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The map label for this gene is gyaR [H]

Identifier: 66046470

GI number: 66046470

Start: 3879840

End: 3880772

Strand: Reverse

Name: gyaR [H]

Synonym: Psyr_3241

Alternate gene names: 66046470

Gene position: 3880772-3879840 (Counterclockwise)

Preceding gene: 66046472

Following gene: 66046469

Centisome position: 63.69

GC content: 63.99

Gene sequence:

>933_bases
ATGACAACGGTATTGGTGCTGGTGGAAAACCTGGACACGTATTTGCCGATTCTTGAAAGCAGCGGTTTTCAGTTGATTCG
CGCCCCGACGGCCGAACTGCGCGCCGCGGCGATTGCCACGCACGGGCAGAGCATCAGCGCGGTGGTGACACGCGGGCCGC
TGGGATTTTTCGCCGAGGAAATGGATGCACTGCCGCAACTGCGCATCATTTGCGTAAGCGGCGCCGGTTACGAGAAGGTC
GATCTGCCTGCCGCGCAGGCGCGGGGCATCGTCGTCACCAATGGTGCAGGCGTCAACGCCGCCACGGTGGCCGATCATAC
GCTGGCGTTGCTGCTGTCTTTGGTGCGCGACATTCCGCAGGCCGATGCCTCGGTGCGCCGCAGCGAATGGCGCAAGGTGG
TACGCCCGTCACTGGCAGGCAAGCGTCTGGGGATCGTCGGGCTGGGAGCGGTGGGGCTGGCGATTGCCAGGCGTGCAGCC
GCTTTCGATATCGTCATCGGTTACCACAACCGCAAGCCGCGCAGCGACTGCGATTACACCTGGCATGCGACGGCGCAGGC
GCTGGCGGCCGCGTCGGATTTTCTGGTCATCGCCACGCCCGGTGGCAGCGGCACGCAGCACCTGATCGACGCCCGGGTGC
TTGAAGCGCTGGGCCCTGACGGGTTTCTGGTCAACATTGCCCGTGCCAGCGTGGTGGATACCCAGGCGTTGGTCAGTGCA
TTGCAGAATGAGCAGATTGCCGGGGCCGCGCTGGACGTGTTCGACGATGAACCGACGGTGCCGGATGTGCTCAAGACCCT
CGGCAATGTGGTGCTGACACCGCACGTGGCAGGCCTGTCCCCCGAGGCCTCGAGAGACAGTGTGCAGAGGGTCAACGATA
ACCTGCTGGCGTTTTTTGCCGGGCAACCGGTGCTGACGCCTGTGACTGAATGA

Upstream 100 bases:

>100_bases
TATTCGGGAAGGCTTTTTTCAGTTCCGGCGTCAGCGACTCTGCACAAGCGCGTCGAGTCGCGTTAAGGTCAGCGTTTTGC
TGATCGAACGGGGAGCGCGC

Downstream 100 bases:

>100_bases
GCAACCGTGCACGCTTGCACGCGAGGCATTGCTGTAACGCCCATTCTGCTGATTTTGCTGCCTGTTTATAGTCCGCCCGG
GCTGTACGAAACCAGACAGG

Product: 2-hydroxyacid dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 310; Mature: 309

Protein sequence:

>310_residues
MTTVLVLVENLDTYLPILESSGFQLIRAPTAELRAAAIATHGQSISAVVTRGPLGFFAEEMDALPQLRIICVSGAGYEKV
DLPAAQARGIVVTNGAGVNAATVADHTLALLLSLVRDIPQADASVRRSEWRKVVRPSLAGKRLGIVGLGAVGLAIARRAA
AFDIVIGYHNRKPRSDCDYTWHATAQALAAASDFLVIATPGGSGTQHLIDARVLEALGPDGFLVNIARASVVDTQALVSA
LQNEQIAGAALDVFDDEPTVPDVLKTLGNVVLTPHVAGLSPEASRDSVQRVNDNLLAFFAGQPVLTPVTE

Sequences:

