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The map label for this gene is mazG [H]

Identifier: 66046923

GI number: 66046923

Start: 4379679

End: 4380512

Strand: Reverse

Name: mazG [H]

Synonym: Psyr_3694

Alternate gene names: 66046923

Gene position: 4380512-4379679 (Counterclockwise)

Preceding gene: 66046924

Following gene: 66046922

Centisome position: 71.89

GC content: 60.43

Gene sequence:

>834_bases
ATGTACACAGTTCAAGACCTGCTGCACCTCATGGCCCGGCTGCGTGATCCGCAGTTCGGCTGTCCGTGGGACCTGAAGCA
GACCTACGCCAGCATCGTGCCGCACACGCTGGAAGAAGCCTATGAAGTGGCTGATGCCATCGAACAGGGCGACCTCGATC
ATCTGAAGGGCGAGCTGGGAGACCTGCTGTTTCAGGTGGTCTTCTATGCGCAGTTGGCCAAAGAGGAAGGCCGGTTTGAA
TTCGACGATGTCATCGACGGTATTACCCGCAAGTTGCTGCGTCGCCATCCGCACGTGTTTCCGACTGGCGAGCTGTACGC
GCCGGCAGAAACGCCGCGCCTGACCGACGAGCAGGTCAATCGTCGTTGGGACGAAATCAAGGCCGAGGAGCGTGCCGAAA
AGGCCGGCGTTCCCGAGCAGTTGTCGTTGCTCGACGACGTGCCGAGGGCCTTGCCCGCGTTGAGTCGTGCGGCCAAACTG
CAGAAGCGTGCAGCGCAGGTGGGTTTCGACTGGCCTGCGGCATTGCCGGTGGTCGACAAGGTGCGTGAAGAACTCGATGA
AATTCTCGAGGCCATGGTCGACAATGACGCCGAGGGCATCGCCGAGGAAGTCGGCGACCTGCTGTTCAGCGTCGTCAACC
TGGCCCGACACCTCAAGGTCGACCCGGAAACTGCGCTACGCTCGGCCAATAGCAAATTCGACAGACGCTTCCGATTCATT
GAACAGGCTTTGCGCCACCTGCAGCGTCCTATCGAAGCGTGCTCGCTCGAAGAAATGGACGCGTTGTGGGGCGAAGCCAA
ACGTCAGGAAAAGAGCACACCCGGCTGCGGCTGA

Upstream 100 bases:

>100_bases
GTAAGTTTCAAGCTGCAAGCTAAAGCGGATTGCGGTGGCTTCTAGCTTGCAGCTTGCAGCTTGAAGCTTGAAGCTAAACC
GCTGCGACCGAAGGAAGCCT

Downstream 100 bases:

>100_bases
GTGTGCGGTAACGGTATAAGTGAGTAGACAATGAGCCTTTCCCTTCGCGATCAGTTGCTCAAGGCAGGTCTGGTCAACCA
AAAGCAGGCCAAGCAGGTCG

Product: nucleoside triphosphate pyrophosphohydrolase

Products: NA

Alternate protein names: NTP-PPase [H]

Number of amino acids: Translated: 277; Mature: 277

Protein sequence:

>277_residues
MYTVQDLLHLMARLRDPQFGCPWDLKQTYASIVPHTLEEAYEVADAIEQGDLDHLKGELGDLLFQVVFYAQLAKEEGRFE
FDDVIDGITRKLLRRHPHVFPTGELYAPAETPRLTDEQVNRRWDEIKAEERAEKAGVPEQLSLLDDVPRALPALSRAAKL
QKRAAQVGFDWPAALPVVDKVREELDEILEAMVDNDAEGIAEEVGDLLFSVVNLARHLKVDPETALRSANSKFDRRFRFI
EQALRHLQRPIEACSLEEMDALWGEAKRQEKSTPGCG

Sequences:

>Translated_277_residues
MYTVQDLLHLMARLRDPQFGCPWDLKQTYASIVPHTLEEAYEVADAIEQGDLDHLKGELGDLLFQVVFYAQLAKEEGRFE
FDDVIDGITRKLLRRHPHVFPTGELYAPAETPRLTDEQVNRRWDEIKAEERAEKAGVPEQLSLLDDVPRALPALSRAAKL
QKRAAQVGFDWPAALPVVDKVREELDEILEAMVDNDAEGIAEEVGDLLFSVVNLARHLKVDPETALRSANSKFDRRFRFI
EQALRHLQRPIEACSLEEMDALWGEAKRQEKSTPGCG
>Mature_277_residues
MYTVQDLLHLMARLRDPQFGCPWDLKQTYASIVPHTLEEAYEVADAIEQGDLDHLKGELGDLLFQVVFYAQLAKEEGRFE
FDDVIDGITRKLLRRHPHVFPTGELYAPAETPRLTDEQVNRRWDEIKAEERAEKAGVPEQLSLLDDVPRALPALSRAAKL
QKRAAQVGFDWPAALPVVDKVREELDEILEAMVDNDAEGIAEEVGDLLFSVVNLARHLKVDPETALRSANSKFDRRFRFI
EQALRHLQRPIEACSLEEMDALWGEAKRQEKSTPGCG

Specific function: Involved in the regulation of bacterial cell survival under conditions of nutritional stress. Regulates the MazEF toxin- antitoxin (TA) module that mediates programmed cell death (PCD). This is achieved by lowering the cellular concentration of (p)ppGpp p

COG id: COG1694

COG function: function code R; Predicted pyrophosphatase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the nucleoside triphosphate pyrophosphohydrolase family [H]

Homologues:

Organism=Escherichia coli, GI1789144, Length=274, Percent_Identity=53.6496350364963, Blast_Score=278, Evalue=2e-76,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004518
- InterPro:   IPR011551 [H]

Pfam domain/function: PF03819 MazG [H]

EC number: =3.6.1.8 [H]

Molecular weight: Translated: 31481; Mature: 31481

Theoretical pI: Translated: 4.60; Mature: 4.60

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYTVQDLLHLMARLRDPQFGCPWDLKQTYASIVPHTLEEAYEVADAIEQGDLDHLKGELG
CCCHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHH
DLLFQVVFYAQLAKEEGRFEFDDVIDGITRKLLRRHPHVFPTGELYAPAETPRLTDEQVN
HHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCCCCCEECCCCCCCCCHHHHH
RRWDEIKAEERAEKAGVPEQLSLLDDVPRALPALSRAAKLQKRAAQVGFDWPAALPVVDK
HHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHH
VREELDEILEAMVDNDAEGIAEEVGDLLFSVVNLARHLKVDPETALRSANSKFDRRFRFI
HHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHH
EQALRHLQRPIEACSLEEMDALWGEAKRQEKSTPGCG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MYTVQDLLHLMARLRDPQFGCPWDLKQTYASIVPHTLEEAYEVADAIEQGDLDHLKGELG
CCCHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHH
DLLFQVVFYAQLAKEEGRFEFDDVIDGITRKLLRRHPHVFPTGELYAPAETPRLTDEQVN
HHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCCCCCEECCCCCCCCCHHHHH
RRWDEIKAEERAEKAGVPEQLSLLDDVPRALPALSRAAKLQKRAAQVGFDWPAALPVVDK
HHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHH
VREELDEILEAMVDNDAEGIAEEVGDLLFSVVNLARHLKVDPETALRSANSKFDRRFRFI
HHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHH
EQALRHLQRPIEACSLEEMDALWGEAKRQEKSTPGCG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]