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The map label for this gene is pucD [H]

Identifier: 66045058

GI number: 66045058

Start: 2087371

End: 2089890

Strand: Reverse

Name: pucD [H]

Synonym: Psyr_1814

Alternate gene names: 66045058

Gene position: 2089890-2087371 (Counterclockwise)

Preceding gene: 66045059

Following gene: 66045057

Centisome position: 34.3

GC content: 62.06

Gene sequence:

>2520_bases
ATGTCTGAGCATTCCTCAAACAGCACCCAGGCGGAGATGCTGGCGGTATTTCAGCAGGGTCTGAACACCGGCGTGGGCCG
CAGCGTCAAGCACGACAGTGCCGACAAACACGTGTCCGGCGAAGCGGTGTACATCGATGATCGCCTGGAATTTCCCAACC
AGTTGCACGTGTACGCACGCCTTTCCGACCGCGCCCATGCGCGCATCGTCAGCATCGATACCTCGCCCTGCTACGCCTTC
GAAGGTGTACGCATCGCGATTACCCATCAGGATATTCCGGGGCTCAAGGACATCGGGCCGTTGCTGCCCGGCGACCCGCT
GCTGGCCATCGACAAGGTGGAGTTCGTCGGGCAACCGGTGCTCGCCGTGGCGGCTCGCGACCTGGACACTGCACGCCAGG
CGGCGATGGCGGCGATCATCGAATACGAAGACCTGCAACCGGTGCTGGATGTGGTCCAGGCCCTGCGCCAGAAACACTTC
GTGCTCGACAGCCATACGCACAAGCGTGGCGACTCTGCCGCTGCGCTGGCGCGCGCAACCCACCGCCTGCAGGGCAACCT
GCACATTGGCGGCCAGGAGCATTTTTACCTGGAAACCCAGATATCCTCGGTGATGCCGACCGAAGACGGCGGCATGATCG
TCTATTGCTCGACCCAGAACCCCACGGAAATCCAGAAACTGGTGGCCGAGGTGCTGGGCGTGCCAATGAACCGCATCGTG
GTCGACATGCGCCGCATGGGCGGTGGTTTTGGCGGAAAGGAAACCCAGGCGGCCAGCCCGGCCTGCCTGTGCGCAGTGAT
CGCCCGATTGACCGGCCAGCCCACCAAGATGCGCCTGCAACGTTTCGAAGACATGCAGATGACCGGTAAGCGCCACCCGT
TCTACATCGAGTACGACGTGGGTTTCGATGATGACGGTCGTCTGCAGGGTATACAGCTGGATCTGGCCGGCAACTGCGGC
TATTCGCCGGACCTCTCGGCGTCCATCGTCGACCGCGCCATGTTCCATGCCGATAACGCGTATTACCTGGGCGAAGCCAC
CGTCAACGGCCACCGCTGCAAGACGCACACCGCGTCCAACACCGCCTACCGGGGCTTCGGCGGCCCGCAGGGCATGGTCG
CCATCGAAGAGGTCATGGACTGCATTGCACGTTTCCTGGGCAAGGACCCGCTGCACGTGCGCAAGGCCAACTATTACGGC
AAGACCGAGCGTAACGTCACCCACTATTACCAGACGGTCGAACACAACCTGCTGGAAGAGATGACCGCCGACCTCGAGCA
AAGCAGCCAGTACGCCGAGCGCCGCGAAGCGATTCGTGCGTTCAATGCCGGCAGTCCGGTTCTGAAAAAAGGCCTGGCGC
TGACGCCGGTCAAGTTCGGCATCTCGTTCACCGCCAGCTTTCTCAATCAGGCCGGTGCGCTGATTCATATCTACACCGAC
GGCAGCATCCACCTGAACCATGGCGGCACTGAAATGGGCCAGGGCTTGAACACCAAGGTCGCGCAGGTGGTCGCCGAGGT
GTTTCAGGTGGACATCGAGCGCATCCAGATCACCGCGACCAACACCGACAAGGTGCCGAACACCTCGCCGACTGCGGCTT
CGAGCGGCACGGACCTGAACGGCAAAGCCGCACAGAATGCCGCTGAAATCCTCAAGCAACGGCTGGTGGAGTTTGCTGCC
AGGCACCATCAGGTGAGCGAAGCGGAGGTCGAATTCCGCAACGGCCATGTGCGGATCGGCGAGCTGTTCCTGCCGTTCGC
CGAACTGGCGCAATTGGCATGGATGGGCCAGGTGTCGCTGTCGAGCACCGGCTATTACAAGACGCCGAAGATTTTTTACG
ACCGCAGCCAGGCGCGTGGTCGGCCGTTCTATTACTACGCCTTTGGCGCAGCCTGCGTGGAGGTCATCGTCGATACGCTG
ACCGGCGAATACAAGATGTTGCGCACCGACATCCTGCACGACGTCGGCGCGTCGCTGAACCCGGCCATCGATATCGGTCA
GGTCGAAGGCGGCTATATTCAGGGCGCCGGCTGGCTGACCACCGAGGAACTGGTGTGGAACGACAAGGGCAAGCTGATGA
CCAGCGGCCCGGCGTCCTACAAGATCCCGGCAGTGGCAGACATGCCGCTCGATCTGCGCATCAAGCTGGTAGAGAACCGC
AAGAATCCGGAAGACACGGTGTTCCATTCCAAGGCCGTCGGCGAGCCGCCGTTCATGCTCGGCATCGCCGCCTGGTGCGC
GATCAAGGACGCCGTGGCGAGTCTGGGCGACTACCGTCATCAACCGAACATCGACGCCCCGGCGACACCGGAAAAAGTGT
TGTGGGGCTGTGAACAGATGCGCCAGAACAGCGCTGCGCGTCGCGCATCCAGCGAAGGCGCCGAGCCGATTGTTTCTGCC
TCTTCACGGGCAAGTGAAGCTTCGCCAGGCTCGCCTTCACCTATTCAGGATGCCCCCGTGGGAGCGAGCTTGCTCGCGAA
GGCGCCTGGCCTGGATCACTCTGTCCTGGAGCAGAAATGA

Upstream 100 bases:

>100_bases
CGGGCGAGCAAAGAATACCGCCTGTTGAGTGCGCAAAACCTGCTGCGCAAGTACTTCATCGAGTTACAGACCCCAGCCGT
TCCAACGCGGGTGACTGACT

Downstream 100 bases:

>100_bases
ACAACTGGATCAGCGCCCTGGCCGAGCTGCAGGCCCGTGGAGAACCCGGCATTCTGGTGACGATCATCGAGGAGCTGGGC
TCCACGCCACGTAATGCCGG

Product: xanthine dehydrogenase

Products: NA

Alternate protein names: XDHase subunit D [H]

Number of amino acids: Translated: 839; Mature: 838

Protein sequence:

>839_residues
MSEHSSNSTQAEMLAVFQQGLNTGVGRSVKHDSADKHVSGEAVYIDDRLEFPNQLHVYARLSDRAHARIVSIDTSPCYAF
EGVRIAITHQDIPGLKDIGPLLPGDPLLAIDKVEFVGQPVLAVAARDLDTARQAAMAAIIEYEDLQPVLDVVQALRQKHF
VLDSHTHKRGDSAAALARATHRLQGNLHIGGQEHFYLETQISSVMPTEDGGMIVYCSTQNPTEIQKLVAEVLGVPMNRIV
VDMRRMGGGFGGKETQAASPACLCAVIARLTGQPTKMRLQRFEDMQMTGKRHPFYIEYDVGFDDDGRLQGIQLDLAGNCG
YSPDLSASIVDRAMFHADNAYYLGEATVNGHRCKTHTASNTAYRGFGGPQGMVAIEEVMDCIARFLGKDPLHVRKANYYG
KTERNVTHYYQTVEHNLLEEMTADLEQSSQYAERREAIRAFNAGSPVLKKGLALTPVKFGISFTASFLNQAGALIHIYTD
GSIHLNHGGTEMGQGLNTKVAQVVAEVFQVDIERIQITATNTDKVPNTSPTAASSGTDLNGKAAQNAAEILKQRLVEFAA
RHHQVSEAEVEFRNGHVRIGELFLPFAELAQLAWMGQVSLSSTGYYKTPKIFYDRSQARGRPFYYYAFGAACVEVIVDTL
TGEYKMLRTDILHDVGASLNPAIDIGQVEGGYIQGAGWLTTEELVWNDKGKLMTSGPASYKIPAVADMPLDLRIKLVENR
KNPEDTVFHSKAVGEPPFMLGIAAWCAIKDAVASLGDYRHQPNIDAPATPEKVLWGCEQMRQNSAARRASSEGAEPIVSA
SSRASEASPGSPSPIQDAPVGASLLAKAPGLDHSVLEQK

Sequences:

>Translated_839_residues
MSEHSSNSTQAEMLAVFQQGLNTGVGRSVKHDSADKHVSGEAVYIDDRLEFPNQLHVYARLSDRAHARIVSIDTSPCYAF
EGVRIAITHQDIPGLKDIGPLLPGDPLLAIDKVEFVGQPVLAVAARDLDTARQAAMAAIIEYEDLQPVLDVVQALRQKHF
VLDSHTHKRGDSAAALARATHRLQGNLHIGGQEHFYLETQISSVMPTEDGGMIVYCSTQNPTEIQKLVAEVLGVPMNRIV
VDMRRMGGGFGGKETQAASPACLCAVIARLTGQPTKMRLQRFEDMQMTGKRHPFYIEYDVGFDDDGRLQGIQLDLAGNCG
YSPDLSASIVDRAMFHADNAYYLGEATVNGHRCKTHTASNTAYRGFGGPQGMVAIEEVMDCIARFLGKDPLHVRKANYYG
KTERNVTHYYQTVEHNLLEEMTADLEQSSQYAERREAIRAFNAGSPVLKKGLALTPVKFGISFTASFLNQAGALIHIYTD
GSIHLNHGGTEMGQGLNTKVAQVVAEVFQVDIERIQITATNTDKVPNTSPTAASSGTDLNGKAAQNAAEILKQRLVEFAA
RHHQVSEAEVEFRNGHVRIGELFLPFAELAQLAWMGQVSLSSTGYYKTPKIFYDRSQARGRPFYYYAFGAACVEVIVDTL
TGEYKMLRTDILHDVGASLNPAIDIGQVEGGYIQGAGWLTTEELVWNDKGKLMTSGPASYKIPAVADMPLDLRIKLVENR
KNPEDTVFHSKAVGEPPFMLGIAAWCAIKDAVASLGDYRHQPNIDAPATPEKVLWGCEQMRQNSAARRASSEGAEPIVSA
SSRASEASPGSPSPIQDAPVGASLLAKAPGLDHSVLEQK
>Mature_838_residues
SEHSSNSTQAEMLAVFQQGLNTGVGRSVKHDSADKHVSGEAVYIDDRLEFPNQLHVYARLSDRAHARIVSIDTSPCYAFE
GVRIAITHQDIPGLKDIGPLLPGDPLLAIDKVEFVGQPVLAVAARDLDTARQAAMAAIIEYEDLQPVLDVVQALRQKHFV
LDSHTHKRGDSAAALARATHRLQGNLHIGGQEHFYLETQISSVMPTEDGGMIVYCSTQNPTEIQKLVAEVLGVPMNRIVV
DMRRMGGGFGGKETQAASPACLCAVIARLTGQPTKMRLQRFEDMQMTGKRHPFYIEYDVGFDDDGRLQGIQLDLAGNCGY
SPDLSASIVDRAMFHADNAYYLGEATVNGHRCKTHTASNTAYRGFGGPQGMVAIEEVMDCIARFLGKDPLHVRKANYYGK
TERNVTHYYQTVEHNLLEEMTADLEQSSQYAERREAIRAFNAGSPVLKKGLALTPVKFGISFTASFLNQAGALIHIYTDG
SIHLNHGGTEMGQGLNTKVAQVVAEVFQVDIERIQITATNTDKVPNTSPTAASSGTDLNGKAAQNAAEILKQRLVEFAAR
HHQVSEAEVEFRNGHVRIGELFLPFAELAQLAWMGQVSLSSTGYYKTPKIFYDRSQARGRPFYYYAFGAACVEVIVDTLT
GEYKMLRTDILHDVGASLNPAIDIGQVEGGYIQGAGWLTTEELVWNDKGKLMTSGPASYKIPAVADMPLDLRIKLVENRK
NPEDTVFHSKAVGEPPFMLGIAAWCAIKDAVASLGDYRHQPNIDAPATPEKVLWGCEQMRQNSAARRASSEGAEPIVSAS
SRASEASPGSPSPIQDAPVGASLLAKAPGLDHSVLEQK

Specific function: Oxidizes hypoxanthine and xanthine to uric acid [H]

COG id: COG4631

COG function: function code F; Xanthine dehydrogenase, molybdopterin-binding subunit B

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the xanthine dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI91823271, Length=760, Percent_Identity=42.5, Blast_Score=598, Evalue=1e-170,
Organism=Homo sapiens, GI71773480, Length=759, Percent_Identity=37.1541501976285, Blast_Score=489, Evalue=1e-138,
Organism=Escherichia coli, GI1789230, Length=746, Percent_Identity=27.8820375335121, Blast_Score=208, Evalue=1e-54,
Organism=Escherichia coli, GI1789246, Length=860, Percent_Identity=25.8139534883721, Blast_Score=202, Evalue=9e-53,
Organism=Escherichia coli, GI1786478, Length=747, Percent_Identity=24.7657295850067, Blast_Score=92, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI17540638, Length=771, Percent_Identity=38.9105058365759, Blast_Score=519, Evalue=1e-147,
Organism=Caenorhabditis elegans, GI32566215, Length=773, Percent_Identity=32.8589909443726, Blast_Score=375, Evalue=1e-104,
Organism=Caenorhabditis elegans, GI17539860, Length=783, Percent_Identity=33.0779054916986, Blast_Score=369, Evalue=1e-102,
Organism=Drosophila melanogaster, GI17737937, Length=768, Percent_Identity=40.625, Blast_Score=565, Evalue=1e-161,
Organism=Drosophila melanogaster, GI24647199, Length=782, Percent_Identity=29.4117647058824, Blast_Score=291, Evalue=1e-78,
Organism=Drosophila melanogaster, GI24647193, Length=762, Percent_Identity=30.5774278215223, Blast_Score=286, Evalue=3e-77,
Organism=Drosophila melanogaster, GI24647195, Length=773, Percent_Identity=29.8835705045278, Blast_Score=274, Evalue=2e-73,
Organism=Drosophila melanogaster, GI24647197, Length=758, Percent_Identity=30.0791556728232, Blast_Score=273, Evalue=2e-73,
Organism=Drosophila melanogaster, GI24647201, Length=788, Percent_Identity=28.1725888324873, Blast_Score=262, Evalue=6e-70,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000674
- InterPro:   IPR008274
- InterPro:   IPR017609 [H]

Pfam domain/function: PF01315 Ald_Xan_dh_C; PF02738 Ald_Xan_dh_C2 [H]

EC number: =1.17.1.4 [H]

Molecular weight: Translated: 91416; Mature: 91285

Theoretical pI: Translated: 6.25; Mature: 6.25

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSEHSSNSTQAEMLAVFQQGLNTGVGRSVKHDSADKHVSGEAVYIDDRLEFPNQLHVYAR
CCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCEEEEECCCCCCCEEEEEEE
LSDRAHARIVSIDTSPCYAFEGVRIAITHQDIPGLKDIGPLLPGDPLLAIDKVEFVGQPV
ECCCCCEEEEEECCCCCEEECCEEEEEEECCCCCHHHHCCCCCCCCEEEEECHHHCCCCH
LAVAARDLDTARQAAMAAIIEYEDLQPVLDVVQALRQKHFVLDSHTHKRGDSAAALARAT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCEEECCCCCCCCCHHHHHHHHH
HRLQGNLHIGGQEHFYLETQISSVMPTEDGGMIVYCSTQNPTEIQKLVAEVLGVPMNRIV
HHHCCCEEECCCCEEEEEEEHHHCCCCCCCCEEEEECCCCHHHHHHHHHHHHCCCHHHHH
VDMRRMGGGFGGKETQAASPACLCAVIARLTGQPTKMRLQRFEDMQMTGKRHPFYIEYDV
HHHHHHCCCCCCCCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCEEEEEEC
GFDDDGRLQGIQLDLAGNCGYSPDLSASIVDRAMFHADNAYYLGEATVNGHRCKTHTASN
CCCCCCCEEEEEEEECCCCCCCCCCHHHHHHHHHHHCCCEEEEEEEEECCCEEECCCCCC
TAYRGFGGPQGMVAIEEVMDCIARFLGKDPLHVRKANYYGKTERNVTHYYQTVEHNLLEE
CCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCCCCHHHHHHHHHHHHHHH
MTADLEQSSQYAERREAIRAFNAGSPVLKKGLALTPVKFGISFTASFLNQAGALIHIYTD
HHHHHHHHHHHHHHHHHHHHCCCCCHHHHCCCEECCHHHHHHHHHHHHHCCCCEEEEEEC
GSIHLNHGGTEMGQGLNTKVAQVVAEVFQVDIERIQITATNTDKVPNTSPTAASSGTDLN
CEEEECCCCHHHCCCCCHHHHHHHHHHHHHEEEEEEEEECCCCCCCCCCCCCCCCCCCCC
GKAAQNAAEILKQRLVEFAARHHQVSEAEVEFRNGHVRIGELFLPFAELAQLAWMGQVSL
CHHHHHHHHHHHHHHHHHHHHHCCCCCHHEEECCCCEEEHHHHCCHHHHHHHHHHCCEEE
SSTGYYKTPKIFYDRSQARGRPFYYYAFGAACVEVIVDTLTGEYKMLRTDILHDVGASLN
CCCCCCCCCCEEEECHHCCCCCEEEEHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCC
PAIDIGQVEGGYIQGAGWLTTEELVWNDKGKLMTSGPASYKIPAVADMPLDLRIKLVENR
CCEEECCCCCCEEECCCCCEEHHHEECCCCCEEECCCCCEECCEEECCCCCEEEEEECCC
KNPEDTVFHSKAVGEPPFMLGIAAWCAIKDAVASLGDYRHQPNIDAPATPEKVLWGCEQM
CCCHHHHEEHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHH
RQNSAARRASSEGAEPIVSASSRASEASPGSPSPIQDAPVGASLLAKAPGLDHSVLEQK
HHHHHHHHHCCCCCCCHHHCCCCCCCCCCCCCCCCCCCCCCHHHHHCCCCCCHHHHCCC
>Mature Secondary Structure 
SEHSSNSTQAEMLAVFQQGLNTGVGRSVKHDSADKHVSGEAVYIDDRLEFPNQLHVYAR
CCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCEEEEECCCCCCCEEEEEEE
LSDRAHARIVSIDTSPCYAFEGVRIAITHQDIPGLKDIGPLLPGDPLLAIDKVEFVGQPV
ECCCCCEEEEEECCCCCEEECCEEEEEEECCCCCHHHHCCCCCCCCEEEEECHHHCCCCH
LAVAARDLDTARQAAMAAIIEYEDLQPVLDVVQALRQKHFVLDSHTHKRGDSAAALARAT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCEEECCCCCCCCCHHHHHHHHH
HRLQGNLHIGGQEHFYLETQISSVMPTEDGGMIVYCSTQNPTEIQKLVAEVLGVPMNRIV
HHHCCCEEECCCCEEEEEEEHHHCCCCCCCCEEEEECCCCHHHHHHHHHHHHCCCHHHHH
VDMRRMGGGFGGKETQAASPACLCAVIARLTGQPTKMRLQRFEDMQMTGKRHPFYIEYDV
HHHHHHCCCCCCCCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCEEEEEEC
GFDDDGRLQGIQLDLAGNCGYSPDLSASIVDRAMFHADNAYYLGEATVNGHRCKTHTASN
CCCCCCCEEEEEEEECCCCCCCCCCHHHHHHHHHHHCCCEEEEEEEEECCCEEECCCCCC
TAYRGFGGPQGMVAIEEVMDCIARFLGKDPLHVRKANYYGKTERNVTHYYQTVEHNLLEE
CCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCCCCHHHHHHHHHHHHHHH
MTADLEQSSQYAERREAIRAFNAGSPVLKKGLALTPVKFGISFTASFLNQAGALIHIYTD
HHHHHHHHHHHHHHHHHHHHCCCCCHHHHCCCEECCHHHHHHHHHHHHHCCCCEEEEEEC
GSIHLNHGGTEMGQGLNTKVAQVVAEVFQVDIERIQITATNTDKVPNTSPTAASSGTDLN
CEEEECCCCHHHCCCCCHHHHHHHHHHHHHEEEEEEEEECCCCCCCCCCCCCCCCCCCCC
GKAAQNAAEILKQRLVEFAARHHQVSEAEVEFRNGHVRIGELFLPFAELAQLAWMGQVSL
CHHHHHHHHHHHHHHHHHHHHHCCCCCHHEEECCCCEEEHHHHCCHHHHHHHHHHCCEEE
SSTGYYKTPKIFYDRSQARGRPFYYYAFGAACVEVIVDTLTGEYKMLRTDILHDVGASLN
CCCCCCCCCCEEEECHHCCCCCEEEEHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCC
PAIDIGQVEGGYIQGAGWLTTEELVWNDKGKLMTSGPASYKIPAVADMPLDLRIKLVENR
CCEEECCCCCCEEECCCCCEEHHHEECCCCCEEECCCCCEECCEEECCCCCEEEEEECCC
KNPEDTVFHSKAVGEPPFMLGIAAWCAIKDAVASLGDYRHQPNIDAPATPEKVLWGCEQM
CCCHHHHEEHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHH
RQNSAARRASSEGAEPIVSASSRASEASPGSPSPIQDAPVGASLLAKAPGLDHSVLEQK
HHHHHHHHHCCCCCCCHHHCCCCCCCCCCCCCCCCCCCCCCHHHHHCCCCCCHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377; 11344136 [H]