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The map label for this gene is relA [H]

Identifier: 66046924

GI number: 66046924

Start: 4380642

End: 4382885

Strand: Reverse

Name: relA [H]

Synonym: Psyr_3695

Alternate gene names: 66046924

Gene position: 4382885-4380642 (Counterclockwise)

Preceding gene: 66046925

Following gene: 66046923

Centisome position: 71.92

GC content: 61.05

Gene sequence:

>2244_bases
ATGGTACAGGTGAGAGCGAACCAGCCGATAAACACAGACGGCAGTATCAATCTCGACGCGTGGCTCGATCATATTGTCAG
CGTCGACCTGGTCCTGGACCGGGAAGTCATGAAAAAGGCCTGTGAATTTGCCCGGGAAGCCGAGCAGACCGACAAGGCTC
ACAAGAATCATTGGGCAGAGGGCACCTCCAGTTTCCAGACCGGTCTGGAAATCGCGGAGATCCTGGCTGACCTCAAGCTG
GATCAGGACTCGCTGGTCGCTGCGGTCATTTACCGTGGCGTGCGTGAAGGTCTCATTGCGCTGCCGGACGTCGAGCAGCG
CTTTGGCGCAACGGTCGCCAAACTCATCGACGGCGTGCTGCGCATGGCCGCGATCAGCGCCAGCCTCAGCCCTCGTCAGT
CATTGGTGCTCGGCAGTCAGGCGCAGGTGGAAAACCTGCGCAAGATGCTGGTGGCGATGGTCGACGACGTTCGCGTTGCG
CTGATCAAGCTGGCCGAACGTACCTGCGCGATTCGTGCGGTGAAGAATGCCGACGACGAAAAACGCAACCGTGTGGCTCG
CGAAGTCTTCGACATCTATGCGCCACTGGCCCACCGCCTGGGTATCGGGCATATCAAGTGGGAGCTGGAGGACCTGTCCT
TCCGCTACCTGGAGCCCGATCAATACAAGCAGATCGCCAAGCTGCTGCATGAACGCAGGCTGGACCGCGAGCGCTTCATC
AGCGACGTCATGTCTCAACTCGATAACGAGCTGCAGGCCACCGGCGTGACCGCTGACATCAGCGGTCGTGCCAAGCATAT
CTACTCCATCTGGCGCAAAATGCAGCGCAAGGGCCTGGCGTTCAGCCAGATCTATGACGTGCGTGCGTTGCGTGTGCTGG
TCCCGGAAATGCGCGACTGCTACACCGCGCTGGGTATCGTGCACACCTTGTGGCGGCATATTCCCAAAGAGTTCGACGAT
TACATCGCCAACCCCAAGGAAAACGGCTATCGCTCGCTGCACACCGCCGTGATCGGGCCGGAAGGCAAGGTGCTGGAAGT
GCAGATCCGCACCCACGCCATGCATGAAGAGGCCGAGCTGGGCGTTTGTGCGCACTGGCGCTATAAAGGCACCGACGTCA
AATCCGGCTCCAATCATTACGAAGAGAAGATTTCCTGGCTGCGTCAGGTGCTCGAATGGCATGAGGAGCTGGGCGACATC
GGCGGTCTGGCCGATCAGTTGCGGGTTGATATCGAGCCCGACCGCGTCTACGTCTTCACCCCGGACGGCCACGCCATCGA
CCTGCCCAAGGGCGCGACACCGCTGGACTTCGCCTATCGGGTGCACACCGAAATCGGCCATAACTGCCGGGGTGCGAAGA
TCAATGGCCGCATCGTACCGCTCAACTACAGCCTGCAGACCGGCGAGCAGGTCGAGATCATCACCAGCAAGCACGGTACG
CCGAGCCGCGACTGGCTGAACTCGAACCTGGGCTACATCACCACCTCGCGCGCGCGGGCCAAGATCGTTCACTGGTTCAA
GTTGCAGGCTCGCGACCAGAACGTCGCCGCCGGCAGAACCCTGATCGAACGCGAACTGGCGCGCCTGGCGTTACCGCAGG
TCGATTTCGACAAGCTGGCGGACAAGGCCAATCACAAGACCGCCGACGACATGTTTGCGGCATTGGGCGCGGGCGATCTG
CGTCTGGCGCAACTGGTCAATCTGGCTCAGCAGCAGGTTGAGCCTGATCGCGTCAATGAACAGCTGGAGCTGATCCCGCG
CAAGGCCACCGGCTACAAGCCCGGCAAGCGTGGCGATATTCAGATTCAGGGCGTCGGCAACCTGATGACGCAGATGGCCG
GCTGCTGCCAGCCGCTGCCGGGCGATGCGATCGTCGGTTATATCACTCAGGGGCGTGGCGTCAGCATTCACCGTCAGGAT
TGCGCTTCGGTGCTGCAATTGGGCGGTCGCGAGCCCGAGCGGATCATTCAGGTCAGTTGGGGGCCGGTGCCGGTACTCAC
CTATCCGGTGGACATCATCATCCGTGCCTACGACCGTTCCGGCTTGCTCCGGGACGTCACCCAGGTGCTGCTCAACGAGC
GGATCAACGTGCTGGCGGTCAATACCCGTTCGAACAAGGAAGACAACACAGCGCTCATGTCTCTGACCATCGAGATTCCG
GGTCTGGACGCGCTGGGGCGGTTGCTGGGGCGCATTTCCCAGCTGCCGAACATCATTGAAACGCGCAGGAACAGGACGCC
CTAG

Upstream 100 bases:

>100_bases
GCCCGCGAATGCCGGTCCTTGCTTGCCCGGCAAGTGGCATTCGCTCAGAAGGCTGGCGACTGATGGCGCTATTCATCGCG
CCGTAGGGAAGGTAAGCAGC

Downstream 100 bases:

>100_bases
GGGCAGCTATAAGCTATAAGCTGCAAGCTGTAAGTTTCAAGCTGCAAGCTAAAGCGGATTGCGGTGGCTTCTAGCTTGCA
GCTTGCAGCTTGAAGCTTGA

Product: RelA/SpoT protein

Products: NA

Alternate protein names: (p)ppGpp synthase; ATP:GTP 3'-pyrophosphotransferase; ppGpp synthase I [H]

Number of amino acids: Translated: 747; Mature: 747

Protein sequence:

>747_residues
MVQVRANQPINTDGSINLDAWLDHIVSVDLVLDREVMKKACEFAREAEQTDKAHKNHWAEGTSSFQTGLEIAEILADLKL
DQDSLVAAVIYRGVREGLIALPDVEQRFGATVAKLIDGVLRMAAISASLSPRQSLVLGSQAQVENLRKMLVAMVDDVRVA
LIKLAERTCAIRAVKNADDEKRNRVAREVFDIYAPLAHRLGIGHIKWELEDLSFRYLEPDQYKQIAKLLHERRLDRERFI
SDVMSQLDNELQATGVTADISGRAKHIYSIWRKMQRKGLAFSQIYDVRALRVLVPEMRDCYTALGIVHTLWRHIPKEFDD
YIANPKENGYRSLHTAVIGPEGKVLEVQIRTHAMHEEAELGVCAHWRYKGTDVKSGSNHYEEKISWLRQVLEWHEELGDI
GGLADQLRVDIEPDRVYVFTPDGHAIDLPKGATPLDFAYRVHTEIGHNCRGAKINGRIVPLNYSLQTGEQVEIITSKHGT
PSRDWLNSNLGYITTSRARAKIVHWFKLQARDQNVAAGRTLIERELARLALPQVDFDKLADKANHKTADDMFAALGAGDL
RLAQLVNLAQQQVEPDRVNEQLELIPRKATGYKPGKRGDIQIQGVGNLMTQMAGCCQPLPGDAIVGYITQGRGVSIHRQD
CASVLQLGGREPERIIQVSWGPVPVLTYPVDIIIRAYDRSGLLRDVTQVLLNERINVLAVNTRSNKEDNTALMSLTIEIP
GLDALGRLLGRISQLPNIIETRRNRTP

Sequences:

>Translated_747_residues
MVQVRANQPINTDGSINLDAWLDHIVSVDLVLDREVMKKACEFAREAEQTDKAHKNHWAEGTSSFQTGLEIAEILADLKL
DQDSLVAAVIYRGVREGLIALPDVEQRFGATVAKLIDGVLRMAAISASLSPRQSLVLGSQAQVENLRKMLVAMVDDVRVA
LIKLAERTCAIRAVKNADDEKRNRVAREVFDIYAPLAHRLGIGHIKWELEDLSFRYLEPDQYKQIAKLLHERRLDRERFI
SDVMSQLDNELQATGVTADISGRAKHIYSIWRKMQRKGLAFSQIYDVRALRVLVPEMRDCYTALGIVHTLWRHIPKEFDD
YIANPKENGYRSLHTAVIGPEGKVLEVQIRTHAMHEEAELGVCAHWRYKGTDVKSGSNHYEEKISWLRQVLEWHEELGDI
GGLADQLRVDIEPDRVYVFTPDGHAIDLPKGATPLDFAYRVHTEIGHNCRGAKINGRIVPLNYSLQTGEQVEIITSKHGT
PSRDWLNSNLGYITTSRARAKIVHWFKLQARDQNVAAGRTLIERELARLALPQVDFDKLADKANHKTADDMFAALGAGDL
RLAQLVNLAQQQVEPDRVNEQLELIPRKATGYKPGKRGDIQIQGVGNLMTQMAGCCQPLPGDAIVGYITQGRGVSIHRQD
CASVLQLGGREPERIIQVSWGPVPVLTYPVDIIIRAYDRSGLLRDVTQVLLNERINVLAVNTRSNKEDNTALMSLTIEIP
GLDALGRLLGRISQLPNIIETRRNRTP
>Mature_747_residues
MVQVRANQPINTDGSINLDAWLDHIVSVDLVLDREVMKKACEFAREAEQTDKAHKNHWAEGTSSFQTGLEIAEILADLKL
DQDSLVAAVIYRGVREGLIALPDVEQRFGATVAKLIDGVLRMAAISASLSPRQSLVLGSQAQVENLRKMLVAMVDDVRVA
LIKLAERTCAIRAVKNADDEKRNRVAREVFDIYAPLAHRLGIGHIKWELEDLSFRYLEPDQYKQIAKLLHERRLDRERFI
SDVMSQLDNELQATGVTADISGRAKHIYSIWRKMQRKGLAFSQIYDVRALRVLVPEMRDCYTALGIVHTLWRHIPKEFDD
YIANPKENGYRSLHTAVIGPEGKVLEVQIRTHAMHEEAELGVCAHWRYKGTDVKSGSNHYEEKISWLRQVLEWHEELGDI
GGLADQLRVDIEPDRVYVFTPDGHAIDLPKGATPLDFAYRVHTEIGHNCRGAKINGRIVPLNYSLQTGEQVEIITSKHGT
PSRDWLNSNLGYITTSRARAKIVHWFKLQARDQNVAAGRTLIERELARLALPQVDFDKLADKANHKTADDMFAALGAGDL
RLAQLVNLAQQQVEPDRVNEQLELIPRKATGYKPGKRGDIQIQGVGNLMTQMAGCCQPLPGDAIVGYITQGRGVSIHRQD
CASVLQLGGREPERIIQVSWGPVPVLTYPVDIIIRAYDRSGLLRDVTQVLLNERINVLAVNTRSNKEDNTALMSLTIEIP
GLDALGRLLGRISQLPNIIETRRNRTP

Specific function: In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. This enzyme catalyzes the formation of pppGpp which i

COG id: COG0317

COG function: function code TK; Guanosine polyphosphate pyrophosphohydrolases/synthetases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ACT domain [H]

Homologues:

Organism=Escherichia coli, GI1789147, Length=754, Percent_Identity=47.7453580901857, Blast_Score=713, Evalue=0.0,
Organism=Escherichia coli, GI1790082, Length=681, Percent_Identity=36.5638766519824, Blast_Score=448, Evalue=1e-127,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR012675
- InterPro:   IPR007685
- InterPro:   IPR004811
- InterPro:   IPR004095
- InterPro:   IPR012676 [H]

Pfam domain/function: PF01842 ACT; PF04607 RelA_SpoT; PF02824 TGS [H]

EC number: =2.7.6.5 [H]

Molecular weight: Translated: 83887; Mature: 83887

Theoretical pI: Translated: 7.37; Mature: 7.37

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVQVRANQPINTDGSINLDAWLDHIVSVDLVLDREVMKKACEFAREAEQTDKAHKNHWAE
CEEEECCCCCCCCCCEEHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCC
GTSSFQTGLEIAEILADLKLDQDSLVAAVIYRGVREGLIALPDVEQRFGATVAKLIDGVL
CCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCEECCCHHHHHHHHHHHHHHHHH
RMAAISASLSPRQSLVLGSQAQVENLRKMLVAMVDDVRVALIKLAERTCAIRAVKNADDE
HHHHHHCCCCCCHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHH
KRNRVAREVFDIYAPLAHRLGIGHIKWELEDLSFRYLEPDQYKQIAKLLHERRLDRERFI
HHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCEEECCCCHHHHHHHHHHHHHCCCHHHHH
SDVMSQLDNELQATGVTADISGRAKHIYSIWRKMQRKGLAFSQIYDVRALRVLVPEMRDC
HHHHHHHHHHHHHCCCEEECCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHH
YTALGIVHTLWRHIPKEFDDYIANPKENGYRSLHTAVIGPEGKVLEVQIRTHAMHEEAEL
HHHHHHHHHHHHHCCHHHHHHHCCCCCCCHHHHHHEEECCCCCEEEEEEHHHHHHHHCCC
GVCAHWRYKGTDVKSGSNHYEEKISWLRQVLEWHEELGDIGGLADQLRVDIEPDRVYVFT
CEEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHEEEECCCEEEEEC
PDGHAIDLPKGATPLDFAYRVHTEIGHNCRGAKINGRIVPLNYSLQTGEQVEIITSKHGT
CCCCEEECCCCCCCHHHHEEEHHHHCCCCCCCEECCEEEEEECEECCCCEEEEEECCCCC
PSRDWLNSNLGYITTSRARAKIVHWFKLQARDQNVAAGRTLIERELARLALPQVDFDKLA
CCHHHHCCCCCEEEECCHHHHHHHHEEEECCCCCHHHHHHHHHHHHHHHHCCCCCHHHHH
DKANHKTADDMFAALGAGDLRLAQLVNLAQQQVEPDRVNEQLELIPRKATGYKPGKRGDI
HHCCCCCHHHHHHHHCCCHHHHHHHHHHHHHCCCHHHHCHHHHHCCCCCCCCCCCCCCCE
QIQGVGNLMTQMAGCCQPLPGDAIVGYITQGRGVSIHRQDCASVLQLGGREPERIIQVSW
EEEEHHHHHHHHHHHCCCCCCCCEEEEEECCCCCEEEHHHHHHHHHCCCCCCCCEEEEEC
GPVPVLTYPVDIIIRAYDRSGLLRDVTQVLLNERINVLAVNTRSNKEDNTALMSLTIEIP
CCEEEEEECHHHEEEECCCCCHHHHHHHHHHHCCCCEEEEECCCCCCCCEEEEEEEEECC
GLDALGRLLGRISQLPNIIETRRNRTP
CHHHHHHHHHHHHHCCHHHHHHCCCCC
>Mature Secondary Structure
MVQVRANQPINTDGSINLDAWLDHIVSVDLVLDREVMKKACEFAREAEQTDKAHKNHWAE
CEEEECCCCCCCCCCEEHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCC
GTSSFQTGLEIAEILADLKLDQDSLVAAVIYRGVREGLIALPDVEQRFGATVAKLIDGVL
CCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCEECCCHHHHHHHHHHHHHHHHH
RMAAISASLSPRQSLVLGSQAQVENLRKMLVAMVDDVRVALIKLAERTCAIRAVKNADDE
HHHHHHCCCCCCHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHH
KRNRVAREVFDIYAPLAHRLGIGHIKWELEDLSFRYLEPDQYKQIAKLLHERRLDRERFI
HHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCEEECCCCHHHHHHHHHHHHHCCCHHHHH
SDVMSQLDNELQATGVTADISGRAKHIYSIWRKMQRKGLAFSQIYDVRALRVLVPEMRDC
HHHHHHHHHHHHHCCCEEECCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHH
YTALGIVHTLWRHIPKEFDDYIANPKENGYRSLHTAVIGPEGKVLEVQIRTHAMHEEAEL
HHHHHHHHHHHHHCCHHHHHHHCCCCCCCHHHHHHEEECCCCCEEEEEEHHHHHHHHCCC
GVCAHWRYKGTDVKSGSNHYEEKISWLRQVLEWHEELGDIGGLADQLRVDIEPDRVYVFT
CEEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHEEEECCCEEEEEC
PDGHAIDLPKGATPLDFAYRVHTEIGHNCRGAKINGRIVPLNYSLQTGEQVEIITSKHGT
CCCCEEECCCCCCCHHHHEEEHHHHCCCCCCCEECCEEEEEECEECCCCEEEEEECCCCC
PSRDWLNSNLGYITTSRARAKIVHWFKLQARDQNVAAGRTLIERELARLALPQVDFDKLA
CCHHHHCCCCCEEEECCHHHHHHHHEEEECCCCCHHHHHHHHHHHHHHHHCCCCCHHHHH
DKANHKTADDMFAALGAGDLRLAQLVNLAQQQVEPDRVNEQLELIPRKATGYKPGKRGDI
HHCCCCCHHHHHHHHCCCHHHHHHHHHHHHHCCCHHHHCHHHHHCCCCCCCCCCCCCCCE
QIQGVGNLMTQMAGCCQPLPGDAIVGYITQGRGVSIHRQDCASVLQLGGREPERIIQVSW
EEEEHHHHHHHHHHHCCCCCCCCEEEEEECCCCCEEEHHHHHHHHHCCCCCCCCEEEEEC
GPVPVLTYPVDIIIRAYDRSGLLRDVTQVLLNERINVLAVNTRSNKEDNTALMSLTIEIP
CCEEEEEECHHHEEEECCCCCHHHHHHHHHHHCCCCEEEEECCCCCCCCEEEEEEEEECC
GLDALGRLLGRISQLPNIIETRRNRTP
CHHHHHHHHHHHHHCCHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]