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The map label for this gene is cobB2 [H]

Identifier: 66046914

GI number: 66046914

Start: 4371438

End: 4372181

Strand: Reverse

Name: cobB2 [H]

Synonym: Psyr_3685

Alternate gene names: 66046914

Gene position: 4372181-4371438 (Counterclockwise)

Preceding gene: 66046915

Following gene: 66046913

Centisome position: 71.75

GC content: 59.01

Gene sequence:

>744_bases
ATGCAGACGGCGGCTGCCTTGCGCCATGCAAAACGGATTCTGGTGATCACCGGGGCGGGGCTGTCTGCCGATTCGGGGCT
GCCGACCTACCGTGGCGTGGGCGGGCTCTACAATGGCAAGACCGACGATGGCCTGCCTATCGAAATGGCCCTGTCCGGGC
CCATGCTGCGTCGTGATCCTGAGCTGTGCTGGAAATACATCGCCGAACTGGGCAAGGCGTGCCTGGGTGGCGAGCCGAAT
GTCGCGCATTACGCCATCGCCCAGTTGCAGCGCATCAAACCCGAGTGCTGGGTGCTGACCCAGAACGTCGACGGTTACCA
TCGCGCAGCGGGCAGTCCACCGGAGCGCCTGATCGAAATTCACGGGCAGCTCTCGCCACTGTTTTGCCAATCCTGCGGTG
CTGAGGATTCGCAATTGAGTGAGCACTTGCAGCGTCCTTTGCCCCCCTTATGCCCGGCATGTAGTGGCATTTTGCGACCG
TCCGTCGTTCTTTTTCAGGAAATGCTTCCCGAAAAAGCGCTGGAAACACTGCATGAACAGCTGGCTAAAGGCTATGACGC
AGTGTTGAGTATCGGCACCACCGCAAGCTTCCCCTACATTCACGAACCGGTCATTCGCACCAGAGTTTCCGGGGGTTTTA
CCGCAGAAATCAATCCGCAGCCGACGGATCACAGCGCGCAGATGGACGTCTTTTTGCCGTACCGCGCGGCACATGTCATG
GCAGAACTCATAAGTCACATCTAG

Upstream 100 bases:

>100_bases
AATTGCTCGAGCGCCTCGATCAGGCGTCACTCCAGGAAAAGCGCAAGCTGACCATTCCCTTCCTTAAAGAGACCCTCGGG
TGGTAGATCAGGCGCTGTTG

Downstream 100 bases:

>100_bases
TTCGATTGAATTTGCAAATCACCTTCATAAAAGGCATAGTCTCGCCATCTTAACTAGTCAGCCACGGTTGTGCCCATGCA
AGTTGTTCGCTTCGCACCCC

Product: NAD-dependent deacetylase

Products: NA

Alternate protein names: Regulatory protein SIR2 homolog 2 [H]

Number of amino acids: Translated: 247; Mature: 247

Protein sequence:

>247_residues
MQTAAALRHAKRILVITGAGLSADSGLPTYRGVGGLYNGKTDDGLPIEMALSGPMLRRDPELCWKYIAELGKACLGGEPN
VAHYAIAQLQRIKPECWVLTQNVDGYHRAAGSPPERLIEIHGQLSPLFCQSCGAEDSQLSEHLQRPLPPLCPACSGILRP
SVVLFQEMLPEKALETLHEQLAKGYDAVLSIGTTASFPYIHEPVIRTRVSGGFTAEINPQPTDHSAQMDVFLPYRAAHVM
AELISHI

Sequences:

>Translated_247_residues
MQTAAALRHAKRILVITGAGLSADSGLPTYRGVGGLYNGKTDDGLPIEMALSGPMLRRDPELCWKYIAELGKACLGGEPN
VAHYAIAQLQRIKPECWVLTQNVDGYHRAAGSPPERLIEIHGQLSPLFCQSCGAEDSQLSEHLQRPLPPLCPACSGILRP
SVVLFQEMLPEKALETLHEQLAKGYDAVLSIGTTASFPYIHEPVIRTRVSGGFTAEINPQPTDHSAQMDVFLPYRAAHVM
AELISHI
>Mature_247_residues
MQTAAALRHAKRILVITGAGLSADSGLPTYRGVGGLYNGKTDDGLPIEMALSGPMLRRDPELCWKYIAELGKACLGGEPN
VAHYAIAQLQRIKPECWVLTQNVDGYHRAAGSPPERLIEIHGQLSPLFCQSCGAEDSQLSEHLQRPLPPLCPACSGILRP
SVVLFQEMLPEKALETLHEQLAKGYDAVLSIGTTASFPYIHEPVIRTRVSGGFTAEINPQPTDHSAQMDVFLPYRAAHVM
AELISHI

Specific function: Modulates the activities of several enzymes which are inactive in their acetylated form [H]

COG id: COG0846

COG function: function code K; NAD-dependent protein deacetylases, SIR2 family

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 deacetylase sirtuin-type domain [H]

