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The map label for this gene is marR [H]

Identifier: 66044974

GI number: 66044974

Start: 1963239

End: 1963727

Strand: Direct

Name: marR [H]

Synonym: Psyr_1729

Alternate gene names: 66044974

Gene position: 1963239-1963727 (Clockwise)

Preceding gene: 66044973

Following gene: 66044975

Centisome position: 32.22

GC content: 57.87

Gene sequence:

>489_bases
ATGAAACATTTCAGCCCCGACAATTTTGAATCCAGCCTCATCGGGCTGCTGGTCGGTCGTACCAATGCGCTCAAAGACCG
CATGCTCGACAAGTACCTGCTGCCCTATGACGTAACGTTCGCGCAATTCAAGGTGCTGATCATCATTGCCCAGTTTTCTA
CCGATACCCCCGTGGAATTGTGTCGGCACCTGTCGCTGGACAGTGGTTCGATGACCCGCATGCTCGATCGCCTGGAACAG
AAGGGGCTGGTGGTGCGCCAGCGCTCCGCGACCGATCGCCGTCAGGTGCGTCTGGCGCTGACCGAGCAGGGGCAGGCGCT
CTCCGATCTGCTGCCGCAGATTGGCGCGGACGCGATGAACGACACGTTCGCGGCGCTCGACAGTGAAGAGGTCGAGAGCC
TGAAAAGAATTCTCACCAAAGTGCTGGTGGCTGCTGATGACCACATCACTCTGACTCGTTTGAGCTTCAACCCCAAAGCT
AAACGCTGA

Upstream 100 bases:

>100_bases
TTATGGGCATTTAGTAAGCAAGCTAATAAATGCTTTGACAACGGCTGCCTAGGCAGTAATATTTTGCAATCACTGCCTAG
GCAGCTATCTGGGTCAATCC

Downstream 100 bases:

>100_bases
GCGGCCGACGTGTTGGCAGGCGTGAGCCTGATCGCCGTCGTTCCGTCGCTTCGCTGATTAAAGGTAACTGCCATGGCCAC
TGCTGCCGCTGAAAACACAT

Product: regulatory protein, MarR

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 162; Mature: 162

Protein sequence:

>162_residues
MKHFSPDNFESSLIGLLVGRTNALKDRMLDKYLLPYDVTFAQFKVLIIIAQFSTDTPVELCRHLSLDSGSMTRMLDRLEQ
KGLVVRQRSATDRRQVRLALTEQGQALSDLLPQIGADAMNDTFAALDSEEVESLKRILTKVLVAADDHITLTRLSFNPKA
KR

Sequences:

>Translated_162_residues
MKHFSPDNFESSLIGLLVGRTNALKDRMLDKYLLPYDVTFAQFKVLIIIAQFSTDTPVELCRHLSLDSGSMTRMLDRLEQ
KGLVVRQRSATDRRQVRLALTEQGQALSDLLPQIGADAMNDTFAALDSEEVESLKRILTKVLVAADDHITLTRLSFNPKA
KR
>Mature_162_residues
MKHFSPDNFESSLIGLLVGRTNALKDRMLDKYLLPYDVTFAQFKVLIIIAQFSTDTPVELCRHLSLDSGSMTRMLDRLEQ
KGLVVRQRSATDRRQVRLALTEQGQALSDLLPQIGADAMNDTFAALDSEEVESLKRILTKVLVAADDHITLTRLSFNPKA
KR

Specific function: Repressor of the marRAB operon which is involved in the activation of both antibiotic resistance and oxidative stress genes. Binds to the marO operator/promoter site [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH marR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI87081927, Length=130, Percent_Identity=43.8461538461538, Blast_Score=96, Evalue=2e-21,
Organism=Escherichia coli, GI87081950, Length=115, Percent_Identity=29.5652173913043, Blast_Score=60, Evalue=5e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000835
- InterPro:   IPR023187
- InterPro:   IPR011991 [H]

Pfam domain/function: PF01047 MarR [H]

EC number: NA

Molecular weight: Translated: 18247; Mature: 18247

Theoretical pI: Translated: 8.49; Mature: 8.49

Prosite motif: PS01117 HTH_MARR_1 ; PS50995 HTH_MARR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKHFSPDNFESSLIGLLVGRTNALKDRMLDKYLLPYDVTFAQFKVLIIIAQFSTDTPVEL
CCCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCHHHHHEEEEEEEECCCCCHHHH
CRHLSLDSGSMTRMLDRLEQKGLVVRQRSATDRRQVRLALTEQGQALSDLLPQIGADAMN
HHHCCCCCCHHHHHHHHHHHCCCEEECCCCCHHHHEEHHHHHCCCHHHHHHHHHCCCHHC
DTFAALDSEEVESLKRILTKVLVAADDHITLTRLSFNPKAKR
HHHHHCCHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCC
>Mature Secondary Structure
MKHFSPDNFESSLIGLLVGRTNALKDRMLDKYLLPYDVTFAQFKVLIIIAQFSTDTPVEL
CCCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCHHHHHEEEEEEEECCCCCHHHH
CRHLSLDSGSMTRMLDRLEQKGLVVRQRSATDRRQVRLALTEQGQALSDLLPQIGADAMN
HHHCCCCCCHHHHHHHHHHHCCCEEECCCCCHHHHEEHHHHHCCCHHHHHHHHHCCCHHC
DTFAALDSEEVESLKRILTKVLVAADDHITLTRLSFNPKAKR
HHHHHCCHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8383113; 9097039; 9278503; 8282690; 7768850; 10760140 [H]