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The map label for this gene is hlyB [H]

Identifier: 66046577

GI number: 66046577

Start: 4003979

End: 4005607

Strand: Direct

Name: hlyB [H]

Synonym: Psyr_3348

Alternate gene names: 66046577

Gene position: 4003979-4005607 (Clockwise)

Preceding gene: 66046576

Following gene: 66046578

Centisome position: 65.71

GC content: 59.79

Gene sequence:

>1629_bases
ATGATCCTGCGAAAACTCAACCTGGCCGCGCGCTCGACGCTTTGTTTCGGCGTGTTCTGCCTGATGATCATTGCCTTGGG
CTTGCTTGCCCTGCGTCAGGCAGCCGAGCTCAATGCGGCGGAAAAATTCATCGAGACCAATGTGCTTCCGAGCGTGAAAC
AGCTCGCATCGATCGATCGGGAGTTTGTCAGTATCCGCGGCAACAACGCCCGTGTGCGCAATCCGATTGAGCCGCAGGAT
CGAAAGACCAAGGCGCTCAGCGATATCCAGCAGTCGCGCTCGCTGATCGCCGGCTATTTTGACACGCTCGGCAAATTGAT
CGTGACTCCGCAAGGGCGCCAGGCCTTCGACGAATTGTCCCAGGCACAGGCCGGGTATCAGGTGGCACAGGATCGCTACC
TCGCCTCGGTAGCCGCCGGCAATCTGGAAGCTGCAGTGGCAACTTCCAATGGCGAAATGAAAAGCGCGGCCGATCAGGTT
GAAACCGGGCTGAAGAAACTCATTGGCGTCAACGACGCCAAAGCCGAGAAAGCCGGCGCTGCCGCTAACGCTGCCTATCA
GCAGACGCTGTGGATGGTGGGCATTTTCATCACCGTAGGCGTCATCACCACGCTGCTCCTCGCCTGGATGTACACCCGCA
GTCTAACTGGCCCGATTGGCGATTCGTTGAGTATCGCGCAACGCATTGCCACCAATGATCTGAGCCAGGACATCCCGCAA
CATGGCACTGACGAGGCGGCGAAACTGATTGCCGCACTCGCCACCATGCAGTCCAACCTGCGCAATGCCCTGACCCTGAT
CGGCGACTCCTCCACCCAGCTGGCTGCGACTTCCGAGGAAATGCATGCCGTCACCGAAGACGCCTCGCGCACCATTCTGC
GCCAGACCAACGAGATCGAAATGGCAGCCACCGCCGTCAACGAGATGAGCGCGGCAGTAGAGGAAGTGGCCAGTAACGCC
GCATCGGCATCTGAGGTGACCTCGCAATCCAGCACTGCAGCCATGGCTGGGCGCGCGCAGGTCGATGAGACCGTCACGGC
GATCAACCTGATGGTCTCCAAGGTGCAGATCACCTCCACTGAGGTACAAGGCCTGGCCGTCATGGCGACGGATATCAGTA
AGGTGCTGGATGTGATCCGTGCCATCGCGGAACAGACCAACCTGCTGGCACTCAACGCAGCCATCGAAGCGGCTCGTGCA
GGTGAAGCCGGGCGGGGTTTTGCGGTGGTGGCGGACGAGGTCAGGGCGCTGGCGCATCGCACCCAGCAATCAACCCGTGA
AATCGAACAGATGGTCGACTCGATCCAGACCGGCACCGGCAATGCTGTCAGCGCAATGGAGCAGACCAGCGTTCAGGCCC
ACAAGACACTGGAGATGGCCAATGGCGCTGGCAAGGCGCTGCTGGAAATCACCGAATCCATCAGCCAGATCAATGAACGC
AACCTGATGATCGCCACCGCCGCCGAAGAACAGGCTCAGGTCGCTCGAGAAGTCGACAGGAGCCTGGTCAGCATTCGTGA
TCTGTCCAGCCAGACATCCGAGGGCTCCAATCAGACGGCCATCGCCACTGCCGAACTGTCGACCCTGGCTTCAAGCCTGA
ACCGTCTCACCAAGCAATTCCGCGTTTAA

Upstream 100 bases:

>100_bases
GAACCGTAATTGCAACCCTTCTGACACACCTTGTTACTCTTTTGCAGCCAAGTTAATCCGAATGAGGGCGATAGCTGTCT
ACCCTCTCGGAGAAATACTC

Downstream 100 bases:

>100_bases
GCCCCTCTGCCGGGAAGCTCGCTTCCCGGCATCTCCCCTTGTCGAATGGCCTTCCCTGATCTAAGTTGTACGACGACAGA
TGAACTCTGTCATCTGCGCC

Product: histidine kinase, HAMP region: chemotaxis sensory transducer

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 542; Mature: 542

Protein sequence:

>542_residues
MILRKLNLAARSTLCFGVFCLMIIALGLLALRQAAELNAAEKFIETNVLPSVKQLASIDREFVSIRGNNARVRNPIEPQD
RKTKALSDIQQSRSLIAGYFDTLGKLIVTPQGRQAFDELSQAQAGYQVAQDRYLASVAAGNLEAAVATSNGEMKSAADQV
ETGLKKLIGVNDAKAEKAGAAANAAYQQTLWMVGIFITVGVITTLLLAWMYTRSLTGPIGDSLSIAQRIATNDLSQDIPQ
HGTDEAAKLIAALATMQSNLRNALTLIGDSSTQLAATSEEMHAVTEDASRTILRQTNEIEMAATAVNEMSAAVEEVASNA
ASASEVTSQSSTAAMAGRAQVDETVTAINLMVSKVQITSTEVQGLAVMATDISKVLDVIRAIAEQTNLLALNAAIEAARA
GEAGRGFAVVADEVRALAHRTQQSTREIEQMVDSIQTGTGNAVSAMEQTSVQAHKTLEMANGAGKALLEITESISQINER
NLMIATAAEEQAQVAREVDRSLVSIRDLSSQTSEGSNQTAIATAELSTLASSLNRLTKQFRV

Sequences:

>Translated_542_residues
MILRKLNLAARSTLCFGVFCLMIIALGLLALRQAAELNAAEKFIETNVLPSVKQLASIDREFVSIRGNNARVRNPIEPQD
RKTKALSDIQQSRSLIAGYFDTLGKLIVTPQGRQAFDELSQAQAGYQVAQDRYLASVAAGNLEAAVATSNGEMKSAADQV
ETGLKKLIGVNDAKAEKAGAAANAAYQQTLWMVGIFITVGVITTLLLAWMYTRSLTGPIGDSLSIAQRIATNDLSQDIPQ
HGTDEAAKLIAALATMQSNLRNALTLIGDSSTQLAATSEEMHAVTEDASRTILRQTNEIEMAATAVNEMSAAVEEVASNA
ASASEVTSQSSTAAMAGRAQVDETVTAINLMVSKVQITSTEVQGLAVMATDISKVLDVIRAIAEQTNLLALNAAIEAARA
GEAGRGFAVVADEVRALAHRTQQSTREIEQMVDSIQTGTGNAVSAMEQTSVQAHKTLEMANGAGKALLEITESISQINER
NLMIATAAEEQAQVAREVDRSLVSIRDLSSQTSEGSNQTAIATAELSTLASSLNRLTKQFRV
>Mature_542_residues
MILRKLNLAARSTLCFGVFCLMIIALGLLALRQAAELNAAEKFIETNVLPSVKQLASIDREFVSIRGNNARVRNPIEPQD
RKTKALSDIQQSRSLIAGYFDTLGKLIVTPQGRQAFDELSQAQAGYQVAQDRYLASVAAGNLEAAVATSNGEMKSAADQV
ETGLKKLIGVNDAKAEKAGAAANAAYQQTLWMVGIFITVGVITTLLLAWMYTRSLTGPIGDSLSIAQRIATNDLSQDIPQ
HGTDEAAKLIAALATMQSNLRNALTLIGDSSTQLAATSEEMHAVTEDASRTILRQTNEIEMAATAVNEMSAAVEEVASNA
ASASEVTSQSSTAAMAGRAQVDETVTAINLMVSKVQITSTEVQGLAVMATDISKVLDVIRAIAEQTNLLALNAAIEAARA
GEAGRGFAVVADEVRALAHRTQQSTREIEQMVDSIQTGTGNAVSAMEQTSVQAHKTLEMANGAGKALLEITESISQINER
NLMIATAAEEQAQVAREVDRSLVSIRDLSSQTSEGSNQTAIATAELSTLASSLNRLTKQFRV

Specific function: May form a pore through which the hemolysin can be exported [H]

COG id: COG0840

COG function: function code NT; Methyl-accepting chemotaxis protein

Gene ontology:

Cell location: Cell outer membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 methyl-accepting transducer domain [H]

Homologues:

Organism=Escherichia coli, GI1788194, Length=343, Percent_Identity=30.0291545189504, Blast_Score=129, Evalue=5e-31,
Organism=Escherichia coli, GI2367378, Length=325, Percent_Identity=29.8461538461538, Blast_Score=124, Evalue=2e-29,
Organism=Escherichia coli, GI1787690, Length=468, Percent_Identity=26.4957264957265, Blast_Score=122, Evalue=9e-29,
Organism=Escherichia coli, GI1788195, Length=295, Percent_Identity=31.1864406779661, Blast_Score=109, Evalue=5e-25,
Organism=Escherichia coli, GI1789453, Length=338, Percent_Identity=27.5147928994083, Blast_Score=89, Evalue=6e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004090
- InterPro:   IPR004089
- InterPro:   IPR003660
- InterPro:   IPR000727 [H]

Pfam domain/function: PF00672 HAMP; PF00015 MCPsignal [H]

EC number: NA

Molecular weight: Translated: 57510; Mature: 57510

Theoretical pI: Translated: 4.78; Mature: 4.78

Prosite motif: PS50885 HAMP ; PS50111 CHEMOTAXIS_TRANSDUC_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MILRKLNLAARSTLCFGVFCLMIIALGLLALRQAAELNAAEKFIETNVLPSVKQLASIDR
CCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHH
EFVSIRGNNARVRNPIEPQDRKTKALSDIQQSRSLIAGYFDTLGKLIVTPQGRQAFDELS
HHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCHHHHHHHH
QAQAGYQVAQDRYLASVAAGNLEAAVATSNGEMKSAADQVETGLKKLIGVNDAKAEKAGA
HHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCHHHHHHHHHHHHHHHHCCCCHHHHHCCC
AANAAYQQTLWMVGIFITVGVITTLLLAWMYTRSLTGPIGDSLSIAQRIATNDLSQDIPQ
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCC
HGTDEAAKLIAALATMQSNLRNALTLIGDSSTQLAATSEEMHAVTEDASRTILRQTNEIE
CCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCHHH
MAATAVNEMSAAVEEVASNAASASEVTSQSSTAAMAGRAQVDETVTAINLMVSKVQITST
HHHHHHHHHHHHHHHHHHCCCHHHHHHHCHHHHHHHCHHHHHHHHHHHHHHHHHHEEEHH
EVQGLAVMATDISKVLDVIRAIAEQTNLLALNAAIEAARAGEAGRGFAVVADEVRALAHR
HHCCHHHHHHHHHHHHHHHHHHHHHCCEEEHHHHHHHHHCCCCCCCHHHHHHHHHHHHHH
TQQSTREIEQMVDSIQTGTGNAVSAMEQTSVQAHKTLEMANGAGKALLEITESISQINER
HHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCC
NLMIATAAEEQAQVAREVDRSLVSIRDLSSQTSEGSNQTAIATAELSTLASSLNRLTKQF
CEEEEECCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEHHHHHHHHHHHHHHHHHHH
RV
CC
>Mature Secondary Structure
MILRKLNLAARSTLCFGVFCLMIIALGLLALRQAAELNAAEKFIETNVLPSVKQLASIDR
CCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHH
EFVSIRGNNARVRNPIEPQDRKTKALSDIQQSRSLIAGYFDTLGKLIVTPQGRQAFDELS
HHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCHHHHHHHH
QAQAGYQVAQDRYLASVAAGNLEAAVATSNGEMKSAADQVETGLKKLIGVNDAKAEKAGA
HHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCHHHHHHHHHHHHHHHHCCCCHHHHHCCC
AANAAYQQTLWMVGIFITVGVITTLLLAWMYTRSLTGPIGDSLSIAQRIATNDLSQDIPQ
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCC
HGTDEAAKLIAALATMQSNLRNALTLIGDSSTQLAATSEEMHAVTEDASRTILRQTNEIE
CCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCHHH
MAATAVNEMSAAVEEVASNAASASEVTSQSSTAAMAGRAQVDETVTAINLMVSKVQITST
HHHHHHHHHHHHHHHHHHCCCHHHHHHHCHHHHHHHCHHHHHHHHHHHHHHHHHHEEEHH
EVQGLAVMATDISKVLDVIRAIAEQTNLLALNAAIEAARAGEAGRGFAVVADEVRALAHR
HHCCHHHHHHHHHHHHHHHHHHHHHCCEEEHHHHHHHHHCCCCCCCHHHHHHHHHHHHHH
TQQSTREIEQMVDSIQTGTGNAVSAMEQTSVQAHKTLEMANGAGKALLEITESISQINER
HHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCC
NLMIATAAEEQAQVAREVDRSLVSIRDLSSQTSEGSNQTAIATAELSTLASSLNRLTKQF
CEEEEECCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEHHHHHHHHHHHHHHHHHHH
RV
CC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 2162464; 10952301 [H]