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The map label for this gene is mmlH [H]

Identifier: 66046363

GI number: 66046363

Start: 3759349

End: 3760635

Strand: Reverse

Name: mmlH [H]

Synonym: Psyr_3134

Alternate gene names: 66046363

Gene position: 3760635-3759349 (Counterclockwise)

Preceding gene: 66046364

Following gene: 66046362

Centisome position: 61.71

GC content: 60.99

Gene sequence:

>1287_bases
ATGTTCAGCTGGTATCGCGATGTCACTTCCAAAGAGCGCAAGACCTTCTGGGCCTGTTTTGGCGGCTGGTCGCTGGACGC
GCTGGAAGTGCAGATGTTCGGTCTGGCCATTCCGGCCCTGATTGCTGCCTTTGCCCTGACCAAGGGCGATGCCGGCCTGA
TCAGTGCGGTAACGCTGGTGACCTCCGCGTTGGGTGGTTGGGTGGGCGGGGCGCTGTCCGACCGCTACGGCCGGGTGCGC
ACGCTGCAGTGGATGATCCTGTGGTTTTCCTTGTTTACCTTTTTGTCTGCGTTCGTGACCGGTTTCAACCAATTGCTGAT
CGTCAAGGCACTGCAGGGCTTTGGTATCGGTGGCGAGTGGGCGGCAGGCGCGGTGTTGATGGCCGAGACGATCCAGTCCC
GCTACCGCGGCAAAGTCATGGCCACTGTGCAAAGTGCCTGGGCCGTGGGTTGGGGGCTGGCGGTGGTGCTGTTTACCCTG
ATTTATTCATTTGTGCCGGAGGATATCGCCTGGCGGGTGATGTTCTTTGTCGGCCTGTTGCCTGCCCTGATGATCATCTG
GGTGCGACGCAACGTCGAAGAGCCGGACAGTTTTCAGCGCATGCAGAAAAGCGCTGCGCCGAAGGGCAGTTTCTTCAGAT
CGATGGCCGGGATTTTTCGCCCCGAGCTGCTGCGCGTTACCTTGCTCGGTGGCTTGCTGGGCCTCGGTGCGCACGGCGGT
TATCACGCGGTCATGACCTGGTTGCCGACCTTCCTCAAAACCGAGCGCAACCTGTCCGTGCTCAGTTCCGGCGGCTATCT
GGCGGTCATTATCGTTGCCTTCTGGTGCGGTTGCGTGTGCAGCGGCCTGTTGATCGACCGTATTGGTCGACGCAAGAACA
TCATGCTGTTCGCCTTGTGCTGCGTGGTCACCGTGCAGTGCTACTTGATGCTGCCGTTGAGCAACACACAGATGCTGTTT
CTCGGCTTTCCGCTGGGCTTCTTTGCCGCAGGCATTCCGGCCAGCCTCGGCTCGTTTTTCAACGAGCTGTACCCGGCAGA
GGTGCGGGGTGCCGGGGTGGGCTTCTGCTACAACTTCGGGCGTGTGCTGTCGGCAGTGTTCCCGTTTCTGGTGGGGCATA
TGAGCCAGTCAATGTCGCTCGGCAGCGCCATCGGAATCGACGCCGGCATTGCCTATGGCGTGGCGATGATTGCTGCGTTC
TGTCTGCCGGAAACCCGTGGGCGCAACCTCGAGGCCACGCCGCCGGTTGCCGAACCACTGGACAAGGGCGCAGCGCAGCA
GGCTTGA

Upstream 100 bases:

>100_bases
CGTTCGCGAGGGCACGCCAGTCATTTCCGCTACAGCGTGGAAATTCGCTGACAGCGCTGCAGCCTGCCCAAGCTGTTCAA
CGCCCATAAGGATAAAAGCC

Downstream 100 bases:

>100_bases
AAATCCTCTCATCCGCGGCGTTGCGGCGCCGCGTTGACTTCTTGTAGACGGACCCATGATTGATTCCTGTACCACACCAA
TGCTGGGCATCGATGCCCAC

Product: major facilitator transporter

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 428; Mature: 428

Protein sequence:

>428_residues
MFSWYRDVTSKERKTFWACFGGWSLDALEVQMFGLAIPALIAAFALTKGDAGLISAVTLVTSALGGWVGGALSDRYGRVR
TLQWMILWFSLFTFLSAFVTGFNQLLIVKALQGFGIGGEWAAGAVLMAETIQSRYRGKVMATVQSAWAVGWGLAVVLFTL
IYSFVPEDIAWRVMFFVGLLPALMIIWVRRNVEEPDSFQRMQKSAAPKGSFFRSMAGIFRPELLRVTLLGGLLGLGAHGG
YHAVMTWLPTFLKTERNLSVLSSGGYLAVIIVAFWCGCVCSGLLIDRIGRRKNIMLFALCCVVTVQCYLMLPLSNTQMLF
LGFPLGFFAAGIPASLGSFFNELYPAEVRGAGVGFCYNFGRVLSAVFPFLVGHMSQSMSLGSAIGIDAGIAYGVAMIAAF
CLPETRGRNLEATPPVAEPLDKGAAQQA

Sequences:

>Translated_428_residues
MFSWYRDVTSKERKTFWACFGGWSLDALEVQMFGLAIPALIAAFALTKGDAGLISAVTLVTSALGGWVGGALSDRYGRVR
TLQWMILWFSLFTFLSAFVTGFNQLLIVKALQGFGIGGEWAAGAVLMAETIQSRYRGKVMATVQSAWAVGWGLAVVLFTL
IYSFVPEDIAWRVMFFVGLLPALMIIWVRRNVEEPDSFQRMQKSAAPKGSFFRSMAGIFRPELLRVTLLGGLLGLGAHGG
YHAVMTWLPTFLKTERNLSVLSSGGYLAVIIVAFWCGCVCSGLLIDRIGRRKNIMLFALCCVVTVQCYLMLPLSNTQMLF
LGFPLGFFAAGIPASLGSFFNELYPAEVRGAGVGFCYNFGRVLSAVFPFLVGHMSQSMSLGSAIGIDAGIAYGVAMIAAF
CLPETRGRNLEATPPVAEPLDKGAAQQA
>Mature_428_residues
MFSWYRDVTSKERKTFWACFGGWSLDALEVQMFGLAIPALIAAFALTKGDAGLISAVTLVTSALGGWVGGALSDRYGRVR
TLQWMILWFSLFTFLSAFVTGFNQLLIVKALQGFGIGGEWAAGAVLMAETIQSRYRGKVMATVQSAWAVGWGLAVVLFTL
IYSFVPEDIAWRVMFFVGLLPALMIIWVRRNVEEPDSFQRMQKSAAPKGSFFRSMAGIFRPELLRVTLLGGLLGLGAHGG
YHAVMTWLPTFLKTERNLSVLSSGGYLAVIIVAFWCGCVCSGLLIDRIGRRKNIMLFALCCVVTVQCYLMLPLSNTQMLF
LGFPLGFFAAGIPASLGSFFNELYPAEVRGAGVGFCYNFGRVLSAVFPFLVGHMSQSMSLGSAIGIDAGIAYGVAMIAAF
CLPETRGRNLEATPPVAEPLDKGAAQQA

Specific function: Probable uptake of 4-methylmuconolactone [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family [H]

Homologues:

Organism=Homo sapiens, GI24308167, Length=438, Percent_Identity=24.8858447488584, Blast_Score=100, Evalue=2e-21,
Organism=Homo sapiens, GI213021148, Length=441, Percent_Identity=23.3560090702948, Blast_Score=81, Evalue=2e-15,
Organism=Escherichia coli, GI87082404, Length=386, Percent_Identity=25.3886010362694, Blast_Score=129, Evalue=3e-31,
Organism=Escherichia coli, GI87082231, Length=220, Percent_Identity=28.1818181818182, Blast_Score=99, Evalue=4e-22,
Organism=Escherichia coli, GI1790550, Length=406, Percent_Identity=24.8768472906404, Blast_Score=96, Evalue=4e-21,
Organism=Escherichia coli, GI87081723, Length=369, Percent_Identity=27.9132791327913, Blast_Score=95, Evalue=1e-20,
Organism=Escherichia coli, GI87082159, Length=365, Percent_Identity=23.2876712328767, Blast_Score=77, Evalue=3e-15,
Organism=Escherichia coli, GI1789152, Length=342, Percent_Identity=24.8538011695906, Blast_Score=75, Evalue=1e-14,
Organism=Escherichia coli, GI1788942, Length=355, Percent_Identity=23.943661971831, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI1788292, Length=159, Percent_Identity=29.559748427673, Blast_Score=66, Evalue=5e-12,
Organism=Caenorhabditis elegans, GI32564663, Length=434, Percent_Identity=24.6543778801843, Blast_Score=100, Evalue=3e-21,
Organism=Drosophila melanogaster, GI19922874, Length=412, Percent_Identity=22.8155339805825, Blast_Score=71, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196
- InterPro:   IPR005829 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 46439; Mature: 46439

Theoretical pI: Translated: 9.09; Mature: 9.09

Prosite motif: PS50850 MFS ; PS00216 SUGAR_TRANSPORT_1 ; PS00217 SUGAR_TRANSPORT_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
5.8 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
5.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HCCCCCCC
>Mature Secondary Structure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HCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9461415 [H]