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The map label for this gene is pyrG [H]

Identifier: 66046469

GI number: 66046469

Start: 3879008

End: 3879730

Strand: Reverse

Name: pyrG [H]

Synonym: Psyr_3240

Alternate gene names: 66046469

Gene position: 3879730-3879008 (Counterclockwise)

Preceding gene: 66046470

Following gene: 66046465

Centisome position: 63.67

GC content: 65.7

Gene sequence:

>723_bases
ATGGGCATAGCAGACAACACACGCAACGGGATACGCATCGGTCTGGTCGGGGACTTCAGTGCGGATGTCCCTGCGCATCA
GGCCATTCCATTGGCCTTGCACAGGGCGGCGGAGGTCGCGCAGGTAGCGGTTGATATCGAATGGCTGCCGACCCCGCAGA
TCGGCAGCGGTGCGCACCTCGCGGAGTTCGACGGCCTGTGGTGCGTCCCGGCCAGTCCGTATCGGGACATGCAGGGCGCG
CTGACCGCCATCCGTTTCGCTCGCGAGCATCGGGTGCCGTTTCTGGGGACGTGCGGGGGCTTTCAGCACGCGTTGCTCGA
GTACGCCCGCCACCAACTGGGCTGGACGGACGCCGAGCATGGCGAAACTGCGCCGGACGCGGCAAACGTGATTATCGAGC
CGCTCAGTTGCTCGCTGGTCGAGTCGGTGGCAGCGATCCAGTTGCAACCCGACACGCTGATTGCCCAGGCCTATGGCAGA
CTCGATATCGACGAGCGCTACCACTGCCGCTACGGCCTGCGCCGCGAGCTGGAGTCGGTGCTGTTCGGCGAGCACCTGAA
GGTCAGCGGGCGCGGTCCCGAGGGCGAAGTGCGCTGTATGGAGTTGCAGGGACACCCGTTCTACGTCGCCACACTGTTCC
AGCCGGAGCGCGCTGCGTTGCTGGGCCAGACGCCACCTGTGGTGGCCGCGTTTGTCCGCGCCTGCCTGAGCAACTTATCG
TGA

Upstream 100 bases:

>100_bases
CACGCTTGCACGCGAGGCATTGCTGTAACGCCCATTCTGCTGATTTTGCTGCCTGTTTATAGTCCGCCCGGGCTGTACGA
AACCAGACAGGGAGCAGGGC

Downstream 100 bases:

>100_bases
TGGCCGCGCGGTTTGCCAAGCCTTACTTCGCCGTGGTGTTCACCTCGTTGCGTACGCCTGACGATGATCAGGCGTACGCC
GAGGCGGCGCAGCGCATGGT

Product: hypothetical protein

Products: NA

Alternate protein names: CTP synthetase; UTP--ammonia ligase [H]

Number of amino acids: Translated: 240; Mature: 239

Protein sequence:

>240_residues
MGIADNTRNGIRIGLVGDFSADVPAHQAIPLALHRAAEVAQVAVDIEWLPTPQIGSGAHLAEFDGLWCVPASPYRDMQGA
LTAIRFAREHRVPFLGTCGGFQHALLEYARHQLGWTDAEHGETAPDAANVIIEPLSCSLVESVAAIQLQPDTLIAQAYGR
LDIDERYHCRYGLRRELESVLFGEHLKVSGRGPEGEVRCMELQGHPFYVATLFQPERAALLGQTPPVVAAFVRACLSNLS

Sequences:

>Translated_240_residues
MGIADNTRNGIRIGLVGDFSADVPAHQAIPLALHRAAEVAQVAVDIEWLPTPQIGSGAHLAEFDGLWCVPASPYRDMQGA
LTAIRFAREHRVPFLGTCGGFQHALLEYARHQLGWTDAEHGETAPDAANVIIEPLSCSLVESVAAIQLQPDTLIAQAYGR
LDIDERYHCRYGLRRELESVLFGEHLKVSGRGPEGEVRCMELQGHPFYVATLFQPERAALLGQTPPVVAAFVRACLSNLS
>Mature_239_residues
GIADNTRNGIRIGLVGDFSADVPAHQAIPLALHRAAEVAQVAVDIEWLPTPQIGSGAHLAEFDGLWCVPASPYRDMQGAL
TAIRFAREHRVPFLGTCGGFQHALLEYARHQLGWTDAEHGETAPDAANVIIEPLSCSLVESVAAIQLQPDTLIAQAYGRL
DIDERYHCRYGLRRELESVLFGEHLKVSGRGPEGEVRCMELQGHPFYVATLFQPERAALLGQTPPVVAAFVRACLSNLS

Specific function: Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen [H]

COG id: COG0504

COG function: function code F; CTP synthase (UTP-ammonia lyase)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 glutamine amidotransferase type-1 domain [H]

Homologues:

Organism=Homo sapiens, GI148491070, Length=253, Percent_Identity=24.5059288537549, Blast_Score=77, Evalue=2e-14,
Organism=Homo sapiens, GI28559085, Length=195, Percent_Identity=27.1794871794872, Blast_Score=67, Evalue=1e-11,
Organism=Homo sapiens, GI28559083, Length=195, Percent_Identity=27.1794871794872, Blast_Score=67, Evalue=1e-11,
Organism=Homo sapiens, GI221316689, Length=195, Percent_Identity=27.1794871794872, Blast_Score=67, Evalue=1e-11,
Organism=Escherichia coli, GI1789142, Length=246, Percent_Identity=28.0487804878049, Blast_Score=97, Evalue=9e-22,
Organism=Saccharomyces cerevisiae, GI6319432, Length=247, Percent_Identity=26.7206477732794, Blast_Score=84, Evalue=3e-17,
Organism=Saccharomyces cerevisiae, GI6322563, Length=246, Percent_Identity=24.7967479674797, Blast_Score=77, Evalue=3e-15,
Organism=Drosophila melanogaster, GI21357815, Length=255, Percent_Identity=23.921568627451, Blast_Score=79, Evalue=3e-15,
Organism=Drosophila melanogaster, GI24664469, Length=255, Percent_Identity=23.921568627451, Blast_Score=79, Evalue=3e-15,

Paralogues:

None

Copy number: 480 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004468
- InterPro:   IPR017456
- InterPro:   IPR017926
- InterPro:   IPR000991 [H]

Pfam domain/function: PF06418 CTP_synth_N; PF00117 GATase [H]

EC number: =6.3.4.2 [H]

Molecular weight: Translated: 26127; Mature: 25996

Theoretical pI: Translated: 5.50; Mature: 5.50

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.5 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
2.5 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGIADNTRNGIRIGLVGDFSADVPAHQAIPLALHRAAEVAQVAVDIEWLPTPQIGSGAHL
CCCCCCCCCCEEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHEEEEEECCCCCCCCCCCC
AEFDGLWCVPASPYRDMQGALTAIRFAREHRVPFLGTCGGFQHALLEYARHQLGWTDAEH
HHCCCEEEECCCCHHHHHHHHHHHHHHHHCCCCEEECCCHHHHHHHHHHHHHCCCCCCCC
GETAPDAANVIIEPLSCSLVESVAAIQLQPDTLIAQAYGRLDIDERYHCRYGLRRELESV
CCCCCCCHHEEECCCHHHHHHHHHHEEECCCHHHHHHHCCCCCCCCHHHHHHHHHHHHHH
LFGEHLKVSGRGPEGEVRCMELQGHPFYVATLFQPERAALLGQTPPVVAAFVRACLSNLS
HCCCCEEECCCCCCCCEEEEEECCCCEEEEEEECCHHHHHCCCCCHHHHHHHHHHHHHCC
>Mature Secondary Structure 
GIADNTRNGIRIGLVGDFSADVPAHQAIPLALHRAAEVAQVAVDIEWLPTPQIGSGAHL
CCCCCCCCCEEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHEEEEEECCCCCCCCCCCC
AEFDGLWCVPASPYRDMQGALTAIRFAREHRVPFLGTCGGFQHALLEYARHQLGWTDAEH
HHCCCEEEECCCCHHHHHHHHHHHHHHHHCCCCEEECCCHHHHHHHHHHHHHCCCCCCCC
GETAPDAANVIIEPLSCSLVESVAAIQLQPDTLIAQAYGRLDIDERYHCRYGLRRELESV
CCCCCCCHHEEECCCHHHHHHHHHHEEECCCHHHHHHHCCCCCCCCHHHHHHHHHHHHHH
LFGEHLKVSGRGPEGEVRCMELQGHPFYVATLFQPERAALLGQTPPVVAAFVRACLSNLS
HCCCCEEECCCCCCCCEEEEEECCCCEEEEEEECCHHHHHCCCCCHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA