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The map label for this gene is tyrR [H]

Identifier: 66046803

GI number: 66046803

Start: 4256450

End: 4258027

Strand: Reverse

Name: tyrR [H]

Synonym: Psyr_3574

Alternate gene names: 66046803

Gene position: 4258027-4256450 (Counterclockwise)

Preceding gene: 66046808

Following gene: 66046801

Centisome position: 69.88

GC content: 62.1

Gene sequence:

>1578_bases
ATGCGCATCAAGGTGCACTGCCAGAACCGCATCGGCATTCTTCGCGACATTCTCGATCTGCTGGTGGCTTACGGCGTCAA
CGTGGCGCGCGGTGAAGTGGGGGGTGAGCACGGTGACGCGATCTATCTGCATTGCCCGAACCTGATCAACCTGCAGTTCC
AGGCCCTGCGCCCGAAGTTCGAGGCGATCACCGGGGTATTCGGCGTCAAGCGTGTCGGGCTGATGCCCAGCGAGCGCCGG
CACATGGAGCTCAATGCCTTGCTCGGCGCGCTGGAATTTCCGGTGTTGTCCATCGACATGGGCGGGGCTATCGTTGCGGC
CAATCGTGCCGCTGCGCAATTGCTGGGTGTGCGGGTCGATGAAGTGCCGGGCATGCCCTTGTCGCGTTACGCCGAAGATT
TCGACCTGCCTGAACTGGTGCGCGCCAGCCAGTCGCGGATCAACGGCCTGCGGGTCAAGGTGTGCGGCGATGTGTTTCTT
GCCGATATCGCGCCCCTGCAATCGGAGCATGACGACAGCGAGGCCATGGCCGGGGCCGTGCTGACGCTGCACCGCGCTGA
TCGGGTCGGCGAGCGCATCTACCATGTGCGCAAGCAGGAGTTGCGCGGCTTCGACAGTATCTTTCAGAGCTCGAAGGTCA
TGGCCGCTGTGGTTCGCGAGGCGCGGCGCATGGCGCCCCTCGATGCGCCGCTGCTGATCGAGGGTGAGACCGGCACCGGC
AAGGAATTGCTGGCCCGCGCCTGCCACCTGGCCAGCCCGCGCGGCCAGTCACCGCTGATGGCGCTCAACTGCGCCGGGTT
GTCGGAGTCGATGGCCGAGATCGAGCTGTTCGGCTATGACCCCGGCGCGTTCGAAGGTGCGCGTGCGGAAGGGCGGCTGG
GGCTATTGGAGCTGACCGCGGGCGGCACGCTGTTTCTCGATGGCGTGGGCGAGCTGAGTGCCCGCATGCAGGCCAAGCTG
CTGCGCTTCATTCAGGACGGCAGTTTTCGCCGGGTCGGCAGCGACGAGGACATGTTTCTCGATGTGCGGGTGATGTGTTC
GACCCAGGTCGATCTTTCGGAGCTGTGCGCCAAGGGCATGTTCAGGCAGGACCTTTATCATCGCCTTAACGTGCTTTCAC
TGCATATACCCCCACTGCGCGACTGTCTGGACGGTCTTGAGCCGCTGGTGGAGCATTTTCTCGATCAGGCCAGCCGGCAG
ATCGGCTGTGCGCTGCCCGGCATATCACCTGCGGCCATCAAACGCCTTGGTCAGTACCACTGGCCCGGTAATGTGCGGCA
ACTGGAAAATGTATTGTTTCAGGCCGTATCGCTGTGTGACGGCGGCAAGGTGCAGGCCGAGCATATTCGTTTGCCGGACT
ACGGCATGCGACAGGGGTTGAGTGAGGTGTCGCTGGAGGGCGGGCTGGGCGCTATTATCGGGCGCTTTGAAAAGTCGGTG
CTGGAACAACTCTATGCGCAATATCCCAGCAGCCGCCAATTAGGCAAACGCCTGGGAGTGTCTCATACAACAATTGCCAA
CAAGTTGCGCGACTATGAAGTGGGGCGCGAATCAGATCCGCATTCAACGGATAAATAA

Upstream 100 bases:

>100_bases
AATCAGTCCTCCTGCCGCTCGCGAAGCGTGCGTGCGTAACGTATTGTTGACATTAATTTTGCCGCCTCATAAAAAACTAC
CCTCACAGGGGCAACGACTC

Downstream 100 bases:

>100_bases
CTCGCTCATTGATAGTTCCGTCACCCACTTCGTGCATGCGCCTCGCACCTTATATAGCGGCGAGGCTATAGCGGCGAGGC
GTCGTGCACAGGTTGCAACG

Product: helix-turn-helix, Fis-type

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 525; Mature: 525

Protein sequence:

>525_residues
MRIKVHCQNRIGILRDILDLLVAYGVNVARGEVGGEHGDAIYLHCPNLINLQFQALRPKFEAITGVFGVKRVGLMPSERR
HMELNALLGALEFPVLSIDMGGAIVAANRAAAQLLGVRVDEVPGMPLSRYAEDFDLPELVRASQSRINGLRVKVCGDVFL
ADIAPLQSEHDDSEAMAGAVLTLHRADRVGERIYHVRKQELRGFDSIFQSSKVMAAVVREARRMAPLDAPLLIEGETGTG
KELLARACHLASPRGQSPLMALNCAGLSESMAEIELFGYDPGAFEGARAEGRLGLLELTAGGTLFLDGVGELSARMQAKL
LRFIQDGSFRRVGSDEDMFLDVRVMCSTQVDLSELCAKGMFRQDLYHRLNVLSLHIPPLRDCLDGLEPLVEHFLDQASRQ
IGCALPGISPAAIKRLGQYHWPGNVRQLENVLFQAVSLCDGGKVQAEHIRLPDYGMRQGLSEVSLEGGLGAIIGRFEKSV
LEQLYAQYPSSRQLGKRLGVSHTTIANKLRDYEVGRESDPHSTDK

Sequences:

>Translated_525_residues
MRIKVHCQNRIGILRDILDLLVAYGVNVARGEVGGEHGDAIYLHCPNLINLQFQALRPKFEAITGVFGVKRVGLMPSERR
HMELNALLGALEFPVLSIDMGGAIVAANRAAAQLLGVRVDEVPGMPLSRYAEDFDLPELVRASQSRINGLRVKVCGDVFL
ADIAPLQSEHDDSEAMAGAVLTLHRADRVGERIYHVRKQELRGFDSIFQSSKVMAAVVREARRMAPLDAPLLIEGETGTG
KELLARACHLASPRGQSPLMALNCAGLSESMAEIELFGYDPGAFEGARAEGRLGLLELTAGGTLFLDGVGELSARMQAKL
LRFIQDGSFRRVGSDEDMFLDVRVMCSTQVDLSELCAKGMFRQDLYHRLNVLSLHIPPLRDCLDGLEPLVEHFLDQASRQ
IGCALPGISPAAIKRLGQYHWPGNVRQLENVLFQAVSLCDGGKVQAEHIRLPDYGMRQGLSEVSLEGGLGAIIGRFEKSV
LEQLYAQYPSSRQLGKRLGVSHTTIANKLRDYEVGRESDPHSTDK
>Mature_525_residues
MRIKVHCQNRIGILRDILDLLVAYGVNVARGEVGGEHGDAIYLHCPNLINLQFQALRPKFEAITGVFGVKRVGLMPSERR
HMELNALLGALEFPVLSIDMGGAIVAANRAAAQLLGVRVDEVPGMPLSRYAEDFDLPELVRASQSRINGLRVKVCGDVFL
ADIAPLQSEHDDSEAMAGAVLTLHRADRVGERIYHVRKQELRGFDSIFQSSKVMAAVVREARRMAPLDAPLLIEGETGTG
KELLARACHLASPRGQSPLMALNCAGLSESMAEIELFGYDPGAFEGARAEGRLGLLELTAGGTLFLDGVGELSARMQAKL
LRFIQDGSFRRVGSDEDMFLDVRVMCSTQVDLSELCAKGMFRQDLYHRLNVLSLHIPPLRDCLDGLEPLVEHFLDQASRQ
IGCALPGISPAAIKRLGQYHWPGNVRQLENVLFQAVSLCDGGKVQAEHIRLPDYGMRQGLSEVSLEGGLGAIIGRFEKSV
LEQLYAQYPSSRQLGKRLGVSHTTIANKLRDYEVGRESDPHSTDK

Specific function: Involved in transcriptional regulation of aromatic amino acid biosynthesis and transport. Modulates the expression of at least 8 unlinked operons. Seven of these operons are regulated in response to changes in the concentration of the three aromatic amino

COG id: COG3283

COG function: function code KE; Transcriptional regulator of aromatic amino acids metabolism

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 sigma-54 factor interaction domain [H]

Homologues:

Organism=Escherichia coli, GI1787583, Length=522, Percent_Identity=43.6781609195402, Blast_Score=409, Evalue=1e-115,
Organism=Escherichia coli, GI1789233, Length=314, Percent_Identity=35.6687898089172, Blast_Score=219, Evalue=3e-58,
Organism=Escherichia coli, GI1788550, Length=311, Percent_Identity=37.620578778135, Blast_Score=207, Evalue=2e-54,
Organism=Escherichia coli, GI1790437, Length=233, Percent_Identity=45.4935622317597, Blast_Score=199, Evalue=3e-52,
Organism=Escherichia coli, GI1788905, Length=238, Percent_Identity=44.1176470588235, Blast_Score=199, Evalue=5e-52,
Organism=Escherichia coli, GI87082117, Length=243, Percent_Identity=41.9753086419753, Blast_Score=196, Evalue=3e-51,
Organism=Escherichia coli, GI1789087, Length=310, Percent_Identity=37.0967741935484, Blast_Score=194, Evalue=9e-51,
Organism=Escherichia coli, GI87082152, Length=264, Percent_Identity=42.8030303030303, Blast_Score=192, Evalue=3e-50,
Organism=Escherichia coli, GI1790299, Length=238, Percent_Identity=41.1764705882353, Blast_Score=184, Evalue=8e-48,
Organism=Escherichia coli, GI87081872, Length=233, Percent_Identity=40.343347639485, Blast_Score=173, Evalue=2e-44,
Organism=Escherichia coli, GI1786524, Length=217, Percent_Identity=42.3963133640553, Blast_Score=170, Evalue=2e-43,
Organism=Escherichia coli, GI1789828, Length=357, Percent_Identity=29.9719887955182, Blast_Score=129, Evalue=6e-31,
Organism=Escherichia coli, GI87081858, Length=459, Percent_Identity=26.5795206971678, Blast_Score=120, Evalue=1e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR009057
- InterPro:   IPR012287
- InterPro:   IPR000014
- InterPro:   IPR002078 [H]

Pfam domain/function: PF00158 Sigma54_activat [H]

EC number: NA

Molecular weight: Translated: 57547; Mature: 57547

Theoretical pI: Translated: 6.56; Mature: 6.56

Prosite motif: PS50112 PAS ; PS00675 SIGMA54_INTERACT_1 ; PS00688 SIGMA54_INTERACT_3 ; PS50045 SIGMA54_INTERACT_4

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRIKVHCQNRIGILRDILDLLVAYGVNVARGEVGGEHGDAIYLHCPNLINLQFQALRPKF
CEEEEEECCHHHHHHHHHHHHHHHCCCEECCCCCCCCCCEEEEECCCEECCCHHHHCCHH
EAITGVFGVKRVGLMPSERRHMELNALLGALEFPVLSIDMGGAIVAANRAAAQLLGVRVD
HHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCEEEEECCCEEEECHHHHHHHHCCCHH
EVPGMPLSRYAEDFDLPELVRASQSRINGLRVKVCGDVFLADIAPLQSEHDDSEAMAGAV
CCCCCCHHHHHHCCCCHHHHHHHHHHCCCEEEEEEHHHHHHHHHHHCCCCCCHHHHHHHH
LTLHRADRVGERIYHVRKQELRGFDSIFQSSKVMAAVVREARRMAPLDAPLLIEGETGTG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCCCCC
KELLARACHLASPRGQSPLMALNCAGLSESMAEIELFGYDPGAFEGARAEGRLGLLELTA
HHHHHHHHHHCCCCCCCCEEEEECCCCHHCHHHEEEEECCCCCCCCCCCCCCEEEEEEEC
GGTLFLDGVGELSARMQAKLLRFIQDGSFRRVGSDEDMFLDVRVMCSTQVDLSELCAKGM
CCEEEECCHHHHHHHHHHHHHHHHHCCCCEECCCCCCEEEEEEEEECCCCCHHHHHHHHH
FRQDLYHRLNVLSLHIPPLRDCLDGLEPLVEHFLDQASRQIGCALPGISPAAIKRLGQYH
HHHHHHHHHHEEEECCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHCCC
WPGNVRQLENVLFQAVSLCDGGKVQAEHIRLPDYGMRQGLSEVSLEGGLGAIIGRFEKSV
CCCCHHHHHHHHHHHHHHCCCCCEEHEEEECCCCHHHCCHHHHHHCCCHHHHHHHHHHHH
LEQLYAQYPSSRQLGKRLGVSHTTIANKLRDYEVGRESDPHSTDK
HHHHHHHCCCHHHHHHHHCCCHHHHHHHHHHHCCCCCCCCCCCCC
>Mature Secondary Structure
MRIKVHCQNRIGILRDILDLLVAYGVNVARGEVGGEHGDAIYLHCPNLINLQFQALRPKF
CEEEEEECCHHHHHHHHHHHHHHHCCCEECCCCCCCCCCEEEEECCCEECCCHHHHCCHH
EAITGVFGVKRVGLMPSERRHMELNALLGALEFPVLSIDMGGAIVAANRAAAQLLGVRVD
HHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCEEEEECCCEEEECHHHHHHHHCCCHH
EVPGMPLSRYAEDFDLPELVRASQSRINGLRVKVCGDVFLADIAPLQSEHDDSEAMAGAV
CCCCCCHHHHHHCCCCHHHHHHHHHHCCCEEEEEEHHHHHHHHHHHCCCCCCHHHHHHHH
LTLHRADRVGERIYHVRKQELRGFDSIFQSSKVMAAVVREARRMAPLDAPLLIEGETGTG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCCCCC
KELLARACHLASPRGQSPLMALNCAGLSESMAEIELFGYDPGAFEGARAEGRLGLLELTA
HHHHHHHHHHCCCCCCCCEEEEECCCCHHCHHHEEEEECCCCCCCCCCCCCCEEEEEEEC
GGTLFLDGVGELSARMQAKLLRFIQDGSFRRVGSDEDMFLDVRVMCSTQVDLSELCAKGM
CCEEEECCHHHHHHHHHHHHHHHHHCCCCEECCCCCCEEEEEEEEECCCCCHHHHHHHHH
FRQDLYHRLNVLSLHIPPLRDCLDGLEPLVEHFLDQASRQIGCALPGISPAAIKRLGQYH
HHHHHHHHHHEEEECCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHCCC
WPGNVRQLENVLFQAVSLCDGGKVQAEHIRLPDYGMRQGLSEVSLEGGLGAIIGRFEKSV
CCCCHHHHHHHHHHHHHHCCCCCEEHEEEECCCCHHHCCHHHHHHCCCHHHHHHHHHHHH
LEQLYAQYPSSRQLGKRLGVSHTTIANKLRDYEVGRESDPHSTDK
HHHHHHHCCCHHHHHHHHCCCHHHHHHHHHHHCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA