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The map label for this gene is lpxK [H]

Identifier: 66044880

GI number: 66044880

Start: 1839118

End: 1840113

Strand: Direct

Name: lpxK [H]

Synonym: Psyr_1635

Alternate gene names: 66044880

Gene position: 1839118-1840113 (Clockwise)

Preceding gene: 66044879

Following gene: 66044881

Centisome position: 30.18

GC content: 61.95

Gene sequence:

>996_bases
ATGGCATTCACTGACCGTTTGCTCGACGCCTGGTACAAGGGCCACCCTGCGCTGGCGCTGTTGCGCCCGCTCGAAGGTCT
TTACCGGCGTGTCGTAGAACGCAAACGGGCGCGGTTTCTGGCGGGCGAAGGTGATATCTATCGCGCGCCGGTGCCGGTCA
TTGTCGTGGGTAATATCACCGTCGGTGGCACGGGCAAGACGCCGTTGATTCTCTGGATGATCGAGCATTGCCGCCGTCGC
GGTTTGCGTGTCGGTGTGGTCAGCCGTGGTTACGGCGCCAAACCGCCAAGCCTGCCGTGGCGCGTCCTGCCTGACCAGAG
CGCCAGCGAGGCGGGGGACGAGCCGTTGCTCATCGTGCAGCGCTGCGGCGTGCCGCTGATGATCGATCCGGATCGCAGTC
GCGCCGTACAGGCCTTGCTCGCTGCTGAACCGCTGGATCTGATTCTTTCCGACGACGGCTTGCAGCATTACCGGCTGGCC
CGCGACCTGGAACTGGTGCTGATCGATGCCGCCCGTGGTCTGGGCAATCGCCGTTGTCTGCCGGCCGGGCCATTGCGCGA
ACCGGTCGAGCGGCTGAGCAGTGTCGACGCCTTGCTTTATAACGGTGCCATGGCTGACAGGGGCGACGGCTACGCCTTCA
GGCTCAAGCCTTCGGCACTGATCAATCTGCGCAGTGGCGAACGTCAGCCGGTGGATTATTTTCCGGCCGGGCAGGCGCTG
CATGCGGTCGCCGGAATCGGCAATCCCCGACGTTTCTTCAATACCCTCGAAGGATTACACTGGCGACCGGTGCCTCACGC
GTTCGCCGACCATGCTGTCTACAGTGCCGAAGCATTGACATTTACACCCGCGCTGCCTTTGGTCATGACCGAAAAGGATG
CGGTCAAATGTCGTGCCTTTGCCGCTGATGACTGGTGGTATCTGGCAGTGGATGCAGTACCTTCCGATGCCTTTGTCGGT
TGGTTCGACCAGCAACTGCTACGTCTTTCTCCATGA

Upstream 100 bases:

>100_bases
AGACCCCGCACCAGTCGGTCATCACGGCCATGGATGCGGCGGGCAAGCTGGGCTTCAGTCACTTGCGCATGACCACTGTC
GAGGCCACACCGGCTAACTG

Downstream 100 bases:

>100_bases
TTGCTTCAGGATCTCCTATGGACACCAAACTACTCGATATCCTCGCCTGCCCTGTCTGCAAGGGACCATTGAAGCTCAGC
GCCGACAAGACCGAGCTGAT

Product: tetraacyldisaccharide 4'-kinase

Products: NA

Alternate protein names: Lipid A 4'-kinase [H]

Number of amino acids: Translated: 331; Mature: 330

Protein sequence:

>331_residues
MAFTDRLLDAWYKGHPALALLRPLEGLYRRVVERKRARFLAGEGDIYRAPVPVIVVGNITVGGTGKTPLILWMIEHCRRR
GLRVGVVSRGYGAKPPSLPWRVLPDQSASEAGDEPLLIVQRCGVPLMIDPDRSRAVQALLAAEPLDLILSDDGLQHYRLA
RDLELVLIDAARGLGNRRCLPAGPLREPVERLSSVDALLYNGAMADRGDGYAFRLKPSALINLRSGERQPVDYFPAGQAL
HAVAGIGNPRRFFNTLEGLHWRPVPHAFADHAVYSAEALTFTPALPLVMTEKDAVKCRAFAADDWWYLAVDAVPSDAFVG
WFDQQLLRLSP

Sequences:

>Translated_331_residues
MAFTDRLLDAWYKGHPALALLRPLEGLYRRVVERKRARFLAGEGDIYRAPVPVIVVGNITVGGTGKTPLILWMIEHCRRR
GLRVGVVSRGYGAKPPSLPWRVLPDQSASEAGDEPLLIVQRCGVPLMIDPDRSRAVQALLAAEPLDLILSDDGLQHYRLA
RDLELVLIDAARGLGNRRCLPAGPLREPVERLSSVDALLYNGAMADRGDGYAFRLKPSALINLRSGERQPVDYFPAGQAL
HAVAGIGNPRRFFNTLEGLHWRPVPHAFADHAVYSAEALTFTPALPLVMTEKDAVKCRAFAADDWWYLAVDAVPSDAFVG
WFDQQLLRLSP
>Mature_330_residues
AFTDRLLDAWYKGHPALALLRPLEGLYRRVVERKRARFLAGEGDIYRAPVPVIVVGNITVGGTGKTPLILWMIEHCRRRG
LRVGVVSRGYGAKPPSLPWRVLPDQSASEAGDEPLLIVQRCGVPLMIDPDRSRAVQALLAAEPLDLILSDDGLQHYRLAR
DLELVLIDAARGLGNRRCLPAGPLREPVERLSSVDALLYNGAMADRGDGYAFRLKPSALINLRSGERQPVDYFPAGQALH
AVAGIGNPRRFFNTLEGLHWRPVPHAFADHAVYSAEALTFTPALPLVMTEKDAVKCRAFAADDWWYLAVDAVPSDAFVGW
FDQQLLRLSP

Specific function: Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA) [H]

COG id: COG1663

COG function: function code M; Tetraacyldisaccharide-1-P 4'-kinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lpxK family [H]

Homologues:

Organism=Escherichia coli, GI1787144, Length=309, Percent_Identity=48.2200647249191, Blast_Score=256, Evalue=1e-69,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003758 [H]

Pfam domain/function: PF02606 LpxK [H]

EC number: =2.7.1.130 [H]

Molecular weight: Translated: 36581; Mature: 36449

Theoretical pI: Translated: 8.59; Mature: 8.59

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAFTDRLLDAWYKGHPALALLRPLEGLYRRVVERKRARFLAGEGDIYRAPVPVIVVGNIT
CCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHEECCCCCEEECCCCEEEEEEEE
VGGTGKTPLILWMIEHCRRRGLRVGVVSRGYGAKPPSLPWRVLPDQSASEAGDEPLLIVQ
ECCCCCCHHHHHHHHHHHHCCCEEEEEECCCCCCCCCCCEEECCCCCHHHCCCCCEEEEE
RCGVPLMIDPDRSRAVQALLAAEPLDLILSDDGLQHYRLARDLELVLIDAARGLGNRRCL
CCCCCEEECCCHHHHHHHHHHCCCEEEEECCCCHHHHHHHCCCEEEEEECCCCCCCCCCC
PAGPLREPVERLSSVDALLYNGAMADRGDGYAFRLKPSALINLRSGERQPVDYFPAGQAL
CCCCHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEECCHHEEEECCCCCCCCCCCCCCHHH
HAVAGIGNPRRFFNTLEGLHWRPVPHAFADHAVYSAEALTFTPALPLVMTEKDAVKCRAF
HHHHCCCCHHHHHHHHCCCCCCCCCHHHHHHHHHCCCEEEECCCCCEEEECCCCEEEEEE
AADDWWYLAVDAVPSDAFVGWFDQQLLRLSP
ECCCEEEEEEECCCCCCHHHHHHHHHHHCCC
>Mature Secondary Structure 
AFTDRLLDAWYKGHPALALLRPLEGLYRRVVERKRARFLAGEGDIYRAPVPVIVVGNIT
CHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHEECCCCCEEECCCCEEEEEEEE
VGGTGKTPLILWMIEHCRRRGLRVGVVSRGYGAKPPSLPWRVLPDQSASEAGDEPLLIVQ
ECCCCCCHHHHHHHHHHHHCCCEEEEEECCCCCCCCCCCEEECCCCCHHHCCCCCEEEEE
RCGVPLMIDPDRSRAVQALLAAEPLDLILSDDGLQHYRLARDLELVLIDAARGLGNRRCL
CCCCCEEECCCHHHHHHHHHHCCCEEEEECCCCHHHHHHHCCCEEEEEECCCCCCCCCCC
PAGPLREPVERLSSVDALLYNGAMADRGDGYAFRLKPSALINLRSGERQPVDYFPAGQAL
CCCCHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEECCHHEEEECCCCCCCCCCCCCCHHH
HAVAGIGNPRRFFNTLEGLHWRPVPHAFADHAVYSAEALTFTPALPLVMTEKDAVKCRAF
HHHHCCCCHHHHHHHHCCCCCCCCCHHHHHHHHHCCCEEEECCCCCEEEECCCCEEEEEE
AADDWWYLAVDAVPSDAFVGWFDQQLLRLSP
ECCCEEEEEEECCCCCCHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA