGGAGTACATCAAGGACACCACAGGCC
TGGTGATTGACCCGTACTTCTCCGGCTCCAAGGTCAAGTGGATCCTGGACAACGTCGAAGGCAGCCGTGAGCGCGCCCGC
AAAGGCGAGCTGATGTTCGGCACCATCGATACCTGGCTGATCTGGAAATTCACCGGTGGCAAGGTTCACGTCACCGACTA
CACCAATGCCTCGCGGACCATGCTGTTCAACATCCATACGCTGGAATGGGATCAGCGCATGCTCGACGTGCTGGATATCC
CGCGCGAGATGCTGCCGGAGGTCAAAGCCTCCTCCGAAGTTTACGGCCACAGCAAGAGCGGCATCCCGATCGCCGGTATC
GCAGGCGACCAGCAGGCGGCGTTGTTCGGCCAGATGTGTGTCGAACCCGGCCAGGCCAAGAACACCTATGGCACTGGCTG
CTTCCTGCTGATGAACACCGGCAAGAAAGCCGTGAAATCGGCGCACGGCATGCTCACCACCATCGGCTGTGGCCCGCGTG
GCGAAGTGGCCTATGCGCTGGAAGGCGCGGTCTTCAACGGTGGCTCGACGGTGCAGTGGCTGCGCGACGAACTCAAACTC
ATCAACGACGCGCTGGACACCGAATACTTCGCCGGCAAGGTCAAGGACAGCAACGGCGTGTACCTGGTGCCGGCGTTCAC
GGGCCTGGGCGCACCTTACTGGGACCCGTACGCACGAGGCGCATTGTTCGGCCTGACCCGTGGCGTGAAAGTCGATCACA
TCATCCGTGCAGCGCTGGAATCCATCGCTTATCAGACCCGCGACGTACTCGATGCCATGCAACAGGACTCCGGCGAACGC
CTCAAGTCGTTGCGTGTGGACGGCGGTGCCGTGGCCAACAACTTCCTGATGCAGTTCCAGGCAGACATCCTCGGCACCCA
CGTCGAGCGCCCGCAAATGCGTGAAACTACGGCACTGGGTGCAGCCTTCCTGGCCGGTCTGGCGATTGGTTTCTGGAGCA
GCCTGGACGAGTTGCGTAACAAGGCCGTGATCGAGCGTGTGTTCGAGCCGTCCTGTGAAGAAGCGCATCGCGAAAAACTT
TACGCAGGCTGGCAGAAAGCAGTCGCGCGCACTCGTGACTGGGAACCGCACGAAAACGAAGAGTGA

Upstream 100 bases:

>100_bases
AGGCTCCTGTGGTTCGCGGCAAAGTTCAGGCTTCATCTTGATTTCACTCAATTTGAATCTCACCCAACTGAATCCCACCC
AATAATGCAAGGCAATCGAC

Downstream 100 bases:

>100_bases
CAGTGCTGTTGTAAGGAGGGGAGCAGGATTCCGGCTGACAGGTTGCACTTTCCTGCGGCATGATGGGCGCCATTTGTAGA
GGGCGCCCAAGGAAAAACAA

Product: glycerol kinase

Products: NA

Alternate protein names: ATP:glycerol 3-phosphotransferase; Glycerokinase; GK [H]

Number of amino acids: Translated: 501; Mature: 500

Protein sequence:

>501_residues
MTDTQNKNYIIALDQGTTSSRAIIFDRDANVVSTAQSEFVQHYPQAGWVEHDPMEIFATQTACMTKALAQADLHHNQIAA
IGITNQRETTVIWERDTGRPIYNAIVWQCRRSTEICQQLKRDGLEEYIKDTTGLVIDPYFSGSKVKWILDNVEGSRERAR
KGELMFGTIDTWLIWKFTGGKVHVTDYTNASRTMLFNIHTLEWDQRMLDVLDIPREMLPEVKASSEVYGHSKSGIPIAGI
AGDQQAALFGQMCVEPGQAKNTYGTGCFLLMNTGKKAVKSAHGMLTTIGCGPRGEVAYALEGAVFNGGSTVQWLRDELKL
INDALDTEYFAGKVKDSNGVYLVPAFTGLGAPYWDPYARGALFGLTRGVKVDHIIRAALESIAYQTRDVLDAMQQDSGER
LKSLRVDGGAVANNFLMQFQADILGTHVERPQMRETTALGAAFLAGLAIGFWSSLDELRNKAVIERVFEPSCEEAHREKL
YAGWQKAVARTRDWEPHENEE

Sequences:

>Translated_501_residues
MTDTQNKNYIIALDQGTTSSRAIIFDRDANVVSTAQSEFVQHYPQAGWVEHDPMEIFATQTACMTKALAQADLHHNQIAA
IGITNQRETTVIWERDTGRPIYNAIVWQCRRSTEICQQLKRDGLEEYIKDTTGLVIDPYFSGSKVKWILDNVEGSRERAR
KGELMFGTIDTWLIWKFTGGKVHVTDYTNASRTMLFNIHTLEWDQRMLDVLDIPREMLPEVKASSEVYGHSKSGIPIAGI
AGDQQAALFGQMCVEPGQAKNTYGTGCFLLMNTGKKAVKSAHGMLTTIGCGPRGEVAYALEGAVFNGGSTVQWLRDELKL
INDALDTEYFAGKVKDSNGVYLVPAFTGLGAPYWDPYARGALFGLTRGVKVDHIIRAALESIAYQTRDVLDAMQQDSGER
LKSLRVDGGAVANNFLMQFQADILGTHVERPQMRETTALGAAFLAGLAIGFWSSLDELRNKAVIERVFEPSCEEAHREKL
YAGWQKAVARTRDWEPHENEE
>Mature_500_residues
TDTQNKNYIIALDQGTTSSRAIIFDRDANVVSTAQSEFVQHYPQAGWVEHDPMEIFATQTACMTKALAQADLHHNQIAAI
GITNQRETTVIWERDTGRPIYNAIVWQCRRSTEICQQLKRDGLEEYIKDTTGLVIDPYFSGSKVKWILDNVEGSRERARK
GELMFGTIDTWLIWKFTGGKVHVTDYTNASRTMLFNIHTLEWDQRMLDVLDIPREMLPEVKASSEVYGHSKSGIPIAGIA
GDQQAALFGQMCVEPGQAKNTYGTGCFLLMNTGKKAVKSAHGMLTTIGCGPRGEVAYALEGAVFNGGSTVQWLRDELKLI
NDALDTEYFAGKVKDSNGVYLVPAFTGLGAPYWDPYARGALFGLTRGVKVDHIIRAALESIAYQTRDVLDAMQQDSGERL
KSLRVDGGAVANNFLMQFQADILGTHVERPQMRETTALGAAFLAGLAIGFWSSLDELRNKAVIERVFEPSCEEAHREKLY
AGWQKAVARTRDWEPHENEE

Specific function: Key enzyme in the regulation of glycerol uptake and metabolism [H]

COG id: COG0554

COG function: function code C; Glycerol kinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FGGY kinase family [H]

Homologues:

Organism=Homo sapiens, GI189409120, Length=507, Percent_Identity=46.9428007889546, Blast_Score=450, Evalue=1e-126,
Organism=Homo sapiens, GI4504007, Length=507, Percent_Identity=46.9428007889546, Blast_Score=450, Evalue=1e-126,
Organism=Homo sapiens, GI42794763, Length=513, Percent_Identity=46.3937621832359, Blast_Score=447, Evalue=1e-126,
Organism=Homo sapiens, GI41393575, Length=507, Percent_Identity=46.1538461538462, Blast_Score=447, Evalue=1e-125,
Organism=Homo sapiens, GI88196792, Length=509, Percent_Identity=33.3988212180747, Blast_Score=313, Evalue=3e-85,
Organism=Escherichia coli, GI1790361, Length=498, Percent_Identity=74.0963855421687, Blast_Score=800, Evalue=0.0,
Organism=Escherichia coli, GI1787789, Length=523, Percent_Identity=25.0478011472275, Blast_Score=107, Evalue=2e-24,
Organism=Escherichia coli, GI1789138, Length=488, Percent_Identity=23.155737704918, Blast_Score=103, Evalue=2e-23,
Organism=Escherichia coli, GI1789987, Length=495, Percent_Identity=24.6464646464646, Blast_Score=102, Evalue=5e-23,
Organism=Escherichia coli, GI1790005, Length=480, Percent_Identity=24.5833333333333, Blast_Score=101, Evalue=1e-22,
Organism=Caenorhabditis elegans, GI17535599, Length=500, Percent_Identity=41, Blast_Score=404, Evalue=1e-113,
Organism=Caenorhabditis elegans, GI71986140, Length=517, Percent_Identity=26.4990328820116, Blast_Score=187, Evalue=9e-48,
Organism=Caenorhabditis elegans, GI71986147, Length=276, Percent_Identity=33.695652173913, Blast_Score=136, Evalue=2e-32,
Organism=Saccharomyces cerevisiae, GI6321755, Length=547, Percent_Identity=36.0146252285192, Blast_Score=315, Evalue=8e-87,
Organism=Drosophila melanogaster, GI17864214, Length=509, Percent_Identity=44.007858546169, Blast_Score=418, Evalue=1e-117,
Organism=Drosophila melanogaster, GI24655555, Length=508, Percent_Identity=41.5354330708661, Blast_Score=404, Evalue=1e-112,
Organism=Drosophila melanogaster, GI24655560, Length=508, Percent_Identity=41.5354330708661, Blast_Score=404, Evalue=1e-112,
Organism=Drosophila melanogaster, GI24655570, Length=508, Percent_Identity=41.5354330708661, Blast_Score=404, Evalue=1e-112,
Organism=Drosophila melanogaster, GI24655574, Length=508, Percent_Identity=41.5354330708661, Blast_Score=404, Evalue=1e-112,
Organism=Drosophila melanogaster, GI24655565, Length=508, Percent_Identity=41.5354330708661, Blast_Score=404, Evalue=1e-112,
Organism=Drosophila melanogaster, GI24654573, Length=463, Percent_Identity=44.4924406047516, Blast_Score=388, Evalue=1e-108,
Organism=Drosophila melanogaster, GI19922058, Length=531, Percent_Identity=34.0866290018832, Blast_Score=311, Evalue=6e-85,
Organism=Drosophila melanogaster, GI24652871, Length=498, Percent_Identity=34.3373493975904, Blast_Score=296, Evalue=2e-80,
Organism=Drosophila melanogaster, GI24656367, Length=517, Percent_Identity=28.8201160541586, Blast_Score=226, Evalue=3e-59,
Organism=Drosophila melanogaster, GI21357867, Length=528, Percent_Identity=28.4090909090909, Blast_Score=221, Evalue=7e-58,
Organism=Drosophila melanogaster, GI24656372, Length=352, Percent_Identity=31.25, Blast_Score=182, Evalue=5e-46,
Organism=Drosophila melanogaster, GI45552909, Length=290, Percent_Identity=28.2758620689655, Blast_Score=130, Evalue=2e-30,

Paralogues:

None

Copy number: 2,500 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000577
- InterPro:   IPR018485
- InterPro:   IPR018483
- InterPro:   IPR018484
- InterPro:   IPR005999 [H]

Pfam domain/function: PF02782 FGGY_C; PF00370 FGGY_N [H]

EC number: =2.7.1.30 [H]

Molecular weight: Translated: 55830; Mature: 55699

Theoretical pI: Translated: 5.65; Mature: 5.65

Prosite motif: PS00933 FGGY_KINASES_1 ; PS00445 FGGY_KINASES_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDTQNKNYIIALDQGTTSSRAIIFDRDANVVSTAQSEFVQHYPQAGWVEHDPMEIFATQ
CCCCCCCCEEEEEECCCCCCEEEEEECCCCHHHHHHHHHHHHCCCCCCCCCCCHHHHHHH
TACMTKALAQADLHHNQIAAIGITNQRETTVIWERDTGRPIYNAIVWQCRRSTEICQQLK
HHHHHHHHHHHHCCCCCEEEEEECCCCCEEEEEECCCCCHHHHHHHHHHCCHHHHHHHHH
RDGLEEYIKDTTGLVIDPYFSGSKVKWILDNVEGSRERARKGELMFGTIDTWLIWKFTGG
HCCHHHHHHCCCCEEEECCCCCCEEEEEEECCCCCHHHHHCCCEEEEEECEEEEEEEECC
KVHVTDYTNASRTMLFNIHTLEWDQRMLDVLDIPREMLPEVKASSEVYGHSKSGIPIAGI
EEEEEECCCCCCEEEEEEEEECHHHHHHHHHHCCHHHHHHHHCCCHHCCCCCCCCEEEEE
AGDQQAALFGQMCVEPGQAKNTYGTGCFLLMNTGKKAVKSAHGMLTTIGCGPRGEVAYAL
CCCCHHHHHHHHHCCCCCCCCCCCCEEEEEECCCHHHHHHHCCCEEEECCCCCCCEEEEE
EGAVFNGGSTVQWLRDELKLINDALDTEYFAGKVKDSNGVYLVPAFTGLGAPYWDPYARG
ECEEECCCCHHHHHHHHHHHHHHHHCCHHHCCEEECCCCEEEEEECCCCCCCCCCHHHCC
ALFGLTRGVKVDHIIRAALESIAYQTRDVLDAMQQDSGERLKSLRVDGGAVANNFLMQFQ
HHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCCCHHHHHHHHHHH
ADILGTHVERPQMRETTALGAAFLAGLAIGFWSSLDELRNKAVIERVFEPSCEEAHREKL
HHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHH
YAGWQKAVARTRDWEPHENEE
HHHHHHHHHHCCCCCCCCCCC
>Mature Secondary Structure 
TDTQNKNYIIALDQGTTSSRAIIFDRDANVVSTAQSEFVQHYPQAGWVEHDPMEIFATQ
CCCCCCCEEEEEECCCCCCEEEEEECCCCHHHHHHHHHHHHCCCCCCCCCCCHHHHHHH
TACMTKALAQADLHHNQIAAIGITNQRETTVIWERDTGRPIYNAIVWQCRRSTEICQQLK
HHHHHHHHHHHHCCCCCEEEEEECCCCCEEEEEECCCCCHHHHHHHHHHCCHHHHHHHHH
RDGLEEYIKDTTGLVIDPYFSGSKVKWILDNVEGSRERARKGELMFGTIDTWLIWKFTGG
HCCHHHHHHCCCCEEEECCCCCCEEEEEEECCCCCHHHHHCCCEEEEEECEEEEEEEECC
KVHVTDYTNASRTMLFNIHTLEWDQRMLDVLDIPREMLPEVKASSEVYGHSKSGIPIAGI
EEEEEECCCCCCEEEEEEEEECHHHHHHHHHHCCHHHHHHHHCCCHHCCCCCCCCEEEEE
AGDQQAALFGQMCVEPGQAKNTYGTGCFLLMNTGKKAVKSAHGMLTTIGCGPRGEVAYAL
CCCCHHHHHHHHHCCCCCCCCCCCCEEEEEECCCHHHHHHHCCCEEEECCCCCCCEEEEE
EGAVFNGGSTVQWLRDELKLINDALDTEYFAGKVKDSNGVYLVPAFTGLGAPYWDPYARG
ECEEECCCCHHHHHHHHHHHHHHHHCCHHHCCEEECCCCEEEEEECCCCCCCCCCHHHCC
ALFGLTRGVKVDHIIRAALESIAYQTRDVLDAMQQDSGERLKSLRVDGGAVANNFLMQFQ
HHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCCCHHHHHHHHHHH
ADILGTHVERPQMRETTALGAAFLAGLAIGFWSSLDELRNKAVIERVFEPSCEEAHREKL
HHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHH
YAGWQKAVARTRDWEPHENEE
HHHHHHHHHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA