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The map label for this gene is pdhA [H]

Identifier: 66044868

GI number: 66044868

Start: 1824444

End: 1825547

Strand: Direct

Name: pdhA [H]

Synonym: Psyr_1623

Alternate gene names: 66044868

Gene position: 1824444-1825547 (Clockwise)

Preceding gene: 66044866

Following gene: 66044870

Centisome position: 29.94

GC content: 64.31

Gene sequence:

>1104_bases
ATGAACAGCGCAAACAGTCATTCGTTGGCACCCCAGACCCGGTTCGCGGCGTTGGCCTGCATGGACAAGATTCAGGCGGT
CACGGGGCTTGCGCTGCGTGGGTGTTGTTCACCCCTGTTCGCGATGGCCGATATCGTCGAGCGTCTGACCAGAGATCCGT
CCACCTCGCGGCGGATATCGGTGGTACGGGCCAGCAAACACATGTCACGCGGACAGGAAGGCATGCTCGCCAGCGCCTGG
CCGCTGAGATTTGCTGCGCAGGCTGGCGCGGTGGAGTTGCCGCTGATTTACATGATCAGCAGCGAAACCTCCGCCGAGTT
GAGCGCGCTCGCATCGGAGTCGTTCCAGCGGGGCATCTTCTGCAACGATATCGAGACGCTGCCGTCACGCTGGCCCAAGG
GTGCCCATCCCTGGTTACCGCTGTGGCTGCTGTCGAACCGCAAATGCCAGCCGTTTGACCCTGCGGATGCTGCCGAAGCG
CGGGCGATCACACTGCACGCCCTGCACAGTCTGTATGTCGAAGGCCGGAGCGGCTTCTATTACATGGCCTTGCACGACGA
GTCCAATGAGGAAGTCAGTGAACTGAGCGATGCTCAGGCTGTGGCGGCCGTACAGGGCATGTACCGGATTGGCGACGCCG
TTTGCGGTCATGAAGGCCGTCGCGTACGCCTTCTGGGGGCGGGTCTGGCGCTGCGCTCGGTACGCCAGGCTGCCCGCCTG
CTCCGTGAACACTGGGACGTCGATTGCGAAATCTGGAGCTGCCCCAGCTATACCCGAGTGGCCCGCGATGCCGCAGCCGC
ACGACGCTGGAATCGTTTCCATTCTGCACAACCCGCACGATCCTGGCACCTGCGCGATTGCCTGGGCGAGGGGCAGGACG
CGGTGGTAGCCGTCACCGGCTACCCGCAGGCCGTGGTTGAACAGCTGCGTGAGCATGTCCCGGGGCGGTTCGTCGGGCTG
GGTGCCGATTCCGCGGCCCCGCAGGGTACGCCTGCAACCCGTCCGGAGTGGATCGTCGTACAGGCCCTGACTGCGCTTGC
GGAAGGCGGGCAACTGGGCTACGAGCCGCTGAAACTCGCCTTGCGACGCTATCAGCTGGTCTGA

Upstream 100 bases:

>100_bases
GCGCTGCGATGAGGCGTGTCAGTGATTTTTATTGCGATTGCAATCATATTCTTGGTTCCATCAAGGTGCAAGGATGCTTG
TCCGACAGCAAGGAGTAGTG

Downstream 100 bases:

>100_bases
TGTCAGCCTTTTCCACCGCTTTGCCGGGCGGCCAGTGCGGCACGCTCCAGCGCGTCGGCGAACACGCGGCGCTGCTGGTC
GTCGAATTGCGTCAGAAACA

Product: pyruvate dehydrogenase (lipoamide)

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 367; Mature: 367

Protein sequence:

>367_residues
MNSANSHSLAPQTRFAALACMDKIQAVTGLALRGCCSPLFAMADIVERLTRDPSTSRRISVVRASKHMSRGQEGMLASAW
PLRFAAQAGAVELPLIYMISSETSAELSALASESFQRGIFCNDIETLPSRWPKGAHPWLPLWLLSNRKCQPFDPADAAEA
RAITLHALHSLYVEGRSGFYYMALHDESNEEVSELSDAQAVAAVQGMYRIGDAVCGHEGRRVRLLGAGLALRSVRQAARL
LREHWDVDCEIWSCPSYTRVARDAAAARRWNRFHSAQPARSWHLRDCLGEGQDAVVAVTGYPQAVVEQLREHVPGRFVGL
GADSAAPQGTPATRPEWIVVQALTALAEGGQLGYEPLKLALRRYQLV

Sequences:

>Translated_367_residues
MNSANSHSLAPQTRFAALACMDKIQAVTGLALRGCCSPLFAMADIVERLTRDPSTSRRISVVRASKHMSRGQEGMLASAW
PLRFAAQAGAVELPLIYMISSETSAELSALASESFQRGIFCNDIETLPSRWPKGAHPWLPLWLLSNRKCQPFDPADAAEA
RAITLHALHSLYVEGRSGFYYMALHDESNEEVSELSDAQAVAAVQGMYRIGDAVCGHEGRRVRLLGAGLALRSVRQAARL
LREHWDVDCEIWSCPSYTRVARDAAAARRWNRFHSAQPARSWHLRDCLGEGQDAVVAVTGYPQAVVEQLREHVPGRFVGL
GADSAAPQGTPATRPEWIVVQALTALAEGGQLGYEPLKLALRRYQLV
>Mature_367_residues
MNSANSHSLAPQTRFAALACMDKIQAVTGLALRGCCSPLFAMADIVERLTRDPSTSRRISVVRASKHMSRGQEGMLASAW
PLRFAAQAGAVELPLIYMISSETSAELSALASESFQRGIFCNDIETLPSRWPKGAHPWLPLWLLSNRKCQPFDPADAAEA
RAITLHALHSLYVEGRSGFYYMALHDESNEEVSELSDAQAVAAVQGMYRIGDAVCGHEGRRVRLLGAGLALRSVRQAARL
LREHWDVDCEIWSCPSYTRVARDAAAARRWNRFHSAQPARSWHLRDCLGEGQDAVVAVTGYPQAVVEQLREHVPGRFVGL
GADSAAPQGTPATRPEWIVVQALTALAEGGQLGYEPLKLALRRYQLV

Specific function: The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components:pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydroge

COG id: COG2609

COG function: function code C; Pyruvate dehydrogenase complex, dehydrogenase (E1) component

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Escherichia coli, GI1786304, Length=227, Percent_Identity=26.8722466960352, Blast_Score=89, Evalue=5e-19,

Paralogues:

None

Copy number: 1140 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). 400 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 6,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004660
- InterPro:   IPR009014
- InterPro:   IPR015941
- InterPro:   IPR005474 [H]

Pfam domain/function: PF00456 Transketolase_N [H]

EC number: =1.2.4.1 [H]

Molecular weight: Translated: 40240; Mature: 40240

Theoretical pI: Translated: 7.98; Mature: 7.98

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.5 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
2.5 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNSANSHSLAPQTRFAALACMDKIQAVTGLALRGCCSPLFAMADIVERLTRDPSTSRRIS
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHH
VVRASKHMSRGQEGMLASAWPLRFAAQAGAVELPLIYMISSETSAELSALASESFQRGIF
HHHHHHHHHCCCCCCEECCCCHHHHHCCCCEECCEEEEECCCCHHHHHHHHHHHHHCCCC
CNDIETLPSRWPKGAHPWLPLWLLSNRKCQPFDPADAAEARAITLHALHSLYVEGRSGFY
CCHHHHHHHHCCCCCCCCEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHEECCCCEE
YMALHDESNEEVSELSDAQAVAAVQGMYRIGDAVCGHEGRRVRLLGAGLALRSVRQAARL
EEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECHHHHHHHHHHHHH
LREHWDVDCEIWSCPSYTRVARDAAAARRWNRFHSAQPARSWHLRDCLGEGQDAVVAVTG
HHHHCCCCEEEECCCCHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHCCCCCEEEEEEC
YPQAVVEQLREHVPGRFVGLGADSAAPQGTPATRPEWIVVQALTALAEGGQLGYEPLKLA
CCHHHHHHHHHHCCCEEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCHHHHHHH
LRRYQLV
HHHHCCC
>Mature Secondary Structure
MNSANSHSLAPQTRFAALACMDKIQAVTGLALRGCCSPLFAMADIVERLTRDPSTSRRIS
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHH
VVRASKHMSRGQEGMLASAWPLRFAAQAGAVELPLIYMISSETSAELSALASESFQRGIF
HHHHHHHHHCCCCCCEECCCCHHHHHCCCCEECCEEEEECCCCHHHHHHHHHHHHHCCCC
CNDIETLPSRWPKGAHPWLPLWLLSNRKCQPFDPADAAEARAITLHALHSLYVEGRSGFY
CCHHHHHHHHCCCCCCCCEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHEECCCCEE
YMALHDESNEEVSELSDAQAVAAVQGMYRIGDAVCGHEGRRVRLLGAGLALRSVRQAARL
EEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECHHHHHHHHHHHHH
LREHWDVDCEIWSCPSYTRVARDAAAARRWNRFHSAQPARSWHLRDCLGEGQDAVVAVTG
HHHHCCCCEEEECCCCHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHCCCCCEEEEEEC
YPQAVVEQLREHVPGRFVGLGADSAAPQGTPATRPEWIVVQALTALAEGGQLGYEPLKLA
CCHHHHHHHHHHCCCEEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCHHHHHHH
LRRYQLV
HHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8021225 [H]