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The map label for this gene is yahK [H]

Identifier: 66045667

GI number: 66045667

Start: 2812968

End: 2814092

Strand: Reverse

Name: yahK [H]

Synonym: Psyr_2431

Alternate gene names: 66045667

Gene position: 2814092-2812968 (Counterclockwise)

Preceding gene: 66045670

Following gene: 66045666

Centisome position: 46.18

GC content: 59.91

Gene sequence:

>1125_bases
ATGCTGTCGTACGGCGTTACACTTATCCCCATTGAACAGGTGACAGTAATGGTCAAGACATACAGCTACGCAGCGCAATC
GGCTCAGGACACACTCAAGCCCCATCAATTCGAACGTTGCTCGCCCGGCGCTGACGATGTTCAGATCGACATCCTTTACT
GCGGCGTGTGCCACTCCGATCTGCATACTGCGCGCAATGAGTGGCACAACACACTCTATCCTTCTGTTCCGGGTCACGAA
ATCGTCGGCCGGGTCACGGCGGTCGGCTCCGACGTCAAGCAATTCAAGGTAGGCGACCTGGCTGGCGTCGGTTGCATGGT
CGACAGTTGCCAGCAATGTGCATCGTGCGCCGAAGGTGACGAGCAATACTGCGAGAGCGGCTTCACCGGCACCTACAATG
GACCGGTATTTGGCGGCGAGAACACATTCGGCGGCTACTCCGACAAGATCGTGGTCAAGGAAAAGTTCGTCTTGCGCATC
TCACATGATGCCAACCTGGCCGCCGTCGCGCCGCTGTTGTGCGCAGGTATCACCACCTATTCCCCCTTGCGCCACTGGAA
GGTCGGCCCCGGCAAGAAAGTCGGCATTGTCGGGCTTGGCGGCCTCGGCCACATGGGCGTCAAGATCGCCCACGCCATGG
GCGCCCATGTGGTGCTGTTCACGACCTCCCCCGACAAGCGCGAAGATGGCTTGCGTCTGGGCGCCGACGAAGTGGTCGTA
TCCAGGGACGCGGGACAGATGGCCGCGCAGGCCAACAGCCTGGACTTTATCCTCAACACGGTCGCAGCGCCGCATGACCT
GGACGCCTTCCTGTCTCTTCTCAAGCGCGACGGCACCATGACACTGGTTGGCGCGCCGGCAGAACCGCATCCGTCACCCG
CAGTGTTCAACCTGATCTTCAAGCGTCGCAGCCTGGCCGGCTCGTTGATCGGAGGCATTCAGGAAACCCAGGAAATGCTG
GACTTCTGCGCCGAGCACGGCATCGTTTCCGACATTGAAGTGATCGCCATGCAGGACATCAACGAGGCTTACGAGCGGAT
GCTCAAGGGCGACGTCAAGTATCGCTTTGTCATCGACATGGACAGCCTCAAGCAGGAAGCGGCTGCCGACTCGAACGCTG
CCTGA

Upstream 100 bases:

>100_bases
TCCCGATCAAGCCTGTGTGATGCGGGGCACTACCTGGCTGCCCCATGGGTCAGATTCAGGTGCATTGCCAGACAGCAAGG
TCAATGAGCGAGGCTCGGCT

Downstream 100 bases:

>100_bases
TGCGCACCTGGCAGCCAAGGACGGCTGCAATTTGACATGCCGTACGTCGCCCCCGGTGAACCGATCGCCGCCAATCGCCC
ACTGATGTCCATACTCTAGG

Product: zinc-containing alcohol dehydrogenase superfamily protein

Products: aldehyde; NADPH; H+

Alternate protein names: NA

Number of amino acids: Translated: 374; Mature: 374

Protein sequence:

>374_residues
MLSYGVTLIPIEQVTVMVKTYSYAAQSAQDTLKPHQFERCSPGADDVQIDILYCGVCHSDLHTARNEWHNTLYPSVPGHE
IVGRVTAVGSDVKQFKVGDLAGVGCMVDSCQQCASCAEGDEQYCESGFTGTYNGPVFGGENTFGGYSDKIVVKEKFVLRI
SHDANLAAVAPLLCAGITTYSPLRHWKVGPGKKVGIVGLGGLGHMGVKIAHAMGAHVVLFTTSPDKREDGLRLGADEVVV
SRDAGQMAAQANSLDFILNTVAAPHDLDAFLSLLKRDGTMTLVGAPAEPHPSPAVFNLIFKRRSLAGSLIGGIQETQEML
DFCAEHGIVSDIEVIAMQDINEAYERMLKGDVKYRFVIDMDSLKQEAAADSNAA

Sequences:

>Translated_374_residues
MLSYGVTLIPIEQVTVMVKTYSYAAQSAQDTLKPHQFERCSPGADDVQIDILYCGVCHSDLHTARNEWHNTLYPSVPGHE
IVGRVTAVGSDVKQFKVGDLAGVGCMVDSCQQCASCAEGDEQYCESGFTGTYNGPVFGGENTFGGYSDKIVVKEKFVLRI
SHDANLAAVAPLLCAGITTYSPLRHWKVGPGKKVGIVGLGGLGHMGVKIAHAMGAHVVLFTTSPDKREDGLRLGADEVVV
SRDAGQMAAQANSLDFILNTVAAPHDLDAFLSLLKRDGTMTLVGAPAEPHPSPAVFNLIFKRRSLAGSLIGGIQETQEML
DFCAEHGIVSDIEVIAMQDINEAYERMLKGDVKYRFVIDMDSLKQEAAADSNAA
>Mature_374_residues
MLSYGVTLIPIEQVTVMVKTYSYAAQSAQDTLKPHQFERCSPGADDVQIDILYCGVCHSDLHTARNEWHNTLYPSVPGHE
IVGRVTAVGSDVKQFKVGDLAGVGCMVDSCQQCASCAEGDEQYCESGFTGTYNGPVFGGENTFGGYSDKIVVKEKFVLRI
SHDANLAAVAPLLCAGITTYSPLRHWKVGPGKKVGIVGLGGLGHMGVKIAHAMGAHVVLFTTSPDKREDGLRLGADEVVV
SRDAGQMAAQANSLDFILNTVAAPHDLDAFLSLLKRDGTMTLVGAPAEPHPSPAVFNLIFKRRSLAGSLIGGIQETQEML
DFCAEHGIVSDIEVIAMQDINEAYERMLKGDVKYRFVIDMDSLKQEAAADSNAA

Specific function: Unknown

COG id: COG1064

COG function: function code R; Zn-dependent alcohol dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI4501939, Length=351, Percent_Identity=26.4957264957265, Blast_Score=87, Evalue=2e-17,
Organism=Homo sapiens, GI156523966, Length=351, Percent_Identity=26.4957264957265, Blast_Score=87, Evalue=2e-17,
Organism=Homo sapiens, GI4501933, Length=354, Percent_Identity=25.9887005649718, Blast_Score=86, Evalue=6e-17,
Organism=Homo sapiens, GI262073058, Length=352, Percent_Identity=26.1363636363636, Blast_Score=86, Evalue=8e-17,
Organism=Homo sapiens, GI71743840, Length=352, Percent_Identity=26.1363636363636, Blast_Score=86, Evalue=8e-17,
Organism=Homo sapiens, GI34577061, Length=349, Percent_Identity=26.0744985673352, Blast_Score=82, Evalue=7e-16,
Organism=Homo sapiens, GI4501929, Length=349, Percent_Identity=24.9283667621776, Blast_Score=80, Evalue=4e-15,
Organism=Homo sapiens, GI71565154, Length=366, Percent_Identity=23.4972677595628, Blast_Score=70, Evalue=2e-12,
Organism=Escherichia coli, GI1786518, Length=348, Percent_Identity=67.5287356321839, Blast_Score=451, Evalue=1e-128,
Organism=Escherichia coli, GI87082401, Length=347, Percent_Identity=35.4466858789625, Blast_Score=201, Evalue=7e-53,
Organism=Escherichia coli, GI87081918, Length=311, Percent_Identity=27.9742765273312, Blast_Score=108, Evalue=8e-25,
Organism=Escherichia coli, GI226510992, Length=255, Percent_Identity=29.0196078431373, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI1788407, Length=272, Percent_Identity=29.0441176470588, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI1788073, Length=278, Percent_Identity=26.6187050359712, Blast_Score=66, Evalue=5e-12,
Organism=Escherichia coli, GI1786552, Length=367, Percent_Identity=26.4305177111717, Blast_Score=64, Evalue=1e-11,
Organism=Escherichia coli, GI1790045, Length=289, Percent_Identity=24.9134948096886, Blast_Score=64, Evalue=1e-11,
Organism=Escherichia coli, GI1788075, Length=269, Percent_Identity=25.6505576208178, Blast_Score=62, Evalue=7e-11,
Organism=Caenorhabditis elegans, GI17562584, Length=337, Percent_Identity=30.2670623145401, Blast_Score=146, Evalue=2e-35,
Organism=Caenorhabditis elegans, GI71988145, Length=333, Percent_Identity=28.8288288288288, Blast_Score=145, Evalue=3e-35,
Organism=Caenorhabditis elegans, GI17562582, Length=336, Percent_Identity=28.5714285714286, Blast_Score=135, Evalue=3e-32,
Organism=Caenorhabditis elegans, GI25146526, Length=371, Percent_Identity=25.0673854447439, Blast_Score=75, Evalue=6e-14,
Organism=Caenorhabditis elegans, GI71997431, Length=365, Percent_Identity=25.4794520547945, Blast_Score=70, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6323980, Length=343, Percent_Identity=37.6093294460641, Blast_Score=185, Evalue=9e-48,
Organism=Saccharomyces cerevisiae, GI6319949, Length=344, Percent_Identity=34.8837209302326, Blast_Score=172, Evalue=1e-43,
Organism=Saccharomyces cerevisiae, GI6319621, Length=325, Percent_Identity=33.8461538461538, Blast_Score=169, Evalue=9e-43,
Organism=Saccharomyces cerevisiae, GI6323961, Length=329, Percent_Identity=33.434650455927, Blast_Score=164, Evalue=3e-41,
Organism=Saccharomyces cerevisiae, GI6324486, Length=330, Percent_Identity=33.3333333333333, Blast_Score=159, Evalue=6e-40,
Organism=Saccharomyces cerevisiae, GI6323729, Length=334, Percent_Identity=31.7365269461078, Blast_Score=154, Evalue=2e-38,
Organism=Saccharomyces cerevisiae, GI6320033, Length=384, Percent_Identity=27.0833333333333, Blast_Score=79, Evalue=8e-16,
Organism=Drosophila melanogaster, GI17737895, Length=362, Percent_Identity=25.9668508287293, Blast_Score=84, Evalue=1e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR006140
- InterPro:   IPR011032
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: 1.1.1.2

Molecular weight: Translated: 40109; Mature: 40109

Theoretical pI: Translated: 5.21; Mature: 5.21

Prosite motif: PS00059 ADH_ZINC ; PS00065 D_2_HYDROXYACID_DH_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.7 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
5.6 %Cys+Met (Translated Protein)
2.7 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
5.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLSYGVTLIPIEQVTVMVKTYSYAAQSAQDTLKPHQFERCSPGADDVQIDILYCGVCHSD
CCCCCEEEEEHHHEEEEEHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEEEEEECCHHH
LHTARNEWHNTLYPSVPGHEIVGRVTAVGSDVKQFKVGDLAGVGCMVDSCQQCASCAEGD
HHHHHHHHHCCCCCCCCCHHHHHHHHHCCCCHHHEECCCCCCHHHHHHHHHHHHHHCCCC
EQYCESGFTGTYNGPVFGGENTFGGYSDKIVVKEKFVLRISHDANLAAVAPLLCAGITTY
HHHHHCCCCCCCCCCEECCCCCCCCCCCEEEEEEEEEEEEECCCCHHHHHHHHHHCCCCC
SPLRHWKVGPGKKVGIVGLGGLGHMGVKIAHAMGAHVVLFTTSPDKREDGLRLGADEVVV
CCHHHCCCCCCCEEEEEEECCCCHHHHHHHHHCCCEEEEEECCCCCCCCCCEECCCCEEE
SRDAGQMAAQANSLDFILNTVAAPHDLDAFLSLLKRDGTMTLVGAPAEPHPSPAVFNLIF
ECCCHHHHHHCCCHHHHHHHHCCCCCHHHHHHHHHCCCCEEEEECCCCCCCCHHHHHHHH
KRRSLAGSLIGGIQETQEMLDFCAEHGIVSDIEVIAMQDINEAYERMLKGDVKYRFVIDM
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCCEEEEEEEH
DSLKQEAAADSNAA
HHHHHHHCCCCCCC
>Mature Secondary Structure
MLSYGVTLIPIEQVTVMVKTYSYAAQSAQDTLKPHQFERCSPGADDVQIDILYCGVCHSD
CCCCCEEEEEHHHEEEEEHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEEEEEECCHHH
LHTARNEWHNTLYPSVPGHEIVGRVTAVGSDVKQFKVGDLAGVGCMVDSCQQCASCAEGD
HHHHHHHHHCCCCCCCCCHHHHHHHHHCCCCHHHEECCCCCCHHHHHHHHHHHHHHCCCC
EQYCESGFTGTYNGPVFGGENTFGGYSDKIVVKEKFVLRISHDANLAAVAPLLCAGITTY
HHHHHCCCCCCCCCCEECCCCCCCCCCCEEEEEEEEEEEEECCCCHHHHHHHHHHCCCCC
SPLRHWKVGPGKKVGIVGLGGLGHMGVKIAHAMGAHVVLFTTSPDKREDGLRLGADEVVV
CCHHHCCCCCCCEEEEEEECCCCHHHHHHHHHCCCEEEEEECCCCCCCCCCEECCCCEEE
SRDAGQMAAQANSLDFILNTVAAPHDLDAFLSLLKRDGTMTLVGAPAEPHPSPAVFNLIF
ECCCHHHHHHCCCHHHHHHHHCCCCCHHHHHHHHHCCCCEEEEECCCCCCCCHHHHHHHH
KRRSLAGSLIGGIQETQEMLDFCAEHGIVSDIEVIAMQDINEAYERMLKGDVKYRFVIDM
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCCEEEEEEEH
DSLKQEAAADSNAA
HHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: alcohol; NADP+

Specific reaction: an alcohol + NADP+ = an aldehyde + NADPH + H+

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9278503 [H]