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The map label for this gene is acsA [H]

Identifier: 66046801

GI number: 66046801

Start: 4253732

End: 4255687

Strand: Reverse

Name: acsA [H]

Synonym: Psyr_3572

Alternate gene names: 66046801

Gene position: 4255687-4253732 (Counterclockwise)

Preceding gene: 66046803

Following gene: 66046800

Centisome position: 69.84

GC content: 61.66

Gene sequence:

>1956_bases
ATGAGTGCAGCTTCCCTGTACCCCGTCCGCCCAGAAGTCGCAGCGACTACGCTGACGGATGAAGCGACCTACAAGGCCAT
GTACCAGCAGTCGGTGGTCAACCCTGATGGTTTCTGGCGTGAACAGGCTCAGCGCCTCGACTGGATCAAACCTTTCAGTG
TGGTCAAACAGACCTCGTTCGATGATCACCGTGTCGATATCAAATGGTTCGCCGACGGCACGCTGAACGTTGCCTACAAC
TGCCTGGATCGCCATCTGGAAGAACGCGGCGACAGCATCGCCATCATCTGGGAGGGCGACGACCCTTCCGAGCACCGGGA
AATCACCTACCGCGAACTGCACGCCGAAGTGTGCAAGTTCGCCAACGCCCTGCGTGGCCAGGATGTGCACCGTGGCGACG
TCGTGACGATCTACATGCCGATGATCCCCGAAGCTGTGGTCGCCATGCTGGCATGCGCCCGGATCGGTGCGATTCACTCG
GTGGTGTTCGGCGGTTTCTCGCCCGAAGCGCTGGCTGGCCGGATCATCGATTGCAGTTCCAAAGTGGTCATCACTGCTGA
CGAAGGTCTGCGTGGCGGCAAGAAGACTGCACTCAAGGCCAACGTCGACCGCGCCCTGACCAACCCGGAAACCAGCAGCG
TGCAGAAGGTTATCGTCTGCAAGCGCACCGGTGGCGAGATCGAATGGAACCGTCACCGTGATATCTGGTACCACTCGCTT
CTGGAAGTGGCGTCCAGCACCTGCGCGCCGAAAGAGATGGGCGCCGAAGAGTCGCTGTTCATTCTCTACACCTCGGGCTC
GACCGGTAAACCCAAGGGCGTGTTGCACACCACCGCAGGTTACTTGCTGTATGCCGCGCTGACCCACGAACGCGTGTTCG
ACTACCGGCCGGGTGAAGTTTACTGGTGCACCGCCGACGTCGGCTGGGTCACCGGGCACAGTTACATTGTCTACGGGCCT
CTGGCCAACGGTGCGACCACGCTGCTGTTCGAAGGCGTGCCGAACTATCCGGACATCACCCGCGTGTCGAAGATCATCGA
CAAGCACAAGGTCAATATCCTCTACACCGCGCCGACCGCGATTCGCGCCATGATGGCTGAAGGCACCAAGTCCGTTGAAG
GTGCCGACGGTTCAAGCCTGCGCCTGCTGGGTTCGGTGGGCGAGCCGATCAACCCGGAAGCCTGGGCCTGGTACTACAAC
ACGGTCGGCAAGCAGAACTGCCCGATTGTCGATACCTGGTGGCAGACCGAAACCGGTGGCATTCTGATCAGCCCGTTGCC
AGGTGCGACCGCCCTGAAGCCGGGCTCGGCGACACGTCCGTTCTTCGGCGTGATCCCGGCGCTGGTGGACAACCTGGGCA
ACCTCATCGAGGGCGCTGCCGAGGGCAACCTGGTGATCCTCGATTCGTGGCCGGGCCAGTCGCGCTCTCTGTACGGCGAT
CACGACCGTTTCGTCGACACCTACTTCAAGACGTTCCGCGGCATGTACTTCACCGGTGACGGCGCCCGTCGTGACGAGGA
CGGCTATTTCTGGATCACCGGGCGTGTGGACGACGTGCTCAACGTTTCCGGCCACCGCATGGGCACGGCTGAAATCGAAA
GCGCGATGGTTGCGCACCCGAAAGTCGCCGAGGCTGCTGTGGTCGGTGTGCCGCATGACCTGAAGGGGCAGGGCATCTAC
GTCTATGTGACCCTCAACGGCGGTGAAGAGCCGAGTGACGCGCTGCGCACCGAATTGCGCAACTGGGTACGCAAGGAGAT
CGGCCCGATTGCCTCGCCTGACTTCATTCAGTGGGCGCCCGGCCTGCCGAAGACCCGTTCGGGCAAGATCATGCGCCGTA
TCCTGCGCAAGATTGCGACTGCCGAGTACGATGCGCTGGGTGACATCTCCACCCTGGCCGACCCGGGCGTGGTGCAGCAT
CTGATCGATACGCACAAGACCATGAACGCTGCCTGA

Upstream 100 bases:

>100_bases
CTCCGGCCCCGCCCGGTAATACCAACGTCGAATGGCCCCTGCGGGTGGGGCGGGATACAACAGGGGCATAAAACAACAAC
TATCCACCGAGGTAACCAAG

Downstream 100 bases:

>100_bases
GCGATCCTGTGACTGAAGCGCCCCGTTCGGTGAGAGCCGATCGGGGCGCTTTTGTTTCCAGGGGCTGAAGCGAGAAACGG
GATATATATCGGGTTGTTAC

Product: acetyl-CoA synthetase

Products: NA

Alternate protein names: Acetate--CoA ligase 1; Acyl-activating enzyme 1 [H]

Number of amino acids: Translated: 651; Mature: 650

Protein sequence:

>651_residues
MSAASLYPVRPEVAATTLTDEATYKAMYQQSVVNPDGFWREQAQRLDWIKPFSVVKQTSFDDHRVDIKWFADGTLNVAYN
CLDRHLEERGDSIAIIWEGDDPSEHREITYRELHAEVCKFANALRGQDVHRGDVVTIYMPMIPEAVVAMLACARIGAIHS
VVFGGFSPEALAGRIIDCSSKVVITADEGLRGGKKTALKANVDRALTNPETSSVQKVIVCKRTGGEIEWNRHRDIWYHSL
LEVASSTCAPKEMGAEESLFILYTSGSTGKPKGVLHTTAGYLLYAALTHERVFDYRPGEVYWCTADVGWVTGHSYIVYGP
LANGATTLLFEGVPNYPDITRVSKIIDKHKVNILYTAPTAIRAMMAEGTKSVEGADGSSLRLLGSVGEPINPEAWAWYYN
TVGKQNCPIVDTWWQTETGGILISPLPGATALKPGSATRPFFGVIPALVDNLGNLIEGAAEGNLVILDSWPGQSRSLYGD
HDRFVDTYFKTFRGMYFTGDGARRDEDGYFWITGRVDDVLNVSGHRMGTAEIESAMVAHPKVAEAAVVGVPHDLKGQGIY
VYVTLNGGEEPSDALRTELRNWVRKEIGPIASPDFIQWAPGLPKTRSGKIMRRILRKIATAEYDALGDISTLADPGVVQH
LIDTHKTMNAA

Sequences:

>Translated_651_residues
MSAASLYPVRPEVAATTLTDEATYKAMYQQSVVNPDGFWREQAQRLDWIKPFSVVKQTSFDDHRVDIKWFADGTLNVAYN
CLDRHLEERGDSIAIIWEGDDPSEHREITYRELHAEVCKFANALRGQDVHRGDVVTIYMPMIPEAVVAMLACARIGAIHS
VVFGGFSPEALAGRIIDCSSKVVITADEGLRGGKKTALKANVDRALTNPETSSVQKVIVCKRTGGEIEWNRHRDIWYHSL
LEVASSTCAPKEMGAEESLFILYTSGSTGKPKGVLHTTAGYLLYAALTHERVFDYRPGEVYWCTADVGWVTGHSYIVYGP
LANGATTLLFEGVPNYPDITRVSKIIDKHKVNILYTAPTAIRAMMAEGTKSVEGADGSSLRLLGSVGEPINPEAWAWYYN
TVGKQNCPIVDTWWQTETGGILISPLPGATALKPGSATRPFFGVIPALVDNLGNLIEGAAEGNLVILDSWPGQSRSLYGD
HDRFVDTYFKTFRGMYFTGDGARRDEDGYFWITGRVDDVLNVSGHRMGTAEIESAMVAHPKVAEAAVVGVPHDLKGQGIY
VYVTLNGGEEPSDALRTELRNWVRKEIGPIASPDFIQWAPGLPKTRSGKIMRRILRKIATAEYDALGDISTLADPGVVQH
LIDTHKTMNAA
>Mature_650_residues
SAASLYPVRPEVAATTLTDEATYKAMYQQSVVNPDGFWREQAQRLDWIKPFSVVKQTSFDDHRVDIKWFADGTLNVAYNC
LDRHLEERGDSIAIIWEGDDPSEHREITYRELHAEVCKFANALRGQDVHRGDVVTIYMPMIPEAVVAMLACARIGAIHSV
VFGGFSPEALAGRIIDCSSKVVITADEGLRGGKKTALKANVDRALTNPETSSVQKVIVCKRTGGEIEWNRHRDIWYHSLL
EVASSTCAPKEMGAEESLFILYTSGSTGKPKGVLHTTAGYLLYAALTHERVFDYRPGEVYWCTADVGWVTGHSYIVYGPL
ANGATTLLFEGVPNYPDITRVSKIIDKHKVNILYTAPTAIRAMMAEGTKSVEGADGSSLRLLGSVGEPINPEAWAWYYNT
VGKQNCPIVDTWWQTETGGILISPLPGATALKPGSATRPFFGVIPALVDNLGNLIEGAAEGNLVILDSWPGQSRSLYGDH
DRFVDTYFKTFRGMYFTGDGARRDEDGYFWITGRVDDVLNVSGHRMGTAEIESAMVAHPKVAEAAVVGVPHDLKGQGIYV
YVTLNGGEEPSDALRTELRNWVRKEIGPIASPDFIQWAPGLPKTRSGKIMRRILRKIATAEYDALGDISTLADPGVVQHL
IDTHKTMNAA

Specific function: Enables The Cell To Use Acetate During Aerobic Growth To Generate Energy Via The Tca Cycle, And Biosynthetic Compounds Via The Glyoxylate Shunt. Acetylates Chey, The Response Regulator Involved In Flagellar Movement And Chemotaxis. [C]

COG id: COG0365

COG function: function code I; Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATP-dependent AMP-binding enzyme family [H]

Homologues:

Organism=Homo sapiens, GI8923896, Length=669, Percent_Identity=52.3168908819133, Blast_Score=690, Evalue=0.0,
Organism=Homo sapiens, GI253970489, Length=682, Percent_Identity=51.3196480938416, Blast_Score=686, Evalue=0.0,
Organism=Homo sapiens, GI28416953, Length=629, Percent_Identity=50.8744038155803, Blast_Score=645, Evalue=0.0,
Organism=Homo sapiens, GI13375727, Length=639, Percent_Identity=36.9327073552426, Blast_Score=390, Evalue=1e-108,
Organism=Homo sapiens, GI42544132, Length=573, Percent_Identity=28.2722513089005, Blast_Score=197, Evalue=4e-50,
Organism=Homo sapiens, GI38505220, Length=558, Percent_Identity=28.494623655914, Blast_Score=179, Evalue=5e-45,
Organism=Homo sapiens, GI122937307, Length=554, Percent_Identity=27.0758122743682, Blast_Score=176, Evalue=7e-44,
Organism=Homo sapiens, GI58082049, Length=551, Percent_Identity=25.9528130671506, Blast_Score=164, Evalue=4e-40,
Organism=Homo sapiens, GI115511026, Length=550, Percent_Identity=26.1818181818182, Blast_Score=162, Evalue=9e-40,
Organism=Homo sapiens, GI31982927, Length=641, Percent_Identity=24.1809672386895, Blast_Score=157, Evalue=2e-38,
Organism=Homo sapiens, GI157311624, Length=551, Percent_Identity=25.4083484573503, Blast_Score=154, Evalue=3e-37,
Organism=Homo sapiens, GI157311622, Length=551, Percent_Identity=25.4083484573503, Blast_Score=154, Evalue=3e-37,
Organism=Homo sapiens, GI195947378, Length=466, Percent_Identity=27.0386266094421, Blast_Score=117, Evalue=2e-26,
Organism=Homo sapiens, GI42544134, Length=388, Percent_Identity=24.4845360824742, Blast_Score=100, Evalue=8e-21,
Organism=Homo sapiens, GI187761345, Length=566, Percent_Identity=24.5583038869258, Blast_Score=99, Evalue=1e-20,
Organism=Homo sapiens, GI187761343, Length=566, Percent_Identity=24.5583038869258, Blast_Score=99, Evalue=1e-20,
Organism=Homo sapiens, GI156151445, Length=390, Percent_Identity=24.1025641025641, Blast_Score=82, Evalue=1e-15,
Organism=Escherichia coli, GI1790505, Length=648, Percent_Identity=67.9012345679012, Blast_Score=950, Evalue=0.0,
Organism=Escherichia coli, GI1786529, Length=630, Percent_Identity=37.6190476190476, Blast_Score=399, Evalue=1e-112,
Organism=Escherichia coli, GI1788107, Length=555, Percent_Identity=25.2252252252252, Blast_Score=98, Evalue=2e-21,
Organism=Escherichia coli, GI145693145, Length=515, Percent_Identity=24.4660194174757, Blast_Score=93, Evalue=7e-20,
Organism=Escherichia coli, GI1786810, Length=555, Percent_Identity=24.1441441441441, Blast_Score=91, Evalue=3e-19,
Organism=Escherichia coli, GI221142682, Length=543, Percent_Identity=21.1786372007366, Blast_Score=88, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI71983001, Length=652, Percent_Identity=50.7668711656442, Blast_Score=628, Evalue=1e-180,
Organism=Caenorhabditis elegans, GI71982997, Length=652, Percent_Identity=50.7668711656442, Blast_Score=628, Evalue=1e-180,
Organism=Caenorhabditis elegans, GI17569507, Length=639, Percent_Identity=23.1611893583725, Blast_Score=137, Evalue=2e-32,
Organism=Caenorhabditis elegans, GI17557194, Length=569, Percent_Identity=22.6713532513181, Blast_Score=96, Evalue=8e-20,
Organism=Caenorhabditis elegans, GI17538037, Length=126, Percent_Identity=32.5396825396825, Blast_Score=79, Evalue=9e-15,
Organism=Caenorhabditis elegans, GI17558820, Length=529, Percent_Identity=21.9281663516068, Blast_Score=73, Evalue=4e-13,
Organism=Caenorhabditis elegans, GI17559526, Length=130, Percent_Identity=27.6923076923077, Blast_Score=69, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6323182, Length=641, Percent_Identity=49.7659906396256, Blast_Score=610, Evalue=1e-175,
Organism=Saccharomyces cerevisiae, GI6319264, Length=643, Percent_Identity=48.3670295489891, Blast_Score=582, Evalue=1e-167,
Organism=Saccharomyces cerevisiae, GI6319699, Length=549, Percent_Identity=23.1329690346084, Blast_Score=107, Evalue=6e-24,
Organism=Drosophila melanogaster, GI24667955, Length=658, Percent_Identity=53.6474164133739, Blast_Score=696, Evalue=0.0,
Organism=Drosophila melanogaster, GI62472339, Length=559, Percent_Identity=57.9606440071556, Blast_Score=649, Evalue=0.0,
Organism=Drosophila melanogaster, GI24667959, Length=517, Percent_Identity=58.8007736943907, Blast_Score=608, Evalue=1e-174,
Organism=Drosophila melanogaster, GI21355225, Length=642, Percent_Identity=35.5140186915888, Blast_Score=369, Evalue=1e-102,
Organism=Drosophila melanogaster, GI18859661, Length=559, Percent_Identity=23.4347048300537, Blast_Score=100, Evalue=6e-21,
Organism=Drosophila melanogaster, GI24581924, Length=568, Percent_Identity=22.3591549295775, Blast_Score=85, Evalue=1e-16,
Organism=Drosophila melanogaster, GI21355181, Length=529, Percent_Identity=21.7391304347826, Blast_Score=74, Evalue=4e-13,
Organism=Drosophila melanogaster, GI21356947, Length=384, Percent_Identity=25, Blast_Score=69, Evalue=8e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011904
- InterPro:   IPR020845
- InterPro:   IPR000873 [H]

Pfam domain/function: PF00501 AMP-binding [H]

EC number: =6.2.1.1 [H]

