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The map label for this gene is ilvA [H]

Identifier: 66044917

GI number: 66044917

Start: 1877991

End: 1879526

Strand: Reverse

Name: ilvA [H]

Synonym: Psyr_1672

Alternate gene names: 66044917

Gene position: 1879526-1877991 (Counterclockwise)

Preceding gene: 66044918

Following gene: 66044887

Centisome position: 30.84

GC content: 64.06

Gene sequence:

>1536_bases
ATGAGCCAGGACCCGCACGCTCTGCTCAACTATTACGCGCGCAAAATCCTCACCTCGCGCGTCTACGACGTTGCCATCGA
AACGCCGCTGCAAGGCGCTCGCCAGCTGTCCGAACGGCTGGGCAATCAGGTGCTGCTCAAGCGCGAAGACCTGCAGCCGG
TGTTCTCGTTCAAGATTCGCGGTGCGTACAACAAGCTCGCGCAACTGCCCGCAGAGCAGACCGCACGGGGCGTGGTGACG
GCCTCGGCAGGCAATCATGCCCAGGGCCTGGCGCTGGCAGCGCGTGAGCTGGGGATCAAGGCGACCATCGTCATGCCGCG
CACCACTCCGGAGATCAAGGTCGAAGGCGTGCGCTCGCGGGGAGCCACCGTGGTGCTGCATGGCGATTCGTTCCCGGAAG
CGCTGGCCTACTCGCTGAAGCTGGTCGACGAACAAGGTTTCGTCTACATCCATCCGTATGACGACCCCGACACCATCGCC
GGGCAAGGCACTGTGGCGATGGAGATCCTTCGCCAGCAACCGGGCCAGCTGGATGCGATCTTTGTTCCGGTCGGGGGTGG
CGGTCTGATTGCTGGTATCGCGGCCTACGTGAAATACCTGCGCCCGGAGATCAAGGTGATCGGCGTCGAGCCGGACGATT
CCAACTGCCTGCAGGCGGCGATGGCCGCCGGGGAGCGCGTGGTGTTGAGCCAGGTCGGGCTGTTTGCCGATGGCGTGGCG
GTCGCGCAGATCGGCCATCACACCTTTGAAGTGTGCCGCCATTATGTCGATGAAGTGATCACCGTCAGCACGGATGAGAT
CTGTGCGGCGATCAAGGACATCTACGATGACACCCGCTCGATCACCGAGCCCTCCGGCGCGTTGGGCGTGGCCGGGATCA
AGAAGTATGTCGAGCAGCGCGGCGTCAGCGGCCAGACGCTGGTGGCGATTGATTCAGGGGCCAACGTCAACTTCGATCGC
TTGCGGCACGTGGCCGAGCGCGCCGAACTGGGCGAAGGCCGCGAGGCGATCATTGCCGTGACCATCCCCGAGCAACCGGG
CAGCTTCAAGGCGTTCTGCGAGGCCATCGGCAAGCGGCAGATCACCGAATTCAACTACCGCTATCACACCGACCGCGAGG
CGCACATCTTCGTCGGCGTGCAGACCCATCCCGAGAACGACCCACGCAGCGCCCTGATCGCCAGCCTGACCGGGCAAGGC
TTCCCGGTGCTGGACCTGACAGACAACGAACTGGCCAAACTGCACATCCGCCACATGGTCGGCGGGCATGCCGAGCGGGT
CGACGATGAAGTGGTGCTGCGCTTCGAGTTCCCGGAGCGACCGGGCGCGCTGTTCAACTTCCTCAACCGCCTGGGCGGGC
GCTGGACCATCTCCATGTTCCACTACCGCAACCACGGCGCAGCCGATGGCCGAGTGGTTGCCGGGCTGGTGGTGCCGGAG
GAAGAGCGGCATCTGGTCGGTGCTGCGCTGGATGAGATTGGTTACCGGTACTGGGATGAAAGCGAGAACCCGGCTTACCG
GTTGTTTCTGGGCTGA

Upstream 100 bases:

>100_bases
TCCCTCGCTCTATCGCCCTTCTCGCTTCTCTGGACCTGATTATCGGTCTGCCGCGCGCGTTCACCGAGTATCCAGGCACG
ACGTATGAAGAGACGATGCG

Downstream 100 bases:

>100_bases
GGCCGAGGATATCTCTCGTTCCTCACGCTCCGCGTCACAAGAGGACGCAGAGCGTCCAGACCGGCATACCCACGCGGAGC
ATGGGCACGATGGTGTTATC

Product: threonine dehydratase

Products: NA

Alternate protein names: Threonine deaminase [H]

Number of amino acids: Translated: 511; Mature: 510

Protein sequence:

>511_residues
MSQDPHALLNYYARKILTSRVYDVAIETPLQGARQLSERLGNQVLLKREDLQPVFSFKIRGAYNKLAQLPAEQTARGVVT
ASAGNHAQGLALAARELGIKATIVMPRTTPEIKVEGVRSRGATVVLHGDSFPEALAYSLKLVDEQGFVYIHPYDDPDTIA
GQGTVAMEILRQQPGQLDAIFVPVGGGGLIAGIAAYVKYLRPEIKVIGVEPDDSNCLQAAMAAGERVVLSQVGLFADGVA
VAQIGHHTFEVCRHYVDEVITVSTDEICAAIKDIYDDTRSITEPSGALGVAGIKKYVEQRGVSGQTLVAIDSGANVNFDR
LRHVAERAELGEGREAIIAVTIPEQPGSFKAFCEAIGKRQITEFNYRYHTDREAHIFVGVQTHPENDPRSALIASLTGQG
FPVLDLTDNELAKLHIRHMVGGHAERVDDEVVLRFEFPERPGALFNFLNRLGGRWTISMFHYRNHGAADGRVVAGLVVPE
EERHLVGAALDEIGYRYWDESENPAYRLFLG

Sequences:

>Translated_511_residues
MSQDPHALLNYYARKILTSRVYDVAIETPLQGARQLSERLGNQVLLKREDLQPVFSFKIRGAYNKLAQLPAEQTARGVVT
ASAGNHAQGLALAARELGIKATIVMPRTTPEIKVEGVRSRGATVVLHGDSFPEALAYSLKLVDEQGFVYIHPYDDPDTIA
GQGTVAMEILRQQPGQLDAIFVPVGGGGLIAGIAAYVKYLRPEIKVIGVEPDDSNCLQAAMAAGERVVLSQVGLFADGVA
VAQIGHHTFEVCRHYVDEVITVSTDEICAAIKDIYDDTRSITEPSGALGVAGIKKYVEQRGVSGQTLVAIDSGANVNFDR
LRHVAERAELGEGREAIIAVTIPEQPGSFKAFCEAIGKRQITEFNYRYHTDREAHIFVGVQTHPENDPRSALIASLTGQG
FPVLDLTDNELAKLHIRHMVGGHAERVDDEVVLRFEFPERPGALFNFLNRLGGRWTISMFHYRNHGAADGRVVAGLVVPE
EERHLVGAALDEIGYRYWDESENPAYRLFLG
>Mature_510_residues
SQDPHALLNYYARKILTSRVYDVAIETPLQGARQLSERLGNQVLLKREDLQPVFSFKIRGAYNKLAQLPAEQTARGVVTA
SAGNHAQGLALAARELGIKATIVMPRTTPEIKVEGVRSRGATVVLHGDSFPEALAYSLKLVDEQGFVYIHPYDDPDTIAG
QGTVAMEILRQQPGQLDAIFVPVGGGGLIAGIAAYVKYLRPEIKVIGVEPDDSNCLQAAMAAGERVVLSQVGLFADGVAV
AQIGHHTFEVCRHYVDEVITVSTDEICAAIKDIYDDTRSITEPSGALGVAGIKKYVEQRGVSGQTLVAIDSGANVNFDRL
RHVAERAELGEGREAIIAVTIPEQPGSFKAFCEAIGKRQITEFNYRYHTDREAHIFVGVQTHPENDPRSALIASLTGQGF
PVLDLTDNELAKLHIRHMVGGHAERVDDEVVLRFEFPERPGALFNFLNRLGGRWTISMFHYRNHGAADGRVVAGLVVPEE
ERHLVGAALDEIGYRYWDESENPAYRLFLG

Specific function: Catalyzes the formation of alpha-ketobutyrate from threonine in a two-step reaction. The first step is a dehydration of threonine, followed by rehydration and liberation of ammonia [H]

COG id: COG1171

COG function: function code E; Threonine dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the serine/threonine dehydratase family [H]

Homologues:

Organism=Homo sapiens, GI11345492, Length=307, Percent_Identity=34.8534201954397, Blast_Score=174, Evalue=2e-43,
Organism=Homo sapiens, GI33469958, Length=314, Percent_Identity=29.2993630573248, Blast_Score=111, Evalue=1e-24,
Organism=Homo sapiens, GI19923959, Length=319, Percent_Identity=29.153605015674, Blast_Score=96, Evalue=1e-19,
Organism=Homo sapiens, GI295821202, Length=144, Percent_Identity=34.0277777777778, Blast_Score=67, Evalue=3e-11,
Organism=Homo sapiens, GI295821200, Length=144, Percent_Identity=34.0277777777778, Blast_Score=67, Evalue=3e-11,
Organism=Homo sapiens, GI4557415, Length=144, Percent_Identity=34.0277777777778, Blast_Score=67, Evalue=3e-11,
Organism=Escherichia coli, GI1790207, Length=499, Percent_Identity=53.3066132264529, Blast_Score=509, Evalue=1e-145,
Organism=Escherichia coli, GI1789505, Length=313, Percent_Identity=38.3386581469649, Blast_Score=191, Evalue=1e-49,
Organism=Escherichia coli, GI1789235, Length=301, Percent_Identity=22.9235880398671, Blast_Score=62, Evalue=9e-11,
Organism=Caenorhabditis elegans, GI71991565, Length=332, Percent_Identity=36.7469879518072, Blast_Score=177, Evalue=1e-44,
Organism=Caenorhabditis elegans, GI17508781, Length=264, Percent_Identity=35.6060606060606, Blast_Score=157, Evalue=2e-38,
Organism=Caenorhabditis elegans, GI17537387, Length=343, Percent_Identity=33.2361516034985, Blast_Score=148, Evalue=6e-36,
Organism=Saccharomyces cerevisiae, GI6320930, Length=513, Percent_Identity=50.8771929824561, Blast_Score=474, Evalue=1e-134,
Organism=Saccharomyces cerevisiae, GI6322631, Length=303, Percent_Identity=37.953795379538, Blast_Score=192, Evalue=1e-49,
Organism=Saccharomyces cerevisiae, GI6319788, Length=244, Percent_Identity=28.2786885245902, Blast_Score=97, Evalue=6e-21,
Organism=Drosophila melanogaster, GI21355833, Length=318, Percent_Identity=34.2767295597484, Blast_Score=149, Evalue=6e-36,
Organism=Drosophila melanogaster, GI24645328, Length=250, Percent_Identity=31.6, Blast_Score=100, Evalue=3e-21,

Paralogues:

None

Copy number: 1344 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. 800 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001926
- InterPro:   IPR000634
- InterPro:   IPR005787
- InterPro:   IPR001721 [H]

Pfam domain/function: PF00291 PALP; PF00585 Thr_dehydrat_C [H]

EC number: =4.3.1.19 [H]

Molecular weight: Translated: 55954; Mature: 55823

Theoretical pI: Translated: 5.83; Mature: 5.83

Prosite motif: PS00165 DEHYDRATASE_SER_THR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSQDPHALLNYYARKILTSRVYDVAIETPLQGARQLSERLGNQVLLKREDLQPVFSFKIR
CCCCHHHHHHHHHHHHHHHHHHHHEECCCHHHHHHHHHHCCCEEEEECCCCCCEEEEEEC
GAYNKLAQLPAEQTARGVVTASAGNHAQGLALAARELGIKATIVMPRTTPEIKVEGVRSR
CHHHHHHHCCHHHHCCEEEEECCCCCCCHHHHHHHHCCCEEEEEECCCCCCEEEEEECCC
GATVVLHGDSFPEALAYSLKLVDEQGFVYIHPYDDPDTIAGQGTVAMEILRQQPGQLDAI
CCEEEEECCCCHHHHHHHHEEECCCCEEEEECCCCCCCCCCCCHHHHHHHHCCCCCEEEE
FVPVGGGGLIAGIAAYVKYLRPEIKVIGVEPDDSNCLQAAMAAGERVVLSQVGLFADGVA
EEEECCCHHHHHHHHHHHHHCCCEEEEEECCCCCHHHHHHHHCCCEEEHHHHCHHHCCHH
VAQIGHHTFEVCRHYVDEVITVSTDEICAAIKDIYDDTRSITEPSGALGVAGIKKYVEQR
HHHHHHHHHHHHHHHHHHEEECCHHHHHHHHHHHHHHHHHCCCCCCCEEHHHHHHHHHHC
GVSGQTLVAIDSGANVNFDRLRHVAERAELGEGREAIIAVTIPEQPGSFKAFCEAIGKRQ
CCCCCEEEEEECCCCCCHHHHHHHHHHHHCCCCCEEEEEEEECCCCCCHHHHHHHHCCCC
ITEFNYRYHTDREAHIFVGVQTHPENDPRSALIASLTGQGFPVLDLTDNELAKLHIRHMV
EEEECCEEECCCCEEEEEEEEECCCCCCHHHHHHHHCCCCCEEEEECCCHHHHHHHHHHH
GGHAERVDDEVVLRFEFPERPGALFNFLNRLGGRWTISMFHYRNHGAADGRVVAGLVVPE
CCCHHCCCCEEEEEEECCCCCCHHHHHHHHCCCEEEEEEEEECCCCCCCCEEEEEEECCC
EERHLVGAALDEIGYRYWDESENPAYRLFLG
HHHHHHHHHHHHCCCEECCCCCCCEEEEEEC
>Mature Secondary Structure 
SQDPHALLNYYARKILTSRVYDVAIETPLQGARQLSERLGNQVLLKREDLQPVFSFKIR
CCCHHHHHHHHHHHHHHHHHHHHEECCCHHHHHHHHHHCCCEEEEECCCCCCEEEEEEC
GAYNKLAQLPAEQTARGVVTASAGNHAQGLALAARELGIKATIVMPRTTPEIKVEGVRSR
CHHHHHHHCCHHHHCCEEEEECCCCCCCHHHHHHHHCCCEEEEEECCCCCCEEEEEECCC
GATVVLHGDSFPEALAYSLKLVDEQGFVYIHPYDDPDTIAGQGTVAMEILRQQPGQLDAI
CCEEEEECCCCHHHHHHHHEEECCCCEEEEECCCCCCCCCCCCHHHHHHHHCCCCCEEEE
FVPVGGGGLIAGIAAYVKYLRPEIKVIGVEPDDSNCLQAAMAAGERVVLSQVGLFADGVA
EEEECCCHHHHHHHHHHHHHCCCEEEEEECCCCCHHHHHHHHCCCEEEHHHHCHHHCCHH
VAQIGHHTFEVCRHYVDEVITVSTDEICAAIKDIYDDTRSITEPSGALGVAGIKKYVEQR
HHHHHHHHHHHHHHHHHHEEECCHHHHHHHHHHHHHHHHHCCCCCCCEEHHHHHHHHHHC
GVSGQTLVAIDSGANVNFDRLRHVAERAELGEGREAIIAVTIPEQPGSFKAFCEAIGKRQ
CCCCCEEEEEECCCCCCHHHHHHHHHHHHCCCCCEEEEEEEECCCCCCHHHHHHHHCCCC
ITEFNYRYHTDREAHIFVGVQTHPENDPRSALIASLTGQGFPVLDLTDNELAKLHIRHMV
EEEECCEEECCCCEEEEEEEEECCCCCCHHHHHHHHCCCCCEEEEECCCHHHHHHHHHHH
GGHAERVDDEVVLRFEFPERPGALFNFLNRLGGRWTISMFHYRNHGAADGRVVAGLVVPE
CCCHHCCCCEEEEEEECCCCCCHHHHHHHHCCCEEEEEEEEECCCCCCCCEEEEEEECCC
EERHLVGAALDEIGYRYWDESENPAYRLFLG
HHHHHHHHHHHHCCCEECCCCCCCEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA