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The map label for this gene is mprA [H]

Identifier: 66045611

GI number: 66045611

Start: 2754245

End: 2754952

Strand: Reverse

Name: mprA [H]

Synonym: Psyr_2375

Alternate gene names: 66045611

Gene position: 2754952-2754245 (Counterclockwise)

Preceding gene: 66045612

Following gene: 66045610

Centisome position: 45.21

GC content: 58.33

Gene sequence:

>708_bases
GTGCTCGAACGATCACTGAGCGTCTTGATTGTCGAAGATAACCTGGCGCTGGCCGCCAACATGTTTGATTACCTGGAGGC
TTGCGGGCATACGCCGGACGCCGCACCGGATGGCAAGTCGGCCATCCGCCTGCTCGCGGAAAACCGTTACGACGTCATTG
TGCTGGACTGGATGATGCCGCGCATGGACGGGATCTCACTGCTGCGTCATCTGCGCAATGAATTGAATAACCCGGTGCCA
GTCATGTTGCTGACTGCCAAGGACCAGCTGGATGACAAGCTGGAAGGCTTTGAATCGGGTGCGGATGACTACATTGTCAA
ACCGCTGGCCTTGCCTGAACTGGAGATTCGCCTGCGAGTGCTGGCAGCGCGTAACCACACGCGGGCAGACAGGCGACAAA
TACTGGAAATCGCTGACCTGCGCTTCGATCTCGGCACGCAATTGGTGACGCGCGATGGCATACCGTTACCGTTCTCGCCG
ATCCGACGAACGCTGCTGGAGGTGCTGATGCGCAACTCACCGCACGTGGTCACACGCACGCAACTCGAATCACTCGTCTG
GGGTGACAGCGTGCCCGATGGCGATCTGCTGCGCTCGCACATGCACCTGCTCAGAAAAACCATTGATGGCGAGCGTGCTG
CCGGGCAAAAATTGCTGCATACCGTGCAGGGCATCGGTTTTCGTCTGTGCGTGTGCGCACATGATTGA

Upstream 100 bases:

>100_bases
CACAGACAGCTCGACGTCGATGTTCATCGGCATATCGCGAAAGTTCTGATGCTGAACTACCACCCTATGCTGCCTTGAAA
CAACTCACCGGGAGCTCGCC

Downstream 100 bases:

>100_bases
CTTCGCTCGCCGACGTGGCAGCCTGCATCGCCTCGTCAGCGTGATAATTCTCGGTTTCGGGCTGCTGATGACCACCGGCC
TGACCACCCTCGCGTTCATG

Product: response regulator receiver:transcriptional regulatory protein, C-terminal

Products: NA

Alternate protein names: Mycobacterial persistence regulator A [H]

Number of amino acids: Translated: 235; Mature: 235

Protein sequence:

>235_residues
MLERSLSVLIVEDNLALAANMFDYLEACGHTPDAAPDGKSAIRLLAENRYDVIVLDWMMPRMDGISLLRHLRNELNNPVP
VMLLTAKDQLDDKLEGFESGADDYIVKPLALPELEIRLRVLAARNHTRADRRQILEIADLRFDLGTQLVTRDGIPLPFSP
IRRTLLEVLMRNSPHVVTRTQLESLVWGDSVPDGDLLRSHMHLLRKTIDGERAAGQKLLHTVQGIGFRLCVCAHD

Sequences:

>Translated_235_residues
MLERSLSVLIVEDNLALAANMFDYLEACGHTPDAAPDGKSAIRLLAENRYDVIVLDWMMPRMDGISLLRHLRNELNNPVP
VMLLTAKDQLDDKLEGFESGADDYIVKPLALPELEIRLRVLAARNHTRADRRQILEIADLRFDLGTQLVTRDGIPLPFSP
IRRTLLEVLMRNSPHVVTRTQLESLVWGDSVPDGDLLRSHMHLLRKTIDGERAAGQKLLHTVQGIGFRLCVCAHD
>Mature_235_residues
MLERSLSVLIVEDNLALAANMFDYLEACGHTPDAAPDGKSAIRLLAENRYDVIVLDWMMPRMDGISLLRHLRNELNNPVP
VMLLTAKDQLDDKLEGFESGADDYIVKPLALPELEIRLRVLAARNHTRADRRQILEIADLRFDLGTQLVTRDGIPLPFSP
IRRTLLEVLMRNSPHVVTRTQLESLVWGDSVPDGDLLRSHMHLLRKTIDGERAAGQKLLHTVQGIGFRLCVCAHD

Specific function: Member of the two-component regulatory system mprB/mprA which contributes to maintaining a balance among several systems involved in stress resistance and is required for establishment and maintenance of persistent infection in the host. Functions as a tr

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1786599, Length=226, Percent_Identity=33.6283185840708, Blast_Score=119, Evalue=1e-28,
Organism=Escherichia coli, GI87082012, Length=228, Percent_Identity=31.5789473684211, Blast_Score=117, Evalue=5e-28,
Organism=Escherichia coli, GI1789402, Length=226, Percent_Identity=33.1858407079646, Blast_Score=117, Evalue=7e-28,
Organism=Escherichia coli, GI1786784, Length=227, Percent_Identity=34.3612334801762, Blast_Score=117, Evalue=8e-28,
Organism=Escherichia coli, GI1790552, Length=226, Percent_Identity=31.858407079646, Blast_Score=108, Evalue=3e-25,
Organism=Escherichia coli, GI1786911, Length=226, Percent_Identity=32.7433628318584, Blast_Score=108, Evalue=3e-25,
Organism=Escherichia coli, GI1787375, Length=227, Percent_Identity=31.2775330396476, Blast_Score=106, Evalue=1e-24,
Organism=Escherichia coli, GI1789809, Length=234, Percent_Identity=28.2051282051282, Blast_Score=98, Evalue=4e-22,
Organism=Escherichia coli, GI1788394, Length=227, Percent_Identity=30.3964757709251, Blast_Score=95, Evalue=5e-21,
Organism=Escherichia coli, GI1790863, Length=233, Percent_Identity=30.0429184549356, Blast_Score=80, Evalue=9e-17,
Organism=Escherichia coli, GI1790860, Length=226, Percent_Identity=27.8761061946903, Blast_Score=77, Evalue=1e-15,
Organism=Escherichia coli, GI2367329, Length=234, Percent_Identity=30.7692307692308, Blast_Score=76, Evalue=2e-15,
Organism=Escherichia coli, GI1787229, Length=194, Percent_Identity=26.8041237113402, Blast_Score=75, Evalue=5e-15,
Organism=Escherichia coli, GI1790437, Length=127, Percent_Identity=28.3464566929134, Blast_Score=69, Evalue=2e-13,
Organism=Escherichia coli, GI1788713, Length=157, Percent_Identity=31.2101910828025, Blast_Score=67, Evalue=1e-12,
Organism=Escherichia coli, GI1788550, Length=109, Percent_Identity=33.0275229357798, Blast_Score=65, Evalue=4e-12,
Organism=Escherichia coli, GI1788191, Length=121, Percent_Identity=29.7520661157025, Blast_Score=63, Evalue=2e-11,
Organism=Escherichia coli, GI1787487, Length=103, Percent_Identity=32.0388349514563, Blast_Score=62, Evalue=2e-11,
Organism=Escherichia coli, GI48994928, Length=115, Percent_Identity=36.5217391304348, Blast_Score=61, Evalue=5e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 26480; Mature: 26480

Theoretical pI: Translated: 6.09; Mature: 6.09

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLERSLSVLIVEDNLALAANMFDYLEACGHTPDAAPDGKSAIRLLAENRYDVIVLDWMMP
CCCCCEEEEEEECCHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHCCCCCEEEEECHHC
RMDGISLLRHLRNELNNPVPVMLLTAKDQLDDKLEGFESGADDYIVKPLALPELEIRLRV
CCHHHHHHHHHHHHHCCCCCEEEEECCHHHHHHHHHHHCCCCCEEECCCCCCCHHHHHHE
LAARNHTRADRRQILEIADLRFDLGTQLVTRDGIPLPFSPIRRTLLEVLMRNSPHVVTRT
EHHCCCCHHHHHHHHHHHHHHHHHCCHHHCCCCCCCCHHHHHHHHHHHHHCCCCCEEEHH
QLESLVWGDSVPDGDLLRSHMHLLRKTIDGERAAGQKLLHTVQGIGFRLCVCAHD
HHHHHHCCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCEEEEEEECC
>Mature Secondary Structure
MLERSLSVLIVEDNLALAANMFDYLEACGHTPDAAPDGKSAIRLLAENRYDVIVLDWMMP
CCCCCEEEEEEECCHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHCCCCCEEEEECHHC
RMDGISLLRHLRNELNNPVPVMLLTAKDQLDDKLEGFESGADDYIVKPLALPELEIRLRV
CCHHHHHHHHHHHHHCCCCCEEEEECCHHHHHHHHHHHCCCCCEEECCCCCCCHHHHHHE
LAARNHTRADRRQILEIADLRFDLGTQLVTRDGIPLPFSPIRRTLLEVLMRNSPHVVTRT
EHHCCCCHHHHHHHHHHHHHHHHHCCHHHCCCCCCCCHHHHHHHHHHHHHCCCCCEEEHH
QLESLVWGDSVPDGDLLRSHMHLLRKTIDGERAAGQKLLHTVQGIGFRLCVCAHD
HHHHHHCCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA