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The map label for this gene is cpxA [H]

Identifier: 66045271

GI number: 66045271

Start: 2355285

End: 2356319

Strand: Reverse

Name: cpxA [H]

Synonym: Psyr_2031

Alternate gene names: 66045271

Gene position: 2356319-2355285 (Counterclockwise)

Preceding gene: 66045272

Following gene: 66045270

Centisome position: 38.67

GC content: 63.0

Gene sequence:

>1035_bases
TTGATCCGCAGATTCGATACGCTGTTCGCGCGACTGTTTGGTGGCGCTCTGTTGGCTATCCTGCTGGCGCACCTGCTGGC
TTTCATCTGGTTCACCCAGTACGGCATGCGCCCCCCGCCGCCAACGCCCAACGAGTTCAACGCCGAGCATGGGCAATTCG
ATCAGCGGCCCATGCACAGACCGCCGATCCTCGGTGGCCCGCTCATATTGCTGTTCTTCCAGTTCATCACCCTGATCATT
GCCGCGTGGTATGGCGCCAAGGCCCTCAGCCGTCCCGTGCGGAGCCTGAGCGAAGCCGCCGAACGCCTGAGTGAAGACCT
CGACAGCCCGCCACTGGAAATCAGCGGCCCGCAGGAAGCCCGACAGGCTGCGCAGACGTTCAATCTGATGCAGCGCAAGA
TCCGCGAACAGATGCAGCAGCGCGGGCGCATGCTGGCTGCGGTCTCCCATGATCTGCGCACGCCCCTTTCGCGGCTCAAG
CTGCGTGTCGAACAGATCGAGGAGCCCAGGCTGCACGGCCAGATGACTCAGGACCTCAATGACATGATCAGCATGCTCGA
CGCCACGCTTGCCTACCTCAATGAGCACCGGCGCAGCGAAGGCCTGCAGCAGTTCGACCTGCAGGCGCTGATCGAGTCGC
AGGCCGAGAATGCCCAGGACAATGGCGACGACGTGCAATACGAAGGCCAGTGCAAGCCGCTCAAGACGCAGCCGATGGCA
CTGCGCTCGTGCCTGCAGAATCTGGTCGACAACGCTCTGCGTTATGCCGGCAGCGCGCGCATTGTGATTGAGGACAGCGC
CGATCACGTGCGCATATCCGTCGTTGATCACGGACCAGGGATTGCGCCCGAGTTTCACGAGACGGTATTCGAACCATTCT
TTCGCCTGGAAAGCTCGCGCAATCGCAACTCCGGCGGAATCGGCATGGGCATGAGTATCGCCCGGGAAGCGGCGCGGCGT
ATCGGCGGCGAGCTGTCGCTTGCGCAGACCCCGGGCGGCGGCCTGACGGCAATACTGGTCCTGCCACGCCTCTGA

Upstream 100 bases:

>100_bases
TCTCGCGTCTGCGCCAGAAGCTCGGCGATGACCCGAAGAATCCGCAACTGATCAAGACCGTGCGCGGTGAAGGCTATCTG
TTCGATGCCAGGGAGCTGGG

Downstream 100 bases:

>100_bases
CATATTCTGTATCACGCCACGTACAAAGCTTACATTCCCTCGACAACTGACGCCCCGAGGCTGCAAAAGCCGGTACACCG
TTATCGGGCACATTCATCTC

Product: sensor histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 344; Mature: 344

Protein sequence:

>344_residues
MIRRFDTLFARLFGGALLAILLAHLLAFIWFTQYGMRPPPPTPNEFNAEHGQFDQRPMHRPPILGGPLILLFFQFITLII
AAWYGAKALSRPVRSLSEAAERLSEDLDSPPLEISGPQEARQAAQTFNLMQRKIREQMQQRGRMLAAVSHDLRTPLSRLK
LRVEQIEEPRLHGQMTQDLNDMISMLDATLAYLNEHRRSEGLQQFDLQALIESQAENAQDNGDDVQYEGQCKPLKTQPMA
LRSCLQNLVDNALRYAGSARIVIEDSADHVRISVVDHGPGIAPEFHETVFEPFFRLESSRNRNSGGIGMGMSIAREAARR
IGGELSLAQTPGGGLTAILVLPRL

Sequences:

>Translated_344_residues
MIRRFDTLFARLFGGALLAILLAHLLAFIWFTQYGMRPPPPTPNEFNAEHGQFDQRPMHRPPILGGPLILLFFQFITLII
AAWYGAKALSRPVRSLSEAAERLSEDLDSPPLEISGPQEARQAAQTFNLMQRKIREQMQQRGRMLAAVSHDLRTPLSRLK
LRVEQIEEPRLHGQMTQDLNDMISMLDATLAYLNEHRRSEGLQQFDLQALIESQAENAQDNGDDVQYEGQCKPLKTQPMA
LRSCLQNLVDNALRYAGSARIVIEDSADHVRISVVDHGPGIAPEFHETVFEPFFRLESSRNRNSGGIGMGMSIAREAARR
IGGELSLAQTPGGGLTAILVLPRL
>Mature_344_residues
MIRRFDTLFARLFGGALLAILLAHLLAFIWFTQYGMRPPPPTPNEFNAEHGQFDQRPMHRPPILGGPLILLFFQFITLII
AAWYGAKALSRPVRSLSEAAERLSEDLDSPPLEISGPQEARQAAQTFNLMQRKIREQMQQRGRMLAAVSHDLRTPLSRLK
LRVEQIEEPRLHGQMTQDLNDMISMLDATLAYLNEHRRSEGLQQFDLQALIESQAENAQDNGDDVQYEGQCKPLKTQPMA
LRSCLQNLVDNALRYAGSARIVIEDSADHVRISVVDHGPGIAPEFHETVFEPFFRLESSRNRNSGGIGMGMSIAREAARR
IGGELSLAQTPGGGLTAILVLPRL

Specific function: This protein is involved in several diverse cellular processes, such as the functioning of acetohydroxyacid synthetase I, in the biosynthesis of isoleucine and valine, the TraJ protein activation activity for tra gene expression in F plasmid, and the synt

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1790346, Length=268, Percent_Identity=32.8358208955224, Blast_Score=123, Evalue=2e-29,
Organism=Escherichia coli, GI1789808, Length=272, Percent_Identity=29.4117647058824, Blast_Score=115, Evalue=5e-27,
Organism=Escherichia coli, GI1787894, Length=278, Percent_Identity=28.7769784172662, Blast_Score=100, Evalue=2e-22,
Organism=Escherichia coli, GI87082128, Length=315, Percent_Identity=26.6666666666667, Blast_Score=89, Evalue=3e-19,
Organism=Escherichia coli, GI1788393, Length=272, Percent_Identity=26.1029411764706, Blast_Score=87, Evalue=1e-18,
Organism=Escherichia coli, GI1786783, Length=298, Percent_Identity=24.8322147651007, Blast_Score=84, Evalue=2e-17,
Organism=Escherichia coli, GI1786600, Length=236, Percent_Identity=28.8135593220339, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI1790861, Length=286, Percent_Identity=25.5244755244755, Blast_Score=74, Evalue=1e-14,
Organism=Escherichia coli, GI87081816, Length=333, Percent_Identity=25.2252252252252, Blast_Score=72, Evalue=4e-14,
Organism=Escherichia coli, GI145693157, Length=223, Percent_Identity=26.0089686098655, Blast_Score=68, Evalue=9e-13,
Organism=Escherichia coli, GI1788549, Length=223, Percent_Identity=26.0089686098655, Blast_Score=67, Evalue=1e-12,
Organism=Escherichia coli, GI1790436, Length=228, Percent_Identity=27.1929824561404, Blast_Score=67, Evalue=1e-12,
Organism=Escherichia coli, GI1789149, Length=266, Percent_Identity=21.8045112781955, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI1788713, Length=257, Percent_Identity=22.568093385214, Blast_Score=65, Evalue=5e-12,
Organism=Escherichia coli, GI1789403, Length=293, Percent_Identity=25.5972696245734, Blast_Score=62, Evalue=6e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 38510; Mature: 38510

Theoretical pI: Translated: 6.80; Mature: 6.80

Prosite motif: PS50885 HAMP ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIRRFDTLFARLFGGALLAILLAHLLAFIWFTQYGMRPPPPTPNEFNAEHGQFDQRPMHR
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCC
PPILGGPLILLFFQFITLIIAAWYGAKALSRPVRSLSEAAERLSEDLDSPPLEISGPQEA
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHH
RQAAQTFNLMQRKIREQMQQRGRMLAAVSHDLRTPLSRLKLRVEQIEEPRLHGQMTQDLN
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHH
DMISMLDATLAYLNEHRRSEGLQQFDLQALIESQAENAQDNGDDVQYEGQCKPLKTQPMA
HHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCCCCCEECCCCCCCCCCCHH
LRSCLQNLVDNALRYAGSARIVIEDSADHVRISVVDHGPGIAPEFHETVFEPFFRLESSR
HHHHHHHHHHHHHHHCCCCEEEEECCCCEEEEEEEECCCCCCCHHHHHHHHHHHHHHHCC
NRNSGGIGMGMSIAREAARRIGGELSLAQTPGGGLTAILVLPRL
CCCCCCCCHHHHHHHHHHHHCCCCEEEEECCCCCEEEEEEECCC
>Mature Secondary Structure
MIRRFDTLFARLFGGALLAILLAHLLAFIWFTQYGMRPPPPTPNEFNAEHGQFDQRPMHR
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCC
PPILGGPLILLFFQFITLIIAAWYGAKALSRPVRSLSEAAERLSEDLDSPPLEISGPQEA
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHH
RQAAQTFNLMQRKIREQMQQRGRMLAAVSHDLRTPLSRLKLRVEQIEEPRLHGQMTQDLN
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHH
DMISMLDATLAYLNEHRRSEGLQQFDLQALIESQAENAQDNGDDVQYEGQCKPLKTQPMA
HHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCCCCCEECCCCCCCCCCCHH
LRSCLQNLVDNALRYAGSARIVIEDSADHVRISVVDHGPGIAPEFHETVFEPFFRLESSR
HHHHHHHHHHHHHHHCCCCEEEEECCCCEEEEEEEECCCCCCCHHHHHHHHHHHHHHHCC
NRNSGGIGMGMSIAREAARRIGGELSLAQTPGGGLTAILVLPRL
CCCCCCCCHHHHHHHHHHHHCCCCEEEEECCCCCEEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]