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The map label for this gene is serS [H]

Identifier: 66046404

GI number: 66046404

Start: 3802292

End: 3803572

Strand: Reverse

Name: serS [H]

Synonym: Psyr_3175

Alternate gene names: 66046404

Gene position: 3803572-3802292 (Counterclockwise)

Preceding gene: 66046405

Following gene: 66046403

Centisome position: 62.42

GC content: 60.81

Gene sequence:

>1281_bases
ATGCTCGATTCCAAACTGTTACGTACTCAACTTCAGGACGTAGCGGATCGCCTGGCTTCCCGTGGCTTCACTCTGGATGT
GGCGCGCATTGAATCGCTGGAAGCCCAGCGCAAGGTAGTGCAGACCCGCACCGAACAGCTGCAGGCCGAGCGCAATGCCC
GTTCCAAATCCATTGGTCAGGCCAAGCAGCGCGGTGAGGATATTGCGCCGTTGATGGCTGATGTCGAGCGCATGGGCAAC
GAGCTGAGCGAAGGCAAGGTCGAGCTGGACGGCATTCAGGCCGAACTGGATGCGCTGGTGCTGAGCATTCCGAACCTGCC
TCATGAGTCCGTGCCGGTCGGTGCCGACGAAGAAGGCAACGTCGAAGTACGTCGCTGGGGTACGCCGACGTCATTCGATT
TCGAGGTCAAGGATCACGTTGCGCTGGGCGAGAAGTTCGGCTGGCTGGATTTCGAGACTGCCGCCAAGCTGTCCGGCGCG
CGCTTTGCGCTGCTGCGTGGCCCGATCGCACGTCTGCACCGTGCCCTCGCACAATTCATGATCAATCTGCACATCAACGA
GCACGGCTACGAAGAGACCTACACGCCCTATCTGGTGCAGGCTCCAGCGTTGCAGGGCACAGGTCAGCTGCCCAAGTTCG
AGGAAGACCTGTTCAAGATCTCCCGCGAAGGTGAAGCCGACCTGTACCTGATTCCGACTGCCGAAGTGTCGCTGACCAAT
ATCGTGTCGGGTGAAATCCTCGACGCCAAACAGCTGCCTCTCAAGTTTGTCGCCCATACCCCTTGCTTCCGCAGTGAAGC
GGGCGCGTCCGGGCGTGATACCCGCGGCATGATCCGCCAGCACCAGTTCGACAAGGTCGAGATGGTCCAGATCGTTGCGC
CTGACGACTCCATGGCCGCGCTCGAGTCGCTGACCGGCAACGCCGAACGCGTGCTGCAACTGCTTGAACTGCCTTATCGC
ACGCTGGCGCTGTGCACCGGCGACATGGGTTTCAGCGCGGTGAAGACCTACGACCTGGAAGTCTGGATTCCGAGCCAGGA
CAAATATCGCGAAATCTCTTCCTGCTCCAACTGCGGTGATTTCCAGGCGCGCCGCATGCAGGCTCGCTGGCGCAACCCGG
AAACCGGCAAGCCGGAGCTGGTCCACACCCTCAACGGGTCGGGCCTGGCGGTAGGCCGCACACTGGTGGCGGTGCTGGAA
AACTATCAGCAGGCGGACGGTTCGATTCGTGTGCCTGAGGTGCTCAAGCCTTACATGGGCGGCCTTGAGGTCATCGGTTA
A

Upstream 100 bases:

>100_bases
CCGCTGGCCCTCGGCTATGCCGGTATCAGTGTATTCGGCGGGCTGCTCGCAACCTGGGCTGGCCTGTCCCTGACCAGACT
TTGATAGACGAGAGAACGAT

Downstream 100 bases:

>100_bases
ATGGAATTTCTGCCGCTGTTCCATAACCTGCGTGGCAGCCGGGTGCTGGTGGTTGGCGGCGGTGAAATCGCCCTGCGCAA
ATCACGTCTGATTGCCGACG

Product: seryl-tRNA synthetase

Products: NA

Alternate protein names: Serine--tRNA ligase; SerRS; Seryl-tRNA(Ser/Sec) synthetase [H]

Number of amino acids: Translated: 426; Mature: 426

Protein sequence:

>426_residues
MLDSKLLRTQLQDVADRLASRGFTLDVARIESLEAQRKVVQTRTEQLQAERNARSKSIGQAKQRGEDIAPLMADVERMGN
ELSEGKVELDGIQAELDALVLSIPNLPHESVPVGADEEGNVEVRRWGTPTSFDFEVKDHVALGEKFGWLDFETAAKLSGA
RFALLRGPIARLHRALAQFMINLHINEHGYEETYTPYLVQAPALQGTGQLPKFEEDLFKISREGEADLYLIPTAEVSLTN
IVSGEILDAKQLPLKFVAHTPCFRSEAGASGRDTRGMIRQHQFDKVEMVQIVAPDDSMAALESLTGNAERVLQLLELPYR
TLALCTGDMGFSAVKTYDLEVWIPSQDKYREISSCSNCGDFQARRMQARWRNPETGKPELVHTLNGSGLAVGRTLVAVLE
NYQQADGSIRVPEVLKPYMGGLEVIG

Sequences:

>Translated_426_residues
MLDSKLLRTQLQDVADRLASRGFTLDVARIESLEAQRKVVQTRTEQLQAERNARSKSIGQAKQRGEDIAPLMADVERMGN
ELSEGKVELDGIQAELDALVLSIPNLPHESVPVGADEEGNVEVRRWGTPTSFDFEVKDHVALGEKFGWLDFETAAKLSGA
RFALLRGPIARLHRALAQFMINLHINEHGYEETYTPYLVQAPALQGTGQLPKFEEDLFKISREGEADLYLIPTAEVSLTN
IVSGEILDAKQLPLKFVAHTPCFRSEAGASGRDTRGMIRQHQFDKVEMVQIVAPDDSMAALESLTGNAERVLQLLELPYR
TLALCTGDMGFSAVKTYDLEVWIPSQDKYREISSCSNCGDFQARRMQARWRNPETGKPELVHTLNGSGLAVGRTLVAVLE
NYQQADGSIRVPEVLKPYMGGLEVIG
>Mature_426_residues
MLDSKLLRTQLQDVADRLASRGFTLDVARIESLEAQRKVVQTRTEQLQAERNARSKSIGQAKQRGEDIAPLMADVERMGN
ELSEGKVELDGIQAELDALVLSIPNLPHESVPVGADEEGNVEVRRWGTPTSFDFEVKDHVALGEKFGWLDFETAAKLSGA
RFALLRGPIARLHRALAQFMINLHINEHGYEETYTPYLVQAPALQGTGQLPKFEEDLFKISREGEADLYLIPTAEVSLTN
IVSGEILDAKQLPLKFVAHTPCFRSEAGASGRDTRGMIRQHQFDKVEMVQIVAPDDSMAALESLTGNAERVLQLLELPYR
TLALCTGDMGFSAVKTYDLEVWIPSQDKYREISSCSNCGDFQARRMQARWRNPETGKPELVHTLNGSGLAVGRTLVAVLE
NYQQADGSIRVPEVLKPYMGGLEVIG

Specific function: Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) [H]

COG id: COG0172

COG function: function code J; Seryl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily [H]

Homologues:

Organism=Homo sapiens, GI16306548, Length=416, Percent_Identity=32.6923076923077, Blast_Score=208, Evalue=9e-54,
Organism=Homo sapiens, GI8923421, Length=399, Percent_Identity=30.5764411027569, Blast_Score=183, Evalue=2e-46,
Organism=Homo sapiens, GI225579074, Length=323, Percent_Identity=32.8173374613003, Blast_Score=182, Evalue=7e-46,
Organism=Escherichia coli, GI1787120, Length=430, Percent_Identity=66.5116279069767, Blast_Score=588, Evalue=1e-169,
Organism=Caenorhabditis elegans, GI17539260, Length=417, Percent_Identity=31.89448441247, Blast_Score=214, Evalue=5e-56,
Organism=Caenorhabditis elegans, GI17542084, Length=317, Percent_Identity=29.3375394321767, Blast_Score=147, Evalue=9e-36,
Organism=Saccharomyces cerevisiae, GI6320226, Length=406, Percent_Identity=33.4975369458128, Blast_Score=215, Evalue=1e-56,
Organism=Saccharomyces cerevisiae, GI6321799, Length=444, Percent_Identity=30.1801801801802, Blast_Score=202, Evalue=1e-52,
Organism=Drosophila melanogaster, GI24581334, Length=440, Percent_Identity=31.5909090909091, Blast_Score=203, Evalue=2e-52,
Organism=Drosophila melanogaster, GI17737985, Length=340, Percent_Identity=32.0588235294118, Blast_Score=159, Evalue=4e-39,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002314
- InterPro:   IPR006195
- InterPro:   IPR002317
- InterPro:   IPR015866
- InterPro:   IPR010978 [H]

Pfam domain/function: PF02403 Seryl_tRNA_N; PF00587 tRNA-synt_2b [H]

EC number: =6.1.1.11 [H]

Molecular weight: Translated: 47232; Mature: 47232

Theoretical pI: Translated: 4.92; Mature: 4.92

Prosite motif: PS50862 AA_TRNA_LIGASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLDSKLLRTQLQDVADRLASRGFTLDVARIESLEAQRKVVQTRTEQLQAERNARSKSIGQ
CCCHHHHHHHHHHHHHHHHHCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AKQRGEDIAPLMADVERMGNELSEGKVELDGIQAELDALVLSIPNLPHESVPVGADEEGN
HHHCCCCHHHHHHHHHHHCCHHHCCCEEECCHHHHHHHHHHCCCCCCCCCCCCCCCCCCC
VEVRRWGTPTSFDFEVKDHVALGEKFGWLDFETAAKLSGARFALLRGPIARLHRALAQFM
EEEEECCCCCCEEEEEHHHHHHCCCCCCCCHHHHHHCCCCEEHHHHCHHHHHHHHHHHHH
INLHINEHGYEETYTPYLVQAPALQGTGQLPKFEEDLFKISREGEADLYLIPTAEVSLTN
HEEEECCCCCCCCCCCEEEECCCCCCCCCCCCHHHHHHHHCCCCCCCEEEEECCCEEHHH
IVSGEILDAKQLPLKFVAHTPCFRSEAGASGRDTRGMIRQHQFDKVEMVQIVAPDDSMAA
HCCCCCCCHHCCCHHHHHCCCCCCCCCCCCCCCHHHHHHHHCCCCEEEEEEECCCCHHHH
LESLTGNAERVLQLLELPYRTLALCTGDMGFSAVKTYDLEVWIPSQDKYREISSCSNCGD
HHHHCCCHHHHHHHHHCCHHHHHHCCCCCCCCEEEEEEEEEEECCCHHHHHHHHCCCCCH
FQARRMQARWRNPETGKPELVHTLNGSGLAVGRTLVAVLENYQQADGSIRVPEVLKPYMG
HHHHHHHHHCCCCCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHCCCCEECHHHHHHHHC
GLEVIG
CEEECC
>Mature Secondary Structure
MLDSKLLRTQLQDVADRLASRGFTLDVARIESLEAQRKVVQTRTEQLQAERNARSKSIGQ
CCCHHHHHHHHHHHHHHHHHCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AKQRGEDIAPLMADVERMGNELSEGKVELDGIQAELDALVLSIPNLPHESVPVGADEEGN
HHHCCCCHHHHHHHHHHHCCHHHCCCEEECCHHHHHHHHHHCCCCCCCCCCCCCCCCCCC
VEVRRWGTPTSFDFEVKDHVALGEKFGWLDFETAAKLSGARFALLRGPIARLHRALAQFM
EEEEECCCCCCEEEEEHHHHHHCCCCCCCCHHHHHHCCCCEEHHHHCHHHHHHHHHHHHH
INLHINEHGYEETYTPYLVQAPALQGTGQLPKFEEDLFKISREGEADLYLIPTAEVSLTN
HEEEECCCCCCCCCCCEEEECCCCCCCCCCCCHHHHHHHHCCCCCCCEEEEECCCEEHHH
IVSGEILDAKQLPLKFVAHTPCFRSEAGASGRDTRGMIRQHQFDKVEMVQIVAPDDSMAA
HCCCCCCCHHCCCHHHHHCCCCCCCCCCCCCCCHHHHHHHHCCCCEEEEEEECCCCHHHH
LESLTGNAERVLQLLELPYRTLALCTGDMGFSAVKTYDLEVWIPSQDKYREISSCSNCGD
HHHHCCCHHHHHHHHHCCHHHHHHCCCCCCCCEEEEEEEEEEECCCHHHHHHHHCCCCCH
FQARRMQARWRNPETGKPELVHTLNGSGLAVGRTLVAVLENYQQADGSIRVPEVLKPYMG
HHHHHHHHHCCCCCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHCCCCEECHHHHHHHHC
GLEVIG
CEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA