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The map label for this gene is nuoM [H]

Identifier: 66046437

GI number: 66046437

Start: 3839648

End: 3841180

Strand: Direct

Name: nuoM [H]

Synonym: Psyr_3208

Alternate gene names: 66046437

Gene position: 3839648-3841180 (Clockwise)

Preceding gene: 66046436

Following gene: 66046438

Centisome position: 63.01

GC content: 60.8

Gene sequence:

>1533_bases
ATGATTCTGCCCTGGCTAATCCTGATCCCCTTCATCGGCGGCCTGCTGTGCTGGCTGGGTGAGCGCTTCGGCTCTACCCT
GCCGCGCTGGATTGCGTTGCTGACAATGACCCTGGAACTGGTTCTCGGCCTCTGGCTGTGGGCTACCGGCAACTTCGGCT
ACGCGCCGGTGCCGGGTGCCGATCCGACCTGGACCCTGGAATTCCACCACCCGTGGATCACCCGCTTCGGCATCGATGTG
CATCTGGCACTCGATGGCCTGTCGCTGCTGATGATCCTGCTGACCGGCCTGCTGGGCGTGCTGTCGGTGCTCTGCTCGTG
GAAGGAAATCCAGCGCAAGGTCGGTTTCTTCCACCTTAACCTGATGTGGATTCTGGGCGGTGTCGTCGGCGTGTTCCTGG
CCATCGACCTGTTCATGTTCTTCTTCTTCTGGGAAATGATGCTGGTGCCGATGTATTTCCTCATCGCGCTCTGGGGTCAC
AGCTCTTCGGATGGCAAGAAAACCCGTATCTACGCGGCCACCAAGTTCTTCATCTTCACTCAGGCCAGTGGCCTGATCAT
GCTGGTGGCGATCCTGGGTCTGGTGCTGGTGCACTTCAATCAGACCGGCGTGATCACCTTTGCCTACGCCGACCTGCTGA
AGACCAAACTGGCACCAGGCACCGAGTACATCCTGATGCTGGGCTTCTTCATAGCCTTCGCCGTCAAGCTGCCGGTGGTG
CCATTGCACTCCTGGCTGCCGGATGCGCATGCCCAGGCACCGACTGCAGGCTCCGTCGACCTGGCGGGTATCCTGCTGAA
GACTGCGGCTTACGGCCTGCTGCGTTTTGCCCTGCCGCTGTTCCCCAACGCATCGGCCGAGTTCGCACCGATTGCAATGA
CGCTGGGCCTGGTCGGTATCTTCTACGGGGCATTCCTGGCGTTTGCCCAGACCGACATCAAGCGTCTGATCGCATTCTCC
AGCGTTTCGCACATGGGCTTCGTACTGATCGGTATCTACTCGGGCAGCCAGCAAGCGCTGCAAGGCGTACTGATCCAGAT
GATCGCCCACGGTCTATCGGCTGCGGCACTGTTCATTCTCAGTGGCCAGTTGTACGAGCGCCTGCACACCCGCGACATGC
GGGAGATGGGCGGTCTGTGGTCACGCATCGCCTACATCCCGGCCATCAGCCTGTTCTTTGCCGCCGCCTCTCTGGGTCTG
CCGGGCACCGGCAACTTCGTCGGCGAGTTCCTGATTCTGCTGGGCAGCTTTGCCAGCTCACCCTGGATCACGGCGATTGC
CACTTCCGGTCTGGTATTTGGTTCTGTCTACTCGCTGATCATGATCCACCGCGCCTACTTCGGCCCGTCGAAGTCCGACG
AGGTTCTGAAGGGCATGGACGGACGGGAAATGATCATGGTGCTGGGCCTTGCCGTGCTGCTGGTCGTGCTCGGGGTATTC
CCGCAGCCGTTCCTCGACACATCGGCGGCGACCATGCACGGCGTGCAGCAATGGCTAGGCACTGCCTTCACTCAACTCGC
TTCGGCCCGGTAA

Upstream 100 bases:

>100_bases
TGCCTCGATCGCCGTGGGTGCCGTTCTGGTACTCGGTGCCGTCGTTCTGGTTGCGATCTGATATGAACCTTGCGAATTTG
CGAAAGGAATTGAGCCCGTC

Downstream 100 bases:

>100_bases
GAGCGCTATGGACCTGACGATTCAACACTTTATTGCGCTTGCGCCACTGCTGATCACCAGCCTCACCGTTGTCGTGGTGA
TGCTTGCGATCGCATGGCGC

Product: NADH dehydrogenase subunit M

Products: NA

Alternate protein names: NADH dehydrogenase I subunit M; NDH-1 subunit M [H]

Number of amino acids: Translated: 510; Mature: 510

Protein sequence:

>510_residues
MILPWLILIPFIGGLLCWLGERFGSTLPRWIALLTMTLELVLGLWLWATGNFGYAPVPGADPTWTLEFHHPWITRFGIDV
HLALDGLSLLMILLTGLLGVLSVLCSWKEIQRKVGFFHLNLMWILGGVVGVFLAIDLFMFFFFWEMMLVPMYFLIALWGH
SSSDGKKTRIYAATKFFIFTQASGLIMLVAILGLVLVHFNQTGVITFAYADLLKTKLAPGTEYILMLGFFIAFAVKLPVV
PLHSWLPDAHAQAPTAGSVDLAGILLKTAAYGLLRFALPLFPNASAEFAPIAMTLGLVGIFYGAFLAFAQTDIKRLIAFS
SVSHMGFVLIGIYSGSQQALQGVLIQMIAHGLSAAALFILSGQLYERLHTRDMREMGGLWSRIAYIPAISLFFAAASLGL
PGTGNFVGEFLILLGSFASSPWITAIATSGLVFGSVYSLIMIHRAYFGPSKSDEVLKGMDGREMIMVLGLAVLLVVLGVF
PQPFLDTSAATMHGVQQWLGTAFTQLASAR

Sequences:

>Translated_510_residues
MILPWLILIPFIGGLLCWLGERFGSTLPRWIALLTMTLELVLGLWLWATGNFGYAPVPGADPTWTLEFHHPWITRFGIDV
HLALDGLSLLMILLTGLLGVLSVLCSWKEIQRKVGFFHLNLMWILGGVVGVFLAIDLFMFFFFWEMMLVPMYFLIALWGH
SSSDGKKTRIYAATKFFIFTQASGLIMLVAILGLVLVHFNQTGVITFAYADLLKTKLAPGTEYILMLGFFIAFAVKLPVV
PLHSWLPDAHAQAPTAGSVDLAGILLKTAAYGLLRFALPLFPNASAEFAPIAMTLGLVGIFYGAFLAFAQTDIKRLIAFS
SVSHMGFVLIGIYSGSQQALQGVLIQMIAHGLSAAALFILSGQLYERLHTRDMREMGGLWSRIAYIPAISLFFAAASLGL
PGTGNFVGEFLILLGSFASSPWITAIATSGLVFGSVYSLIMIHRAYFGPSKSDEVLKGMDGREMIMVLGLAVLLVVLGVF
PQPFLDTSAATMHGVQQWLGTAFTQLASAR
>Mature_510_residues
MILPWLILIPFIGGLLCWLGERFGSTLPRWIALLTMTLELVLGLWLWATGNFGYAPVPGADPTWTLEFHHPWITRFGIDV
HLALDGLSLLMILLTGLLGVLSVLCSWKEIQRKVGFFHLNLMWILGGVVGVFLAIDLFMFFFFWEMMLVPMYFLIALWGH
SSSDGKKTRIYAATKFFIFTQASGLIMLVAILGLVLVHFNQTGVITFAYADLLKTKLAPGTEYILMLGFFIAFAVKLPVV
PLHSWLPDAHAQAPTAGSVDLAGILLKTAAYGLLRFALPLFPNASAEFAPIAMTLGLVGIFYGAFLAFAQTDIKRLIAFS
SVSHMGFVLIGIYSGSQQALQGVLIQMIAHGLSAAALFILSGQLYERLHTRDMREMGGLWSRIAYIPAISLFFAAASLGL
PGTGNFVGEFLILLGSFASSPWITAIATSGLVFGSVYSLIMIHRAYFGPSKSDEVLKGMDGREMIMVLGLAVLLVVLGVF
PQPFLDTSAATMHGVQQWLGTAFTQLASAR

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocat

COG id: COG1008

COG function: function code C; NADH:ubiquinone oxidoreductase subunit 4 (chain M)

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I subunit 4 family [H]

Homologues:

Organism=Homo sapiens, GI251831116, Length=323, Percent_Identity=34.3653250773994, Blast_Score=153, Evalue=3e-37,
Organism=Homo sapiens, GI251831117, Length=211, Percent_Identity=31.7535545023697, Blast_Score=70, Evalue=7e-12,
Organism=Escherichia coli, GI1788613, Length=507, Percent_Identity=72.3865877712032, Blast_Score=717, Evalue=0.0,
Organism=Escherichia coli, GI1788827, Length=351, Percent_Identity=29.0598290598291, Blast_Score=119, Evalue=6e-28,
Organism=Escherichia coli, GI1788831, Length=364, Percent_Identity=26.9230769230769, Blast_Score=105, Evalue=5e-24,
Organism=Escherichia coli, GI1788614, Length=408, Percent_Identity=27.2058823529412, Blast_Score=86, Evalue=8e-18,
Organism=Escherichia coli, GI145693160, Length=392, Percent_Identity=26.2755102040816, Blast_Score=80, Evalue=3e-16,
Organism=Escherichia coli, GI1788829, Length=413, Percent_Identity=27.3607748184019, Blast_Score=74, Evalue=3e-14,
Organism=Escherichia coli, GI2367154, Length=346, Percent_Identity=24.5664739884393, Blast_Score=69, Evalue=9e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010227
- InterPro:   IPR001750
- InterPro:   IPR003918 [H]

Pfam domain/function: PF00361 Oxidored_q1 [H]

EC number: =1.6.99.5 [H]

Molecular weight: Translated: 55701; Mature: 55701

Theoretical pI: Translated: 8.25; Mature: 8.25

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MILPWLILIPFIGGLLCWLGERFGSTLPRWIALLTMTLELVLGLWLWATGNFGYAPVPGA
CCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCC
DPTWTLEFHHPWITRFGIDVHLALDGLSLLMILLTGLLGVLSVLCSWKEIQRKVGFFHLN
CCCEEEEECCCCHHHHCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LMWILGGVVGVFLAIDLFMFFFFWEMMLVPMYFLIALWGHSSSDGKKTRIYAATKFFIFT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEEEEEEEEE
QASGLIMLVAILGLVLVHFNQTGVITFAYADLLKTKLAPGTEYILMLGFFIAFAVKLPVV
CCCHHHHHHHHHHHHHHHCCCCCEEHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCC
PLHSWLPDAHAQAPTAGSVDLAGILLKTAAYGLLRFALPLFPNASAEFAPIAMTLGLVGI
HHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHH
FYGAFLAFAQTDIKRLIAFSSVSHMGFVLIGIYSGSQQALQGVLIQMIAHGLSAAALFIL
HHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHH
SGQLYERLHTRDMREMGGLWSRIAYIPAISLFFAAASLGLPGTGNFVGEFLILLGSFASS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCC
PWITAIATSGLVFGSVYSLIMIHRAYFGPSKSDEVLKGMDGREMIMVLGLAVLLVVLGVF
CCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHCCCCHHHHHHHHHHHHHHHHHCC
PQPFLDTSAATMHGVQQWLGTAFTQLASAR
CCCCCCCHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MILPWLILIPFIGGLLCWLGERFGSTLPRWIALLTMTLELVLGLWLWATGNFGYAPVPGA
CCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCC
DPTWTLEFHHPWITRFGIDVHLALDGLSLLMILLTGLLGVLSVLCSWKEIQRKVGFFHLN
CCCEEEEECCCCHHHHCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LMWILGGVVGVFLAIDLFMFFFFWEMMLVPMYFLIALWGHSSSDGKKTRIYAATKFFIFT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEEEEEEEEE
QASGLIMLVAILGLVLVHFNQTGVITFAYADLLKTKLAPGTEYILMLGFFIAFAVKLPVV
CCCHHHHHHHHHHHHHHHCCCCCEEHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCC
PLHSWLPDAHAQAPTAGSVDLAGILLKTAAYGLLRFALPLFPNASAEFAPIAMTLGLVGI
HHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHH
FYGAFLAFAQTDIKRLIAFSSVSHMGFVLIGIYSGSQQALQGVLIQMIAHGLSAAALFIL
HHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHH
SGQLYERLHTRDMREMGGLWSRIAYIPAISLFFAAASLGLPGTGNFVGEFLILLGSFASS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCC
PWITAIATSGLVFGSVYSLIMIHRAYFGPSKSDEVLKGMDGREMIMVLGLAVLLVVLGVF
CCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHCCCCHHHHHHHHHHHHHHHHHCC
PQPFLDTSAATMHGVQQWLGTAFTQLASAR
CCCCCCCHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 10984043 [H]