Click here to switch to the map view.

The map label for this gene is trpF [H]

Identifier: 66044908

GI number: 66044908

Start: 1868005

End: 1868625

Strand: Direct

Name: trpF [H]

Synonym: Psyr_1663

Alternate gene names: 66044908

Gene position: 1868005-1868625 (Clockwise)

Preceding gene: 66044907

Following gene: 66044909

Centisome position: 30.65

GC content: 62.32

Gene sequence:

>621_bases
ATGTCAGCCGTTCGCAGCAAGATCTGCGGGATTACCCGCATAGAAGATGCACTGGCTGCCGCCGAGGCAGGTGCCGACGC
GATCGGCCTGGTGTTCTACCCGAAAAGCCCGCGTGCGGTGACGGTATTGCAGGCGCGTGCCATTATTGCCGCGCTGCCGC
CGTTCATCACCACGGTGGGCCTGTTCGTCAACGCCAGTCGCTGCGAGCTCAACGAGACACTGGATGCGGTTGCGCTGGAC
ATGCTGCAGTTTCATGGCGATGAGACACCCGAGGAATGCGATGGGTATCATCGCCCGTACGTCAAGGCGCTGCGGGTCAA
GGCCGGTGATGACATTGCCGGGGTCTGCCGGACCTATCGCAATGCACGCGGCGTGCTGCTCGATACCTACGTCGAAGGGG
TGCCCGGCGGTACCGGAGAAACCTTCGATTGGGCATTGATTCCGGACGACCTGGACAAGCCGGTCATTCTGGCAGGCGGG
CTGACGTCGGCCAATGTGGCGCAGGCCATCGCTCAGGTCCGGCCCTATGCAGTGGATGTCAGCGGCGGCGTTGAAAAGAG
CAAGGGCATCAAGGATCGGGAGAAGATCCTGGCGTTCATGAGTGCGGTGCACGGCACCTGA

Upstream 100 bases:

>100_bases
CCCCATTTTCTTACGGGCTTTGCGGAATTGGACGGCTGACGATCCGGGCCGCATTTGCTAACATCCGGGACTTTCCGAAA
GGCCTGAGGTTACTCACGAC

Downstream 100 bases:

>100_bases
TGTGACGGCTATTGATCGGCCGCCGTCCATAAGCCTGTCCGCGCCAAGAGGCACGCGGGTCGAATCGAGTAAGCGGTGGT
GCCACTGAGCAACGCCGTCG

Product: N-(5'-phosphoribosyl)anthranilate isomerase

Products: NA

Alternate protein names: PRAI [H]

Number of amino acids: Translated: 206; Mature: 205

Protein sequence:

>206_residues
MSAVRSKICGITRIEDALAAAEAGADAIGLVFYPKSPRAVTVLQARAIIAALPPFITTVGLFVNASRCELNETLDAVALD
MLQFHGDETPEECDGYHRPYVKALRVKAGDDIAGVCRTYRNARGVLLDTYVEGVPGGTGETFDWALIPDDLDKPVILAGG
LTSANVAQAIAQVRPYAVDVSGGVEKSKGIKDREKILAFMSAVHGT

Sequences:

>Translated_206_residues
MSAVRSKICGITRIEDALAAAEAGADAIGLVFYPKSPRAVTVLQARAIIAALPPFITTVGLFVNASRCELNETLDAVALD
MLQFHGDETPEECDGYHRPYVKALRVKAGDDIAGVCRTYRNARGVLLDTYVEGVPGGTGETFDWALIPDDLDKPVILAGG
LTSANVAQAIAQVRPYAVDVSGGVEKSKGIKDREKILAFMSAVHGT
>Mature_205_residues
SAVRSKICGITRIEDALAAAEAGADAIGLVFYPKSPRAVTVLQARAIIAALPPFITTVGLFVNASRCELNETLDAVALDM
LQFHGDETPEECDGYHRPYVKALRVKAGDDIAGVCRTYRNARGVLLDTYVEGVPGGTGETFDWALIPDDLDKPVILAGGL
TSANVAQAIAQVRPYAVDVSGGVEKSKGIKDREKILAFMSAVHGT

Specific function: Bifunctional Enzyme That Catalyzes Two Sequential Steps Of Tryptophan Biosynthetic Pathway. The First Reaction Is Catalyzed By The Isomerase, Coded By The Trpf Domain; The Second Reaction Is Catalyzed By The Synthase, Coded By The Trpc Domain. [C]

COG id: COG0135

COG function: function code E; Phosphoribosylanthranilate isomerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the trpF family [H]

Homologues:

Organism=Escherichia coli, GI87081863, Length=193, Percent_Identity=35.7512953367876, Blast_Score=92, Evalue=4e-20,
Organism=Saccharomyces cerevisiae, GI6320210, Length=210, Percent_Identity=30, Blast_Score=80, Evalue=3e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR001240
- InterPro:   IPR011060 [H]

Pfam domain/function: PF00697 PRAI [H]

EC number: =5.3.1.24 [H]

Molecular weight: Translated: 21831; Mature: 21700

Theoretical pI: Translated: 5.06; Mature: 5.06

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSAVRSKICGITRIEDALAAAEAGADAIGLVFYPKSPRAVTVLQARAIIAALPPFITTVG
CCHHHHHHCCHHHHHHHHHHHHCCCCEEEEEEECCCCCEEHHHHHHHHHHHHHHHHHHHH
LFVNASRCELNETLDAVALDMLQFHGDETPEECDGYHRPYVKALRVKAGDDIAGVCRTYR
HHHCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHCCCCCHHHHHHHHCCCCCHHHHHHHHH
NARGVLLDTYVEGVPGGTGETFDWALIPDDLDKPVILAGGLTSANVAQAIAQVRPYAVDV
CCCCCEEEHHHCCCCCCCCCCEEEEECCCCCCCCEEEECCCCHHHHHHHHHHHCCEEEEC
SGGVEKSKGIKDREKILAFMSAVHGT
CCCCCCCCCCHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
SAVRSKICGITRIEDALAAAEAGADAIGLVFYPKSPRAVTVLQARAIIAALPPFITTVG
CHHHHHHCCHHHHHHHHHHHHCCCCEEEEEEECCCCCEEHHHHHHHHHHHHHHHHHHHH
LFVNASRCELNETLDAVALDMLQFHGDETPEECDGYHRPYVKALRVKAGDDIAGVCRTYR
HHHCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHCCCCCHHHHHHHHCCCCCHHHHHHHHH
NARGVLLDTYVEGVPGGTGETFDWALIPDDLDKPVILAGGLTSANVAQAIAQVRPYAVDV
CCCCCEEEHHHCCCCCCCCCCEEEEECCCCCCCCEEEECCCCHHHHHHHHHHHCCEEEEC
SGGVEKSKGIKDREKILAFMSAVHGT
CCCCCCCCCCHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA