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The map label for this gene is lon [H]

Identifier: 66044994

GI number: 66044994

Start: 1987022

End: 1989418

Strand: Direct

Name: lon [H]

Synonym: Psyr_1749

Alternate gene names: 66044994

Gene position: 1987022-1989418 (Clockwise)

Preceding gene: 66044993

Following gene: 66044995

Centisome position: 32.61

GC content: 57.41

Gene sequence:

>2397_bases
ATGAAGACCACTATTGAATTGCCTCTCTTGCCATTGCGTGATGTCGTGGTTTATCCGCACATGGTGATCCCGCTGTTCGT
GGGGCGCGAGAAGTCTATCGAAGCCCTTGAAGCGGCAATGACAGGCGACAAGCAGATCCTGCTGCTCGCGCAAAGAAACC
CGGCTGACGACGATCCTGATGAAAAGGCTCTGTACAGCGTCGGCACCATCGCCACCGTATTGCAGTTGCTCAAGCTGCCC
GATGGCACCGTCAAGGTGCTGGTCGAAGGCGAGCAGCGCGGTTCGGTAGAGCGTTTCATCGAAGTCGATGGCCACTACCG
CGCAGACGTCGCGCTAATCGAAGAAATCGATGCGCCGGACCGTGAATCCGAAGTCTTCGTGCGCAGCCTGCTGGCTCAGT
TCGAGCAGTACGTGCAACTGGGCAAGAAAGTCCCCGCAGAGGTCCTGTCGTCGCTTAACAGCATCGATGAGCCGGGTCGC
CTGGTTGACACCATGGCTGCGCACATGGCGCTCAAAATCGAGCAGAAGCAGGAAATCCTCGAGATTATCGACCTGTCAGC
CCGTGTCGAGCACGTGCTGGCCTTGCTGGATGCCGAAATCGACCTGCTGCAGGTCGAAAAGCGCATTCGCGGTCGCGTGA
AAAAGCAAATGGAGCGCAGCCAGCGCGAGTACTACCTGAATGAGCAGATGAAGGCCATTCAGAAGGAGCTCGGCGATGGC
GACGAAGGCCACAACGAAATCGAAGAGCTGAAAAAGCGTATCGACGCTGCGGGCCTGCCCAAGGATGCTCTGACCAAGGC
GAATGCCGAGCTGAACAAGCTCAAGCAAATGTCGCCGATGTCGGCTGAAGCGACCGTGGTGCGCTCCTACATTGACTGGC
TGGTTCAGGTGCCGTGGAAGGCGCAGAGCAAAGTACGTCTGGACCTTGCGCGTGCCGAAGCGATTCTCGATGCCGACCAC
TATGGTCTGGACGAGGTCAAGGAACGCATCCTCGAATACCTCGCCGTGCAGAAGCGCGTGAAGAAGATTCGCGGCCCTGT
GCTGTGTCTGGTAGGTCCACCGGGTGTGGGTAAAACCTCCCTGGCCGAGTCCATCGCCAACGCGACCAATCGCAAATTCG
TGCGTATGGCACTCGGTGGCGTGCGTGACGAGGCTGAAATTCGTGGTCACCGCCGGACTTACATCGGTTCGATGCCAGGA
AGATTGATACAAAAGATGACAAAGGTGGGCGTTCGCAACCCGCTGTTCCTGCTTGACGAAATCGACAAGATGGGCAGCGA
CATGCGTGGCGACCCGGCGTCGGCGTTGCTCGAGGTGCTTGATCCCGAGCAGAACCACAATTTCAACGATCACTACCTTG
AGGTCGACTACGATCTTTCGGACGTGATGTTCCTCTGCACGTCGAACTCGATGAACATTCCGCCAGCGCTGCTGGACCGG
ATGGAAGTCATCCGCCTGCCGGGCTACACCGAAGACGAAAAGATCAACATCGCGGTCAAATACCTCTCGCCCAAGCAGAT
TCAGGCCAATGGCTTGAAGAAAGGCGAGATCAGCTTTGACGAGGAAGCGATCCGCGACATCATTCGTTACTACACCCGTG
AAGCGGGCGTGCGCGGGCTTGAGCGTCAGATTGCCAAGGTCTGCCGCAAGGCGGTCAAAGAGCACGCGATGGAAAAACGT
TTTGCGGTGCAGGTCACGGCCGACATGCTCGAGCACTTCCTGGGCGTGCGCAAGTTCCGCTACGGGCTGGCAGAGCAGCA
GGATCAGATCGGTCAGGTGACCGGTCTGGCGTGGACCCAGGTGGGCGGTGAATTGCTGACCATCGAGGCTGCCGTGGTAT
CGGGCAAGGGCCAGTTGATCAAGACCGGTTCGCTGGGTGATGTGATGGTCGAATCCATTACTGCAGCCCAGACCGTGGTT
CGCAGCCGTGCCCGCAGCCTGGGCATTCCAGCTGATTTCCACGAGAAGCACGACACGCATATCCACATGCCGGAAGGTGC
TACGCCGAAGGATGGGCCGAGTGCTGGCGTGGGCATGTGCACTGCACTTGTCTCGGCGCTTACACAGATTCCGGTGCGGG
CAGATGTGGCAATGACGGGCGAAATTACCCTGCGTGGTCAAGTGCTGGCGATTGGTGGTTTGAAGGAAAAACTTCTGGCC
GCACACCGTGGTGGAATCAAGACGGTGATCATCCCAGAAGAAAACGTGCGTGATTTGAAGGAGATTCCTGACAATATCAA
GCAGGATCTGCAGATCAAGCCCGTTAAATGGATTGACGAAGTCCTGCAAATTGCGCTGCAATACGCGCCGGAGCCTTTGC
CGGACGTGGCTACAGATCTGGTCGCCAAGGAAGAGAAGCGCGAGTCTGACTCTAAGGACAGAATTAGCACGCATTAA

Upstream 100 bases:

>100_bases
GTCGCGCCTCTAGAGCTTGTTTTTTTTGGACGCTACCCCCATCTTGGCTTCAAGCTAATTCCATCTGTCCCGGCCAATGG
GCCGCCGTAGAGGCGAAATC

Downstream 100 bases:

>100_bases
GTCTGGGCAGGCTTCCTTGACAGCTTTTTGGAGCCCTTGTTATAAAGCGGCTCTTTAAAGCAATCACCGGCAAGCCTTCC
AGCGCTCGTTTTGCTTAACA

Product: peptidase S16, ATP-dependent protease La

Products: NA

Alternate protein names: ATP-dependent protease La [H]

Number of amino acids: Translated: 798; Mature: 798

Protein sequence:

>798_residues
MKTTIELPLLPLRDVVVYPHMVIPLFVGREKSIEALEAAMTGDKQILLLAQRNPADDDPDEKALYSVGTIATVLQLLKLP
DGTVKVLVEGEQRGSVERFIEVDGHYRADVALIEEIDAPDRESEVFVRSLLAQFEQYVQLGKKVPAEVLSSLNSIDEPGR
LVDTMAAHMALKIEQKQEILEIIDLSARVEHVLALLDAEIDLLQVEKRIRGRVKKQMERSQREYYLNEQMKAIQKELGDG
DEGHNEIEELKKRIDAAGLPKDALTKANAELNKLKQMSPMSAEATVVRSYIDWLVQVPWKAQSKVRLDLARAEAILDADH
YGLDEVKERILEYLAVQKRVKKIRGPVLCLVGPPGVGKTSLAESIANATNRKFVRMALGGVRDEAEIRGHRRTYIGSMPG
RLIQKMTKVGVRNPLFLLDEIDKMGSDMRGDPASALLEVLDPEQNHNFNDHYLEVDYDLSDVMFLCTSNSMNIPPALLDR
MEVIRLPGYTEDEKINIAVKYLSPKQIQANGLKKGEISFDEEAIRDIIRYYTREAGVRGLERQIAKVCRKAVKEHAMEKR
FAVQVTADMLEHFLGVRKFRYGLAEQQDQIGQVTGLAWTQVGGELLTIEAAVVSGKGQLIKTGSLGDVMVESITAAQTVV
RSRARSLGIPADFHEKHDTHIHMPEGATPKDGPSAGVGMCTALVSALTQIPVRADVAMTGEITLRGQVLAIGGLKEKLLA
AHRGGIKTVIIPEENVRDLKEIPDNIKQDLQIKPVKWIDEVLQIALQYAPEPLPDVATDLVAKEEKRESDSKDRISTH

Sequences:

>Translated_798_residues
MKTTIELPLLPLRDVVVYPHMVIPLFVGREKSIEALEAAMTGDKQILLLAQRNPADDDPDEKALYSVGTIATVLQLLKLP
DGTVKVLVEGEQRGSVERFIEVDGHYRADVALIEEIDAPDRESEVFVRSLLAQFEQYVQLGKKVPAEVLSSLNSIDEPGR
LVDTMAAHMALKIEQKQEILEIIDLSARVEHVLALLDAEIDLLQVEKRIRGRVKKQMERSQREYYLNEQMKAIQKELGDG
DEGHNEIEELKKRIDAAGLPKDALTKANAELNKLKQMSPMSAEATVVRSYIDWLVQVPWKAQSKVRLDLARAEAILDADH
YGLDEVKERILEYLAVQKRVKKIRGPVLCLVGPPGVGKTSLAESIANATNRKFVRMALGGVRDEAEIRGHRRTYIGSMPG
RLIQKMTKVGVRNPLFLLDEIDKMGSDMRGDPASALLEVLDPEQNHNFNDHYLEVDYDLSDVMFLCTSNSMNIPPALLDR
MEVIRLPGYTEDEKINIAVKYLSPKQIQANGLKKGEISFDEEAIRDIIRYYTREAGVRGLERQIAKVCRKAVKEHAMEKR
FAVQVTADMLEHFLGVRKFRYGLAEQQDQIGQVTGLAWTQVGGELLTIEAAVVSGKGQLIKTGSLGDVMVESITAAQTVV
RSRARSLGIPADFHEKHDTHIHMPEGATPKDGPSAGVGMCTALVSALTQIPVRADVAMTGEITLRGQVLAIGGLKEKLLA
AHRGGIKTVIIPEENVRDLKEIPDNIKQDLQIKPVKWIDEVLQIALQYAPEPLPDVATDLVAKEEKRESDSKDRISTH
>Mature_798_residues
MKTTIELPLLPLRDVVVYPHMVIPLFVGREKSIEALEAAMTGDKQILLLAQRNPADDDPDEKALYSVGTIATVLQLLKLP
DGTVKVLVEGEQRGSVERFIEVDGHYRADVALIEEIDAPDRESEVFVRSLLAQFEQYVQLGKKVPAEVLSSLNSIDEPGR
LVDTMAAHMALKIEQKQEILEIIDLSARVEHVLALLDAEIDLLQVEKRIRGRVKKQMERSQREYYLNEQMKAIQKELGDG
DEGHNEIEELKKRIDAAGLPKDALTKANAELNKLKQMSPMSAEATVVRSYIDWLVQVPWKAQSKVRLDLARAEAILDADH
YGLDEVKERILEYLAVQKRVKKIRGPVLCLVGPPGVGKTSLAESIANATNRKFVRMALGGVRDEAEIRGHRRTYIGSMPG
RLIQKMTKVGVRNPLFLLDEIDKMGSDMRGDPASALLEVLDPEQNHNFNDHYLEVDYDLSDVMFLCTSNSMNIPPALLDR
MEVIRLPGYTEDEKINIAVKYLSPKQIQANGLKKGEISFDEEAIRDIIRYYTREAGVRGLERQIAKVCRKAVKEHAMEKR
FAVQVTADMLEHFLGVRKFRYGLAEQQDQIGQVTGLAWTQVGGELLTIEAAVVSGKGQLIKTGSLGDVMVESITAAQTVV
RSRARSLGIPADFHEKHDTHIHMPEGATPKDGPSAGVGMCTALVSALTQIPVRADVAMTGEITLRGQVLAIGGLKEKLLA
AHRGGIKTVIIPEENVRDLKEIPDNIKQDLQIKPVKWIDEVLQIALQYAPEPLPDVATDLVAKEEKRESDSKDRISTH

Specific function: ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced

COG id: COG0466

COG function: function code O; ATP-dependent Lon protease, bacterial type

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 Lon domain [H]

Homologues:

Organism=Homo sapiens, GI31377667, Length=775, Percent_Identity=38.9677419354839, Blast_Score=511, Evalue=1e-144,
Organism=Homo sapiens, GI21396489, Length=686, Percent_Identity=39.6501457725948, Blast_Score=497, Evalue=1e-140,
Organism=Escherichia coli, GI1786643, Length=767, Percent_Identity=70.013037809648, Blast_Score=1088, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17505831, Length=684, Percent_Identity=40.7894736842105, Blast_Score=483, Evalue=1e-136,
Organism=Caenorhabditis elegans, GI17556486, Length=791, Percent_Identity=32.3640960809102, Blast_Score=419, Evalue=1e-117,
Organism=Saccharomyces cerevisiae, GI6319449, Length=675, Percent_Identity=40, Blast_Score=501, Evalue=1e-142,
Organism=Drosophila melanogaster, GI221513036, Length=625, Percent_Identity=43.68, Blast_Score=497, Evalue=1e-140,
Organism=Drosophila melanogaster, GI24666867, Length=625, Percent_Identity=43.68, Blast_Score=496, Evalue=1e-140,

Paralogues:

None

Copy number: 2,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR003959
- InterPro:   IPR008269
- InterPro:   IPR004815
- InterPro:   IPR003111
- InterPro:   IPR001984
- InterPro:   IPR015947
- InterPro:   IPR020568 [H]

Pfam domain/function: PF00004 AAA; PF02190 LON; PF05362 Lon_C [H]

EC number: =3.4.21.53 [H]

Molecular weight: Translated: 88858; Mature: 88858

Theoretical pI: Translated: 5.72; Mature: 5.72

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKTTIELPLLPLRDVVVYPHMVIPLFVGREKSIEALEAAMTGDKQILLLAQRNPADDDPD
CCCEEECCCCCHHHHHHCCHHHHHHHCCCCHHHHHHHHHHCCCCEEEEEEECCCCCCCCC
EKALYSVGTIATVLQLLKLPDGTVKVLVEGEQRGSVERFIEVDGHYRADVALIEEIDAPD
HHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCHHHHHEECCCCCHHHHHHHHCCCCC
RESEVFVRSLLAQFEQYVQLGKKVPAEVLSSLNSIDEPGRLVDTMAAHMALKIEQKQEIL
CHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHH
EIIDLSARVEHVLALLDAEIDLLQVEKRIRGRVKKQMERSQREYYLNEQMKAIQKELGDG
HHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
DEGHNEIEELKKRIDAAGLPKDALTKANAELNKLKQMSPMSAEATVVRSYIDWLVQVPWK
CCCHHHHHHHHHHHCCCCCCHHHHHHCCHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCC
AQSKVRLDLARAEAILDADHYGLDEVKERILEYLAVQKRVKKIRGPVLCLVGPPGVGKTS
CCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCHHH
LAESIANATNRKFVRMALGGVRDEAEIRGHRRTYIGSMPGRLIQKMTKVGVRNPLFLLDE
HHHHHHHHHHHHHHHHHHCCCCCHHHHCCCHHHHHCCCHHHHHHHHHHHCCCCCHHHHHH
IDKMGSDMRGDPASALLEVLDPEQNHNFNDHYLEVDYDLSDVMFLCTSNSMNIPPALLDR
HHHHCCCCCCCHHHHHHHHHCCCCCCCCCCCEEEEECCHHHEEEEEECCCCCCCHHHHHH
MEVIRLPGYTEDEKINIAVKYLSPKQIQANGLKKGEISFDEEAIRDIIRYYTREAGVRGL
HHHHCCCCCCCCCEEEEEEEECCCCHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHH
ERQIAKVCRKAVKEHAMEKRFAVQVTADMLEHFLGVRKFRYGLAEQQDQIGQVTGLAWTQ
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHH
VGGELLTIEAAVVSGKGQLIKTGSLGDVMVESITAAQTVVRSRARSLGIPADFHEKHDTH
CCCEEEEEEEEEECCCCCEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCE
IHMPEGATPKDGPSAGVGMCTALVSALTQIPVRADVAMTGEITLRGQVLAIGGLKEKLLA
EECCCCCCCCCCCCCHHHHHHHHHHHHHHCCCEECEEEECEEEEEEEEEEECCHHHHHHH
AHRGGIKTVIIPEENVRDLKEIPDNIKQDLQIKPVKWIDEVLQIALQYAPEPLPDVATDL
HHCCCCEEEEECCCCHHHHHHCCHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHH
VAKEEKRESDSKDRISTH
HHHHHHHCCCCCCCCCCC
>Mature Secondary Structure
MKTTIELPLLPLRDVVVYPHMVIPLFVGREKSIEALEAAMTGDKQILLLAQRNPADDDPD
CCCEEECCCCCHHHHHHCCHHHHHHHCCCCHHHHHHHHHHCCCCEEEEEEECCCCCCCCC
EKALYSVGTIATVLQLLKLPDGTVKVLVEGEQRGSVERFIEVDGHYRADVALIEEIDAPD
HHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCHHHHHEECCCCCHHHHHHHHCCCCC
RESEVFVRSLLAQFEQYVQLGKKVPAEVLSSLNSIDEPGRLVDTMAAHMALKIEQKQEIL
CHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHH
EIIDLSARVEHVLALLDAEIDLLQVEKRIRGRVKKQMERSQREYYLNEQMKAIQKELGDG
HHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
DEGHNEIEELKKRIDAAGLPKDALTKANAELNKLKQMSPMSAEATVVRSYIDWLVQVPWK
CCCHHHHHHHHHHHCCCCCCHHHHHHCCHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCC
AQSKVRLDLARAEAILDADHYGLDEVKERILEYLAVQKRVKKIRGPVLCLVGPPGVGKTS
CCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCHHH
LAESIANATNRKFVRMALGGVRDEAEIRGHRRTYIGSMPGRLIQKMTKVGVRNPLFLLDE
HHHHHHHHHHHHHHHHHHCCCCCHHHHCCCHHHHHCCCHHHHHHHHHHHCCCCCHHHHHH
IDKMGSDMRGDPASALLEVLDPEQNHNFNDHYLEVDYDLSDVMFLCTSNSMNIPPALLDR
HHHHCCCCCCCHHHHHHHHHCCCCCCCCCCCEEEEECCHHHEEEEEECCCCCCCHHHHHH
MEVIRLPGYTEDEKINIAVKYLSPKQIQANGLKKGEISFDEEAIRDIIRYYTREAGVRGL
HHHHCCCCCCCCCEEEEEEEECCCCHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHH
ERQIAKVCRKAVKEHAMEKRFAVQVTADMLEHFLGVRKFRYGLAEQQDQIGQVTGLAWTQ
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHH
VGGELLTIEAAVVSGKGQLIKTGSLGDVMVESITAAQTVVRSRARSLGIPADFHEKHDTH
CCCEEEEEEEEEECCCCCEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCE
IHMPEGATPKDGPSAGVGMCTALVSALTQIPVRADVAMTGEITLRGQVLAIGGLKEKLLA
EECCCCCCCCCCCCCHHHHHHHHHHHHHHCCCEECEEEECEEEEEEEEEEECCHHHHHHH
AHRGGIKTVIIPEENVRDLKEIPDNIKQDLQIKPVKWIDEVLQIALQYAPEPLPDVATDL
HHCCCCEEEEECCCCHHHHHHCCHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHH
VAKEEKRESDSKDRISTH
HHHHHHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8981986; 12620739 [H]