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The map label for this gene is cobQ [H]

Identifier: 66046905

GI number: 66046905

Start: 4361979

End: 4363439

Strand: Reverse

Name: cobQ [H]

Synonym: Psyr_3676

Alternate gene names: 66046905

Gene position: 4363439-4361979 (Counterclockwise)

Preceding gene: 66046906

Following gene: 66046904

Centisome position: 71.61

GC content: 63.72

Gene sequence:

>1461_bases
ATGAGCACGCTGATGGTACAAGGCACCACCTCCGATGCCGGCAAAAGCACCCTGGTGACGGCCCTGTGCCGCTGGCTGAC
CCGCCAGGGCGTCAAGGTCGTGCCGTTCAAGCCGCAGAACATGGCGCTCAACAGCGCGGTGACCGCAGACGGCGGCGAGA
TCGGCCGCGCACAGGCCGTGCAGGCGCAGGCGTGCTACCTCGAACCGCACACCGACATGAACCCGGTGCTGCTCAAGCCC
AACAGTGACACCGGCGCGCAGGTGATCATTCACGGCCGCGCCGTGACCACCATGAACGCGGTGGCGTATCACGGCTATAA
AGAGATCGCCATGCAGGCGGTGCTGGAATCGCATCGGCGCCTGGGTGAAAGCTATCCGGTGATCGTGGTCGAGGGCGCGG
GTTCACCGGCCGAGATCAACCTGCGCGCCAACGATATCGCCAACATGGGATTTGCCGAGGCGGTCGACTGCCCGGTGCTG
CTGATTGCCGACATCAATCGTGGCGGGGTGTTTGCCCATCTGGTCGGCACGCTAGAGTTGCTGTCGCTCAGCGAGCAGGC
GCGGGTCAAGGGTTTCATCATCAACCGTTTTCGTGGCGACATCGCCTTGTTGCAGCCGGGCCTGGACTGGCTGGAAGCAC
GCACCGGCAAGCCGGTGGTTGGCGTGCTGCCCTATGTGATGGATCTGCACCTGGAGGCCGAAGACGGCCTGGACCAGCGT
CAGACCGACAAGGTCGAGCATGTGCTGAACGTGGTGGTCCCGGTGCTGCCTCGCATCAGTAATCACACCGACTTCGACCC
GTTGCGCCTGCACCCTCAGGTCAATCTGCAATTCATCGGCCCCGGCAAGGCGATTCCTCCTGCGGACCTGATCATTCTGC
CCGGCTCCAAGAGCGTGCGCAGCGATCTGAACTACCTGCGCAACAATGGCTGGGACACCGCCATCGCTCGGCATTTGCGT
TACGGCGGCAAGCTGATGGGCATCTGCGGCGGCCTGCAAATGCTCGGTGAGCAGGTACACGATCCACTCGGGCTGGAAGG
CGCAGCCGGGTCCAGTGCCGGGTTCGGCTTGCTGGCCATGAGCACGGTGCTGGAAGCGGAAAAGCAACTGCGCAATGTGC
GCGGTCGTCTGACCCTGGAAGATGCCGAGGTCAGCGGTTACGAAATTCATGCCGGCGTAACGACAGGGCCGGCGCTGGAG
CAGGCTGCCGTGCAACTGGACGATGGGCGTTGCGATGGCGCGCAGAGTGCCGACGGGCAGGTGCTGGGGACTTACCTGCA
CGGCCTGTTCGAATCACCTGCTGCGTGTAGCGCGTTGCTGCGCTGGGCGGGGTTGGCGAACGTGCAATCCGTCGATTATC
ACGCCCTGCGCGAGCGTGACATCGAACGTCTGGCGGACCTGGTGGAAAAGCATCTGGACGGCCCATTGCTTCGCGAACTG
TGTGGCCTGGAGGCGAACTGA

Upstream 100 bases:

>100_bases
ATTCCCCCGAGTCGTCCAGTCTGCGTTTTGGCCTGCCCTGCGACGAGGCCGACTGGCTGCGGCTGCACGATGTTCTGCTT
GAATACCGCAAGGAATACCC

Downstream 100 bases:

>100_bases
ATGCTGCAATTGATCCTCGGCGGCGCGCGTTCCGGCAAGAGTCGCCTGGCGGAAAAACTGGCCGCCGACAGCGCGCTGAA
GGTGACCTACATCGCTACCA

Product: cobyric acid synthase

Products: ADP; phosphate; adenosylcobyric acid; L-glutamate

Alternate protein names: NA

Number of amino acids: Translated: 486; Mature: 485

Protein sequence:

