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The map label for this gene is pdhA [H]

Identifier: 66044870

GI number: 66044870

Start: 1826147

End: 1828816

Strand: Direct

Name: pdhA [H]

Synonym: Psyr_1625

Alternate gene names: 66044870

Gene position: 1826147-1828816 (Clockwise)

Preceding gene: 66044868

Following gene: 66044874

Centisome position: 29.97

GC content: 59.63

Gene sequence:

>2670_bases
ATGGCACAGCAACCCCGGTTTCTTGACGAGGATCCGCAAGAAACCCGCGAATGGCTCGAATCGATTGAGTCGGTACTCAA
CACTGAAGGGCGCCCGCGCGCGCACTATCTGATCGATCAGTTGCTGGACTTCGACGTCGCCCAACATGGCGATTTCTACG
GTCGGGTCACCACGCCTTACGTCAACACCATTCCCAGTGACCGCCAGCAGCCTTATCCGGGCGACCTTCAGGTTGAAAAA
CGTATCAACGCGTTCATCCGCTGGAACGCCCTGGTGATGGTGCTGCGTGCCGGCAAGCATTCCGGCGTGGGCGGCCATAT
CGCTTCCTACGCATCTGCTGCCGTGCTTTACGACGTCGGGTTCGACCACTTCTTCCGGGGGCGTACCGAGCAGTTTGCCG
GTGACCTCGTCTATATTCAGGGGCATTCTTCGCCGGGCATTTACGGCAGGGCGTATCTGGAAGGTCGTCTGAGCGAAGAG
CAACTGGACAACTTCCGTCGCGAAACCGATCGTGACGGCATTTCTTCCTATCCGCACCCGCGCCTGATGCCGGACTTCTG
GCAGTTCCCCACCGTCTCCATGGGGCTGGGGCCCATCACTGCGGCGTATCAGGCACGCTTCATGCGCTACCTGGAGAATC
GTGGACTCAAGGAGCATCAAGGACGCAAGGTCTGGGCGTTCCTGGGCGATGGCGAGATGGATCAGCCTGAGTCACAGGCA
GCCATCGCTCTGGCCGGGCGCGAGAAACTCGACAACATCATTTTCGTCGTCAACTGCAACCTGCAACGCCTTGACGGGCC
GGTACGCGGCAACAGCAAGGTCATTCAGGAGTTCGAAAGTCTGTATCGCGCCGCAGGCTGGAACGTGATCAAGGTCATCT
GGGGCGGCGGTTGGGATGCGCTGCTCGAGAAGGACAAGAGCGGGCTGCTGCGTCAGCGCATGATGGAATGCGTGGATGGC
GAGTACCAGAACTACAAATCCCAGAATGGCGCCTACGTTCGCGAGCATTTCTTCGGCAAGTACCCGGAGCTGCTGGAACT
GGTCAGCGACATGAGCGATGACGACATCTGGAAGCTCTCGCGTGGCGGCCACGATCCGGAAAAAGTCTACAACGCCTATG
CTGCCGCGATGCGCCACAAGGGTGGGCCGACCGTGATCCTGGCCAAGACCGTCAAAGGTTTCGGCATGGGCGAGGCGGGT
GAGGGGCAGAACATCAACCACCAGTTGAAGAAGCTTGGGGCAGAGGCGATCAAGGCCTTCCGCGACCGCTTCTCGCTGGA
CATCACCGATGACCAGCTGGGCGACATGCCGTACCTGAAACCGGCCGAGGGCAGTACTGAAGCGCTGTACCTCAAGGCCC
GCCGGGCTCAACTGGGCGGTTACATTCCGGCCCGTTTCAGTGACGCTGCCACCCTGCAGATTCCGCCGCTCTCGGTGCTG
GATACCCAGCTCAAGAACACCGGCGATCGCGGCATATCCACGACCATGGCCTTCGTGCGCATCCTCTCGACGCTGCTCAA
GGATCCGAACATCGGCAAACTGATCGTGCCGATCGTGCCGGATGAGTCACGAACCTTCGGTATGGAAAATCTGTTCCGTC
AGATCGGTATTCATTCCCACGTCGGTCAGTTGTACACGCCGCAGGATGCAGGGCAACTGAGCTACTACAAGGAAAGCACC
GACGGGCAGATCATGCAGGAAGGTCTGAATGAGTCAGGTGCGATTTCTTCCTGGATCGCGGCCAGTACTTCCTACGCCAA
CCACGGTGTGATGACCGTGCCGTTCTATATCTTCTACTCGATGTTCGGCTTCCAGCGTGTAGGCGATCTTGCCTGGGCAG
CGGGCGACGCCAGGGCGCGGGGTTTTCTGCTGGGCGCCACGTCAGGCCGAACCACGCTGATGGGCGAGGGGCTGCAGCAT
GACGACGGGCACAGCCATGTCATGTCGTCGACGATACCGTGCTGCGTGTCTTACGACCCGACGTTTGCCTTCGAGCTGGC
GGTGATCATTCAGGACGGCATGCGTCGTATGTTTGCCGAAAATGAGGATATCTATTACTACATCACCTTGCTCAACGAGA
ACTACCCGCACCCGGATCTGCCCGAAGGCGCAGAAGCCGGCATTCTCAAGGGGATGTACCCGTTGCAGGCCAGTGCATCG
ATCAATACCGGCAAGCACGTGCAGTTGATGGGCTGCGGGTCGATCCTGCTGGAAGTCATCGCGGCCGCCAGGCTGCTCGA
AGACGACTTTGGCGTGAGCAGCGAAATCTGGAGTGTCACCAGCCTGACCGAACTGCGTCGTGAAGGTCAGGATGCCGAAC
GCTGGAACCTGCTGAATCCCCAGCAGGAGCCGCGTCTGAGCTACGTGGAAAGCTGTCTGGCAGACAGGGAAGGGCCGGTG
ATTGTGGCGACCGATTACATGAAAATCTTCGCCGACCAGATCCGTCCCTTTGTACCCATGCGCCGTTTCGTGGCACTGGG
CACTGACGGTTTTGGCCAGTCCGATACGCGCGAGTCGCTGCGCCACTTCTTCGAAGTGGACCGTTACTTCGTGGCGGTGG
CTGCACTCAAGGCGCTGGCCGATGACGGCAAGGTCGAGCGCAAGGTGGTGGCGCAGGCCATAGAACGTTACAAGATCGAC
CCAGGCAAGCAGAACCCTGTGCTGGTCTGA

Upstream 100 bases:

>100_bases
AGCGCGGGATAAATTCCGGTATTTGATTGCAATTGCAATCAGATTTTTCAAGGCAGACGCCTGTCCGGCGTCCACTGCCG
CATCACAGTAGGAGACGACG

Downstream 100 bases:

>100_bases
GTCGCGCTCGTATCTGCTCTGACACCAGCAAAGCGGTCCGCCTTGCTGGTGAAGGGGCCGCTACAGACGAAGGGAAGTCT
GACGGTCCGAACCGGGTTCA

Product: 2-oxoacid dehydrogenase subunit E1

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 889; Mature: 888

Protein sequence:

>889_residues
MAQQPRFLDEDPQETREWLESIESVLNTEGRPRAHYLIDQLLDFDVAQHGDFYGRVTTPYVNTIPSDRQQPYPGDLQVEK
RINAFIRWNALVMVLRAGKHSGVGGHIASYASAAVLYDVGFDHFFRGRTEQFAGDLVYIQGHSSPGIYGRAYLEGRLSEE
QLDNFRRETDRDGISSYPHPRLMPDFWQFPTVSMGLGPITAAYQARFMRYLENRGLKEHQGRKVWAFLGDGEMDQPESQA
AIALAGREKLDNIIFVVNCNLQRLDGPVRGNSKVIQEFESLYRAAGWNVIKVIWGGGWDALLEKDKSGLLRQRMMECVDG
EYQNYKSQNGAYVREHFFGKYPELLELVSDMSDDDIWKLSRGGHDPEKVYNAYAAAMRHKGGPTVILAKTVKGFGMGEAG
EGQNINHQLKKLGAEAIKAFRDRFSLDITDDQLGDMPYLKPAEGSTEALYLKARRAQLGGYIPARFSDAATLQIPPLSVL
DTQLKNTGDRGISTTMAFVRILSTLLKDPNIGKLIVPIVPDESRTFGMENLFRQIGIHSHVGQLYTPQDAGQLSYYKEST
DGQIMQEGLNESGAISSWIAASTSYANHGVMTVPFYIFYSMFGFQRVGDLAWAAGDARARGFLLGATSGRTTLMGEGLQH
DDGHSHVMSSTIPCCVSYDPTFAFELAVIIQDGMRRMFAENEDIYYYITLLNENYPHPDLPEGAEAGILKGMYPLQASAS
INTGKHVQLMGCGSILLEVIAAARLLEDDFGVSSEIWSVTSLTELRREGQDAERWNLLNPQQEPRLSYVESCLADREGPV
IVATDYMKIFADQIRPFVPMRRFVALGTDGFGQSDTRESLRHFFEVDRYFVAVAALKALADDGKVERKVVAQAIERYKID
PGKQNPVLV

