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The map label for this gene is uao [H]

Identifier: 66045052

GI number: 66045052

Start: 2081657

End: 2082172

Strand: Reverse

Name: uao [H]

Synonym: Psyr_1808

Alternate gene names: 66045052

Gene position: 2082172-2081657 (Counterclockwise)

Preceding gene: 66045053

Following gene: 66045051

Centisome position: 34.17

GC content: 60.85

Gene sequence:

>516_bases
ATGAGCACGTTCAAGACACTGACACCTTCAAGCCTGGGCCGGGATGCGTTCATCGCGGCCTTTGCCGATATCTACGAACA
CTCACCGTGGGTCGCGCAGCAGGCGTTCGACCAAAGCACAGGCGCGCAACTCGATCAGGTCGAGACCCTGCATGCGCGCA
CGAGCGCGATCCTGCTGGGTGCCACTCACGAGCAACAACTGGCACTGATCAATGCCCACCCGGACCTGGCGGGCAAGGCT
GCCGTTCGAGGCGAGCTGACTCAGGCCAGTACCGATGAACAGGCCGGCGCCGGTATCCACCATTGCACGCCTGAGGAGTT
CCAGCGCTTTACCGAGCTGAACGAGGCTTACAAGGCCCGCTTCGGCTTTCCGTTCATCATGGCGGTCAAGGGCAGCGACA
GGCATAAGATTCTGGCGGCGTTCGAGCAACGCATTCACCACTCGCTCGAGGCCGAGTTCGCTTGCGCCCTGTCCGAGATC
AACAAGATCGCACTGTTTCGTCTACAGGCGCTTTGA

Upstream 100 bases:

>100_bases
TCGAGTACGCCAAAGGCCATGAGCAGGTGTGGTTTGCCCGTCGTGTCGATATCGCCCGGCACTGGCACACTGAATATCCA
TTTACCGGCAAGGCCGAGCA

Downstream 100 bases:

>100_bases
GCGTCGCAGTCATAACCGTATTCAGAAGGCAGACAAAGAGCATGAAAGTTTACGCCGCACCGTTCGAGAAGTTCGTGAAC
CTGGCCGACGCGCGTCTGGG

Product: hypothetical protein

Products: NA

Alternate protein names: 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase; OHCU decarboxylase; Uricase; Urate oxidase [H]

Number of amino acids: Translated: 171; Mature: 170

Protein sequence:

>171_residues
MSTFKTLTPSSLGRDAFIAAFADIYEHSPWVAQQAFDQSTGAQLDQVETLHARTSAILLGATHEQQLALINAHPDLAGKA
AVRGELTQASTDEQAGAGIHHCTPEEFQRFTELNEAYKARFGFPFIMAVKGSDRHKILAAFEQRIHHSLEAEFACALSEI
NKIALFRLQAL

Sequences:

>Translated_171_residues
MSTFKTLTPSSLGRDAFIAAFADIYEHSPWVAQQAFDQSTGAQLDQVETLHARTSAILLGATHEQQLALINAHPDLAGKA
AVRGELTQASTDEQAGAGIHHCTPEEFQRFTELNEAYKARFGFPFIMAVKGSDRHKILAAFEQRIHHSLEAEFACALSEI
NKIALFRLQAL
>Mature_170_residues
STFKTLTPSSLGRDAFIAAFADIYEHSPWVAQQAFDQSTGAQLDQVETLHARTSAILLGATHEQQLALINAHPDLAGKAA
VRGELTQASTDEQAGAGIHHCTPEEFQRFTELNEAYKARFGFPFIMAVKGSDRHKILAAFEQRIHHSLEAEFACALSEIN
KIALFRLQAL

Specific function: Catalyzes two steps in the degradation of uric acid, i.e. the oxidation of uric acid to 5-hydroxyisourate (HIU) and the stereoselective decarboxylation of 2-oxo-4-hydroxy-4-carboxy-5- ureidoimidazoline (OHCU) to (S)-allantoin [H]

COG id: COG3195

COG function: function code S; Uncharacterized protein conserved in bacteria

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the uricase family [H]

Homologues:

Organism=Homo sapiens, GI157743280, Length=155, Percent_Identity=34.8387096774194, Blast_Score=90, Evalue=1e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018020
- InterPro:   IPR017580
- InterPro:   IPR002042
- InterPro:   IPR019842 [H]

Pfam domain/function: PF09349 OHCU_decarbox; PF01014 Uricase [H]

EC number: =1.7.3.3 [H]

Molecular weight: Translated: 18806; Mature: 18675

Theoretical pI: Translated: 6.22; Mature: 6.22

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
0.6 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTFKTLTPSSLGRDAFIAAFADIYEHSPWVAQQAFDQSTGAQLDQVETLHARTSAILLG
CCCCCCCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHCCCCCCCHHHHHHHHHHHHEEEEE
ATHEQQLALINAHPDLAGKAAVRGELTQASTDEQAGAGIHHCTPEEFQRFTELNEAYKAR
CCCCCEEEEEECCCCCCCCHHHHCCCCCCCCCHHHCCCCCCCCHHHHHHHHHHHHHHHHH
FGFPFIMAVKGSDRHKILAAFEQRIHHSLEAEFACALSEINKIALFRLQAL
CCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECC
>Mature Secondary Structure 
STFKTLTPSSLGRDAFIAAFADIYEHSPWVAQQAFDQSTGAQLDQVETLHARTSAILLG
CCCCCCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHCCCCCCCHHHHHHHHHHHHEEEEE
ATHEQQLALINAHPDLAGKAAVRGELTQASTDEQAGAGIHHCTPEEFQRFTELNEAYKAR
CCCCCEEEEEECCCCCCCCHHHHCCCCCCCCCHHHCCCCCCCCHHHHHHHHHHHHHHHHH
FGFPFIMAVKGSDRHKILAAFEQRIHHSLEAEFACALSEINKIALFRLQAL
CCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8907179 [H]