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The map label for this gene is adhc1 [H]

Identifier: 66045232

GI number: 66045232

Start: 2312799

End: 2313851

Strand: Reverse

Name: adhc1 [H]

Synonym: Psyr_1992

Alternate gene names: 66045232

Gene position: 2313851-2312799 (Counterclockwise)

Preceding gene: 66045234

Following gene: 66045222

Centisome position: 37.97

GC content: 61.35

Gene sequence:

>1053_bases
ATGTACACAGCTATCGGTTACGCCGCACAGTCAGCTAACGCTCCCCTCGCCCCGATGACCTTCGAACGTCGCGCTCTGCG
TGCCGACGACGTTGCCATCGAAATCCTTTATTGCGGCGTCTGCCACTCCGATATTCACCAGGCACGCAACGAATGGGGCA
TTGCCGTCTACCCGCTGATGCCGGGCCACGAAATTGTCGGTCGCGTCACTGCCACCGGCAGCAGTGCAACCCAATACCAG
GTCGGTGACATGGTCGGTGTCGGCTGCATGGTCGATTCGTGCCGCGAATGCTCGGCCTGCAAGTCGGACCTCGAGCAGTA
CTGCCTGGAAGGCCCGACCATGACTTACGCCACGCCAGATCGTGTGGACGGCAGCAACACCATGGGCGGTTACTCGAACA
GCATCGTGGTCGCCGAGCACTTCGTCGTGCGCGTCCCGGAAAAACTCGATCCGGCCGCTGCTGCGCCGATTCTCTGCGCA
GGCATCACCACCTATTCGCCGCTCAAGCACTACGGCGTCAAGGCGGGCGACAAGGTCGGCATTCTGGGCATGGGCGGCCT
GGGCCACATGGGCATCAAGTTCGCCAAGGCCATGGGCGCTGAAGTGACCCTGTTCACCCGCTCCGCCGCCAAGGCTCAGG
AAGCACATCGTCAAGGCGCCGATCATGTGATCGTGTCCACCGATGCCGAACAGATGAAGGCTGCTGCCGGGCACTTCGAC
TTCCTGCTCGACACCATTCCGGTGCAGCACGACCTGAACCCCTACCTGGAAACCCTGCGTTTCGACGGCGCCCACATTCT
GGTCGGCCTGATCGAGCCGATCGAGCCACCAGTACACGCAGCCAATCTGGTAATGAGCCGCCGCGTGCTGGCCGGTTCGT
TGATCGGCGGTATCGCGGAAACTCAGGAAGTGCTGGATTTCTGCGCCGAGAACGACATCACCTGCGACATCGAAATGCTC
GATATCCGCAACATCAACGAAGCCTACGAGCGCATGCTGGCCGGTGACGTGAAGTACCGCTTCGTGATCGACATGGCCAC
GCTGAAGGCCTGA

Upstream 100 bases:

>100_bases
GAGGAATAGGCATGAAACACGGAGGATTCACCATAGCCGCGAAGGGCCCGTATCAGGACAATGGTTCGCCTCTCTTCCGT
CACACCTTGCGAGGTCAAAC

Downstream 100 bases:

>100_bases
TCGACTGCCGATCAGCCGCCGAGATCGGCCGAGAGTTCCGCCGCGATGGTTTTGATCAGCGGAACCAGCTCGGCCATCTT
CTCCAGCGGCATGTAGGGCA

Product: zinc-containing alcohol dehydrogenase superfamily protein

Products: NA

Alternate protein names: Ms-ADHC 1 [H]

Number of amino acids: Translated: 350; Mature: 350

Protein sequence:

>350_residues
MYTAIGYAAQSANAPLAPMTFERRALRADDVAIEILYCGVCHSDIHQARNEWGIAVYPLMPGHEIVGRVTATGSSATQYQ
VGDMVGVGCMVDSCRECSACKSDLEQYCLEGPTMTYATPDRVDGSNTMGGYSNSIVVAEHFVVRVPEKLDPAAAAPILCA
GITTYSPLKHYGVKAGDKVGILGMGGLGHMGIKFAKAMGAEVTLFTRSAAKAQEAHRQGADHVIVSTDAEQMKAAAGHFD
FLLDTIPVQHDLNPYLETLRFDGAHILVGLIEPIEPPVHAANLVMSRRVLAGSLIGGIAETQEVLDFCAENDITCDIEML
DIRNINEAYERMLAGDVKYRFVIDMATLKA

Sequences:

>Translated_350_residues
MYTAIGYAAQSANAPLAPMTFERRALRADDVAIEILYCGVCHSDIHQARNEWGIAVYPLMPGHEIVGRVTATGSSATQYQ
VGDMVGVGCMVDSCRECSACKSDLEQYCLEGPTMTYATPDRVDGSNTMGGYSNSIVVAEHFVVRVPEKLDPAAAAPILCA
GITTYSPLKHYGVKAGDKVGILGMGGLGHMGIKFAKAMGAEVTLFTRSAAKAQEAHRQGADHVIVSTDAEQMKAAAGHFD
FLLDTIPVQHDLNPYLETLRFDGAHILVGLIEPIEPPVHAANLVMSRRVLAGSLIGGIAETQEVLDFCAENDITCDIEML
DIRNINEAYERMLAGDVKYRFVIDMATLKA
>Mature_350_residues
MYTAIGYAAQSANAPLAPMTFERRALRADDVAIEILYCGVCHSDIHQARNEWGIAVYPLMPGHEIVGRVTATGSSATQYQ
VGDMVGVGCMVDSCRECSACKSDLEQYCLEGPTMTYATPDRVDGSNTMGGYSNSIVVAEHFVVRVPEKLDPAAAAPILCA
GITTYSPLKHYGVKAGDKVGILGMGGLGHMGIKFAKAMGAEVTLFTRSAAKAQEAHRQGADHVIVSTDAEQMKAAAGHFD
FLLDTIPVQHDLNPYLETLRFDGAHILVGLIEPIEPPVHAANLVMSRRVLAGSLIGGIAETQEVLDFCAENDITCDIEML
DIRNINEAYERMLAGDVKYRFVIDMATLKA

Specific function: Prefers aldehydes over alcohols [H]

COG id: COG1064

COG function: function code R; Zn-dependent alcohol dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI71743840, Length=356, Percent_Identity=22.1910112359551, Blast_Score=69, Evalue=6e-12,
Organism=Homo sapiens, GI262073058, Length=356, Percent_Identity=22.1910112359551, Blast_Score=69, Evalue=7e-12,
Organism=Escherichia coli, GI1786518, Length=341, Percent_Identity=54.2521994134897, Blast_Score=337, Evalue=5e-94,
Organism=Escherichia coli, GI87082401, Length=340, Percent_Identity=36.7647058823529, Blast_Score=212, Evalue=4e-56,
Organism=Escherichia coli, GI87081918, Length=326, Percent_Identity=28.2208588957055, Blast_Score=111, Evalue=7e-26,
Organism=Escherichia coli, GI1788073, Length=209, Percent_Identity=29.1866028708134, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI226510992, Length=324, Percent_Identity=25.9259259259259, Blast_Score=66, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI71988145, Length=339, Percent_Identity=26.8436578171091, Blast_Score=139, Evalue=3e-33,
Organism=Caenorhabditis elegans, GI17562584, Length=333, Percent_Identity=27.9279279279279, Blast_Score=120, Evalue=8e-28,
Organism=Caenorhabditis elegans, GI17562582, Length=348, Percent_Identity=26.7241379310345, Blast_Score=113, Evalue=2e-25,
Organism=Caenorhabditis elegans, GI25146526, Length=362, Percent_Identity=25.414364640884, Blast_Score=73, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI71997431, Length=364, Percent_Identity=25.2747252747253, Blast_Score=68, Evalue=7e-12,
Organism=Saccharomyces cerevisiae, GI6323980, Length=349, Percent_Identity=38.6819484240688, Blast_Score=189, Evalue=4e-49,
Organism=Saccharomyces cerevisiae, GI6319949, Length=336, Percent_Identity=37.797619047619, Blast_Score=182, Evalue=8e-47,
Organism=Saccharomyces cerevisiae, GI6324486, Length=337, Percent_Identity=29.3768545994065, Blast_Score=144, Evalue=2e-35,
Organism=Saccharomyces cerevisiae, GI6323961, Length=336, Percent_Identity=28.5714285714286, Blast_Score=139, Evalue=5e-34,
Organism=Saccharomyces cerevisiae, GI6323729, Length=327, Percent_Identity=29.6636085626911, Blast_Score=139, Evalue=8e-34,
Organism=Saccharomyces cerevisiae, GI6319621, Length=342, Percent_Identity=28.9473684210526, Blast_Score=133, Evalue=4e-32,
Organism=Saccharomyces cerevisiae, GI6319258, Length=340, Percent_Identity=24.4117647058824, Blast_Score=86, Evalue=1e-17,
Organism=Saccharomyces cerevisiae, GI6320033, Length=370, Percent_Identity=26.2162162162162, Blast_Score=69, Evalue=9e-13,
Organism=Saccharomyces cerevisiae, GI6322619, Length=256, Percent_Identity=28.125, Blast_Score=64, Evalue=5e-11,
Organism=Saccharomyces cerevisiae, GI6319955, Length=256, Percent_Identity=28.125, Blast_Score=63, Evalue=6e-11,
Organism=Drosophila melanogaster, GI17737895, Length=361, Percent_Identity=23.5457063711911, Blast_Score=72, Evalue=7e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR011032
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: =1.1.1.2 [H]

Molecular weight: Translated: 37657; Mature: 37657

Theoretical pI: Translated: 4.96; Mature: 4.96

Prosite motif: PS00059 ADH_ZINC ; PS00065 D_2_HYDROXYACID_DH_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.9 %Cys     (Translated Protein)
4.3 %Met     (Translated Protein)
7.1 %Cys+Met (Translated Protein)
2.9 %Cys     (Mature Protein)
4.3 %Met     (Mature Protein)
7.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYTAIGYAAQSANAPLAPMTFERRALRADDVAIEILYCGVCHSDIHQARNEWGIAVYPLM
CCCEEEEHHCCCCCCCCCCHHHHHHHCCCCEEEEEEEECCCHHHHHHHHHCCCEEEEECC
PGHEIVGRVTATGSSATQYQVGDMVGVGCMVDSCRECSACKSDLEQYCLEGPTMTYATPD
CCHHHHEEEEECCCCCCEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEECCCCC
RVDGSNTMGGYSNSIVVAEHFVVRVPEKLDPAAAAPILCAGITTYSPLKHYGVKAGDKVG
CCCCCCCCCCCCCCEEEEEHEEEECCCCCCCHHHCCCCEECCCCCCHHHHCCCCCCCCEE
ILGMGGLGHMGIKFAKAMGAEVTLFTRSAAKAQEAHRQGADHVIVSTDAEQMKAAAGHFD
EEECCCCCHHHHHHHHHCCCEEEEEECCHHHHHHHHHCCCCEEEEECCHHHHHHHHCHHH
FLLDTIPVQHDLNPYLETLRFDGAHILVGLIEPIEPPVHAANLVMSRRVLAGSLIGGIAE
HHHHCCCCCCCCCHHHHHHHCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
TQEVLDFCAENDITCDIEMLDIRNINEAYERMLAGDVKYRFVIDMATLKA
HHHHHHHHCCCCCEEEEEEEECCCHHHHHHHHHHCCCEEEEEEEEHHHCC
>Mature Secondary Structure
MYTAIGYAAQSANAPLAPMTFERRALRADDVAIEILYCGVCHSDIHQARNEWGIAVYPLM
CCCEEEEHHCCCCCCCCCCHHHHHHHCCCCEEEEEEEECCCHHHHHHHHHCCCEEEEECC
PGHEIVGRVTATGSSATQYQVGDMVGVGCMVDSCRECSACKSDLEQYCLEGPTMTYATPD
CCHHHHEEEEECCCCCCEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEECCCCC
RVDGSNTMGGYSNSIVVAEHFVVRVPEKLDPAAAAPILCAGITTYSPLKHYGVKAGDKVG
CCCCCCCCCCCCCCEEEEEHEEEECCCCCCCHHHCCCCEECCCCCCHHHHCCCCCCCCEE
ILGMGGLGHMGIKFAKAMGAEVTLFTRSAAKAQEAHRQGADHVIVSTDAEQMKAAAGHFD
EEECCCCCHHHHHHHHHCCCEEEEEECCHHHHHHHHHCCCCEEEEECCHHHHHHHHCHHH
FLLDTIPVQHDLNPYLETLRFDGAHILVGLIEPIEPPVHAANLVMSRRVLAGSLIGGIAE
HHHHCCCCCCCCCHHHHHHHCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
TQEVLDFCAENDITCDIEMLDIRNINEAYERMLAGDVKYRFVIDMATLKA
HHHHHHHHCCCCCEEEEEEEECCCHHHHHHHHHHCCCEEEEEEEEHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11257547 [H]