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The map label for this gene is cpg2 [H]

Identifier: 66046309

GI number: 66046309

Start: 3682286

End: 3683527

Strand: Reverse

Name: cpg2 [H]

Synonym: Psyr_3078

Alternate gene names: 66046309

Gene position: 3683527-3682286 (Counterclockwise)

Preceding gene: 66046310

Following gene: 66046308

Centisome position: 60.45

GC content: 61.35

Gene sequence:

>1242_bases
ATGCGCTCATTTTCCCGCTCGCCACTGGCTGCTCATCTCGCTCTGGCGCTTGCGTTGACAGCTCTGGCACCGGCGGCCAT
GGCCGAACCGCACAAGGCCATCCAGGCCGATGCCGAGCAATACAAGGACGAAGCCTTGAAGCTGCTGGAGCGCCTGGTGA
ACATCGACTCGGGGTCCGGGTATGTACCGGGCCTGACCAAGGTCAGCGACATCGCGATCGAAGAACTGAAAAAGCTCGGT
GCCACCATCGAGCTCGTTCCAAATACGCCAGAAGCCAGCAACCACGTCATCGCCACCCTGAAAGGCACCGGCAAGGCGAA
GATTCTGCTGATGGCGCACATGGACACCGTGTTCAAGGAAGGCTCTGCGGCCGAGCGTCCGTTCCATATCAAGGACGGGC
GTGCCTACGGCCCAGGCGTGATGGATGACAAAGGCGGCATCGTTGCGGCTATCTATGCGCTGAAAGTCTTGCACAACCTG
AAGTTCACCGACTACGCGCAGATCACGGTGCTGCTCGACGCCAGTGAGGAGACTGGCTCAGGCGTCGCTACCGAGCTGAT
CAAGAAAACCGCGAAGGAGCATGACGTCACGCTCAACCTGGAGCCGGGACGTCCTGCCGACGGTCTGGTGGTGTGGCGCA
AAGGCTCGGCAACCGCACTGGTCGAAGTCAAGGGCAAGGCCTCGCATGCAGGCGTTGCGCCTGAGTTGGGACGTAACGCT
GCTACCGAAGTGGCCCATCAGATCCTGCAACTCGGCAAGCTGGGTGACGAGGAGAAGAAAACCACCATCAACTTCACCGT
GCTCAAGGCGGGAGACCGCACCAACGTGATTCCTGATCAGGCCAGCGCCAAGGCCGATGTGCGTGCTGCCGTACCGGAGG
AGTTTGACCGCGTCGAGCAGGATCTGGCCAGGGTGTCGGCCAACAGGTTGGTGCCTGATACCGAGGTCAAGACCAGTCTG
GTCCGTGGCCTGCCACCGATGCCGCAGACCGCGCAGTCCGATGCATTGGTCGCGATGGCACAAGGCATCTACGGCGAACT
GGGCCGCACCCTGACCATCGAGGGCAGCGGCGGGGCGGCTGATTCAAGTCTGTCTGCCAGCGTGGGCACACCGACGCTGG
ACGGCTTCGGTATTGTCGGCGGCAATATCCATACGCCTGAAGAGTATGCCGAAGTGGGCAGCGTGGCGCCGCGGATCTAC
TTGCTGTCGCGAATGATCATGAAGTTGTCCGGGCAACAGTGA

Upstream 100 bases:

>100_bases
TTCGAGCGCTGGCGCAAGGCGAGCTGAGCCATGACGGCCGGTGCCTGTGTAAGGTATGGTCTTGAAAAACCTCGACGAAC
CGAACACAAGGATGGAACAC

Downstream 100 bases:

>100_bases
TTCGACAGGCCTCCCGTGCGTGGCGCGGGAGGCTGTAGAGTCGATGACTCGCTTTTAAACAAATACAGGGCTGCCCCCCC
CCCCCGAACCTGCTGACTCT

Product: glutamate carboxypeptidase

Products: NA

Alternate protein names: CPDG2; Folate hydrolase G2; Glutamate carboxypeptidase; Pteroylmonoglutamic acid hydrolase G2; Glucarpidase [H]

Number of amino acids: Translated: 413; Mature: 413

Protein sequence:

>413_residues
MRSFSRSPLAAHLALALALTALAPAAMAEPHKAIQADAEQYKDEALKLLERLVNIDSGSGYVPGLTKVSDIAIEELKKLG
ATIELVPNTPEASNHVIATLKGTGKAKILLMAHMDTVFKEGSAAERPFHIKDGRAYGPGVMDDKGGIVAAIYALKVLHNL
KFTDYAQITVLLDASEETGSGVATELIKKTAKEHDVTLNLEPGRPADGLVVWRKGSATALVEVKGKASHAGVAPELGRNA
ATEVAHQILQLGKLGDEEKKTTINFTVLKAGDRTNVIPDQASAKADVRAAVPEEFDRVEQDLARVSANRLVPDTEVKTSL
VRGLPPMPQTAQSDALVAMAQGIYGELGRTLTIEGSGGAADSSLSASVGTPTLDGFGIVGGNIHTPEEYAEVGSVAPRIY
LLSRMIMKLSGQQ

Sequences:

>Translated_413_residues
MRSFSRSPLAAHLALALALTALAPAAMAEPHKAIQADAEQYKDEALKLLERLVNIDSGSGYVPGLTKVSDIAIEELKKLG
ATIELVPNTPEASNHVIATLKGTGKAKILLMAHMDTVFKEGSAAERPFHIKDGRAYGPGVMDDKGGIVAAIYALKVLHNL
KFTDYAQITVLLDASEETGSGVATELIKKTAKEHDVTLNLEPGRPADGLVVWRKGSATALVEVKGKASHAGVAPELGRNA
ATEVAHQILQLGKLGDEEKKTTINFTVLKAGDRTNVIPDQASAKADVRAAVPEEFDRVEQDLARVSANRLVPDTEVKTSL
VRGLPPMPQTAQSDALVAMAQGIYGELGRTLTIEGSGGAADSSLSASVGTPTLDGFGIVGGNIHTPEEYAEVGSVAPRIY
LLSRMIMKLSGQQ
>Mature_413_residues
MRSFSRSPLAAHLALALALTALAPAAMAEPHKAIQADAEQYKDEALKLLERLVNIDSGSGYVPGLTKVSDIAIEELKKLG
ATIELVPNTPEASNHVIATLKGTGKAKILLMAHMDTVFKEGSAAERPFHIKDGRAYGPGVMDDKGGIVAAIYALKVLHNL
KFTDYAQITVLLDASEETGSGVATELIKKTAKEHDVTLNLEPGRPADGLVVWRKGSATALVEVKGKASHAGVAPELGRNA
ATEVAHQILQLGKLGDEEKKTTINFTVLKAGDRTNVIPDQASAKADVRAAVPEEFDRVEQDLARVSANRLVPDTEVKTSL
VRGLPPMPQTAQSDALVAMAQGIYGELGRTLTIEGSGGAADSSLSASVGTPTLDGFGIVGGNIHTPEEYAEVGSVAPRIY
LLSRMIMKLSGQQ

Specific function: Catalyzes the hydrolysis of reduced and non-reduced folates to pteroates and L-glutamate. This enzyme has a broad specificity [H]

COG id: COG0624

COG function: function code E; Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M20A family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001261
- InterPro:   IPR017150
- InterPro:   IPR002933
- InterPro:   IPR011650 [H]

Pfam domain/function: PF07687 M20_dimer; PF01546 Peptidase_M20 [H]

EC number: =3.4.17.11 [H]

Molecular weight: Translated: 43544; Mature: 43544

Theoretical pI: Translated: 6.20; Mature: 6.20

Prosite motif: PS00758 ARGE_DAPE_CPG2_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRSFSRSPLAAHLALALALTALAPAAMAEPHKAIQADAEQYKDEALKLLERLVNIDSGSG
CCCCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
YVPGLTKVSDIAIEELKKLGATIELVPNTPEASNHVIATLKGTGKAKILLMAHMDTVFKE
CCCCCHHHHHHHHHHHHHCCCEEEEECCCCCCCCCEEEEEECCCCEEEEEEEHHHHHHHC
GSAAERPFHIKDGRAYGPGVMDDKGGIVAAIYALKVLHNLKFTDYAQITVLLDASEETGS
CCCCCCCEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCEEEEEEEEECCCCCCC
GVATELIKKTAKEHDVTLNLEPGRPADGLVVWRKGSATALVEVKGKASHAGVAPELGRNA
HHHHHHHHHHHHHCCEEEEECCCCCCCCEEEEECCCCEEEEEECCCCCCCCCCHHHCCHH
ATEVAHQILQLGKLGDEEKKTTINFTVLKAGDRTNVIPDQASAKADVRAAVPEEFDRVEQ
HHHHHHHHHHHHCCCCCCCCEEEEEEEEECCCCCCCCCCCCCCCCHHHHCCHHHHHHHHH
DLARVSANRLVPDTEVKTSLVRGLPPMPQTAQSDALVAMAQGIYGELGRTLTIEGSGGAA
HHHHHHHHCCCCCHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHCCCEEEEECCCCCC
DSSLSASVGTPTLDGFGIVGGNIHTPEEYAEVGSVAPRIYLLSRMIMKLSGQQ
CCCCCCCCCCCCCCCCEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MRSFSRSPLAAHLALALALTALAPAAMAEPHKAIQADAEQYKDEALKLLERLVNIDSGSG
CCCCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
YVPGLTKVSDIAIEELKKLGATIELVPNTPEASNHVIATLKGTGKAKILLMAHMDTVFKE
CCCCCHHHHHHHHHHHHHCCCEEEEECCCCCCCCCEEEEEECCCCEEEEEEEHHHHHHHC
GSAAERPFHIKDGRAYGPGVMDDKGGIVAAIYALKVLHNLKFTDYAQITVLLDASEETGS
CCCCCCCEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCEEEEEEEEECCCCCCC
GVATELIKKTAKEHDVTLNLEPGRPADGLVVWRKGSATALVEVKGKASHAGVAPELGRNA
HHHHHHHHHHHHHCCEEEEECCCCCCCCEEEEECCCCEEEEEECCCCCCCCCCHHHCCHH
ATEVAHQILQLGKLGDEEKKTTINFTVLKAGDRTNVIPDQASAKADVRAAVPEEFDRVEQ
HHHHHHHHHHHHCCCCCCCCEEEEEEEEECCCCCCCCCCCCCCCCHHHHCCHHHHHHHHH
DLARVSANRLVPDTEVKTSLVRGLPPMPQTAQSDALVAMAQGIYGELGRTLTIEGSGGAA
HHHHHHHHCCCCCHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHCCCEEEEECCCCCC
DSSLSASVGTPTLDGFGIVGGNIHTPEEYAEVGSVAPRIYLLSRMIMKLSGQQ
CCCCCCCCCCCCCCCCEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 6396165; 3838935; 9083113 [H]