Molecular weight: Translated: 71555; Mature: 71424

Theoretical pI: Translated: 6.05; Mature: 6.05

Prosite motif: PS00455 AMP_BINDING

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSAASLYPVRPEVAATTLTDEATYKAMYQQSVVNPDGFWREQAQRLDWIKPFSVVKQTSF
CCCCCCCCCCCCCEEEEECCHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCHHHHHHHCCC
DDHRVDIKWFADGTLNVAYNCLDRHLEERGDSIAIIWEGDDPSEHREITYRELHAEVCKF
CCCEEEEEEEECCCHHHHHHHHHHHHHHCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHH
ANALRGQDVHRGDVVTIYMPMIPEAVVAMLACARIGAIHSVVFGGFSPEALAGRIIDCSS
HHHHCCCCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHCEEEECCC
KVVITADEGLRGGKKTALKANVDRALTNPETSSVQKVIVCKRTGGEIEWNRHRDIWYHSL
CEEEEECCCCCCCCCCEEEECHHHHHCCCCCCCCEEEEEEECCCCCEEECCCCHHHHHHH
LEVASSTCAPKEMGAEESLFILYTSGSTGKPKGVLHTTAGYLLYAALTHERVFDYRPGEV
HHHHHCCCCHHHCCCCCCEEEEEECCCCCCCCCEEEEHHHHHHHHHHHHHHHHCCCCCEE
YWCTADVGWVTGHSYIVYGPLANGATTLLFEGVPNYPDITRVSKIIDKHKVNILYTAPTA
EEEECCCCEEECCCEEEEECCCCCCEEEEECCCCCCCCHHHHHHHHHHHCEEEEEECHHH
IRAMMAEGTKSVEGADGSSLRLLGSVGEPINPEAWAWYYNTVGKQNCPIVDTWWQTETGG
HHHHHHCCCCCCCCCCCCCEEEEECCCCCCCCCCEEEEEECCCCCCCCEEECCCCCCCCC
ILISPLPGATALKPGSATRPFFGVIPALVDNLGNLIEGAAEGNLVILDSWPGQSRSLYGD
EEEECCCCCCEECCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCCCCC
HDRFVDTYFKTFRGMYFTGDGARRDEDGYFWITGRVDDVLNVSGHRMGTAEIESAMVAHP
HHHHHHHHHHHHCCEEEECCCCCCCCCCEEEEECCCCHHHCCCCCCCCHHHHHHHHHCCC
KVAEAAVVGVPHDLKGQGIYVYVTLNGGEEPSDALRTELRNWVRKEIGPIASPDFIQWAP
CHHCEEEECCCCCCCCCEEEEEEEECCCCCHHHHHHHHHHHHHHHHHCCCCCCCCEECCC
GLPKTRSGKIMRRILRKIATAEYDALGDISTLADPGVVQHLIDTHKTMNAA
CCCCCCCCHHHHHHHHHHHHCCHHCCCCHHHHCCCHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
SAASLYPVRPEVAATTLTDEATYKAMYQQSVVNPDGFWREQAQRLDWIKPFSVVKQTSF
CCCCCCCCCCCCEEEEECCHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCHHHHHHHCCC
DDHRVDIKWFADGTLNVAYNCLDRHLEERGDSIAIIWEGDDPSEHREITYRELHAEVCKF
CCCEEEEEEEECCCHHHHHHHHHHHHHHCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHH
ANALRGQDVHRGDVVTIYMPMIPEAVVAMLACARIGAIHSVVFGGFSPEALAGRIIDCSS
HHHHCCCCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHCEEEECCC
KVVITADEGLRGGKKTALKANVDRALTNPETSSVQKVIVCKRTGGEIEWNRHRDIWYHSL
CEEEEECCCCCCCCCCEEEECHHHHHCCCCCCCCEEEEEEECCCCCEEECCCCHHHHHHH
LEVASSTCAPKEMGAEESLFILYTSGSTGKPKGVLHTTAGYLLYAALTHERVFDYRPGEV
HHHHHCCCCHHHCCCCCCEEEEEECCCCCCCCCEEEEHHHHHHHHHHHHHHHHCCCCCEE
YWCTADVGWVTGHSYIVYGPLANGATTLLFEGVPNYPDITRVSKIIDKHKVNILYTAPTA
EEEECCCCEEECCCEEEEECCCCCCEEEEECCCCCCCCHHHHHHHHHHHCEEEEEECHHH
IRAMMAEGTKSVEGADGSSLRLLGSVGEPINPEAWAWYYNTVGKQNCPIVDTWWQTETGG
HHHHHHCCCCCCCCCCCCCEEEEECCCCCCCCCCEEEEEECCCCCCCCEEECCCCCCCCC
ILISPLPGATALKPGSATRPFFGVIPALVDNLGNLIEGAAEGNLVILDSWPGQSRSLYGD
EEEECCCCCCEECCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCCCCC
HDRFVDTYFKTFRGMYFTGDGARRDEDGYFWITGRVDDVLNVSGHRMGTAEIESAMVAHP
HHHHHHHHHHHHCCEEEECCCCCCCCCCEEEEECCCCHHHCCCCCCCCHHHHHHHHHCCC
KVAEAAVVGVPHDLKGQGIYVYVTLNGGEEPSDALRTELRNWVRKEIGPIASPDFIQWAP
CHHCEEEECCCCCCCCCEEEEEEEECCCCCHHHHHHHHHHHHHHHHHCCCCCCCCEECCC
GLPKTRSGKIMRRILRKIATAEYDALGDISTLADPGVVQHLIDTHKTMNAA
CCCCCCCCHHHHHHHHHHHHCCHHCCCCHHHHCCCHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12534463 [H]