>486_residues
MSTLMVQGTTSDAGKSTLVTALCRWLTRQGVKVVPFKPQNMALNSAVTADGGEIGRAQAVQAQACYLEPHTDMNPVLLKP
NSDTGAQVIIHGRAVTTMNAVAYHGYKEIAMQAVLESHRRLGESYPVIVVEGAGSPAEINLRANDIANMGFAEAVDCPVL
LIADINRGGVFAHLVGTLELLSLSEQARVKGFIINRFRGDIALLQPGLDWLEARTGKPVVGVLPYVMDLHLEAEDGLDQR
QTDKVEHVLNVVVPVLPRISNHTDFDPLRLHPQVNLQFIGPGKAIPPADLIILPGSKSVRSDLNYLRNNGWDTAIARHLR
YGGKLMGICGGLQMLGEQVHDPLGLEGAAGSSAGFGLLAMSTVLEAEKQLRNVRGRLTLEDAEVSGYEIHAGVTTGPALE
QAAVQLDDGRCDGAQSADGQVLGTYLHGLFESPAACSALLRWAGLANVQSVDYHALRERDIERLADLVEKHLDGPLLREL
CGLEAN

Sequences:

>Translated_486_residues
MSTLMVQGTTSDAGKSTLVTALCRWLTRQGVKVVPFKPQNMALNSAVTADGGEIGRAQAVQAQACYLEPHTDMNPVLLKP
NSDTGAQVIIHGRAVTTMNAVAYHGYKEIAMQAVLESHRRLGESYPVIVVEGAGSPAEINLRANDIANMGFAEAVDCPVL
LIADINRGGVFAHLVGTLELLSLSEQARVKGFIINRFRGDIALLQPGLDWLEARTGKPVVGVLPYVMDLHLEAEDGLDQR
QTDKVEHVLNVVVPVLPRISNHTDFDPLRLHPQVNLQFIGPGKAIPPADLIILPGSKSVRSDLNYLRNNGWDTAIARHLR
YGGKLMGICGGLQMLGEQVHDPLGLEGAAGSSAGFGLLAMSTVLEAEKQLRNVRGRLTLEDAEVSGYEIHAGVTTGPALE
QAAVQLDDGRCDGAQSADGQVLGTYLHGLFESPAACSALLRWAGLANVQSVDYHALRERDIERLADLVEKHLDGPLLREL
CGLEAN
>Mature_485_residues
STLMVQGTTSDAGKSTLVTALCRWLTRQGVKVVPFKPQNMALNSAVTADGGEIGRAQAVQAQACYLEPHTDMNPVLLKPN
SDTGAQVIIHGRAVTTMNAVAYHGYKEIAMQAVLESHRRLGESYPVIVVEGAGSPAEINLRANDIANMGFAEAVDCPVLL
IADINRGGVFAHLVGTLELLSLSEQARVKGFIINRFRGDIALLQPGLDWLEARTGKPVVGVLPYVMDLHLEAEDGLDQRQ
TDKVEHVLNVVVPVLPRISNHTDFDPLRLHPQVNLQFIGPGKAIPPADLIILPGSKSVRSDLNYLRNNGWDTAIARHLRY
GGKLMGICGGLQMLGEQVHDPLGLEGAAGSSAGFGLLAMSTVLEAEKQLRNVRGRLTLEDAEVSGYEIHAGVTTGPALEQ
AAVQLDDGRCDGAQSADGQVLGTYLHGLFESPAACSALLRWAGLANVQSVDYHALRERDIERLADLVEKHLDGPLLRELC
GLEAN

Specific function: Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation [H]

COG id: COG1492

COG function: function code H; Cobyric acid synthase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 GATase cobBQ-type domain [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002586
- InterPro:   IPR017929
- InterPro:   IPR004459
- InterPro:   IPR011698 [H]

Pfam domain/function: PF01656 CbiA; PF07685 GATase_3 [H]

