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The map label for this gene is nuoL [H]

Identifier: 66046436

GI number: 66046436

Start: 3837755

End: 3839608

Strand: Direct

Name: nuoL [H]

Synonym: Psyr_3207

Alternate gene names: 66046436

Gene position: 3837755-3839608 (Clockwise)

Preceding gene: 66046435

Following gene: 66046437

Centisome position: 62.98

GC content: 60.73

Gene sequence:

>1854_bases
ATGAATCTTCTCTTTCTGACTTTCGTATTCCCCCTCATCGGCTTTCTGCTGCTGTCGTTCTCCCGTGGACGCATCTCGGA
AAACCTCGCTGCGCTGATCGGCGTCGGCTCCATCGGCCTGTCAGCCATTGTCACTGCCTGGGTCATCTGGCAGTTCAACG
TAGCACCCCCCGAAGGCGGTCACTACAGCCAGGTGCTGTGGCGCTGGATGGACGTCGATGGCTTCCAGCCCAACTTCGCA
CTGTATCTGGACGGGCTGTCCGTCACGATGCTGGGCGTCGTGGTTGGCGTCGGCTTCCTGATCCACCTGTTCGCGTCCTG
GTACATGCGCGGTGAAGCGGGCTATTCGCGCTTCTTCTCCTACACCAACCTGTTCATTGCCAGCATGCTGTTCCTGATCC
TGGGCGACAACCTGCTGTTCATCTACTTCGGTTGGGAAGGCGTAGGGCTGTGCAGCTACCTGTTGATCGGTTTCTATTAC
AGCAACCGCAACAACGGCAACGCAGCGCTCAAAGCGTTCATCGTCACCCGTATCGGTGACGTATTCATGGCTATCGGTCT
GTTCATCCTGTTCCAGCAACTGGGCACGCTCAATGTGCAGGAACTGCTGGTCAGGGCGCCGGAACACTTCAAGGTCGGCG
ATTTCTGGATCGTGCTGGCGACGTTGATGCTGCTGGGCGGTGCGGTCGGTAAATCCGCCCAGCTGCCACTGCAAACCTGG
CTGGCTGACGCGATGGCCGGTCCTACTCCGGTTTCGGCGCTGATCCACGCAGCGACCATGGTCACGGCGGGCGTTTACCT
GATCGCGCGTACTCACGGCCTGTTTGCACTGGCACCCGACATTCTGCATCTGGTCGGGATTGTCGGCGGCGTCACGCTGG
TTCTGGCGGGTTTCGCCGCATTGGTGCAGACCGACATCAAGCGTATCCTCGCCTACTCGACCATGAGCCAGATCGGCTAC
ATGTTCCTGGCACTGGGCGTCGGCGCCTGGGAAGGCGCGATCTTCCACCTGATGACCCACGCCTTCTTCAAGGCGCTGCT
GTTCCTTGCTTCCGGTGCGGTGATCGTTGCCTGCCACCACGAGCAGAACATCTTCAAGATGGGCGGTCTGTGGAAGAAAC
TGCCATTGGCCTACGCCAGCTTCATCGTCGGTGGCGCTGCTCTTTCCGCTCTGCCGCTGCTGACGGCGGGCTTCTACTCC
AAGGACGAAATTCTCTGGGAAGCATTTGCCAGCGGTAACAACGGTTTGCTGTATGCCGGCCTGGTGGGCGCGTTCATGAC
GTCGCTGTACACCTTCCGCCTGATCTTCATCGCGTTCCACGGAGAAGCCAAGACCGAAGCACACGCAGGTCACGGCATCG
CTCACTGGCTGCCACTGTCGGTGCTGATCGTGCTGTCGACGTTCATCGGCGCGCTGATCACTCCGCCGCTGGCCGGTGTG
CTGCCGCAGAGCGTCGGCCATGCCGGTGGCGAAGCCAAGCACAGTCTGGAGATCGCCTCCGGCGCCATCGCGCTGGCCGG
TATCCTGCTGGCAGCGTTGCTGTTCCTCGGCAAGCGCCGCCTGGCAACGGCTATCGCCAACAGCGCTCCGGGCCGTTTCC
TCTCGGCCTGGTGGTTCGCGGCATGGGGCTTCGACTGGATCTACGACAAGCTGTTCGTCAAGCCGTATCTGGCAATCAGC
CATGTACTGCGTAGTGATCCGTTCGACCGCACCATCGGCTTGATCCCACGTCTGGTCAAAGGCGGTCATGACACCATGAG
CCGCACCGAGACCGGCCAGTTGCGTTGGTATGCTGCCTCGATCGCCGTGGGTGCCGTTCTGGTACTCGGTGCCGTCGTTC
TGGTTGCGATCTGA

Upstream 100 bases:

>100_bases
GCCTTGCGGCAGCCGAGGCCAGTATCGGCCTGGCGATCCTGATGCAACTGTATCGCCGCTTCCACACTCTCGATATCGAT
GCTGCCAGCGAGATGCGCGG

Downstream 100 bases:

>100_bases
TATGAACCTTGCGAATTTGCGAAAGGAATTGAGCCCGTCATGATTCTGCCCTGGCTAATCCTGATCCCCTTCATCGGCGG
CCTGCTGTGCTGGCTGGGTG

Product: NADH dehydrogenase subunit L

Products: NA

Alternate protein names: NADH dehydrogenase I subunit L; NDH-1 subunit L [H]

Number of amino acids: Translated: 617; Mature: 617

Protein sequence:

>617_residues
MNLLFLTFVFPLIGFLLLSFSRGRISENLAALIGVGSIGLSAIVTAWVIWQFNVAPPEGGHYSQVLWRWMDVDGFQPNFA
LYLDGLSVTMLGVVVGVGFLIHLFASWYMRGEAGYSRFFSYTNLFIASMLFLILGDNLLFIYFGWEGVGLCSYLLIGFYY
SNRNNGNAALKAFIVTRIGDVFMAIGLFILFQQLGTLNVQELLVRAPEHFKVGDFWIVLATLMLLGGAVGKSAQLPLQTW
LADAMAGPTPVSALIHAATMVTAGVYLIARTHGLFALAPDILHLVGIVGGVTLVLAGFAALVQTDIKRILAYSTMSQIGY
MFLALGVGAWEGAIFHLMTHAFFKALLFLASGAVIVACHHEQNIFKMGGLWKKLPLAYASFIVGGAALSALPLLTAGFYS
KDEILWEAFASGNNGLLYAGLVGAFMTSLYTFRLIFIAFHGEAKTEAHAGHGIAHWLPLSVLIVLSTFIGALITPPLAGV
LPQSVGHAGGEAKHSLEIASGAIALAGILLAALLFLGKRRLATAIANSAPGRFLSAWWFAAWGFDWIYDKLFVKPYLAIS
HVLRSDPFDRTIGLIPRLVKGGHDTMSRTETGQLRWYAASIAVGAVLVLGAVVLVAI

Sequences:

>Translated_617_residues
MNLLFLTFVFPLIGFLLLSFSRGRISENLAALIGVGSIGLSAIVTAWVIWQFNVAPPEGGHYSQVLWRWMDVDGFQPNFA
LYLDGLSVTMLGVVVGVGFLIHLFASWYMRGEAGYSRFFSYTNLFIASMLFLILGDNLLFIYFGWEGVGLCSYLLIGFYY
SNRNNGNAALKAFIVTRIGDVFMAIGLFILFQQLGTLNVQELLVRAPEHFKVGDFWIVLATLMLLGGAVGKSAQLPLQTW
LADAMAGPTPVSALIHAATMVTAGVYLIARTHGLFALAPDILHLVGIVGGVTLVLAGFAALVQTDIKRILAYSTMSQIGY
MFLALGVGAWEGAIFHLMTHAFFKALLFLASGAVIVACHHEQNIFKMGGLWKKLPLAYASFIVGGAALSALPLLTAGFYS
KDEILWEAFASGNNGLLYAGLVGAFMTSLYTFRLIFIAFHGEAKTEAHAGHGIAHWLPLSVLIVLSTFIGALITPPLAGV
LPQSVGHAGGEAKHSLEIASGAIALAGILLAALLFLGKRRLATAIANSAPGRFLSAWWFAAWGFDWIYDKLFVKPYLAIS
HVLRSDPFDRTIGLIPRLVKGGHDTMSRTETGQLRWYAASIAVGAVLVLGAVVLVAI
>Mature_617_residues
MNLLFLTFVFPLIGFLLLSFSRGRISENLAALIGVGSIGLSAIVTAWVIWQFNVAPPEGGHYSQVLWRWMDVDGFQPNFA
LYLDGLSVTMLGVVVGVGFLIHLFASWYMRGEAGYSRFFSYTNLFIASMLFLILGDNLLFIYFGWEGVGLCSYLLIGFYY
SNRNNGNAALKAFIVTRIGDVFMAIGLFILFQQLGTLNVQELLVRAPEHFKVGDFWIVLATLMLLGGAVGKSAQLPLQTW
LADAMAGPTPVSALIHAATMVTAGVYLIARTHGLFALAPDILHLVGIVGGVTLVLAGFAALVQTDIKRILAYSTMSQIGY
MFLALGVGAWEGAIFHLMTHAFFKALLFLASGAVIVACHHEQNIFKMGGLWKKLPLAYASFIVGGAALSALPLLTAGFYS
KDEILWEAFASGNNGLLYAGLVGAFMTSLYTFRLIFIAFHGEAKTEAHAGHGIAHWLPLSVLIVLSTFIGALITPPLAGV
LPQSVGHAGGEAKHSLEIASGAIALAGILLAALLFLGKRRLATAIANSAPGRFLSAWWFAAWGFDWIYDKLFVKPYLAIS
HVLRSDPFDRTIGLIPRLVKGGHDTMSRTETGQLRWYAASIAVGAVLVLGAVVLVAI

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocat

COG id: COG1009

COG function: function code CP; NADH:ubiquinone oxidoreductase subunit 5 (chain L)/Multisubunit Na+/H+ antiporter, MnhA subunit

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I subunit 5 family [H]

Homologues:

Organism=Homo sapiens, GI251831117, Length=387, Percent_Identity=39.5348837209302, Blast_Score=257, Evalue=2e-68,
Organism=Escherichia coli, GI1788614, Length=604, Percent_Identity=68.2119205298013, Blast_Score=813, Evalue=0.0,
Organism=Escherichia coli, GI1788829, Length=426, Percent_Identity=34.2723004694836, Blast_Score=170, Evalue=3e-43,
Organism=Escherichia coli, GI1788827, Length=366, Percent_Identity=30.327868852459, Blast_Score=119, Evalue=4e-28,
Organism=Escherichia coli, GI1788831, Length=346, Percent_Identity=29.1907514450867, Blast_Score=114, Evalue=2e-26,
Organism=Escherichia coli, GI2367154, Length=324, Percent_Identity=29.6296296296296, Blast_Score=92, Evalue=1e-19,
Organism=Escherichia coli, GI1788613, Length=394, Percent_Identity=26.9035532994924, Blast_Score=83, Evalue=6e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001750
- InterPro:   IPR001516
- InterPro:   IPR003945
- InterPro:   IPR018393 [H]

Pfam domain/function: PF00361 Oxidored_q1; PF00662 Oxidored_q1_N [H]

EC number: =1.6.99.5 [H]

Molecular weight: Translated: 66559; Mature: 66559

Theoretical pI: Translated: 9.04; Mature: 9.04

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNLLFLTFVFPLIGFLLLSFSRGRISENLAALIGVGSIGLSAIVTAWVIWQFNVAPPEGG
CCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCCC
HYSQVLWRWMDVDGFQPNFALYLDGLSVTMLGVVVGVGFLIHLFASWYMRGEAGYSRFFS
CHHHHHHHHHCCCCCCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHH
YTNLFIASMLFLILGDNLLFIYFGWEGVGLCSYLLIGFYYSNRNNGNAALKAFIVTRIGD
HHHHHHHHHHHHHHCCCEEEEEECCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHH
VFMAIGLFILFQQLGTLNVQELLVRAPEHFKVGDFWIVLATLMLLGGAVGKSAQLPLQTW
HHHHHHHHHHHHHHCCCCHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCHHHH
LADAMAGPTPVSALIHAATMVTAGVYLIARTHGLFALAPDILHLVGIVGGVTLVLAGFAA
HHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
LVQTDIKRILAYSTMSQIGYMFLALGVGAWEGAIFHLMTHAFFKALLFLASGAVIVACHH
HHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEC
EQNIFKMGGLWKKLPLAYASFIVGGAALSALPLLTAGFYSKDEILWEAFASGNNGLLYAG
CCCHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCEEHHH
LVGAFMTSLYTFRLIFIAFHGEAKTEAHAGHGIAHWLPLSVLIVLSTFIGALITPPLAGV
HHHHHHHHHHHHHHHHHEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHH
LPQSVGHAGGEAKHSLEIASGAIALAGILLAALLFLGKRRLATAIANSAPGRFLSAWWFA
CHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHH
AWGFDWIYDKLFVKPYLAISHVLRSDPFDRTIGLIPRLVKGGHDTMSRTETGQLRWYAAS
HHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCHHCCCCCCCEEEEHHH
IAVGAVLVLGAVVLVAI
HHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MNLLFLTFVFPLIGFLLLSFSRGRISENLAALIGVGSIGLSAIVTAWVIWQFNVAPPEGG
CCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCCC
HYSQVLWRWMDVDGFQPNFALYLDGLSVTMLGVVVGVGFLIHLFASWYMRGEAGYSRFFS
CHHHHHHHHHCCCCCCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHH
YTNLFIASMLFLILGDNLLFIYFGWEGVGLCSYLLIGFYYSNRNNGNAALKAFIVTRIGD
HHHHHHHHHHHHHHCCCEEEEEECCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHH
VFMAIGLFILFQQLGTLNVQELLVRAPEHFKVGDFWIVLATLMLLGGAVGKSAQLPLQTW
HHHHHHHHHHHHHHCCCCHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCHHHH
LADAMAGPTPVSALIHAATMVTAGVYLIARTHGLFALAPDILHLVGIVGGVTLVLAGFAA
HHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
LVQTDIKRILAYSTMSQIGYMFLALGVGAWEGAIFHLMTHAFFKALLFLASGAVIVACHH
HHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEC
EQNIFKMGGLWKKLPLAYASFIVGGAALSALPLLTAGFYSKDEILWEAFASGNNGLLYAG
CCCHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCEEHHH
LVGAFMTSLYTFRLIFIAFHGEAKTEAHAGHGIAHWLPLSVLIVLSTFIGALITPPLAGV
HHHHHHHHHHHHHHHHHEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHH
LPQSVGHAGGEAKHSLEIASGAIALAGILLAALLFLGKRRLATAIANSAPGRFLSAWWFA
CHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHH
AWGFDWIYDKLFVKPYLAISHVLRSDPFDRTIGLIPRLVKGGHDTMSRTETGQLRWYAAS
HHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCHHCCCCCCCEEEEHHH
IAVGAVLVLGAVVLVAI
HHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 10984043 [H]