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The map label for this gene is macA [H]

Identifier: 66046310

GI number: 66046310

Start: 3686678

End: 3687811

Strand: Reverse

Name: macA [H]

Synonym: Psyr_3081

Alternate gene names: 66046310

Gene position: 3687811-3686678 (Counterclockwise)

Preceding gene: 66046311

Following gene: 66046309

Centisome position: 60.52

GC content: 64.46

Gene sequence:

>1134_bases
ATGCGATTGAATCCTGATGCGTTTCCTGCTCTACGGCGGTGTGTGTCACGCGCTTGCGGCGTCGTACTGATCACTCTGAT
GATCAGTGGTTGCGGTGATAAACAGACGACCAGTGCTTCGCCTGTCCGGGCGGTCAAGGTTGAGACGGTGCGGGCAGGAG
AGGGCGCTGCGTTACGCTTCATCGGCACTGTTCGAGAGCAGGAGCGCGCCAGTCTGGCGTTTGAATCGGCAGGCACCCTG
ACAGAGCTGCGGGTCGACATTGGCGATAGCGTCAAGCCGGGCCAGGTGCTCGCCCGCCTTGATCCGCAGCCTGCGCAATT
GCGTCTGCAGGAGGCGCAGGCCGCTTTGCGGCTGGCTCGGGCTCAGGCGCTGGAGCGCCAGCGTAACTACCAGCGTCAGC
AAAACCTGCTCGCAGCGGGCAGTGTCGCCCAGAGCGTGGTCGAGTCGGCCCAGTCGTCCAGTGAACAAGCCAGCGCCGAG
CTGATCCGCACGCAAGCCGAGCTGGACCTGGCCCGTCGCGAACTGGATCGCACCCGCTTGATCGCCCCCTTTGCCGGGCG
CGTGGTGGCCCGTCATGCACAACCGCAGAGCTTGTTGTCCGCCGGGCAGGTGGTGCTGGATGTCGAATCCGCTGCAGAGC
AACAAGTGGTGGCAGCTGTTCCGCTGGCACTTGCCGATTCGCTTGAGCCTGGCGACCTCGCCAGGGCCTCGAACAGTGCA
GACGGTACGGCAGGGTTTGATCTCGCCCTGGAAGGCATTTCGCCCCGAGCCGATGACGGGCTGGTCAGAACGGCCGTGTT
CCGAGTGCTGCGGCCTGCCGGCAGGCTGCCCAGTGGCGTCACGCTGCTTGTGCAAATGCATCCCGCTGCCGACGCACAGG
CACTGTCGGTTCCGCTGCAAGCTTTATGGATGGGGACCGGCAGCCACCTTGCCGAAGTCTTCGTCTATCAGTCGGGAGGA
ACAGTCGCCGTCCGCTCTGTCACGCTGGGTACGGTCAGAGAAGGCCGTGCACTGATCGTCAGCGGGCTGGTCGCAGGTGA
GCAGGTGGTCACTGCCGGCGCCGCCTTTCTGCAGGACGGCCAGCCCGTCACGCTGTTTCATTCAGACACTCGCCTGACCG
GTGCCGTGCAATGA

Upstream 100 bases:

>100_bases
TACACCGACCAGACCCGGGGCAGCCCGTTGGTCGAGACCGATGCCGAAGGCAGTGGCCTGATTGCCTTGAATTACGCTTT
CTGAAGGGTTGAAGCCTGCC

Downstream 100 bases:

>100_bases
ACCTTACCTCCCGCGCCATGGGCGCAAGCCGTTTGACGCTGTTTGCGGCCTTGCTGATTTTGCTGGCTGGTGTCGCTACC
TTTTTGAGCTTTCCTTCTCA

Product: secretion protein HlyD

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 377; Mature: 377

Protein sequence:

>377_residues
MRLNPDAFPALRRCVSRACGVVLITLMISGCGDKQTTSASPVRAVKVETVRAGEGAALRFIGTVREQERASLAFESAGTL
TELRVDIGDSVKPGQVLARLDPQPAQLRLQEAQAALRLARAQALERQRNYQRQQNLLAAGSVAQSVVESAQSSSEQASAE
LIRTQAELDLARRELDRTRLIAPFAGRVVARHAQPQSLLSAGQVVLDVESAAEQQVVAAVPLALADSLEPGDLARASNSA
DGTAGFDLALEGISPRADDGLVRTAVFRVLRPAGRLPSGVTLLVQMHPAADAQALSVPLQALWMGTGSHLAEVFVYQSGG
TVAVRSVTLGTVREGRALIVSGLVAGEQVVTAGAAFLQDGQPVTLFHSDTRLTGAVQ

Sequences:

>Translated_377_residues
MRLNPDAFPALRRCVSRACGVVLITLMISGCGDKQTTSASPVRAVKVETVRAGEGAALRFIGTVREQERASLAFESAGTL
TELRVDIGDSVKPGQVLARLDPQPAQLRLQEAQAALRLARAQALERQRNYQRQQNLLAAGSVAQSVVESAQSSSEQASAE
LIRTQAELDLARRELDRTRLIAPFAGRVVARHAQPQSLLSAGQVVLDVESAAEQQVVAAVPLALADSLEPGDLARASNSA
DGTAGFDLALEGISPRADDGLVRTAVFRVLRPAGRLPSGVTLLVQMHPAADAQALSVPLQALWMGTGSHLAEVFVYQSGG
TVAVRSVTLGTVREGRALIVSGLVAGEQVVTAGAAFLQDGQPVTLFHSDTRLTGAVQ
>Mature_377_residues
MRLNPDAFPALRRCVSRACGVVLITLMISGCGDKQTTSASPVRAVKVETVRAGEGAALRFIGTVREQERASLAFESAGTL
TELRVDIGDSVKPGQVLARLDPQPAQLRLQEAQAALRLARAQALERQRNYQRQQNLLAAGSVAQSVVESAQSSSEQASAE
LIRTQAELDLARRELDRTRLIAPFAGRVVARHAQPQSLLSAGQVVLDVESAAEQQVVAAVPLALADSLEPGDLARASNSA
DGTAGFDLALEGISPRADDGLVRTAVFRVLRPAGRLPSGVTLLVQMHPAADAQALSVPLQALWMGTGSHLAEVFVYQSGG
TVAVRSVTLGTVREGRALIVSGLVAGEQVVTAGAAFLQDGQPVTLFHSDTRLTGAVQ

Specific function: Efflux transporter for macrolide antibiotics [H]

COG id: COG0845

COG function: function code M; Membrane-fusion protein

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family [H]

Homologues:

Organism=Escherichia coli, GI87081796, Length=367, Percent_Identity=28.3378746594005, Blast_Score=100, Evalue=1e-22,
Organism=Escherichia coli, GI1787013, Length=213, Percent_Identity=28.169014084507, Blast_Score=63, Evalue=3e-11,
Organism=Escherichia coli, GI87082036, Length=355, Percent_Identity=23.6619718309859, Blast_Score=63, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006143 [H]

Pfam domain/function: PF00529 HlyD [H]

EC number: NA

Molecular weight: Translated: 39640; Mature: 39640

Theoretical pI: Translated: 7.52; Mature: 7.52

Prosite motif: PS00013 PROKAR_LIPOPROTEIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRLNPDAFPALRRCVSRACGVVLITLMISGCGDKQTTSASPVRAVKVETVRAGEGAALRF
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEEEEEECCCCCEEEE
IGTVREQERASLAFESAGTLTELRVDIGDSVKPGQVLARLDPQPAQLRLQEAQAALRLAR
HHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCHHHEECCCCHHHHHHHHHHHHHHHHH
AQALERQRNYQRQQNLLAAGSVAQSVVESAQSSSEQASAELIRTQAELDLARRELDRTRL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHE
IAPFAGRVVARHAQPQSLLSAGQVVLDVESAAEQQVVAAVPLALADSLEPGDLARASNSA
ECHHHHHHHHHCCCHHHHHHCCCEEEEEHHHHHHHHHHHHHHHHHCCCCCCHHHHCCCCC
DGTAGFDLALEGISPRADDGLVRTAVFRVLRPAGRLPSGVTLLVQMHPAADAQALSVPLQ
CCCCCCEEEEECCCCCCCCHHHHHHHHHHHHHCCCCCCCEEEEEEECCCCCCHHHHCCHH
ALWMGTGSHLAEVFVYQSGGTVAVRSVTLGTVREGRALIVSGLVAGEQVVTAGAAFLQDG
HHHCCCCHHEEEEEEECCCCEEEEEEEEECCCCCCCEEEEEHHHCCHHHHHHHHHHHCCC
QPVTLFHSDTRLTGAVQ
CEEEEEECCCCCCCCCC
>Mature Secondary Structure
MRLNPDAFPALRRCVSRACGVVLITLMISGCGDKQTTSASPVRAVKVETVRAGEGAALRF
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEEEEEECCCCCEEEE
IGTVREQERASLAFESAGTLTELRVDIGDSVKPGQVLARLDPQPAQLRLQEAQAALRLAR
HHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCHHHEECCCCHHHHHHHHHHHHHHHHH
AQALERQRNYQRQQNLLAAGSVAQSVVESAQSSSEQASAELIRTQAELDLARRELDRTRL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHE
IAPFAGRVVARHAQPQSLLSAGQVVLDVESAAEQQVVAAVPLALADSLEPGDLARASNSA
ECHHHHHHHHHCCCHHHHHHCCCEEEEEHHHHHHHHHHHHHHHHHCCCCCCHHHHCCCCC
DGTAGFDLALEGISPRADDGLVRTAVFRVLRPAGRLPSGVTLLVQMHPAADAQALSVPLQ
CCCCCCEEEEECCCCCCCCHHHHHHHHHHHHHCCCCCCCEEEEEEECCCCCCHHHHCCHH
ALWMGTGSHLAEVFVYQSGGTVAVRSVTLGTVREGRALIVSGLVAGEQVVTAGAAFLQDG
HHHCCCCHHEEEEEEECCCCEEEEEEEEECCCCCCCEEEEEHHHCCHHHHHHHHHHHCCC
QPVTLFHSDTRLTGAVQ
CEEEEEECCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]