EC number: 6.3.5.10

Molecular weight: Translated: 52168; Mature: 52037

Theoretical pI: Translated: 5.56; Mature: 5.56

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTLMVQGTTSDAGKSTLVTALCRWLTRQGVKVVPFKPQNMALNSAVTADGGEIGRAQAV
CCEEEEECCCCCCCHHHHHHHHHHHHHHCCCEEEECCCCCCEECCEEECCCCCCCCHHHH
QAQACYLEPHTDMNPVLLKPNSDTGAQVIIHGRAVTTMNAVAYHGYKEIAMQAVLESHRR
EEHEEEECCCCCCCCEEECCCCCCCCEEEEECCEEHHHHHHHHCCHHHHHHHHHHHHHHH
LGESYPVIVVEGAGSPAEINLRANDIANMGFAEAVDCPVLLIADINRGGVFAHLVGTLEL
CCCCCCEEEEECCCCCEEEEEEHHHHCCCCCHHHCCCCEEEEEECCCCCCHHHHHHHHHH
LSLSEQARVKGFIINRFRGDIALLQPGLDWLEARTGKPVVGVLPYVMDLHLEAEDGLDQR
HHCCHHHHHHHEEEEHHCCCEEEECCCCHHHHHCCCCCHHHHHHHHHEEEEECCCCCCHH
QTDKVEHVLNVVVPVLPRISNHTDFDPLRLHPQVNLQFIGPGKAIPPADLIILPGSKSVR
HHHHHHHHHHHHHHHHCCCCCCCCCCCEEECCCEEEEEECCCCCCCCCCEEEECCCHHHH
SDLNYLRNNGWDTAIARHLRYGGKLMGICGGLQMLGEQVHDPLGLEGAAGSSAGFGLLAM
HHHHHHHCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHH
STVLEAEKQLRNVRGRLTLEDAEVSGYEIHAGVTTGPALEQAAVQLDDGRCDGAQSADGQ
HHHHHHHHHHHHHCCCEEEECCCCCCEEEEECCCCCCHHHHHHEEECCCCCCCCCCCCCC
VLGTYLHGLFESPAACSALLRWAGLANVQSVDYHALRERDIERLADLVEKHLDGPLLREL
CHHHHHHHHHCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHH
CGLEAN
HCCCCC
>Mature Secondary Structure 
STLMVQGTTSDAGKSTLVTALCRWLTRQGVKVVPFKPQNMALNSAVTADGGEIGRAQAV
CEEEEECCCCCCCHHHHHHHHHHHHHHCCCEEEECCCCCCEECCEEECCCCCCCCHHHH
QAQACYLEPHTDMNPVLLKPNSDTGAQVIIHGRAVTTMNAVAYHGYKEIAMQAVLESHRR
EEHEEEECCCCCCCCEEECCCCCCCCEEEEECCEEHHHHHHHHCCHHHHHHHHHHHHHHH
LGESYPVIVVEGAGSPAEINLRANDIANMGFAEAVDCPVLLIADINRGGVFAHLVGTLEL
CCCCCCEEEEECCCCCEEEEEEHHHHCCCCCHHHCCCCEEEEEECCCCCCHHHHHHHHHH
LSLSEQARVKGFIINRFRGDIALLQPGLDWLEARTGKPVVGVLPYVMDLHLEAEDGLDQR
HHCCHHHHHHHEEEEHHCCCEEEECCCCHHHHHCCCCCHHHHHHHHHEEEEECCCCCCHH
QTDKVEHVLNVVVPVLPRISNHTDFDPLRLHPQVNLQFIGPGKAIPPADLIILPGSKSVR
HHHHHHHHHHHHHHHHCCCCCCCCCCCEEECCCEEEEEECCCCCCCCCCEEEECCCHHHH
SDLNYLRNNGWDTAIARHLRYGGKLMGICGGLQMLGEQVHDPLGLEGAAGSSAGFGLLAM
HHHHHHHCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHH
STVLEAEKQLRNVRGRLTLEDAEVSGYEIHAGVTTGPALEQAAVQLDDGRCDGAQSADGQ
HHHHHHHHHHHHHCCCEEEECCCCCCEEEEECCCCCCHHHHHHEEECCCCCCCCCCCCCC
VLGTYLHGLFESPAACSALLRWAGLANVQSVDYHALRERDIERLADLVEKHLDGPLLREL
CHHHHHHHHHCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHH
CGLEAN
HCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; adenosylcobyrinic acid a,c-diamide; L-glutamine; H2O

Specific reaction: 4 ATP + adenosylcobyrinic acid a,c-diamide + 4 L-glutamine + 4 H2O = 4 ADP + 4 phosphate + adenosylcobyric acid + 4 L-glutamate

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA