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The map label for this gene is tetA [H]

Identifier: 66044951

GI number: 66044951

Start: 1930813

End: 1932048

Strand: Direct

Name: tetA [H]

Synonym: Psyr_1706

Alternate gene names: 66044951

Gene position: 1930813-1932048 (Clockwise)

Preceding gene: 66044950

Following gene: 66044954

Centisome position: 31.69

GC content: 60.03

Gene sequence:

>1236_bases
ATGCCTGGAGGTTACTCAAAAGGTGACACCCGTCCACCCATGCGCTTCATTCTTCTGATATTGGGGCTCGATGTGCTTGG
CATCGGTCTGGCGATCCCTGTCATGCCGACGCTGATCGCGACTATCTGGCCATCGTCTACCGAGCATGTCTCGTTGGCGC
TGGGTGTGGCGTTGACACTTTATTCAGCAATGCAGTTTCTGTGTGCGCCGCTGCTGGGGGCGCTGAGCGACTGCCATGGG
CGTCGACCGATATTGCTTCTGGCGCTGGCCGGCATGTGCCTGGGCAATCTGATGGCTGGCTTCGCCGGCAGCCTGACGGT
CTTGCTGATAGGCCGTGCCATCGCAGGAATCACTGCCGCCAATATCGCCACTGCGATGGCCTATATTGCGGACATCAGTG
AGGGTGAGCAGCGCACGCATTTCTACGGTGCAGCGGGCAGTGTCATCGCCATAGCGCTTGTTTTCGGCCCGGTCATAGGC
GGGGGACTTGCGTCTTACGGACCGCACTTGCCCTTTCTGGTCGCTGGCGGCCTGGCGGCAATCAACCTGCTGTATGGCTA
CATGAGGTTGCCGGAAAGCCTTGCGGCCGAGCATCGGCGTGCTTTCGAATGGCGGCGAACCAACCCGTTTGGCAGCCTGC
GAGGACTCTGGAGTACGCAAGGCCTGCGGCCGTATCTGCTGGCTGCGACGTGCTCGTGGTTCGCCTACGGGATATTTCAA
AGCTGCTTTGTGCTGGCCAATCAGATGCGTTATGGCTGGAGCATGCTTGAAGTGTCGTACGCATTGGCGGCACTCGCCCT
GGGCATGGCGTTCGCGCAGCGCGTACTGGTACGCAAGCTGACGCCAATCATGTCCAACCAGCGGATCATCGTTACAGGTT
ATGCCTGTTGCCTGCTGGGTTATGGTTTCTATACGGCTGCTGCAAGCGTCTGGCTGACGGTGGTGGGCATGTGTTTCCAT
GCTGTCGGACTGATCGCCGAGCCGGCATTGCGCAGTGAGCTCTCGCGTCATGCCAGTGCAGGGCATCAGGGCGAGTTGCA
GGGCGGGCTGACATCCCTGTTGAGTCTGGTGGGCGGTGTAGCGCCAGTGATTGGCGCCCTGATATTTGCGGGTAACGTTG
GCTCAGGCCAGCATGTCCTGTGGCTGGGCGCTCCCTTTCTGGTCAGCCTGTTGATGTACGTGCTGGCGATAGGCTGCATC
CAGAGGGGGAGAACGTCAGCCGCCTGTAACGGTTGA

Upstream 100 bases:

>100_bases
CGAGCAACTCGCCGAGTGTGATCGATAACCCGTTCTTTGCGGAACATGGCGAGCAGGCTCAGCGCCTGCTCGCCTACATT
AATCAGTCTGAGGTTTACAT

Downstream 100 bases:

>100_bases
TCCTCGCGCTGGTAACCCATCAGCCTCCGCCGAGCACCACACTCAGCGCGTTGCGTGCATCGTCCAGTTGCACCAGCGAG
GCGTGGCGTGCGCCCAGCGC

Product: major facilitator transporter

Products: NA

Alternate protein names: TetA(C) [H]

Number of amino acids: Translated: 411; Mature: 410

Protein sequence:

>411_residues
MPGGYSKGDTRPPMRFILLILGLDVLGIGLAIPVMPTLIATIWPSSTEHVSLALGVALTLYSAMQFLCAPLLGALSDCHG
RRPILLLALAGMCLGNLMAGFAGSLTVLLIGRAIAGITAANIATAMAYIADISEGEQRTHFYGAAGSVIAIALVFGPVIG
GGLASYGPHLPFLVAGGLAAINLLYGYMRLPESLAAEHRRAFEWRRTNPFGSLRGLWSTQGLRPYLLAATCSWFAYGIFQ
SCFVLANQMRYGWSMLEVSYALAALALGMAFAQRVLVRKLTPIMSNQRIIVTGYACCLLGYGFYTAAASVWLTVVGMCFH
AVGLIAEPALRSELSRHASAGHQGELQGGLTSLLSLVGGVAPVIGALIFAGNVGSGQHVLWLGAPFLVSLLMYVLAIGCI
QRGRTSAACNG

Sequences:

>Translated_411_residues
MPGGYSKGDTRPPMRFILLILGLDVLGIGLAIPVMPTLIATIWPSSTEHVSLALGVALTLYSAMQFLCAPLLGALSDCHG
RRPILLLALAGMCLGNLMAGFAGSLTVLLIGRAIAGITAANIATAMAYIADISEGEQRTHFYGAAGSVIAIALVFGPVIG
GGLASYGPHLPFLVAGGLAAINLLYGYMRLPESLAAEHRRAFEWRRTNPFGSLRGLWSTQGLRPYLLAATCSWFAYGIFQ
SCFVLANQMRYGWSMLEVSYALAALALGMAFAQRVLVRKLTPIMSNQRIIVTGYACCLLGYGFYTAAASVWLTVVGMCFH
AVGLIAEPALRSELSRHASAGHQGELQGGLTSLLSLVGGVAPVIGALIFAGNVGSGQHVLWLGAPFLVSLLMYVLAIGCI
QRGRTSAACNG
>Mature_410_residues
PGGYSKGDTRPPMRFILLILGLDVLGIGLAIPVMPTLIATIWPSSTEHVSLALGVALTLYSAMQFLCAPLLGALSDCHGR
RPILLLALAGMCLGNLMAGFAGSLTVLLIGRAIAGITAANIATAMAYIADISEGEQRTHFYGAAGSVIAIALVFGPVIGG
GLASYGPHLPFLVAGGLAAINLLYGYMRLPESLAAEHRRAFEWRRTNPFGSLRGLWSTQGLRPYLLAATCSWFAYGIFQS
CFVLANQMRYGWSMLEVSYALAALALGMAFAQRVLVRKLTPIMSNQRIIVTGYACCLLGYGFYTAAASVWLTVVGMCFHA
VGLIAEPALRSELSRHASAGHQGELQGGLTSLLSLVGGVAPVIGALIFAGNVGSGQHVLWLGAPFLVSLLMYVLAIGCIQ
RGRTSAACNG

Specific function: Resistance to tetracycline by an active tetracycline efflux. This is an energy-dependent process that decreases the accumulation of the antibiotic in whole cells. This protein functions as a metal-tetracycline/H(+) antiporter [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. TCR/tet family [H]

Homologues:

Organism=Homo sapiens, GI39753965, Length=377, Percent_Identity=26.790450928382, Blast_Score=112, Evalue=9e-25,
Organism=Homo sapiens, GI94721311, Length=370, Percent_Identity=25.4054054054054, Blast_Score=103, Evalue=2e-22,
Organism=Homo sapiens, GI225703104, Length=140, Percent_Identity=35, Blast_Score=81, Evalue=1e-15,
Organism=Homo sapiens, GI225703102, Length=140, Percent_Identity=35, Blast_Score=81, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI71996331, Length=368, Percent_Identity=25.2717391304348, Blast_Score=100, Evalue=1e-21,
Organism=Drosophila melanogaster, GI21357569, Length=371, Percent_Identity=25.8760107816712, Blast_Score=122, Evalue=5e-28,
Organism=Drosophila melanogaster, GI161080926, Length=371, Percent_Identity=25.8760107816712, Blast_Score=119, Evalue=3e-27,
Organism=Drosophila melanogaster, GI161080924, Length=371, Percent_Identity=25.8760107816712, Blast_Score=119, Evalue=3e-27,
Organism=Drosophila melanogaster, GI24656463, Length=371, Percent_Identity=25.8760107816712, Blast_Score=119, Evalue=4e-27,
Organism=Drosophila melanogaster, GI24656468, Length=371, Percent_Identity=25.8760107816712, Blast_Score=119, Evalue=4e-27,
Organism=Drosophila melanogaster, GI221513297, Length=371, Percent_Identity=24.7978436657682, Blast_Score=94, Evalue=1e-19,
Organism=Drosophila melanogaster, GI17738085, Length=338, Percent_Identity=22.7810650887574, Blast_Score=77, Evalue=2e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196
- InterPro:   IPR005829
- InterPro:   IPR001958 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 43196; Mature: 43065

Theoretical pI: Translated: 8.94; Mature: 8.94

Prosite motif: PS50850 MFS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.4 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
5.8 %Cys+Met (Translated Protein)
2.4 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
5.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPGGYSKGDTRPPMRFILLILGLDVLGIGLAIPVMPTLIATIWPSSTEHVSLALGVALTL
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHH
YSAMQFLCAPLLGALSDCHGRRPILLLALAGMCLGNLMAGFAGSLTVLLIGRAIAGITAA
HHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
NIATAMAYIADISEGEQRTHFYGAAGSVIAIALVFGPVIGGGLASYGPHLPFLVAGGLAA
HHHHHHHHHHHHCCCCHHHHHCCCHHHHHHHHHHHHHHHCCCHHHCCCCCHHHHHHHHHH
INLLYGYMRLPESLAAEHRRAFEWRRTNPFGSLRGLWSTQGLRPYLLAATCSWFAYGIFQ
HHHHHHHHHCCHHHHHHHHHHHHHHCCCCCHHHCCCHHCCCCCHHHHHHHHHHHHHHHHH
SCFVLANQMRYGWSMLEVSYALAALALGMAFAQRVLVRKLTPIMSNQRIIVTGYACCLLG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEHHHHHHHH
YGFYTAAASVWLTVVGMCFHAVGLIAEPALRSELSRHASAGHQGELQGGLTSLLSLVGGV
HHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHH
APVIGALIFAGNVGSGQHVLWLGAPFLVSLLMYVLAIGCIQRGRTSAACNG
HHHHHHHHHCCCCCCCCEEEEECCHHHHHHHHHHHHHHHHHCCCCCCCCCC
>Mature Secondary Structure 
PGGYSKGDTRPPMRFILLILGLDVLGIGLAIPVMPTLIATIWPSSTEHVSLALGVALTL
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHH
YSAMQFLCAPLLGALSDCHGRRPILLLALAGMCLGNLMAGFAGSLTVLLIGRAIAGITAA
HHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
NIATAMAYIADISEGEQRTHFYGAAGSVIAIALVFGPVIGGGLASYGPHLPFLVAGGLAA
HHHHHHHHHHHHCCCCHHHHHCCCHHHHHHHHHHHHHHHCCCHHHCCCCCHHHHHHHHHH
INLLYGYMRLPESLAAEHRRAFEWRRTNPFGSLRGLWSTQGLRPYLLAATCSWFAYGIFQ
HHHHHHHHHCCHHHHHHHHHHHHHHCCCCCHHHCCCHHCCCCCHHHHHHHHHHHHHHHHH
SCFVLANQMRYGWSMLEVSYALAALALGMAFAQRVLVRKLTPIMSNQRIIVTGYACCLLG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEHHHHHHHH
YGFYTAAASVWLTVVGMCFHAVGLIAEPALRSELSRHASAGHQGELQGGLTSLLSLVGGV
HHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHH
APVIGALIFAGNVGSGQHVLWLGAPFLVSLLMYVLAIGCIQRGRTSAACNG
HHHHHHHHHCCCCCCCCEEEEECCHHHHHHHHHHHHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 383387; 6337373; 6307828; 1517220 [H]