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The map label for this gene is tibA [H]

Identifier: 66046637

GI number: 66046637

Start: 4068972

End: 4071101

Strand: Reverse

Name: tibA [H]

Synonym: Psyr_3408

Alternate gene names: 66046637

Gene position: 4071101-4068972 (Counterclockwise)

Preceding gene: 66046641

Following gene: 66046632

Centisome position: 66.81

GC content: 57.79

Gene sequence:

>2130_bases
ATGGCTGACTCTCCGCTTAGGGAGATTGTCAGCGACCGGACAGAGTATGTGGATGCGGCCAGCGCATTTCATAATTACTC
TGTATACGGTACTGGATACCTTCATTCCGATGGGGCTGCGATCAAACGTATCTCTTCTTATGGCGGAAGGACCGAATTAA
CGGGCAATACCCTGGTCAAGGATGGAATGTTGTCTGACGGCGACGCTCGAGTTTCAGTTAAAGACTCCACCATCCTCAGC
GATAGCACGATAGCGCTCGTGGTGCAGGGCAACTCGAACATGACACTTGAACACAGTGTCGTTGAGGGAAAAGGGGGCGG
CATCACCGTTGCCGAGGACGCCTTCGCCCTGATCAGCAATACACAGGTCGGCTCGCTGCAGGGTGAAGTTGGTAGACACA
CTGGCTGGGGCGTTGGCATTTTTGGCGCTCGCGCTGACATCACTTCCCGAAGCTACATAAAAGGCTTGTCTCACGGGGTA
TGGTTCACTCATCCACGCCTCACAGTGGGTGATGGAACGCAGTTCAATTACGGTCAACTGAGCATCGACAACTCTACCGT
CGAAGGGCTGACAGGAGCCGCCATAAGGGTGGAAGGGCGTGAGGGTATAAGCCACCTTGCGGATATTGAGATCAAGAACA
ACACCCTCCTGCTGTCCGGCAATGGCATGCTTCTTGAGGTTCTGAACCAGAGCACCGCCAACTTCAACGTCGACAACAGC
ACCCTCAATGGCAACCTTGTCGCCGATGACACCAGCACCCTGAACATCACGCTGCAAAACGGCGCGCAATTGAACGGCGA
CATCGTCAATGGCAACCGTCTGGCGATTACCTCGGGTAGTCACTGGCAGATGCAGGGCGACAATGCCGTCAGGTCGCTTT
CCCTGCAGGGTGGCAGGGTTTCGTTTGCTGGCGAAGGGTTTCATACCCTTTCGCTGAATGAGTTGTCAGGCGCTGGCACG
TTCGGCTTGCGCGTGGATCTGGACAACGGCGTCGGAGACCTCATCGACGTCAACGGCCAGGCCAGTGGGCAGTTCGGCTT
GCGCGTGCGCAATACGGGGGTGGAGGTTGTGTCTGCCGACATGGCACCGCTCAAGGTGGTGCATACCGAAGGTGGCGACG
CGCAATTCAGCCTGCTGGGCGGGCGGGTTGACCTGGGGGCCTATTCGTATTTGCTGGAGCAGCAGGGCAATGACTGGTTC
ATCGTCGGTAAAGACAAGGTCATAAGCCCTTCGACCCAGAGCGCGCTTGCCCTTTACAGCGCGGCACCTGCGATCTGGAT
GAGTGAGCTCTCTACCTTGCGTTCGCGCATGGGTGAGGTTCGTGCAAGCGGCAGGGCGGGCGGCTGGATGCGTGCCTATG
GCAACAGGCTGAATGCCACGACCAGTGACGGTGTCGACTACCGGCAGAAACAAAGTGGCCTGTCGCTGGGTGCCGATGCG
CCCGTCGAGGTCAGCAATGGCCAACTGGTGGTCGGTGTGCTGGGAGGGTACAGCACCTCCGGTATCGATTTGAGCCGTGG
CACCACGGGTAAAGTCGACAGCTACTATGCAGGCGCCTATGCCACCTGGCTGTCGGACGATGGCTACTACGTTGACGGCG
TGCTCAAACTCAACCGCTTTCGCAACAAGGCAGATGTTGCCATGAGCGATGCAAGCAAGGCCAAGGGTGACTACACCAAC
AACGGGATAGGGGGCTGGGTCGAGTTCGGCCGCCACATCAAACTGGCGGACGATTACTTTCTCGAACCGTTCGCTCAGTT
GTCCAGTGTCGTCGTTCAGGGGCAGGAGCTGCGCCTGGACAACGGCATGAAAGCGAAGAACGACCAGACCCAATCGGTAT
TGGGCAAGGTGGGCACCTCGCTGGGCCGCAGTGTTGCGCTCAAGGATGGCGGAGTATTGCAGCCTTATGTACGTGTCGCC
ATTGCACAGGAGTTTTCGCGCCGCAACGAGGTGAAAGCCAACGATGTGAAATTCGATAACAGCCTGTTCGGTTCGCGCGG
CGAACTGGGAGCCGGGGTATCGGTGTCGCTGTCCGAGCGTCTGAAACTGCACGCGGACTTCGATTACATGAAAGGTCGGC
ATATCGAGCAACCCTGGGGAGCGAATGTGGGGCTGCGCCTGGCATTCTGA

Upstream 100 bases:

>100_bases
ATTTTGAGGGTTTCTTATTGTGGCTGAGTGTTTTATTGGGAAGTGTGGGCTTTACAGGGCAGGGCTGGGCGCTATTGCGT
GCCTCGCATCGACTCACGTG

Downstream 100 bases:

>100_bases
TTCTTGAGGCCAGTGCCTGAGCAACACCAGAGCCCCCGGTAGTGATCACCGGGGGCTTTTCAGTTATTGATCGGTAAACC
TGCGTTTGCGTTGTCTCTGT

Product: Outer membrane autotransporter barrel

Products: NA

Alternate protein names: Glycoprotein TibA [H]

Number of amino acids: Translated: 709; Mature: 708

Protein sequence:

>709_residues
MADSPLREIVSDRTEYVDAASAFHNYSVYGTGYLHSDGAAIKRISSYGGRTELTGNTLVKDGMLSDGDARVSVKDSTILS
DSTIALVVQGNSNMTLEHSVVEGKGGGITVAEDAFALISNTQVGSLQGEVGRHTGWGVGIFGARADITSRSYIKGLSHGV
WFTHPRLTVGDGTQFNYGQLSIDNSTVEGLTGAAIRVEGREGISHLADIEIKNNTLLLSGNGMLLEVLNQSTANFNVDNS
TLNGNLVADDTSTLNITLQNGAQLNGDIVNGNRLAITSGSHWQMQGDNAVRSLSLQGGRVSFAGEGFHTLSLNELSGAGT
FGLRVDLDNGVGDLIDVNGQASGQFGLRVRNTGVEVVSADMAPLKVVHTEGGDAQFSLLGGRVDLGAYSYLLEQQGNDWF
IVGKDKVISPSTQSALALYSAAPAIWMSELSTLRSRMGEVRASGRAGGWMRAYGNRLNATTSDGVDYRQKQSGLSLGADA
PVEVSNGQLVVGVLGGYSTSGIDLSRGTTGKVDSYYAGAYATWLSDDGYYVDGVLKLNRFRNKADVAMSDASKAKGDYTN
NGIGGWVEFGRHIKLADDYFLEPFAQLSSVVVQGQELRLDNGMKAKNDQTQSVLGKVGTSLGRSVALKDGGVLQPYVRVA
IAQEFSRRNEVKANDVKFDNSLFGSRGELGAGVSVSLSERLKLHADFDYMKGRHIEQPWGANVGLRLAF

Sequences:

>Translated_709_residues
MADSPLREIVSDRTEYVDAASAFHNYSVYGTGYLHSDGAAIKRISSYGGRTELTGNTLVKDGMLSDGDARVSVKDSTILS
DSTIALVVQGNSNMTLEHSVVEGKGGGITVAEDAFALISNTQVGSLQGEVGRHTGWGVGIFGARADITSRSYIKGLSHGV
WFTHPRLTVGDGTQFNYGQLSIDNSTVEGLTGAAIRVEGREGISHLADIEIKNNTLLLSGNGMLLEVLNQSTANFNVDNS
TLNGNLVADDTSTLNITLQNGAQLNGDIVNGNRLAITSGSHWQMQGDNAVRSLSLQGGRVSFAGEGFHTLSLNELSGAGT
FGLRVDLDNGVGDLIDVNGQASGQFGLRVRNTGVEVVSADMAPLKVVHTEGGDAQFSLLGGRVDLGAYSYLLEQQGNDWF
IVGKDKVISPSTQSALALYSAAPAIWMSELSTLRSRMGEVRASGRAGGWMRAYGNRLNATTSDGVDYRQKQSGLSLGADA
PVEVSNGQLVVGVLGGYSTSGIDLSRGTTGKVDSYYAGAYATWLSDDGYYVDGVLKLNRFRNKADVAMSDASKAKGDYTN
NGIGGWVEFGRHIKLADDYFLEPFAQLSSVVVQGQELRLDNGMKAKNDQTQSVLGKVGTSLGRSVALKDGGVLQPYVRVA
IAQEFSRRNEVKANDVKFDNSLFGSRGELGAGVSVSLSERLKLHADFDYMKGRHIEQPWGANVGLRLAF
>Mature_708_residues
ADSPLREIVSDRTEYVDAASAFHNYSVYGTGYLHSDGAAIKRISSYGGRTELTGNTLVKDGMLSDGDARVSVKDSTILSD
STIALVVQGNSNMTLEHSVVEGKGGGITVAEDAFALISNTQVGSLQGEVGRHTGWGVGIFGARADITSRSYIKGLSHGVW
FTHPRLTVGDGTQFNYGQLSIDNSTVEGLTGAAIRVEGREGISHLADIEIKNNTLLLSGNGMLLEVLNQSTANFNVDNST
LNGNLVADDTSTLNITLQNGAQLNGDIVNGNRLAITSGSHWQMQGDNAVRSLSLQGGRVSFAGEGFHTLSLNELSGAGTF
GLRVDLDNGVGDLIDVNGQASGQFGLRVRNTGVEVVSADMAPLKVVHTEGGDAQFSLLGGRVDLGAYSYLLEQQGNDWFI
VGKDKVISPSTQSALALYSAAPAIWMSELSTLRSRMGEVRASGRAGGWMRAYGNRLNATTSDGVDYRQKQSGLSLGADAP
VEVSNGQLVVGVLGGYSTSGIDLSRGTTGKVDSYYAGAYATWLSDDGYYVDGVLKLNRFRNKADVAMSDASKAKGDYTNN
GIGGWVEFGRHIKLADDYFLEPFAQLSSVVVQGQELRLDNGMKAKNDQTQSVLGKVGTSLGRSVALKDGGVLQPYVRVAI
AQEFSRRNEVKANDVKFDNSLFGSRGELGAGVSVSLSERLKLHADFDYMKGRHIEQPWGANVGLRLAF

Specific function: Mediates both adhesion to and invasion of human intestine epithelial cells. Also mediates bacterial cell aggregation via intercellular TibA-TibA interaction. Enhances biofilm formation [H]

COG id: COG3468

COG function: function code MU; Type V secretory pathway, adhesin AidA

Gene ontology:

Cell location: Adhesin/invasin TibA translocator:Cell outer membrane; Multi-pass membrane protein (Potential). Note=The cleaved C-terminal fragment (autotransporter domain) is localized in the outer membrane [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 autotransporter (TC 1.B.12) domain [H]

Homologues:

Organism=Escherichia coli, GI87082145, Length=448, Percent_Identity=33.7053571428571, Blast_Score=237, Evalue=2e-63,
Organism=Escherichia coli, GI1787452, Length=492, Percent_Identity=27.4390243902439, Blast_Score=136, Evalue=6e-33,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005546
- InterPro:   IPR006315
- InterPro:   IPR012332
- InterPro:   IPR011050
- InterPro:   IPR004899
- InterPro:   IPR003991 [H]

Pfam domain/function: PF03797 Autotransporter; PF03212 Pertactin [H]

EC number: NA

Molecular weight: Translated: 75337; Mature: 75206

Theoretical pI: Translated: 5.51; Mature: 5.51

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MADSPLREIVSDRTEYVDAASAFHNYSVYGTGYLHSDGAAIKRISSYGGRTELTGNTLVK
CCCCHHHHHHHHHHHHHHHHHHHCCEEEEEEEEEECCCHHHHHHHHCCCEEEECCCEEEE
DGMLSDGDARVSVKDSTILSDSTIALVVQGNSNMTLEHSVVEGKGGGITVAEDAFALISN
CCCCCCCCCEEEEECCEEECCCEEEEEEECCCCEEEEEEEEECCCCCEEEECCCEEEECC
TQVGSLQGEVGRHTGWGVGIFGARADITSRSYIKGLSHGVWFTHPRLTVGDGTQFNYGQL
CCCCCCCCCCCCCCCCEEEEEECCCCCCCHHHHHHCCCCEEEECCEEEECCCCEECCEEE
SIDNSTVEGLTGAAIRVEGREGISHLADIEIKNNTLLLSGNGMLLEVLNQSTANFNVDNS
EECCCCCCCCCCEEEEEECCCCCCCEEEEEECCCEEEEECCCEEEEEECCCCCCEECCCC
TLNGNLVADDTSTLNITLQNGAQLNGDIVNGNRLAITSGSHWQMQGDNAVRSLSLQGGRV
CCCCCEEECCCCEEEEEECCCCEECCEEECCCEEEEECCCCEEECCCCCEEEEEECCCEE
SFAGEGFHTLSLNELSGAGTFGLRVDLDNGVGDLIDVNGQASGQFGLRVRNTGVEVVSAD
EEECCCEEEEEECCCCCCCEEEEEEEECCCCCCEEECCCCCCCEEEEEEECCCCEEEECC
MAPLKVVHTEGGDAQFSLLGGRVDLGAYSYLLEQQGNDWFIVGKDKVISPSTQSALALYS
CCCEEEEEECCCCEEEEEECCEECHHHHHHHHHCCCCEEEEEECCEEECCCCHHHHHHHH
AAPAIWMSELSTLRSRMGEVRASGRAGGWMRAYGNRLNATTSDGVDYRQKQSGLSLGADA
CCHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHCCCCCCCCCCCCCHHHHHCCCCCCCCC
PVEVSNGQLVVGVLGGYSTSGIDLSRGTTGKVDSYYAGAYATWLSDDGYYVDGVLKLNRF
CEEECCCEEEEEEECCCCCCCEEECCCCCCCCCCEECCEEEEEECCCCEEEEEEEEEHHC
RNKADVAMSDASKAKGDYTNNGIGGWVEFGRHIKLADDYFLEPFAQLSSVVVQGQELRLD
CCCCCEEECCCHHCCCCCCCCCCCHHHHCCCEEEECCHHHHHHHHHHHHHHHCCCEEEEC
NGMKAKNDQTQSVLGKVGTSLGRSVALKDGGVLQPYVRVAIAQEFSRRNEVKANDVKFDN
CCCCCCCCHHHHHHHHHHHHHCCEEEECCCCCCCHHHHHHHHHHHHHCCCCCCCCEEECC
SLFGSRGELGAGVSVSLSERLKLHADFDYMKGRHIEQPWGANVGLRLAF
CCCCCCCCCCCCEEEEECCCEEEEECCHHHCCCCCCCCCCCCCEEEEEC
>Mature Secondary Structure 
ADSPLREIVSDRTEYVDAASAFHNYSVYGTGYLHSDGAAIKRISSYGGRTELTGNTLVK
CCCHHHHHHHHHHHHHHHHHHHCCEEEEEEEEEECCCHHHHHHHHCCCEEEECCCEEEE
DGMLSDGDARVSVKDSTILSDSTIALVVQGNSNMTLEHSVVEGKGGGITVAEDAFALISN
CCCCCCCCCEEEEECCEEECCCEEEEEEECCCCEEEEEEEEECCCCCEEEECCCEEEECC
TQVGSLQGEVGRHTGWGVGIFGARADITSRSYIKGLSHGVWFTHPRLTVGDGTQFNYGQL
CCCCCCCCCCCCCCCCEEEEEECCCCCCCHHHHHHCCCCEEEECCEEEECCCCEECCEEE
SIDNSTVEGLTGAAIRVEGREGISHLADIEIKNNTLLLSGNGMLLEVLNQSTANFNVDNS
EECCCCCCCCCCEEEEEECCCCCCCEEEEEECCCEEEEECCCEEEEEECCCCCCEECCCC
TLNGNLVADDTSTLNITLQNGAQLNGDIVNGNRLAITSGSHWQMQGDNAVRSLSLQGGRV
CCCCCEEECCCCEEEEEECCCCEECCEEECCCEEEEECCCCEEECCCCCEEEEEECCCEE
SFAGEGFHTLSLNELSGAGTFGLRVDLDNGVGDLIDVNGQASGQFGLRVRNTGVEVVSAD
EEECCCEEEEEECCCCCCCEEEEEEEECCCCCCEEECCCCCCCEEEEEEECCCCEEEECC
MAPLKVVHTEGGDAQFSLLGGRVDLGAYSYLLEQQGNDWFIVGKDKVISPSTQSALALYS
CCCEEEEEECCCCEEEEEECCEECHHHHHHHHHCCCCEEEEEECCEEECCCCHHHHHHHH
AAPAIWMSELSTLRSRMGEVRASGRAGGWMRAYGNRLNATTSDGVDYRQKQSGLSLGADA
CCHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHCCCCCCCCCCCCCHHHHHCCCCCCCCC
PVEVSNGQLVVGVLGGYSTSGIDLSRGTTGKVDSYYAGAYATWLSDDGYYVDGVLKLNRF
CEEECCCEEEEEEECCCCCCCEEECCCCCCCCCCEECCEEEEEECCCCEEEEEEEEEHHC
RNKADVAMSDASKAKGDYTNNGIGGWVEFGRHIKLADDYFLEPFAQLSSVVVQGQELRLD
CCCCCEEECCCHHCCCCCCCCCCCHHHHCCCEEEECCHHHHHHHHHHHHHHHCCCEEEEC
NGMKAKNDQTQSVLGKVGTSLGRSVALKDGGVLQPYVRVAIAQEFSRRNEVKANDVKFDN
CCCCCCCCHHHHHHHHHHHHHCCEEEECCCCCCCHHHHHHHHHHHHHCCCCCCCCEEECC
SLFGSRGELGAGVSVSLSERLKLHADFDYMKGRHIEQPWGANVGLRLAF
CCCCCCCCCCCCEEEEECCCEEEEECCHHHCCCCCCCCCCCCCEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 10417177 [H]