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The map label for this gene is gabT [H]

Identifier: 66046744

GI number: 66046744

Start: 4191043

End: 4192290

Strand: Direct

Name: gabT [H]

Synonym: Psyr_3515

Alternate gene names: 66046744

Gene position: 4191043-4192290 (Clockwise)

Preceding gene: 66046741

Following gene: 66046745

Centisome position: 68.78

GC content: 63.14

Gene sequence:

>1248_bases
ATGAGCGAACACATCAGCGAATCCATTTCGTTTGTCCACAACATCACGCTGTCCCACGGCCGCAACGCTGAAGTCTGGGA
CACCGCCGGCAAGCGCTATATCGACTTTGTCGGCGGCATCGGGGTGCTCAATCTGGGGCATTGCAACCCGCAGGTGGTCA
CGGCCATTCAGGACCAGGCGGCAAAACTGACCCACTATTGCTTCAACGCCACGCCTCACGACCCGTACATCCGCTTCATG
CAGCAGCTCACGCAGTTCGTACCGGTCAGTTATCCCCTCAGCGGCATGCTCACCAACAGCGGTGCGGAAGCGGCCGAAAA
TGCCCTGAAGATCGTACGCGGCGCCACAGGGCGCACGGCGGTCATCGCCTTCGACGGTGGTTTTCATGGCCGCACTCTGG
CGACCCTGAACCTCAACGGCAAGGTGGCCCCCTATAAACAGAAAGTCGGCGTGCTGCCCGGCCCGGTCTTTCACGTTCCG
TTCCCCAGCAAGGACAACGGCGTGTCCACCGAGCAGGCGCTCAAGGCCATGGACCGGCTGTTCAGCGTCGAGATCGACGT
CAATGACGTGGGCTGCATCATCTTCGAACCGGTGCAGGGCGAAGGCGGTTTTCTGGCCATGCAGCCGGACTTTGCCCAGG
CATTGCGAGCGTTCTGCGATAAACACGGCATCGTGCTGATCGCCGATGAAATCCAGTCCGGCTTCGGCCGTACCGGGCAG
CGTTTTGCGTTCAGTCGTCTGGGCATCGAGCCCGATCTGATTCTGCTGGGCAAAAGCATTGCGGGCGGCATCCCGCTGGG
CGCGGTGGTGGGTCGCAAGCCGTTGCTGGACAACCTGCCCAAGGGCGGCCTGGGCGGCACGTACTCTGGCAACCCGATTG
GCTGCGCAGCGGGCCTCGCGTCACTGGCGCAGATGACCGATGCCAACCTGTCCAGTTGGGGCGAGCAGCAGGAGCGCGCC
ATCGTTTCACGCTATGAAGCCTGGCGGGCAAGCGGACTGTCGCCGTATCTGGGCAGGCTGACCGGTGTCGGTTGCATGCG
CGGTATCGAACTGATCACGCCGGAAGGTGAGCCCGGCACCCGACCGCTCGCCGAACTGCTGAGCTCAGCGAGGGACGCCG
GGCTGCTGCTGATGCCCAGCGGCAAGGCGCGGCACATTATCCGCCTGCTGATCCCGCTGACCATCGAACCCGACGTGCTG
CACGAAGGGCTGGATATTTTCGAGCGCTGCCTGGCAGCGCTGGCTTGA

Upstream 100 bases:

>100_bases
AATTATTGGAATGACCCGGTGATTTTATTTCGTTTGCGAGCGCTGCCCGATGTTTGTTTGGATAAGGCCATCATGATCAC
CCGGAGTCGGGGCCAGACCG

Downstream 100 bases:

>100_bases
ACCCGTACGGAGAAAACACCCTGATGAGCACAGCACGCTTTGCCGACCCGGACCAGATCCGCGCGGGCTTTTCTCGCGCC
ATGTCGCAGATGTACAAGCA

Product: aminotransferase class-III

Products: NA

Alternate protein names: (S)-3-amino-2-methylpropionate transaminase; GABA aminotransferase; GABA-AT; Gamma-amino-N-butyrate transaminase; GABA transaminase; Glutamate:succinic semialdehyde transaminase; L-AIBAT [H]

Number of amino acids: Translated: 415; Mature: 414

Protein sequence:

>415_residues
MSEHISESISFVHNITLSHGRNAEVWDTAGKRYIDFVGGIGVLNLGHCNPQVVTAIQDQAAKLTHYCFNATPHDPYIRFM
QQLTQFVPVSYPLSGMLTNSGAEAAENALKIVRGATGRTAVIAFDGGFHGRTLATLNLNGKVAPYKQKVGVLPGPVFHVP
FPSKDNGVSTEQALKAMDRLFSVEIDVNDVGCIIFEPVQGEGGFLAMQPDFAQALRAFCDKHGIVLIADEIQSGFGRTGQ
RFAFSRLGIEPDLILLGKSIAGGIPLGAVVGRKPLLDNLPKGGLGGTYSGNPIGCAAGLASLAQMTDANLSSWGEQQERA
IVSRYEAWRASGLSPYLGRLTGVGCMRGIELITPEGEPGTRPLAELLSSARDAGLLLMPSGKARHIIRLLIPLTIEPDVL
HEGLDIFERCLAALA

Sequences:

>Translated_415_residues
MSEHISESISFVHNITLSHGRNAEVWDTAGKRYIDFVGGIGVLNLGHCNPQVVTAIQDQAAKLTHYCFNATPHDPYIRFM
QQLTQFVPVSYPLSGMLTNSGAEAAENALKIVRGATGRTAVIAFDGGFHGRTLATLNLNGKVAPYKQKVGVLPGPVFHVP
FPSKDNGVSTEQALKAMDRLFSVEIDVNDVGCIIFEPVQGEGGFLAMQPDFAQALRAFCDKHGIVLIADEIQSGFGRTGQ
RFAFSRLGIEPDLILLGKSIAGGIPLGAVVGRKPLLDNLPKGGLGGTYSGNPIGCAAGLASLAQMTDANLSSWGEQQERA
IVSRYEAWRASGLSPYLGRLTGVGCMRGIELITPEGEPGTRPLAELLSSARDAGLLLMPSGKARHIIRLLIPLTIEPDVL
HEGLDIFERCLAALA
>Mature_414_residues
SEHISESISFVHNITLSHGRNAEVWDTAGKRYIDFVGGIGVLNLGHCNPQVVTAIQDQAAKLTHYCFNATPHDPYIRFMQ
QLTQFVPVSYPLSGMLTNSGAEAAENALKIVRGATGRTAVIAFDGGFHGRTLATLNLNGKVAPYKQKVGVLPGPVFHVPF
PSKDNGVSTEQALKAMDRLFSVEIDVNDVGCIIFEPVQGEGGFLAMQPDFAQALRAFCDKHGIVLIADEIQSGFGRTGQR
FAFSRLGIEPDLILLGKSIAGGIPLGAVVGRKPLLDNLPKGGLGGTYSGNPIGCAAGLASLAQMTDANLSSWGEQQERAI
VSRYEAWRASGLSPYLGRLTGVGCMRGIELITPEGEPGTRPLAELLSSARDAGLLLMPSGKARHIIRLLIPLTIEPDVLH
EGLDIFERCLAALA

Specific function: 4-aminobutyrate (GABA) degradation. [C]

COG id: COG0160

COG function: function code E; 4-aminobutyrate aminotransferase and related aminotransferases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

Organism=Homo sapiens, GI4557809, Length=410, Percent_Identity=29.5121951219512, Blast_Score=168, Evalue=7e-42,
Organism=Homo sapiens, GI13994255, Length=413, Percent_Identity=28.0871670702179, Blast_Score=136, Evalue=4e-32,
Organism=Homo sapiens, GI37574042, Length=417, Percent_Identity=26.1390887290168, Blast_Score=134, Evalue=2e-31,
Organism=Homo sapiens, GI24119277, Length=390, Percent_Identity=27.6923076923077, Blast_Score=129, Evalue=4e-30,
Organism=Homo sapiens, GI284507298, Length=322, Percent_Identity=30.7453416149068, Blast_Score=127, Evalue=3e-29,
Organism=Homo sapiens, GI226442709, Length=387, Percent_Identity=26.8733850129199, Blast_Score=125, Evalue=5e-29,
Organism=Homo sapiens, GI226442705, Length=417, Percent_Identity=25.6594724220624, Blast_Score=119, Evalue=4e-27,
Organism=Homo sapiens, GI188536080, Length=299, Percent_Identity=25.752508361204, Blast_Score=78, Evalue=1e-14,
Organism=Homo sapiens, GI38679950, Length=299, Percent_Identity=25.752508361204, Blast_Score=78, Evalue=1e-14,
Organism=Homo sapiens, GI38679946, Length=299, Percent_Identity=25.752508361204, Blast_Score=78, Evalue=1e-14,
Organism=Escherichia coli, GI1789016, Length=416, Percent_Identity=42.0673076923077, Blast_Score=350, Evalue=9e-98,
Organism=Escherichia coli, GI1787560, Length=404, Percent_Identity=41.3366336633663, Blast_Score=309, Evalue=2e-85,
Organism=Escherichia coli, GI1789759, Length=402, Percent_Identity=30.3482587064677, Blast_Score=198, Evalue=7e-52,
Organism=Escherichia coli, GI1788044, Length=397, Percent_Identity=30.2267002518892, Blast_Score=181, Evalue=5e-47,
Organism=Escherichia coli, GI145693181, Length=337, Percent_Identity=33.2344213649852, Blast_Score=166, Evalue=4e-42,
Organism=Escherichia coli, GI1786349, Length=286, Percent_Identity=35.6643356643357, Blast_Score=142, Evalue=3e-35,
Organism=Escherichia coli, GI1786991, Length=281, Percent_Identity=30.2491103202847, Blast_Score=123, Evalue=2e-29,
Organism=Caenorhabditis elegans, GI25144271, Length=413, Percent_Identity=26.8765133171913, Blast_Score=155, Evalue=3e-38,
Organism=Caenorhabditis elegans, GI32564660, Length=432, Percent_Identity=28.0092592592593, Blast_Score=153, Evalue=2e-37,
Organism=Caenorhabditis elegans, GI71992977, Length=430, Percent_Identity=28.3720930232558, Blast_Score=140, Evalue=1e-33,
Organism=Caenorhabditis elegans, GI25144274, Length=300, Percent_Identity=25.6666666666667, Blast_Score=99, Evalue=6e-21,
Organism=Caenorhabditis elegans, GI17541228, Length=170, Percent_Identity=31.1764705882353, Blast_Score=82, Evalue=6e-16,
Organism=Caenorhabditis elegans, GI71981843, Length=132, Percent_Identity=31.0606060606061, Blast_Score=74, Evalue=2e-13,
Organism=Saccharomyces cerevisiae, GI6324432, Length=412, Percent_Identity=29.3689320388349, Blast_Score=184, Evalue=2e-47,
Organism=Saccharomyces cerevisiae, GI6323470, Length=412, Percent_Identity=30.0970873786408, Blast_Score=183, Evalue=4e-47,
Organism=Saccharomyces cerevisiae, GI6324386, Length=309, Percent_Identity=24.5954692556634, Blast_Score=96, Evalue=1e-20,
Organism=Drosophila melanogaster, GI21357415, Length=411, Percent_Identity=27.007299270073, Blast_Score=150, Evalue=1e-36,
Organism=Drosophila melanogaster, GI28574759, Length=419, Percent_Identity=26.9689737470167, Blast_Score=132, Evalue=4e-31,
Organism=Drosophila melanogaster, GI161085790, Length=435, Percent_Identity=26.2068965517241, Blast_Score=131, Evalue=1e-30,
Organism=Drosophila melanogaster, GI21356575, Length=440, Percent_Identity=27.9545454545455, Blast_Score=130, Evalue=1e-30,
Organism=Drosophila melanogaster, GI281366494, Length=184, Percent_Identity=29.8913043478261, Blast_Score=84, Evalue=2e-16,
Organism=Drosophila melanogaster, GI24667139, Length=184, Percent_Identity=29.8913043478261, Blast_Score=84, Evalue=2e-16,
Organism=Drosophila melanogaster, GI24667143, Length=184, Percent_Identity=29.8913043478261, Blast_Score=84, Evalue=2e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004632
- InterPro:   IPR005814
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00202 Aminotran_3 [H]

EC number: =2.6.1.19; =2.6.1.22 [H]

Molecular weight: Translated: 44276; Mature: 44145

Theoretical pI: Translated: 6.73; Mature: 6.73

Prosite motif: PS00600 AA_TRANSFER_CLASS_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSEHISESISFVHNITLSHGRNAEVWDTAGKRYIDFVGGIGVLNLGHCNPQVVTAIQDQA
CCHHHHHHHHHHHHHHHCCCCCCCHHHHCCHHHHHHHCCCCEEEECCCCHHHHHHHHHHH
AKLTHYCFNATPHDPYIRFMQQLTQFVPVSYPLSGMLTNSGAEAAENALKIVRGATGRTA
HHHHHHHCCCCCCCHHHHHHHHHHHHCCCCCCCCCEEECCCHHHHHHHHHHHHCCCCCEE
VIAFDGGFHGRTLATLNLNGKVAPYKQKVGVLPGPVFHVPFPSKDNGVSTEQALKAMDRL
EEEECCCCCCCEEEEEECCCCCCCHHHHCCCCCCCEEECCCCCCCCCCCHHHHHHHHHHH
FSVEIDVNDVGCIIFEPVQGEGGFLAMQPDFAQALRAFCDKHGIVLIADEIQSGFGRTGQ
EEEEEECCCCCEEEEEEECCCCCEEEECCHHHHHHHHHHCCCCEEEEEHHHHHCCCCCCH
RFAFSRLGIEPDLILLGKSIAGGIPLGAVVGRKPLLDNLPKGGLGGTYSGNPIGCAAGLA
HHHHHHCCCCCCEEEEECHHCCCCCHHHHHCCCCHHHCCCCCCCCCCCCCCCCHHHHHHH
SLAQMTDANLSSWGEQQERAIVSRYEAWRASGLSPYLGRLTGVGCMRGIELITPEGEPGT
HHHHHHCCCHHHHCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCEEECCCCCCCC
RPLAELLSSARDAGLLLMPSGKARHIIRLLIPLTIEPDVLHEGLDIFERCLAALA
CHHHHHHHCCCCCCEEEECCCCHHHEEHEEECCCCCHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
SEHISESISFVHNITLSHGRNAEVWDTAGKRYIDFVGGIGVLNLGHCNPQVVTAIQDQA
CHHHHHHHHHHHHHHHCCCCCCCHHHHCCHHHHHHHCCCCEEEECCCCHHHHHHHHHHH
AKLTHYCFNATPHDPYIRFMQQLTQFVPVSYPLSGMLTNSGAEAAENALKIVRGATGRTA
HHHHHHHCCCCCCCHHHHHHHHHHHHCCCCCCCCCEEECCCHHHHHHHHHHHHCCCCCEE
VIAFDGGFHGRTLATLNLNGKVAPYKQKVGVLPGPVFHVPFPSKDNGVSTEQALKAMDRL
EEEECCCCCCCEEEEEECCCCCCCHHHHCCCCCCCEEECCCCCCCCCCCHHHHHHHHHHH
FSVEIDVNDVGCIIFEPVQGEGGFLAMQPDFAQALRAFCDKHGIVLIADEIQSGFGRTGQ
EEEEEECCCCCEEEEEEECCCCCEEEECCHHHHHHHHHHCCCCEEEEEHHHHHCCCCCCH
RFAFSRLGIEPDLILLGKSIAGGIPLGAVVGRKPLLDNLPKGGLGGTYSGNPIGCAAGLA
HHHHHHCCCCCCEEEEECHHCCCCCHHHHHCCCCHHHCCCCCCCCCCCCCCCCHHHHHHH
SLAQMTDANLSSWGEQQERAIVSRYEAWRASGLSPYLGRLTGVGCMRGIELITPEGEPGT
HHHHHHCCCHHHHCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCEEECCCCCCCC
RPLAELLSSARDAGLLLMPSGKARHIIRLLIPLTIEPDVLHEGLDIFERCLAALA
CHHHHHHHCCCCCCEEEECCCCHHHEEHEEECCCCCHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2254272; 9205837; 9278503; 2178550 [H]