>Translated_310_residues
MTTVLVLVENLDTYLPILESSGFQLIRAPTAELRAAAIATHGQSISAVVTRGPLGFFAEEMDALPQLRIICVSGAGYEKV
DLPAAQARGIVVTNGAGVNAATVADHTLALLLSLVRDIPQADASVRRSEWRKVVRPSLAGKRLGIVGLGAVGLAIARRAA
AFDIVIGYHNRKPRSDCDYTWHATAQALAAASDFLVIATPGGSGTQHLIDARVLEALGPDGFLVNIARASVVDTQALVSA
LQNEQIAGAALDVFDDEPTVPDVLKTLGNVVLTPHVAGLSPEASRDSVQRVNDNLLAFFAGQPVLTPVTE
>Mature_309_residues
TTVLVLVENLDTYLPILESSGFQLIRAPTAELRAAAIATHGQSISAVVTRGPLGFFAEEMDALPQLRIICVSGAGYEKVD
LPAAQARGIVVTNGAGVNAATVADHTLALLLSLVRDIPQADASVRRSEWRKVVRPSLAGKRLGIVGLGAVGLAIARRAAA
FDIVIGYHNRKPRSDCDYTWHATAQALAAASDFLVIATPGGSGTQHLIDARVLEALGPDGFLVNIARASVVDTQALVSAL
QNEQIAGAALDVFDDEPTVPDVLKTLGNVVLTPHVAGLSPEASRDSVQRVNDNLLAFFAGQPVLTPVTE

Specific function: Unknown

COG id: COG1052

COG function: function code CHR; Lactate dehydrogenase and related dehydrogenases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. GyaR subfamily [H]

Homologues:

Organism=Homo sapiens, GI23308577, Length=272, Percent_Identity=31.6176470588235, Blast_Score=124, Evalue=7e-29,
Organism=Homo sapiens, GI6912396, Length=250, Percent_Identity=32, Blast_Score=101, Evalue=8e-22,
Organism=Homo sapiens, GI4557497, Length=241, Percent_Identity=31.9502074688797, Blast_Score=100, Evalue=1e-21,
Organism=Homo sapiens, GI61743967, Length=241, Percent_Identity=31.9502074688797, Blast_Score=100, Evalue=1e-21,
Organism=Homo sapiens, GI145580578, Length=241, Percent_Identity=31.5352697095436, Blast_Score=99, Evalue=5e-21,
Organism=Homo sapiens, GI4557499, Length=241, Percent_Identity=31.5352697095436, Blast_Score=99, Evalue=5e-21,
Organism=Homo sapiens, GI145580575, Length=241, Percent_Identity=31.5352697095436, Blast_Score=95, Evalue=8e-20,
Organism=Escherichia coli, GI87082289, Length=252, Percent_Identity=32.1428571428571, Blast_Score=125, Evalue=4e-30,
Organism=Escherichia coli, GI1789279, Length=261, Percent_Identity=31.4176245210728, Blast_Score=110, Evalue=9e-26,
Organism=Escherichia coli, GI1787645, Length=250, Percent_Identity=25.6, Blast_Score=82, Evalue=5e-17,
Organism=Caenorhabditis elegans, GI17532191, Length=291, Percent_Identity=27.8350515463918, Blast_Score=108, Evalue=3e-24,
Organism=Caenorhabditis elegans, GI25147481, Length=246, Percent_Identity=30.0813008130081, Blast_Score=90, Evalue=1e-18,
Organism=Saccharomyces cerevisiae, GI6324055, Length=272, Percent_Identity=30.1470588235294, Blast_Score=107, Evalue=2e-24,
Organism=Saccharomyces cerevisiae, GI6320925, Length=296, Percent_Identity=27.3648648648649, Blast_Score=102, Evalue=6e-23,
Organism=Saccharomyces cerevisiae, GI6322116, Length=296, Percent_Identity=26.3513513513513, Blast_Score=97, Evalue=4e-21,
Organism=Saccharomyces cerevisiae, GI6321253, Length=173, Percent_Identity=26.5895953757225, Blast_Score=70, Evalue=4e-13,
Organism=Drosophila melanogaster, GI28574286, Length=263, Percent_Identity=32.6996197718631, Blast_Score=123, Evalue=2e-28,
Organism=Drosophila melanogaster, GI24585514, Length=296, Percent_Identity=30.4054054054054, Blast_Score=122, Evalue=4e-28,
Organism=Drosophila melanogaster, GI28574282, Length=296, Percent_Identity=30.4054054054054, Blast_Score=122, Evalue=4e-28,
Organism=Drosophila melanogaster, GI45552429, Length=296, Percent_Identity=30.4054054054054, Blast_Score=122, Evalue=4e-28,
Organism=Drosophila melanogaster, GI45551003, Length=296, Percent_Identity=30.4054054054054, Blast_Score=122, Evalue=4e-28,
Organism=Drosophila melanogaster, GI28574284, Length=296, Percent_Identity=30.4054054054054, Blast_Score=121, Evalue=5e-28,
Organism=Drosophila melanogaster, GI19921140, Length=302, Percent_Identity=28.8079470198675, Blast_Score=109, Evalue=2e-24,
Organism=Drosophila melanogaster, GI24646446, Length=239, Percent_Identity=34.7280334728033, Blast_Score=106, Evalue=3e-23,
Organism=Drosophila melanogaster, GI24646448, Length=239, Percent_Identity=34.7280334728033, Blast_Score=106, Evalue=3e-23,
Organism=Drosophila melanogaster, GI24646452, Length=239, Percent_Identity=34.7280334728033, Blast_Score=106, Evalue=3e-23,
Organism=Drosophila melanogaster, GI24646450, Length=239, Percent_Identity=34.7280334728033, Blast_Score=106, Evalue=3e-23,
Organism=Drosophila melanogaster, GI62472511, Length=239, Percent_Identity=34.7280334728033, Blast_Score=105, Evalue=5e-23,
Organism=Drosophila melanogaster, GI24585516, Length=251, Percent_Identity=28.6852589641434, Blast_Score=105, Evalue=5e-23,
Organism=Drosophila melanogaster, GI28571528, Length=254, Percent_Identity=30.3149606299213, Blast_Score=93, Evalue=2e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006139
- InterPro:   IPR006140
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00389 2-Hacid_dh; PF02826 2-Hacid_dh_C [H]

EC number: =1.1.1.26 [H]

Molecular weight: Translated: 32489; Mature: 32357

Theoretical pI: Translated: 5.33; Mature: 5.33

Prosite motif: PS00065 D_2_HYDROXYACID_DH_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
0.6 %Met     (Translated Protein)
1.3 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
0.3 %Met     (Mature Protein)
1.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTVLVLVENLDTYLPILESSGFQLIRAPTAELRAAAIATHGQSISAVVTRGPLGFFAEE
CCEEEEEEECCCHHHHHHCCCCCEEEECCHHHHHHHHHHHCCCCEEEEEECCCCHHHHHH
MDALPQLRIICVSGAGYEKVDLPAAQARGIVVTNGAGVNAATVADHTLALLLSLVRDIPQ
HHCCCCEEEEEEECCCCCEECCCHHHHCCEEEECCCCCCHHHHHHHHHHHHHHHHHHCCC
ADASVRRSEWRKVVRPSLAGKRLGIVGLGAVGLAIARRAAAFDIVIGYHNRKPRSDCDYT
CHHHHHHHHHHHHHCCCCCCCEECEEEEHHHHHHHHHHHHEEEEEEEECCCCCCCCCCEE
WHATAQALAAASDFLVIATPGGSGTQHLIDARVLEALGPDGFLVNIARASVVDTQALVSA
HHHHHHHHHHCCCEEEEECCCCCCHHHHHHHHHHHHHCCCCEEEEEHHHHHHHHHHHHHH
LQNEQIAGAALDVFDDEPTVPDVLKTLGNVVLTPHVAGLSPEASRDSVQRVNDNLLAFFA
HHCCCCCCEEEECCCCCCCHHHHHHHHCCEEECCCCCCCCCCCCHHHHHHHCCCEEEEEC
GQPVLTPVTE
CCCCCCCCCC
>Mature Secondary Structure 
TTVLVLVENLDTYLPILESSGFQLIRAPTAELRAAAIATHGQSISAVVTRGPLGFFAEE
CEEEEEEECCCHHHHHHCCCCCEEEECCHHHHHHHHHHHCCCCEEEEEECCCCHHHHHH
MDALPQLRIICVSGAGYEKVDLPAAQARGIVVTNGAGVNAATVADHTLALLLSLVRDIPQ
HHCCCCEEEEEEECCCCCEECCCHHHHCCEEEECCCCCCHHHHHHHHHHHHHHHHHHCCC
ADASVRRSEWRKVVRPSLAGKRLGIVGLGAVGLAIARRAAAFDIVIGYHNRKPRSDCDYT
CHHHHHHHHHHHHHCCCCCCCEECEEEEHHHHHHHHHHHHEEEEEEEECCCCCCCCCCEE
WHATAQALAAASDFLVIATPGGSGTQHLIDARVLEALGPDGFLVNIARASVVDTQALVSA
HHHHHHHHHHCCCEEEEECCCCCCHHHHHHHHHHHHHCCCCEEEEEHHHHHHHHHHHHHH
LQNEQIAGAALDVFDDEPTVPDVLKTLGNVVLTPHVAGLSPEASRDSVQRVNDNLLAFFA
HHCCCCCCEEEECCCCCCCHHHHHHHHCCEEECCCCCCCCCCCCHHHHHHHCCCEEEEEC
GQPVLTPVTE
CCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA