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The map label for this gene is arcB [H]

Identifier: 66045921

GI number: 66045921

Start: 3259968

End: 3260978

Strand: Direct

Name: arcB [H]

Synonym: Psyr_2685

Alternate gene names: 66045921

Gene position: 3259968-3260978 (Clockwise)

Preceding gene: 66045920

Following gene: 66045922

Centisome position: 53.5

GC content: 55.69

Gene sequence:

>1011_bases
ATGGCTTTCAACATGCGTAACCGCAGCCTGCTCTCGCTCATGCACCACACTCCTCGCGAGCTGCTGTACCTTTTGGACCT
GTCCCGAGATCTCAAACGTGCCAAATATACAGGCACCGAGCGTCAGCACTTGAAGGGCAAGAACATAGCGCTGATATTCG
AGAAAACCTCAACGCGCACCCGTTGTGCATTTGAGGTCGCCGCCCACGATCAGGGGGCTCACGTCACTTATATCGACCCT
GTGTCCTCGCAAATCGGCCACAAGGAAAGCATGAAAGACACCGCTCGCGTACTGGGGCGGATGTTTGATGCCATCGAGTA
CCGAGGGTTTGCCCAGGACATCGTCGAAGAGCTGGCTCACTTTGCCGGTGTCCCGGTGTTCAATGGTCTGACCGCCGAGT
TTCACCCTACGCAGATGATCGCAGACGTACTCACCATGCGCGAGCACAGCGATAAACCGCTGCACGAGATCAGCTACGCT
TACCTCGGCGATGCGCGTTACAACATGGGCAACTCGCTGTTGATGATCGGTGCCAAGCTGGGCATGGATGTGCGTATTGC
GGCGCCTGCAGCCCTTTGGCCGCACACTGATTTTATTGCCCAGTGCAAAGCCTTTGCCGAAGAAAGCGGCGCGCGTATCA
CGATTACCGAAGACCCGCTGCAAGCCGTCAAAGGCGTGGACTTTATTCATACCGACATCTGGGTATCCATGGGCGAGCCG
GTAGATGCCTGGGATGAGCGTATTGGACAATTGCTGCCCTATCAGGTGAACCCGGCGATGATGAAGGCGTCTGGCAACCC
GCGGGTAAAGTTCATGCATTGCCTGCCTGCATTTCACAACAGCGAAACCAAAGTCGGTAAAGACATCGCAACCCGGTATC
CGAATCTGGCCAACGGCGTTGAAGTGACCGAGGAAGTGTTTGAGTCGCCAGCCAATATCGCGTTTGAGCAGGCGGAAAAC
CGCATGCACACCATCAAGGCCATTCTGGTCTCGGCACTGGCCGATATTTAA

Upstream 100 bases:

>100_bases
TGCCCGATCATTCGCGACGCTATCGATTATTAAACCCGGTCACTGTGATGCGGTTTTAAAGCCGCCTGCAAACCGTCAGT
CCAGATTGAGGATATCCACC

Downstream 100 bases:

>100_bases
GCGCCAGCCTTCTTTCTGCCACCAGACTGCCCAACTGCAGCACATATTTGATGCCGATGCTGCAGTGGCTTTCGAACGCC
TACAGGACTGTACTATGCGT

Product: ornithine carbamoyltransferase

Products: NA

Alternate protein names: OTCase [H]

Number of amino acids: Translated: 336; Mature: 335

Protein sequence:

>336_residues
MAFNMRNRSLLSLMHHTPRELLYLLDLSRDLKRAKYTGTERQHLKGKNIALIFEKTSTRTRCAFEVAAHDQGAHVTYIDP
VSSQIGHKESMKDTARVLGRMFDAIEYRGFAQDIVEELAHFAGVPVFNGLTAEFHPTQMIADVLTMREHSDKPLHEISYA
YLGDARYNMGNSLLMIGAKLGMDVRIAAPAALWPHTDFIAQCKAFAEESGARITITEDPLQAVKGVDFIHTDIWVSMGEP
VDAWDERIGQLLPYQVNPAMMKASGNPRVKFMHCLPAFHNSETKVGKDIATRYPNLANGVEVTEEVFESPANIAFEQAEN
RMHTIKAILVSALADI

Sequences:

>Translated_336_residues
MAFNMRNRSLLSLMHHTPRELLYLLDLSRDLKRAKYTGTERQHLKGKNIALIFEKTSTRTRCAFEVAAHDQGAHVTYIDP
VSSQIGHKESMKDTARVLGRMFDAIEYRGFAQDIVEELAHFAGVPVFNGLTAEFHPTQMIADVLTMREHSDKPLHEISYA
YLGDARYNMGNSLLMIGAKLGMDVRIAAPAALWPHTDFIAQCKAFAEESGARITITEDPLQAVKGVDFIHTDIWVSMGEP
VDAWDERIGQLLPYQVNPAMMKASGNPRVKFMHCLPAFHNSETKVGKDIATRYPNLANGVEVTEEVFESPANIAFEQAEN
RMHTIKAILVSALADI
>Mature_335_residues
AFNMRNRSLLSLMHHTPRELLYLLDLSRDLKRAKYTGTERQHLKGKNIALIFEKTSTRTRCAFEVAAHDQGAHVTYIDPV
SSQIGHKESMKDTARVLGRMFDAIEYRGFAQDIVEELAHFAGVPVFNGLTAEFHPTQMIADVLTMREHSDKPLHEISYAY
LGDARYNMGNSLLMIGAKLGMDVRIAAPAALWPHTDFIAQCKAFAEESGARITITEDPLQAVKGVDFIHTDIWVSMGEPV
DAWDERIGQLLPYQVNPAMMKASGNPRVKFMHCLPAFHNSETKVGKDIATRYPNLANGVEVTEEVFESPANIAFEQAENR
MHTIKAILVSALADI

Specific function: Arginine biosynthesis; sixth step. [C]

COG id: COG0078

COG function: function code E; Ornithine carbamoyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATCase/OTCase family [H]

Homologues:

Organism=Homo sapiens, GI38788445, Length=332, Percent_Identity=36.144578313253, Blast_Score=199, Evalue=4e-51,
Organism=Homo sapiens, GI18105007, Length=335, Percent_Identity=23.2835820895522, Blast_Score=66, Evalue=5e-11,
Organism=Escherichia coli, GI1790703, Length=328, Percent_Identity=58.5365853658537, Blast_Score=409, Evalue=1e-115,
Organism=Escherichia coli, GI1786469, Length=333, Percent_Identity=57.3573573573574, Blast_Score=405, Evalue=1e-114,
Organism=Escherichia coli, GI48994908, Length=377, Percent_Identity=24.1379310344828, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI2367364, Length=128, Percent_Identity=36.71875, Blast_Score=66, Evalue=3e-12,
Organism=Saccharomyces cerevisiae, GI6322373, Length=330, Percent_Identity=31.2121212121212, Blast_Score=151, Evalue=2e-37,
Organism=Saccharomyces cerevisiae, GI6322331, Length=164, Percent_Identity=28.6585365853659, Blast_Score=69, Evalue=9e-13,
Organism=Drosophila melanogaster, GI24642586, Length=290, Percent_Identity=24.8275862068966, Blast_Score=69, Evalue=5e-12,

Paralogues:

None

Copy number: 140 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 2066 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006132
- InterPro:   IPR006130
- InterPro:   IPR006131
- InterPro:   IPR002292 [H]

Pfam domain/function: PF00185 OTCace; PF02729 OTCace_N [H]

EC number: =2.1.3.3 [H]

Molecular weight: Translated: 37611; Mature: 37479

Theoretical pI: Translated: 6.57; Mature: 6.57

Prosite motif: PS00097 CARBAMOYLTRANSFERASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
4.5 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
4.2 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAFNMRNRSLLSLMHHTPRELLYLLDLSRDLKRAKYTGTERQHLKGKNIALIFEKTSTRT
CCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCHHHHCCCCCEEEEEECCCCCC
RCAFEVAAHDQGAHVTYIDPVSSQIGHKESMKDTARVLGRMFDAIEYRGFAQDIVEELAH
EEEEEEEECCCCCEEEEECCHHHHHCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHH
FAGVPVFNGLTAEFHPTQMIADVLTMREHSDKPLHEISYAYLGDARYNMGNSLLMIGAKL
HCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCHHCCCCEEEEEEHHC
GMDVRIAAPAALWPHTDFIAQCKAFAEESGARITITEDPLQAVKGVDFIHTDIWVSMGEP
CCCEEEECCCCCCCCHHHHHHHHHHHHCCCCEEEEECCHHHHHCCCHHEEHHHEEECCCC
VDAWDERIGQLLPYQVNPAMMKASGNPRVKFMHCLPAFHNSETKVGKDIATRYPNLANGV
HHHHHHHHHCCCCCCCCHHHEECCCCCCEEEEEECCCCCCCCHHHHHHHHHHCCCCCCHH
EVTEEVFESPANIAFEQAENRMHTIKAILVSALADI
HHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
AFNMRNRSLLSLMHHTPRELLYLLDLSRDLKRAKYTGTERQHLKGKNIALIFEKTSTRT
CCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCHHHHCCCCCEEEEEECCCCCC
RCAFEVAAHDQGAHVTYIDPVSSQIGHKESMKDTARVLGRMFDAIEYRGFAQDIVEELAH
EEEEEEEECCCCCEEEEECCHHHHHCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHH
FAGVPVFNGLTAEFHPTQMIADVLTMREHSDKPLHEISYAYLGDARYNMGNSLLMIGAKL
HCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCHHCCCCEEEEEEHHC
GMDVRIAAPAALWPHTDFIAQCKAFAEESGARITITEDPLQAVKGVDFIHTDIWVSMGEP
CCCEEEECCCCCCCCHHHHHHHHHHHHCCCCEEEEECCHHHHHCCCHHEEHHHEEECCCC
VDAWDERIGQLLPYQVNPAMMKASGNPRVKFMHCLPAFHNSETKVGKDIATRYPNLANGV
HHHHHHHHHCCCCCCCCHHHEECCCCCCEEEEEECCCCCCCCHHHHHHHHHHCCCCCCHH
EVTEEVFESPANIAFEQAENRMHTIKAILVSALADI
HHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 3109911; 10984043; 2118516; 7479879 [H]