Homologues:

Organism=Homo sapiens, GI300795542, Length=200, Percent_Identity=35.5, Blast_Score=103, Evalue=2e-22,
Organism=Homo sapiens, GI13787215, Length=218, Percent_Identity=32.5688073394495, Blast_Score=97, Evalue=1e-20,
Organism=Homo sapiens, GI6912664, Length=218, Percent_Identity=32.5688073394495, Blast_Score=97, Evalue=2e-20,
Organism=Homo sapiens, GI6912660, Length=212, Percent_Identity=31.6037735849057, Blast_Score=92, Evalue=6e-19,
Organism=Homo sapiens, GI6912662, Length=217, Percent_Identity=30.4147465437788, Blast_Score=87, Evalue=1e-17,
Organism=Homo sapiens, GI63054862, Length=194, Percent_Identity=31.4432989690722, Blast_Score=86, Evalue=3e-17,
Organism=Homo sapiens, GI300797577, Length=246, Percent_Identity=26.0162601626016, Blast_Score=83, Evalue=3e-16,
Organism=Homo sapiens, GI300797705, Length=191, Percent_Identity=27.2251308900524, Blast_Score=75, Evalue=5e-14,
Organism=Homo sapiens, GI13775602, Length=190, Percent_Identity=27.3684210526316, Blast_Score=74, Evalue=1e-13,
Organism=Homo sapiens, GI13775600, Length=190, Percent_Identity=27.3684210526316, Blast_Score=73, Evalue=2e-13,
Organism=Homo sapiens, GI7657575, Length=192, Percent_Identity=28.125, Blast_Score=68, Evalue=7e-12,
Organism=Escherichia coli, GI308199517, Length=221, Percent_Identity=31.2217194570136, Blast_Score=78, Evalue=5e-16,
Organism=Caenorhabditis elegans, GI17567771, Length=271, Percent_Identity=25.830258302583, Blast_Score=80, Evalue=8e-16,
Organism=Caenorhabditis elegans, GI17505510, Length=259, Percent_Identity=26.6409266409266, Blast_Score=70, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17541892, Length=195, Percent_Identity=27.1794871794872, Blast_Score=69, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6325242, Length=175, Percent_Identity=29.7142857142857, Blast_Score=72, Evalue=1e-13,
Organism=Drosophila melanogaster, GI24648389, Length=189, Percent_Identity=29.1005291005291, Blast_Score=72, Evalue=3e-13,
Organism=Drosophila melanogaster, GI17137536, Length=197, Percent_Identity=27.9187817258883, Blast_Score=70, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003000 [H]

Pfam domain/function: PF02146 SIR2 [H]

EC number: 3.5.1.- [C]

Molecular weight: Translated: 26840; Mature: 26840

Theoretical pI: Translated: 6.50; Mature: 6.50

Prosite motif: PS50305 SIRTUIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.8 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
2.8 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
5.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQTAAALRHAKRILVITGAGLSADSGLPTYRGVGGLYNGKTDDGLPIEMALSGPMLRRDP
CCHHHHHHHCCEEEEEECCCCCCCCCCCCHHCCCCCCCCCCCCCCCEEEECCCCCCCCCH
ELCWKYIAELGKACLGGEPNVAHYAIAQLQRIKPECWVLTQNVDGYHRAAGSPPERLIEI
HHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCEEEEECCCCCHHHCCCCCHHHHHHH
HGQLSPLFCQSCGAEDSQLSEHLQRPLPPLCPACSGILRPSVVLFQEMLPEKALETLHEQ
HCCCCHHHHHHCCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LAKGYDAVLSIGTTASFPYIHEPVIRTRVSGGFTAEINPQPTDHSAQMDVFLPYRAAHVM
HHHHHHHHHHCCCCCCCCCHHHHHHHHHCCCCEEEECCCCCCCCCCCEEEECCHHHHHHH
AELISHI
HHHHHCC
>Mature Secondary Structure
MQTAAALRHAKRILVITGAGLSADSGLPTYRGVGGLYNGKTDDGLPIEMALSGPMLRRDP
CCHHHHHHHCCEEEEEECCCCCCCCCCCCHHCCCCCCCCCCCCCCCEEEECCCCCCCCCH
ELCWKYIAELGKACLGGEPNVAHYAIAQLQRIKPECWVLTQNVDGYHRAAGSPPERLIEI
HHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCEEEEECCCCCHHHCCCCCHHHHHHH
HGQLSPLFCQSCGAEDSQLSEHLQRPLPPLCPACSGILRPSVVLFQEMLPEKALETLHEQ
HCCCCHHHHHHCCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LAKGYDAVLSIGTTASFPYIHEPVIRTRVSGGFTAEINPQPTDHSAQMDVFLPYRAAHVM
HHHHHHHHHHCCCCCCCCCHHHHHHHHHCCCCEEEECCCCCCCCCCCEEEECCHHHHHHH
AELISHI
HHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12928499 [H]