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The map label for this gene is cobC [H]

Identifier: 66046906

GI number: 66046906

Start: 4363436

End: 4364440

Strand: Reverse

Name: cobC [H]

Synonym: Psyr_3677

Alternate gene names: 66046906

Gene position: 4364440-4363436 (Counterclockwise)

Preceding gene: 66046907

Following gene: 66046905

Centisome position: 71.62

GC content: 66.07

Gene sequence:

>1005_bases
ATGCTTGAGCACGGCGGGCGGTTGCGCGCGGCGGCGCAGCATTACGGTATTCATCTGGCCGACTGGCTGGACCTGTCCAC
CGGGATCGCACCCTGGTCGTGGCCCATCCCGGAGATCCCGACGCGTGCCTGGGCGCGGTTGCCCGAGACCGACGATGGTC
TGGAAGCGGCGGCCTGCACTTATTACGGCGTGACCCGGTTATTGCCGGTGTCCGGTTCGCAGGCTGCGATTCAGGCGCTG
CCGCGGGTGCGCAGCGGAGGGCGGGTCGGCGTTCTGTCGCCCTGCTACGCAGAGCACGCGCATGCCTGGCGCAAGAACGG
TTTCGTGGTGCGTGAGGTAGGTGAGCAGGAGGTCGAATACTTCCTCGACAGCCTGGACGTGCTGGTGGTGGTCAACCCCA
ACAACCCGACCGGCCTGCACCTGAGCGCCGAGCGCCTGCTGGAGTGGCATGCGCGACTGGCCGAGCGCGGTGGCTGGCTG
GTCGTCGATGAAGCGTTCATGGATAACACGCCGGGCGTGAGCCTGGCGGCCGAGACGTGGCGCACCGGGCTGATCGTCCT
GCGTTCGTTTGGCAAGTTTTTCGGCCTGGCCGGCGTCCGGCTCGGTTTTGTCATGGCCGAACCGGTGTTGTTGAGGATGC
TGGCGCAGGAAATCGGCCCCTGGTCGGTCAGTGGGCCAACCCGGATCATCGGTCAGGTGTGCCTCAGCGATCAGCAGGGG
CAGGCGCGTCAGCGTGAGCGCTGTGAGCAGGCCCGCGACCGGCTGGTGGCGCTGCTCGACCAGTACGCCCTGACCCCGCA
AGGCGGCTGTGCGCTGTTTCAATGGCTGGTGACCCCTGAAGCGCAGACGCTCTATGAGTTTTGTGCGCTGCGTGGCGTGC
TGCTGCGCCTGTTCAAGGGTGATTCCCCCGAGTCGTCCAGTCTGCGTTTTGGCCTGCCCTGCGACGAGGCCGACTGGCTG
CGGCTGCACGATGTTCTGCTTGAATACCGCAAGGAATACCCATGA

Upstream 100 bases:

>100_bases
GGTGCGCCTGCCGATGCGGACTCGATCGATCGCGGCTGGCAACTGGTGCAGCGCGGCGTGTGGTTATGGCTGCTGGTCAT
CTGCGTGGCGGCTGAATTTT

Downstream 100 bases:

>100_bases
GCACGCTGATGGTACAAGGCACCACCTCCGATGCCGGCAAAAGCACCCTGGTGACGGCCCTGTGCCGCTGGCTGACCCGC
CAGGGCGTCAAGGTCGTGCC

Product: threonine-phosphate decarboxylase

Products: NA

Alternate protein names: L-threonine-O-3-phosphate decarboxylase [H]

Number of amino acids: Translated: 334; Mature: 334

Protein sequence:

>334_residues
MLEHGGRLRAAAQHYGIHLADWLDLSTGIAPWSWPIPEIPTRAWARLPETDDGLEAAACTYYGVTRLLPVSGSQAAIQAL
PRVRSGGRVGVLSPCYAEHAHAWRKNGFVVREVGEQEVEYFLDSLDVLVVVNPNNPTGLHLSAERLLEWHARLAERGGWL
VVDEAFMDNTPGVSLAAETWRTGLIVLRSFGKFFGLAGVRLGFVMAEPVLLRMLAQEIGPWSVSGPTRIIGQVCLSDQQG
QARQRERCEQARDRLVALLDQYALTPQGGCALFQWLVTPEAQTLYEFCALRGVLLRLFKGDSPESSSLRFGLPCDEADWL
RLHDVLLEYRKEYP

Sequences:

>Translated_334_residues
MLEHGGRLRAAAQHYGIHLADWLDLSTGIAPWSWPIPEIPTRAWARLPETDDGLEAAACTYYGVTRLLPVSGSQAAIQAL
PRVRSGGRVGVLSPCYAEHAHAWRKNGFVVREVGEQEVEYFLDSLDVLVVVNPNNPTGLHLSAERLLEWHARLAERGGWL
VVDEAFMDNTPGVSLAAETWRTGLIVLRSFGKFFGLAGVRLGFVMAEPVLLRMLAQEIGPWSVSGPTRIIGQVCLSDQQG
QARQRERCEQARDRLVALLDQYALTPQGGCALFQWLVTPEAQTLYEFCALRGVLLRLFKGDSPESSSLRFGLPCDEADWL
RLHDVLLEYRKEYP
>Mature_334_residues
MLEHGGRLRAAAQHYGIHLADWLDLSTGIAPWSWPIPEIPTRAWARLPETDDGLEAAACTYYGVTRLLPVSGSQAAIQAL
PRVRSGGRVGVLSPCYAEHAHAWRKNGFVVREVGEQEVEYFLDSLDVLVVVNPNNPTGLHLSAERLLEWHARLAERGGWL
VVDEAFMDNTPGVSLAAETWRTGLIVLRSFGKFFGLAGVRLGFVMAEPVLLRMLAQEIGPWSVSGPTRIIGQVCLSDQQG
QARQRERCEQARDRLVALLDQYALTPQGGCALFQWLVTPEAQTLYEFCALRGVLLRLFKGDSPESSSLRFGLPCDEADWL
RLHDVLLEYRKEYP

Specific function: Decarboxylates L-threonine-O-3-phosphate to yield (R)-1- amino-2-propanol O-2-phosphate, the precursor for the linkage between the nucleotide loop and the corrin ring in cobalamin [H]

COG id: COG0079

COG function: function code E; Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

Organism=Escherichia coli, GI1788332, Length=156, Percent_Identity=35.8974358974359, Blast_Score=70, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004839
- InterPro:   IPR005860
- InterPro:   IPR004838
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =4.1.1.81 [H]

Molecular weight: Translated: 37200; Mature: 37200

Theoretical pI: Translated: 5.88; Mature: 5.88

Prosite motif: PS00105 AA_TRANSFER_CLASS_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLEHGGRLRAAAQHYGIHLADWLDLSTGIAPWSWPIPEIPTRAWARLPETDDGLEAAACT
CCCCCCCHHHHHHHCCCCHHHHHHHHCCCCCCCCCCCCCCCHHHHCCCCCCCCHHHHHHH
YYGVTRLLPVSGSQAAIQALPRVRSGGRVGVLSPCYAEHAHAWRKNGFVVREVGEQEVEY
HHHHHHEEECCCCHHHHHHHHHHCCCCCEEECCHHHHHHHHHHHHCCEEEECCCHHHHHH
FLDSLDVLVVVNPNNPTGLHLSAERLLEWHARLAERGGWLVVDEAFMDNTPGVSLAAETW
HHCCCCEEEEECCCCCCCEEECHHHHHHHHHHHHHCCCEEEEEHHHHCCCCCCEEEHHHH
RTGLIVLRSFGKFFGLAGVRLGFVMAEPVLLRMLAQEIGPWSVSGPTRIIGQVCLSDQQG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCC
QARQRERCEQARDRLVALLDQYALTPQGGCALFQWLVTPEAQTLYEFCALRGVLLRLFKG
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCC
DSPESSSLRFGLPCDEADWLRLHDVLLEYRKEYP
CCCCCCCEEECCCCCCCHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MLEHGGRLRAAAQHYGIHLADWLDLSTGIAPWSWPIPEIPTRAWARLPETDDGLEAAACT
CCCCCCCHHHHHHHCCCCHHHHHHHHCCCCCCCCCCCCCCCHHHHCCCCCCCCHHHHHHH
YYGVTRLLPVSGSQAAIQALPRVRSGGRVGVLSPCYAEHAHAWRKNGFVVREVGEQEVEY
HHHHHHEEECCCCHHHHHHHHHHCCCCCEEECCHHHHHHHHHHHHCCEEEECCCHHHHHH
FLDSLDVLVVVNPNNPTGLHLSAERLLEWHARLAERGGWLVVDEAFMDNTPGVSLAAETW
HHCCCCEEEEECCCCCCCEEECHHHHHHHHHHHHHCCCEEEEEHHHHCCCCCCEEEHHHH
RTGLIVLRSFGKFFGLAGVRLGFVMAEPVLLRMLAQEIGPWSVSGPTRIIGQVCLSDQQG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCC
QARQRERCEQARDRLVALLDQYALTPQGGCALFQWLVTPEAQTLYEFCALRGVLLRLFKG
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCC
DSPESSSLRFGLPCDEADWLRLHDVLLEYRKEYP
CCCCCCCEEECCCCCCCHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10984043 [H]