Click here to switch to the map view.

The map label for this gene is ybdR [H]

Identifier: 66046756

GI number: 66046756

Start: 4203866

End: 4205101

Strand: Direct

Name: ybdR [H]

Synonym: Psyr_3527

Alternate gene names: 66046756

Gene position: 4203866-4205101 (Clockwise)

Preceding gene: 66046755

Following gene: 66046757

Centisome position: 68.99

GC content: 59.55

Gene sequence:

>1236_bases
ATGAGAGCTTTGACTTACCACGGCGCGAACAGTGTAAAAGTCGATACAGTGCCGGACCCTGTGATCGAGCAAGCGGATGA
CATCATTCTGCGCGTAACGGCGACCGCTATCTGCGGTTCCGACCTGCACTTGTATCGCGGCAAAATCCCTACGGTTGAAC
ACGGCGACATCTTCGGTCACGAGTTCATGGGCGTCGTTGAAGAGACCGGCTCGGCCGTCACGGCTGTAGCCAAAGGCGAT
CGCGTGGTGATCCCGTTCGTCATCGCCTGCGGCAGCTGCTTTTTCTGCAACCTCGACCAGTTCGCGGCCTGCGAAACCAC
CAACACCGGACGTGGCGCGATTCTCAACAAAAAGTCGATTCCACCAGGGGCGGCGCTGTTCGGCTTCAGCCATCTGTATG
GCGGCGTTCCGGGCGGCCAGGCTGAATACGTGCGAGTGCCCAAGGCCAACGTTGGTCCGTTCAAGGTGCCAGGCACACTG
GCTGACGAGAAGGTTCTGTTCCTCTCCGACATTCTCCCCACCGCCTGGCAGGCTGTACTCAACGCCGGGATTGGCCAGGG
TTCGACGGTTGCCATTTACGGTGCTGGCCCGGTCGGCCTGATGAGCGCGGCGTGCGCAAAAATGCTCGGTGCGGAAAAGA
TCTTCATGGTCGATCACCATCCGTATCGTCTGGCCTATGCGCAGAAAACTTACGGCGTGATCCCGATCAATTTCGATGAA
GACGATGATCCGGCTGACACGATCATTCGCCAGACCGCCGGCATGCGCGGCGTGGATGGCGTAATCGACGCGGTGGGTTT
CGAGGCCAAAGGCAGCACCACGGAAACCATTCTGGCAACGCTGAAGCTGGAAGGCAGCAGCGGCAAGGCATTGCGTCAGT
GCATCGCAGCAGTACGACGCGGCGGCGTGGTCAGTGTGCCGGGGGTATATGCCGGGTTCATCCATGGCTTCATGTTCGGC
GATGCGTTCGACAAGGGCCTGACCTTCAAAATGGGCCAGACCCACGTGCATCGCTTCATGCCTGAATTGCTGGAACACAT
CGAGGCCGGCCGCCTGGAACCCGAAGCCATCATCACGCACCGGATGTCACTGGAAGATGCCGCAAAGGGCTACAAGCTGT
TCGACAAGAAGGAAGAGGATTGCCGCAAGGTCATCCTGACGCCTGGCAACAACACCATTGTGGTGCCGGACGACACGACC
GAAGCCCTGGTCGGGGGTGGCGTGCCGGCTATGTAA

Upstream 100 bases:

>100_bases
CCGTTAGTCCGCGCGTCAAGCAATCGCGCTGAACCAACAAAAAGCTCATGGTTCATCTTCAGTAACGGAGCGGAATTCCT
GCTGCCACTGAGGATTGATC

Downstream 100 bases:

>100_bases
GGTACGGGTTCGCCTTTGATTCTGGCCTAAGGCCGCAGGAGCGAACGTGTTCGGGAACGGTATTGCAGACGATGTATGTT
CATCGTTCATGCCACCCCTT

Product: zinc-containing alcohol dehydrogenase superfamily protein

Products: S-formylglutathione; NADH; H+

Alternate protein names: NA

Number of amino acids: Translated: 411; Mature: 411

Protein sequence:

>411_residues
MRALTYHGANSVKVDTVPDPVIEQADDIILRVTATAICGSDLHLYRGKIPTVEHGDIFGHEFMGVVEETGSAVTAVAKGD
RVVIPFVIACGSCFFCNLDQFAACETTNTGRGAILNKKSIPPGAALFGFSHLYGGVPGGQAEYVRVPKANVGPFKVPGTL
ADEKVLFLSDILPTAWQAVLNAGIGQGSTVAIYGAGPVGLMSAACAKMLGAEKIFMVDHHPYRLAYAQKTYGVIPINFDE
DDDPADTIIRQTAGMRGVDGVIDAVGFEAKGSTTETILATLKLEGSSGKALRQCIAAVRRGGVVSVPGVYAGFIHGFMFG
DAFDKGLTFKMGQTHVHRFMPELLEHIEAGRLEPEAIITHRMSLEDAAKGYKLFDKKEEDCRKVILTPGNNTIVVPDDTT
EALVGGGVPAM

Sequences:

>Translated_411_residues
MRALTYHGANSVKVDTVPDPVIEQADDIILRVTATAICGSDLHLYRGKIPTVEHGDIFGHEFMGVVEETGSAVTAVAKGD
RVVIPFVIACGSCFFCNLDQFAACETTNTGRGAILNKKSIPPGAALFGFSHLYGGVPGGQAEYVRVPKANVGPFKVPGTL
ADEKVLFLSDILPTAWQAVLNAGIGQGSTVAIYGAGPVGLMSAACAKMLGAEKIFMVDHHPYRLAYAQKTYGVIPINFDE
DDDPADTIIRQTAGMRGVDGVIDAVGFEAKGSTTETILATLKLEGSSGKALRQCIAAVRRGGVVSVPGVYAGFIHGFMFG
DAFDKGLTFKMGQTHVHRFMPELLEHIEAGRLEPEAIITHRMSLEDAAKGYKLFDKKEEDCRKVILTPGNNTIVVPDDTT
EALVGGGVPAM
>Mature_411_residues
MRALTYHGANSVKVDTVPDPVIEQADDIILRVTATAICGSDLHLYRGKIPTVEHGDIFGHEFMGVVEETGSAVTAVAKGD
RVVIPFVIACGSCFFCNLDQFAACETTNTGRGAILNKKSIPPGAALFGFSHLYGGVPGGQAEYVRVPKANVGPFKVPGTL
ADEKVLFLSDILPTAWQAVLNAGIGQGSTVAIYGAGPVGLMSAACAKMLGAEKIFMVDHHPYRLAYAQKTYGVIPINFDE
DDDPADTIIRQTAGMRGVDGVIDAVGFEAKGSTTETILATLKLEGSSGKALRQCIAAVRRGGVVSVPGVYAGFIHGFMFG
DAFDKGLTFKMGQTHVHRFMPELLEHIEAGRLEPEAIITHRMSLEDAAKGYKLFDKKEEDCRKVILTPGNNTIVVPDDTT
EALVGGGVPAM

Specific function: Unknown

COG id: COG1063

COG function: function code ER; Threonine dehydrogenase and related Zn-dependent dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily [H]

Homologues:

Organism=Homo sapiens, GI156523966, Length=370, Percent_Identity=25.4054054054054, Blast_Score=90, Evalue=3e-18,
Organism=Homo sapiens, GI4501939, Length=358, Percent_Identity=25.1396648044693, Blast_Score=88, Evalue=1e-17,
Organism=Homo sapiens, GI4501929, Length=364, Percent_Identity=26.0989010989011, Blast_Score=84, Evalue=2e-16,
Organism=Homo sapiens, GI34577061, Length=359, Percent_Identity=26.1838440111421, Blast_Score=82, Evalue=1e-15,
Organism=Homo sapiens, GI4501933, Length=361, Percent_Identity=26.8698060941828, Blast_Score=82, Evalue=1e-15,
Organism=Homo sapiens, GI71565154, Length=248, Percent_Identity=29.0322580645161, Blast_Score=80, Evalue=4e-15,
Organism=Homo sapiens, GI71565152, Length=366, Percent_Identity=24.5901639344262, Blast_Score=75, Evalue=8e-14,
Organism=Homo sapiens, GI71743840, Length=360, Percent_Identity=24.4444444444444, Blast_Score=75, Evalue=1e-13,
Organism=Homo sapiens, GI262073058, Length=360, Percent_Identity=24.4444444444444, Blast_Score=75, Evalue=1e-13,
Organism=Escherichia coli, GI1786825, Length=404, Percent_Identity=74.2574257425743, Blast_Score=631, Evalue=0.0,
Organism=Escherichia coli, GI1787863, Length=396, Percent_Identity=23.989898989899, Blast_Score=103, Evalue=3e-23,
Organism=Escherichia coli, GI1790045, Length=395, Percent_Identity=26.0759493670886, Blast_Score=96, Evalue=5e-21,
Organism=Escherichia coli, GI87082125, Length=380, Percent_Identity=27.1052631578947, Blast_Score=86, Evalue=6e-18,
Organism=Escherichia coli, GI1788073, Length=358, Percent_Identity=24.8603351955307, Blast_Score=82, Evalue=4e-17,
Organism=Escherichia coli, GI226510992, Length=357, Percent_Identity=24.6498599439776, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI1790718, Length=230, Percent_Identity=28.695652173913, Blast_Score=76, Evalue=5e-15,
Organism=Escherichia coli, GI1788075, Length=403, Percent_Identity=25.5583126550869, Blast_Score=69, Evalue=5e-13,
Organism=Escherichia coli, GI1786552, Length=368, Percent_Identity=25, Blast_Score=69, Evalue=6e-13,
Organism=Escherichia coli, GI1788407, Length=302, Percent_Identity=25.1655629139073, Blast_Score=68, Evalue=9e-13,
Organism=Caenorhabditis elegans, GI25146526, Length=365, Percent_Identity=26.5753424657534, Blast_Score=81, Evalue=8e-16,
Organism=Caenorhabditis elegans, GI71997431, Length=361, Percent_Identity=26.5927977839335, Blast_Score=79, Evalue=6e-15,
Organism=Caenorhabditis elegans, GI17565904, Length=357, Percent_Identity=26.6106442577031, Blast_Score=77, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI17562876, Length=379, Percent_Identity=24.0105540897098, Blast_Score=77, Evalue=2e-14,
Organism=Saccharomyces cerevisiae, GI6319258, Length=418, Percent_Identity=29.1866028708134, Blast_Score=99, Evalue=2e-21,
Organism=Saccharomyces cerevisiae, GI6320033, Length=393, Percent_Identity=25.6997455470738, Blast_Score=86, Evalue=1e-17,
Organism=Drosophila melanogaster, GI17737895, Length=367, Percent_Identity=27.2479564032698, Blast_Score=84, Evalue=1e-16,
Organism=Drosophila melanogaster, GI45551930, Length=240, Percent_Identity=25.4166666666667, Blast_Score=73, Evalue=3e-13,
Organism=Drosophila melanogaster, GI45550770, Length=240, Percent_Identity=25.4166666666667, Blast_Score=73, Evalue=3e-13,
Organism=Drosophila melanogaster, GI221457811, Length=240, Percent_Identity=25.4166666666667, Blast_Score=73, Evalue=3e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR011032
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: 1.2.1.1

Molecular weight: Translated: 43628; Mature: 43628

Theoretical pI: Translated: 5.93; Mature: 5.93

Prosite motif: PS00059 ADH_ZINC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRALTYHGANSVKVDTVPDPVIEQADDIILRVTATAICGSDLHLYRGKIPTVEHGDIFGH
CCEEEECCCCCEEECCCCCHHHHCCCCEEEEEEEHHHCCCCCEEECCCCCCCCCCCCCHH
EFMGVVEETGSAVTAVAKGDRVVIPFVIACGSCFFCNLDQFAACETTNTGRGAILNKKSI
HHHHHHHHCCCEEEEEECCCEEEEEHHHHCCCEEEECCHHHEEECCCCCCCCEEEECCCC
PPGAALFGFSHLYGGVPGGQAEYVRVPKANVGPFKVPGTLADEKVLFLSDILPTAWQAVL
CCCHHHHHHHHHHCCCCCCCCCEEECCCCCCCCEECCCCCCCCEEHHHHHHHHHHHHHHH
NAGIGQGSTVAIYGAGPVGLMSAACAKMLGAEKIFMVDHHPYRLAYAQKTYGVIPINFDE
HCCCCCCCEEEEEECCHHHHHHHHHHHHHCCCEEEEEECCCEEEEEECCCCEEEEECCCC
DDDPADTIIRQTAGMRGVDGVIDAVGFEAKGSTTETILATLKLEGSSGKALRQCIAAVRR
CCCHHHHHHHHHCCCCCCCHHHHHCCCCCCCCCCEEEEEEEEEECCCCHHHHHHHHHHHC
GGVVSVPGVYAGFIHGFMFGDAFDKGLTFKMGQTHVHRFMPELLEHIEAGRLEPEAIITH
CCEEECCHHHHHHHHHHHHHHHHCCCCEEECCHHHHHHHHHHHHHHHHCCCCCHHHHHHH
RMSLEDAAKGYKLFDKKEEDCRKVILTPGNNTIVVPDDTTEALVGGGVPAM
HCCHHHHHCCCHHCCCCCCCCCEEEECCCCCEEEECCCCHHHHHCCCCCCC
>Mature Secondary Structure
MRALTYHGANSVKVDTVPDPVIEQADDIILRVTATAICGSDLHLYRGKIPTVEHGDIFGH
CCEEEECCCCCEEECCCCCHHHHCCCCEEEEEEEHHHCCCCCEEECCCCCCCCCCCCCHH
EFMGVVEETGSAVTAVAKGDRVVIPFVIACGSCFFCNLDQFAACETTNTGRGAILNKKSI
HHHHHHHHCCCEEEEEECCCEEEEEHHHHCCCEEEECCHHHEEECCCCCCCCEEEECCCC
PPGAALFGFSHLYGGVPGGQAEYVRVPKANVGPFKVPGTLADEKVLFLSDILPTAWQAVL
CCCHHHHHHHHHHCCCCCCCCCEEECCCCCCCCEECCCCCCCCEEHHHHHHHHHHHHHHH
NAGIGQGSTVAIYGAGPVGLMSAACAKMLGAEKIFMVDHHPYRLAYAQKTYGVIPINFDE
HCCCCCCCEEEEEECCHHHHHHHHHHHHHCCCEEEEEECCCEEEEEECCCCEEEEECCCC
DDDPADTIIRQTAGMRGVDGVIDAVGFEAKGSTTETILATLKLEGSSGKALRQCIAAVRR
CCCHHHHHHHHHCCCCCCCHHHHHCCCCCCCCCCEEEEEEEEEECCCCHHHHHHHHHHHC
GGVVSVPGVYAGFIHGFMFGDAFDKGLTFKMGQTHVHRFMPELLEHIEAGRLEPEAIITH
CCEEECCHHHHHHHHHHHHHHHHCCCCEEECCHHHHHHHHHHHHHHHHCCCCCHHHHHHH
RMSLEDAAKGYKLFDKKEEDCRKVILTPGNNTIVVPDDTTEALVGGGVPAM
HCCHHHHHCCCHHCCCCCCCCCEEEECCCCCEEEECCCCHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: formaldehyde; glutathione; NAD+

Specific reaction: formaldehyde + glutathione + NAD+ = S-formylglutathione + NADH + H+

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8905232; 9278503 [H]