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The map label for this gene is recQ [H]

Identifier: 66046966

GI number: 66046966

Start: 4452018

End: 4454147

Strand: Reverse

Name: recQ [H]

Synonym: Psyr_3738

Alternate gene names: 66046966

Gene position: 4454147-4452018 (Counterclockwise)

Preceding gene: 66046969

Following gene: 66046965

Centisome position: 73.09

GC content: 62.72

Gene sequence:

>2130_bases
ATGCTTGAGCAGGCACAACGCGTACTTAAAGACATCTTCGGTTACGACAGCTTTCGTGGTCGCCAGGGTGCCATTATTGA
GCGTGTAGCCAGCGGTGGTGATGCGCTGGTGCTGATGCCCACCGGTGGCGGCAAGTCCCTGTGTTTTCAGGTGCCGGGGC
TGTTGCGTGACGGGCTGTGCGTGGTCGTGTCGCCACTCATCGCGCTGATGGACGACCAGGTTGCCACGCTGGATGAGCTG
GGCGTGTCGGCCGCTGCACTCAACTCGACCCTCAGCGCCGAGCAGCAGCGCGACCTGGCGAACCGCATTCGTCTGGGCGA
AGTCAAAATGCTCTACCTCGCCCCGGAGCGCCTGGTCCAGCCGCGCATGCTGTCATTCCTGCAAAACCTCAAGATCGCCC
TGTTTGCCATCGACGAAGCGCACTGCGTGTCGCAATGGGGCCATGACTTCCGCCCTGAATACCTGCAACTGGGGCAACTC
GCCGAGCTGTTTCCGGAGGTGCCGCGCATCGCGCTGACCGCCACCGCCGACAAGCGCACCCGTGAAGAAATCGTCACGCG
TCTGCACCTGCAGAACGCCGAGCGCTTTCTGTCGAGCTTCGACCGGCCCAACATCTTCTATCGCATCGTGCCCAAGGAAC
AGCCGCGCAAGCAACTGCTGGCGTTTCTTTCCGAGCGCCGCAGCGACGCCGGTATCGTTTACTGCCTGTCACGCAAGAAG
GTCGATGAGGTCGCCGTATTCCTGAGTGACAACGGCTATCCCGCGCTGCCTTATCACGCCGGTCTGCCGTCCGAAACCCG
AGCTGCGAACCAGAAGCGCTTTCTCAACGAGGAAGGGCTGATCATGGTTGCCACCATCGCGTTCGGCATGGGCATCGACA
AGCCCAACGTGCGTTTTGTCGCGCACATGGACCTGCCCAAATCGCTTGAGGCTTATTATCAGGAAACCGGCCGGGCAGGG
CGTGATGGCCTGCCCGCCGATGCCTGGATGGCCTACGGTCTGCAAGACGTGCTGATGCTCAAGCAGATGCTGCAGAACTC
CGAAGGCGACGAGCGCCACAAACGGCTGGAGCAGCACAAGCTCGATGCCATGCTGGCCCTGTGCGAAGAAACCCGTTGCC
GTCGGCAGACCCTGCTGGCCTATTTCGACGAAGACATGCCCAACCCGTGCGGCCATTGCGACAACTGCGTCGATGGCGTG
CAAACCTGGGATGCCACGGAACCTGCGCGTCAGGCGCTGTCGGCCATCTACCGTACCGGCCAGCGTTATGGCGTCGGTCA
TCTGGTTGACGTGTTGCTCGGCAAGTCCAACGACAAGGTGGAGAGCTTCGGTCATCAGCATCTGTCGGTGTTCGGGGTCG
GCAAGGCGCGCACCGAGTCCGAGTGGCGCTCGCTGTTCCGCCAGCTGGTTGCGCGCGGTCTGGCGGACATCGACCTTGAA
GGCTATGGCGGCCTGCGCCTCAGCGAGACGTGCCGCCCTTTGCTGCGGGGCGAAGTTTCTCTGGAACTGCGCCAGGACCT
CAAGCCACAAACCACGTCGAGAAGCAGTTCCGGCAGCCCGGCCAGTCAACTGGTGCGTGGCGAAGAGCGCGAGCAGTGGG
AAGCCCTGCGCGCGCTGCGCCGCAAGCTGGCCGAAGAGCACGGCGTCCCGCCTTACGTTATTTTCCCGGACTCGACCCTG
CTGGAGATGCTGCGCAGCAAACCCGGATCGATGGCCGAGATGGCCAAGGTCAGTGGCGTCGGTGCGCGCAAGCTGGAGCG
TTATGGCGAAGCCTTTCTCGAAGTGCTCAGCGGCAAGGCCGAGGCACCACGGGTGGTCGCCGATGTGCGTCACGAACTGA
TCAGCCTGGCGCGCGCGGGTATGACCCCGACGCAGATCGCCGGTCAGTTGCAGTGCTCGGAAAAGAATGTCTACACCCTG
CTGGCCGAAGCCATCGGCAAGCAGCAGTTATCCATCGAGCAGGCGCTGGACTTGCCGGAGGACCTGCTGGGTGAGGTGCA
GGACGCCTTTCTCGACGGCGAAGGCGAACTGCCGCCGGTGTCGGCGATTGCCGAGCAGTTTGCCGGGCGGGTGCCTGAGG
GTGTTTTGTATTGCGTGCGTGCAGCGCTGCAATCGGAGTTTGAGGTATAA

Upstream 100 bases:

>100_bases
CAGTTAATTTCGACCGCTCATGTCCCAGTCATCCATTGCTCCCGAGTGCTCGGGTATACTCCCCCGTTTTGCAGTGCAGC
AGGATATTCCGGGGTTTTTT

Downstream 100 bases:

>100_bases
CGGCGTGCGACGGAGCGTCACCGTCCCGTGCTTGCCTGAACATAAGGACCATGCTTAGCTCGCTAATAATTAGTTTGAAT
CACGAGTTTCCTTATGCCAA

Product: ATP-dependent DNA helicase RecQ:ATP-requiring DNA helicase RecQ

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 709; Mature: 709

Protein sequence:

>709_residues
MLEQAQRVLKDIFGYDSFRGRQGAIIERVASGGDALVLMPTGGGKSLCFQVPGLLRDGLCVVVSPLIALMDDQVATLDEL
GVSAAALNSTLSAEQQRDLANRIRLGEVKMLYLAPERLVQPRMLSFLQNLKIALFAIDEAHCVSQWGHDFRPEYLQLGQL
AELFPEVPRIALTATADKRTREEIVTRLHLQNAERFLSSFDRPNIFYRIVPKEQPRKQLLAFLSERRSDAGIVYCLSRKK
VDEVAVFLSDNGYPALPYHAGLPSETRAANQKRFLNEEGLIMVATIAFGMGIDKPNVRFVAHMDLPKSLEAYYQETGRAG
RDGLPADAWMAYGLQDVLMLKQMLQNSEGDERHKRLEQHKLDAMLALCEETRCRRQTLLAYFDEDMPNPCGHCDNCVDGV
QTWDATEPARQALSAIYRTGQRYGVGHLVDVLLGKSNDKVESFGHQHLSVFGVGKARTESEWRSLFRQLVARGLADIDLE
GYGGLRLSETCRPLLRGEVSLELRQDLKPQTTSRSSSGSPASQLVRGEEREQWEALRALRRKLAEEHGVPPYVIFPDSTL
LEMLRSKPGSMAEMAKVSGVGARKLERYGEAFLEVLSGKAEAPRVVADVRHELISLARAGMTPTQIAGQLQCSEKNVYTL
LAEAIGKQQLSIEQALDLPEDLLGEVQDAFLDGEGELPPVSAIAEQFAGRVPEGVLYCVRAALQSEFEV

Sequences:

>Translated_709_residues
MLEQAQRVLKDIFGYDSFRGRQGAIIERVASGGDALVLMPTGGGKSLCFQVPGLLRDGLCVVVSPLIALMDDQVATLDEL
GVSAAALNSTLSAEQQRDLANRIRLGEVKMLYLAPERLVQPRMLSFLQNLKIALFAIDEAHCVSQWGHDFRPEYLQLGQL
AELFPEVPRIALTATADKRTREEIVTRLHLQNAERFLSSFDRPNIFYRIVPKEQPRKQLLAFLSERRSDAGIVYCLSRKK
VDEVAVFLSDNGYPALPYHAGLPSETRAANQKRFLNEEGLIMVATIAFGMGIDKPNVRFVAHMDLPKSLEAYYQETGRAG
RDGLPADAWMAYGLQDVLMLKQMLQNSEGDERHKRLEQHKLDAMLALCEETRCRRQTLLAYFDEDMPNPCGHCDNCVDGV
QTWDATEPARQALSAIYRTGQRYGVGHLVDVLLGKSNDKVESFGHQHLSVFGVGKARTESEWRSLFRQLVARGLADIDLE
GYGGLRLSETCRPLLRGEVSLELRQDLKPQTTSRSSSGSPASQLVRGEEREQWEALRALRRKLAEEHGVPPYVIFPDSTL
LEMLRSKPGSMAEMAKVSGVGARKLERYGEAFLEVLSGKAEAPRVVADVRHELISLARAGMTPTQIAGQLQCSEKNVYTL
LAEAIGKQQLSIEQALDLPEDLLGEVQDAFLDGEGELPPVSAIAEQFAGRVPEGVLYCVRAALQSEFEV
>Mature_709_residues
MLEQAQRVLKDIFGYDSFRGRQGAIIERVASGGDALVLMPTGGGKSLCFQVPGLLRDGLCVVVSPLIALMDDQVATLDEL
GVSAAALNSTLSAEQQRDLANRIRLGEVKMLYLAPERLVQPRMLSFLQNLKIALFAIDEAHCVSQWGHDFRPEYLQLGQL
AELFPEVPRIALTATADKRTREEIVTRLHLQNAERFLSSFDRPNIFYRIVPKEQPRKQLLAFLSERRSDAGIVYCLSRKK
VDEVAVFLSDNGYPALPYHAGLPSETRAANQKRFLNEEGLIMVATIAFGMGIDKPNVRFVAHMDLPKSLEAYYQETGRAG
RDGLPADAWMAYGLQDVLMLKQMLQNSEGDERHKRLEQHKLDAMLALCEETRCRRQTLLAYFDEDMPNPCGHCDNCVDGV
QTWDATEPARQALSAIYRTGQRYGVGHLVDVLLGKSNDKVESFGHQHLSVFGVGKARTESEWRSLFRQLVARGLADIDLE
GYGGLRLSETCRPLLRGEVSLELRQDLKPQTTSRSSSGSPASQLVRGEEREQWEALRALRRKLAEEHGVPPYVIFPDSTL
LEMLRSKPGSMAEMAKVSGVGARKLERYGEAFLEVLSGKAEAPRVVADVRHELISLARAGMTPTQIAGQLQCSEKNVYTL
LAEAIGKQQLSIEQALDLPEDLLGEVQDAFLDGEGELPPVSAIAEQFAGRVPEGVLYCVRAALQSEFEV

Specific function: Involved in the recF recombination pathway; its gene expression is under the regulation of the SOS system. It is a DNA helicase [H]

COG id: COG0514

COG function: function code L; Superfamily II DNA helicase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HRDC domain [H]

Homologues:

Organism=Homo sapiens, GI4557365, Length=649, Percent_Identity=35.5932203389831, Blast_Score=356, Evalue=5e-98,
Organism=Homo sapiens, GI14591902, Length=465, Percent_Identity=35.2688172043011, Blast_Score=294, Evalue=2e-79,
Organism=Homo sapiens, GI14591904, Length=465, Percent_Identity=35.2688172043011, Blast_Score=294, Evalue=2e-79,
Organism=Homo sapiens, GI148612816, Length=416, Percent_Identity=39.9038461538462, Blast_Score=292, Evalue=9e-79,
Organism=Homo sapiens, GI169218196, Length=505, Percent_Identity=35.2475247524752, Blast_Score=284, Evalue=2e-76,
Organism=Homo sapiens, GI110735439, Length=505, Percent_Identity=35.2475247524752, Blast_Score=284, Evalue=2e-76,
Organism=Homo sapiens, GI51242947, Length=394, Percent_Identity=40.1015228426396, Blast_Score=276, Evalue=3e-74,
Organism=Homo sapiens, GI51242943, Length=394, Percent_Identity=40.1015228426396, Blast_Score=276, Evalue=6e-74,
Organism=Homo sapiens, GI284005309, Length=383, Percent_Identity=36.0313315926893, Blast_Score=197, Evalue=3e-50,
Organism=Escherichia coli, GI48994977, Length=602, Percent_Identity=47.0099667774086, Blast_Score=563, Evalue=1e-161,
Organism=Caenorhabditis elegans, GI25145561, Length=502, Percent_Identity=37.0517928286853, Blast_Score=321, Evalue=1e-87,
Organism=Caenorhabditis elegans, GI32564293, Length=746, Percent_Identity=29.8927613941019, Blast_Score=293, Evalue=3e-79,
Organism=Caenorhabditis elegans, GI71987993, Length=436, Percent_Identity=37.8440366972477, Blast_Score=287, Evalue=2e-77,
Organism=Caenorhabditis elegans, GI71987997, Length=436, Percent_Identity=37.8440366972477, Blast_Score=286, Evalue=2e-77,
Organism=Caenorhabditis elegans, GI17552866, Length=449, Percent_Identity=37.1937639198218, Blast_Score=280, Evalue=2e-75,
Organism=Caenorhabditis elegans, GI17555296, Length=335, Percent_Identity=26.5671641791045, Blast_Score=80, Evalue=4e-15,
Organism=Saccharomyces cerevisiae, GI6323844, Length=537, Percent_Identity=34.2644320297952, Blast_Score=322, Evalue=1e-88,
Organism=Saccharomyces cerevisiae, GI6324217, Length=340, Percent_Identity=24.7058823529412, Blast_Score=77, Evalue=6e-15,
Organism=Saccharomyces cerevisiae, GI6320224, Length=332, Percent_Identity=22.289156626506, Blast_Score=74, Evalue=1e-13,
Organism=Saccharomyces cerevisiae, GI6321360, Length=329, Percent_Identity=23.4042553191489, Blast_Score=71, Evalue=7e-13,
Organism=Saccharomyces cerevisiae, GI6323947, Length=347, Percent_Identity=24.4956772334294, Blast_Score=68, Evalue=6e-12,
Organism=Saccharomyces cerevisiae, GI6320041, Length=325, Percent_Identity=26.1538461538462, Blast_Score=67, Evalue=8e-12,
Organism=Drosophila melanogaster, GI24646066, Length=647, Percent_Identity=36.4760432766615, Blast_Score=362, Evalue=1e-100,
Organism=Drosophila melanogaster, GI24664226, Length=424, Percent_Identity=38.2075471698113, Blast_Score=278, Evalue=1e-74,
Organism=Drosophila melanogaster, GI62472181, Length=421, Percent_Identity=38.0047505938242, Blast_Score=275, Evalue=9e-74,
Organism=Drosophila melanogaster, GI24664230, Length=421, Percent_Identity=38.0047505938242, Blast_Score=275, Evalue=9e-74,
Organism=Drosophila melanogaster, GI21358123, Length=348, Percent_Identity=38.2183908045977, Blast_Score=210, Evalue=3e-54,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014001
- InterPro:   IPR011545
- InterPro:   IPR004589
- InterPro:   IPR006293
- InterPro:   IPR002121
- InterPro:   IPR001650
- InterPro:   IPR014021
- InterPro:   IPR010997
- InterPro:   IPR018982 [H]

Pfam domain/function: PF00270 DEAD; PF00271 Helicase_C; PF00570 HRDC; PF09382 RQC [H]

EC number: =3.6.4.12 [H]

Molecular weight: Translated: 78762; Mature: 78762

Theoretical pI: Translated: 5.61; Mature: 5.61

Prosite motif: PS50967 HRDC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLEQAQRVLKDIFGYDSFRGRQGAIIERVASGGDALVLMPTGGGKSLCFQVPGLLRDGLC
CCHHHHHHHHHHHCCCCCCCCCCHHHHHHHCCCCEEEEEECCCCCCCCEECCHHHHCCHH
VVVSPLIALMDDQVATLDELGVSAAALNSTLSAEQQRDLANRIRLGEVKMLYLAPERLVQ
HHHHHHHHHHCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECHHHHCC
PRMLSFLQNLKIALFAIDEAHCVSQWGHDFRPEYLQLGQLAELFPEVPRIALTATADKRT
HHHHHHHHCCCEEEEEECHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCEEEEECCCHHH
REEIVTRLHLQNAERFLSSFDRPNIFYRIVPKEQPRKQLLAFLSERRSDAGIVYCLSRKK
HHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCHHHHHHHHHHHCCCCCCEEEEECCCC
VDEVAVFLSDNGYPALPYHAGLPSETRAANQKRFLNEEGLIMVATIAFGMGIDKPNVRFV
CCCEEEEEECCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCEEEEEHHHHCCCCCCCCEEE
AHMDLPKSLEAYYQETGRAGRDGLPADAWMAYGLQDVLMLKQMLQNSEGDERHKRLEQHK
EECCCCHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHH
LDAMLALCEETRCRRQTLLAYFDEDMPNPCGHCDNCVDGVQTWDATEPARQALSAIYRTG
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHCC
QRYGVGHLVDVLLGKSNDKVESFGHQHLSVFGVGKARTESEWRSLFRQLVARGLADIDLE
CCCCHHHHHHHHHCCCCCHHHHHCCHHEEEEECCCCCCHHHHHHHHHHHHHCCCCCCCCC
GYGGLRLSETCRPLLRGEVSLELRQDLKPQTTSRSSSGSPASQLVRGEEREQWEALRALR
CCCCCCHHHHHHHHHCCCHHHHHHHCCCCCCCCCCCCCCCHHHHHCCCHHHHHHHHHHHH
RKLAEEHGVPPYVIFPDSTLLEMLRSKPGSMAEMAKVSGVGARKLERYGEAFLEVLSGKA
HHHHHHCCCCCEEECCCHHHHHHHHCCCCCHHHHHHHCCCCHHHHHHHHHHHHHHHCCCC
EAPRVVADVRHELISLARAGMTPTQIAGQLQCSEKNVYTLLAEAIGKQQLSIEQALDLPE
CCCHHHHHHHHHHHHHHHCCCCHHHHHCCCEECCCHHHHHHHHHHCHHHHHHHHHHCCCH
DLLGEVQDAFLDGEGELPPVSAIAEQFAGRVPEGVLYCVRAALQSEFEV
HHHHHHHHHHCCCCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MLEQAQRVLKDIFGYDSFRGRQGAIIERVASGGDALVLMPTGGGKSLCFQVPGLLRDGLC
CCHHHHHHHHHHHCCCCCCCCCCHHHHHHHCCCCEEEEEECCCCCCCCEECCHHHHCCHH
VVVSPLIALMDDQVATLDELGVSAAALNSTLSAEQQRDLANRIRLGEVKMLYLAPERLVQ
HHHHHHHHHHCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECHHHHCC
PRMLSFLQNLKIALFAIDEAHCVSQWGHDFRPEYLQLGQLAELFPEVPRIALTATADKRT
HHHHHHHHCCCEEEEEECHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCEEEEECCCHHH
REEIVTRLHLQNAERFLSSFDRPNIFYRIVPKEQPRKQLLAFLSERRSDAGIVYCLSRKK
HHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCHHHHHHHHHHHCCCCCCEEEEECCCC
VDEVAVFLSDNGYPALPYHAGLPSETRAANQKRFLNEEGLIMVATIAFGMGIDKPNVRFV
CCCEEEEEECCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCEEEEEHHHHCCCCCCCCEEE
AHMDLPKSLEAYYQETGRAGRDGLPADAWMAYGLQDVLMLKQMLQNSEGDERHKRLEQHK
EECCCCHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHH
LDAMLALCEETRCRRQTLLAYFDEDMPNPCGHCDNCVDGVQTWDATEPARQALSAIYRTG
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHCC
QRYGVGHLVDVLLGKSNDKVESFGHQHLSVFGVGKARTESEWRSLFRQLVARGLADIDLE
CCCCHHHHHHHHHCCCCCHHHHHCCHHEEEEECCCCCCHHHHHHHHHHHHHCCCCCCCCC
GYGGLRLSETCRPLLRGEVSLELRQDLKPQTTSRSSSGSPASQLVRGEEREQWEALRALR
CCCCCCHHHHHHHHHCCCHHHHHHHCCCCCCCCCCCCCCCHHHHHCCCHHHHHHHHHHHH
RKLAEEHGVPPYVIFPDSTLLEMLRSKPGSMAEMAKVSGVGARKLERYGEAFLEVLSGKA
HHHHHHCCCCCEEECCCHHHHHHHHCCCCCHHHHHHHCCCCHHHHHHHHHHHHHHHCCCC
EAPRVVADVRHELISLARAGMTPTQIAGQLQCSEKNVYTLLAEAIGKQQLSIEQALDLPE
CCCHHHHHHHHHHHHHHHCCCCHHHHHCCCEECCCHHHHHHHHHHCHHHHHHHHHHCCCH
DLLGEVQDAFLDGEGELPPVSAIAEQFAGRVPEGVLYCVRAALQSEFEV
HHHHHHHHHHCCCCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3027506; 1379743; 9278503; 2164680 [H]