Sequences:

>Translated_889_residues
MAQQPRFLDEDPQETREWLESIESVLNTEGRPRAHYLIDQLLDFDVAQHGDFYGRVTTPYVNTIPSDRQQPYPGDLQVEK
RINAFIRWNALVMVLRAGKHSGVGGHIASYASAAVLYDVGFDHFFRGRTEQFAGDLVYIQGHSSPGIYGRAYLEGRLSEE
QLDNFRRETDRDGISSYPHPRLMPDFWQFPTVSMGLGPITAAYQARFMRYLENRGLKEHQGRKVWAFLGDGEMDQPESQA
AIALAGREKLDNIIFVVNCNLQRLDGPVRGNSKVIQEFESLYRAAGWNVIKVIWGGGWDALLEKDKSGLLRQRMMECVDG
EYQNYKSQNGAYVREHFFGKYPELLELVSDMSDDDIWKLSRGGHDPEKVYNAYAAAMRHKGGPTVILAKTVKGFGMGEAG
EGQNINHQLKKLGAEAIKAFRDRFSLDITDDQLGDMPYLKPAEGSTEALYLKARRAQLGGYIPARFSDAATLQIPPLSVL
DTQLKNTGDRGISTTMAFVRILSTLLKDPNIGKLIVPIVPDESRTFGMENLFRQIGIHSHVGQLYTPQDAGQLSYYKEST
DGQIMQEGLNESGAISSWIAASTSYANHGVMTVPFYIFYSMFGFQRVGDLAWAAGDARARGFLLGATSGRTTLMGEGLQH
DDGHSHVMSSTIPCCVSYDPTFAFELAVIIQDGMRRMFAENEDIYYYITLLNENYPHPDLPEGAEAGILKGMYPLQASAS
INTGKHVQLMGCGSILLEVIAAARLLEDDFGVSSEIWSVTSLTELRREGQDAERWNLLNPQQEPRLSYVESCLADREGPV
IVATDYMKIFADQIRPFVPMRRFVALGTDGFGQSDTRESLRHFFEVDRYFVAVAALKALADDGKVERKVVAQAIERYKID
PGKQNPVLV
>Mature_888_residues
AQQPRFLDEDPQETREWLESIESVLNTEGRPRAHYLIDQLLDFDVAQHGDFYGRVTTPYVNTIPSDRQQPYPGDLQVEKR
INAFIRWNALVMVLRAGKHSGVGGHIASYASAAVLYDVGFDHFFRGRTEQFAGDLVYIQGHSSPGIYGRAYLEGRLSEEQ
LDNFRRETDRDGISSYPHPRLMPDFWQFPTVSMGLGPITAAYQARFMRYLENRGLKEHQGRKVWAFLGDGEMDQPESQAA
IALAGREKLDNIIFVVNCNLQRLDGPVRGNSKVIQEFESLYRAAGWNVIKVIWGGGWDALLEKDKSGLLRQRMMECVDGE
YQNYKSQNGAYVREHFFGKYPELLELVSDMSDDDIWKLSRGGHDPEKVYNAYAAAMRHKGGPTVILAKTVKGFGMGEAGE
GQNINHQLKKLGAEAIKAFRDRFSLDITDDQLGDMPYLKPAEGSTEALYLKARRAQLGGYIPARFSDAATLQIPPLSVLD
TQLKNTGDRGISTTMAFVRILSTLLKDPNIGKLIVPIVPDESRTFGMENLFRQIGIHSHVGQLYTPQDAGQLSYYKESTD
GQIMQEGLNESGAISSWIAASTSYANHGVMTVPFYIFYSMFGFQRVGDLAWAAGDARARGFLLGATSGRTTLMGEGLQHD
DGHSHVMSSTIPCCVSYDPTFAFELAVIIQDGMRRMFAENEDIYYYITLLNENYPHPDLPEGAEAGILKGMYPLQASASI
NTGKHVQLMGCGSILLEVIAAARLLEDDFGVSSEIWSVTSLTELRREGQDAERWNLLNPQQEPRLSYVESCLADREGPVI
VATDYMKIFADQIRPFVPMRRFVALGTDGFGQSDTRESLRHFFEVDRYFVAVAALKALADDGKVERKVVAQAIERYKIDP
GKQNPVLV

Specific function: The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components:pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydroge

COG id: COG2609

COG function: function code C; Pyruvate dehydrogenase complex, dehydrogenase (E1) component

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Escherichia coli, GI1786304, Length=886, Percent_Identity=57.7878103837472, Blast_Score=1062, Evalue=0.0,

Paralogues:

None

Copy number: 1140 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). 400 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 6,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004660
- InterPro:   IPR009014
- InterPro:   IPR015941
- InterPro:   IPR005474 [H]

Pfam domain/function: PF00456 Transketolase_N [H]

EC number: =1.2.4.1 [H]

Molecular weight: Translated: 99486; Mature: 99355

Theoretical pI: Translated: 5.47; Mature: 5.47

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAQQPRFLDEDPQETREWLESIESVLNTEGRPRAHYLIDQLLDFDVAQHGDFYGRVTTPY
CCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCCCEEECCC
VNTIPSDRQQPYPGDLQVEKRINAFIRWNALVMVLRAGKHSGVGGHIASYASAAVLYDVG
CCCCCCCCCCCCCCCEEHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHEECC
FDHFFRGRTEQFAGDLVYIQGHSSPGIYGRAYLEGRLSEEQLDNFRRETDRDGISSYPHP
HHHHHCCCCHHHCCCEEEEEECCCCCCEEEHHHHCCCCHHHHHHHHHHCCCCCCCCCCCC
RLMPDFWQFPTVSMGLGPITAAYQARFMRYLENRGLKEHQGRKVWAFLGDGEMDQPESQA
CCCCHHHCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCHHCCCEEEEEECCCCCCCCCCCC
AIALAGREKLDNIIFVVNCNLQRLDGPVRGNSKVIQEFESLYRAAGWNVIKVIWGGGWDA
EEEECCHHCCCCEEEEEECCHHHCCCCCCCCHHHHHHHHHHHHHCCCCEEEEEECCCHHH
LLEKDKSGLLRQRMMECVDGEYQNYKSQNGAYVREHFFGKYPELLELVSDMSDDDIWKLS
HHHHHHHHHHHHHHHHHHCCHHHHHCCCCCCHHHHHHCCCCHHHHHHHHCCCCCCHHHHH
RGGHDPEKVYNAYAAAMRHKGGPTVILAKTVKGFGMGEAGEGQNINHQLKKLGAEAIKAF
CCCCCHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHH
RDRFSLDITDDQLGDMPYLKPAEGSTEALYLKARRAQLGGYIPARFSDAATLQIPPLSVL
HHHCCCCCCCHHCCCCCCCCCCCCCCCEEEEEEHHHHHCCCCCCCCCCCCEEECCCHHHH
DTQLKNTGDRGISTTMAFVRILSTLLKDPNIGKLIVPIVPDESRTFGMENLFRQIGIHSH
HHHHHCCCCCCHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCHHHHHHHHCCHHH
VGQLYTPQDAGQLSYYKESTDGQIMQEGLNESGAISSWIAASTSYANHGVMTVPFYIFYS
CCCCCCCCCCCCCEEECCCCCHHHHHHCCCCCCCHHHHHHHCCCCCCCCCCHHHHHHHHH
MFGFQRVGDLAWAAGDARARGFLLGATSGRTTLMGEGLQHDDGHSHVMSSTIPCCVSYDP
HHHHHHHHHHHHCCCCCCCCEEEEECCCCCCEEECCCCCCCCCCHHHHHCCCCEEEECCC
TFAFELAVIIQDGMRRMFAENEDIYYYITLLNENYPHPDLPEGAEAGILKGMYPLQASAS
CHHHHHHHHHHHHHHHHHCCCCCEEEEEEEECCCCCCCCCCCCCCCCHHCCCCCCCCCCC
INTGKHVQLMGCGSILLEVIAAARLLEDDFGVSSEIWSVTSLTELRREGQDAERWNLLNP
CCCCCEEEEEEHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCHHCCCCCC
QQEPRLSYVESCLADREGPVIVATDYMKIFADQIRPFVPMRRFVALGTDGFGQSDTRESL
CCCHHHHHHHHHHCCCCCCEEEEHHHHHHHHHHHCHHHHHHHHHHCCCCCCCCCHHHHHH
RHFFEVDRYFVAVAALKALADDGKVERKVVAQAIERYKIDPGKQNPVLV
HHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCCCCCC
>Mature Secondary Structure 
AQQPRFLDEDPQETREWLESIESVLNTEGRPRAHYLIDQLLDFDVAQHGDFYGRVTTPY
CCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCCCEEECCC
VNTIPSDRQQPYPGDLQVEKRINAFIRWNALVMVLRAGKHSGVGGHIASYASAAVLYDVG
CCCCCCCCCCCCCCCEEHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHEECC
FDHFFRGRTEQFAGDLVYIQGHSSPGIYGRAYLEGRLSEEQLDNFRRETDRDGISSYPHP
HHHHHCCCCHHHCCCEEEEEECCCCCCEEEHHHHCCCCHHHHHHHHHHCCCCCCCCCCCC
RLMPDFWQFPTVSMGLGPITAAYQARFMRYLENRGLKEHQGRKVWAFLGDGEMDQPESQA
CCCCHHHCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCHHCCCEEEEEECCCCCCCCCCCC
AIALAGREKLDNIIFVVNCNLQRLDGPVRGNSKVIQEFESLYRAAGWNVIKVIWGGGWDA
EEEECCHHCCCCEEEEEECCHHHCCCCCCCCHHHHHHHHHHHHHCCCCEEEEEECCCHHH
LLEKDKSGLLRQRMMECVDGEYQNYKSQNGAYVREHFFGKYPELLELVSDMSDDDIWKLS
HHHHHHHHHHHHHHHHHHCCHHHHHCCCCCCHHHHHHCCCCHHHHHHHHCCCCCCHHHHH
RGGHDPEKVYNAYAAAMRHKGGPTVILAKTVKGFGMGEAGEGQNINHQLKKLGAEAIKAF
CCCCCHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHH
RDRFSLDITDDQLGDMPYLKPAEGSTEALYLKARRAQLGGYIPARFSDAATLQIPPLSVL
HHHCCCCCCCHHCCCCCCCCCCCCCCCEEEEEEHHHHHCCCCCCCCCCCCEEECCCHHHH
DTQLKNTGDRGISTTMAFVRILSTLLKDPNIGKLIVPIVPDESRTFGMENLFRQIGIHSH
HHHHHCCCCCCHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCHHHHHHHHCCHHH
VGQLYTPQDAGQLSYYKESTDGQIMQEGLNESGAISSWIAASTSYANHGVMTVPFYIFYS
CCCCCCCCCCCCCEEECCCCCHHHHHHCCCCCCCHHHHHHHCCCCCCCCCCHHHHHHHHH
MFGFQRVGDLAWAAGDARARGFLLGATSGRTTLMGEGLQHDDGHSHVMSSTIPCCVSYDP
HHHHHHHHHHHHCCCCCCCCEEEEECCCCCCEEECCCCCCCCCCHHHHHCCCCEEEECCC
TFAFELAVIIQDGMRRMFAENEDIYYYITLLNENYPHPDLPEGAEAGILKGMYPLQASAS
CHHHHHHHHHHHHHHHHHCCCCCEEEEEEEECCCCCCCCCCCCCCCCHHCCCCCCCCCCC
INTGKHVQLMGCGSILLEVIAAARLLEDDFGVSSEIWSVTSLTELRREGQDAERWNLLNP
CCCCCEEEEEEHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCHHCCCCCC
QQEPRLSYVESCLADREGPVIVATDYMKIFADQIRPFVPMRRFVALGTDGFGQSDTRESL
CCCHHHHHHHHHHCCCCCCEEEEHHHHHHHHHHHCHHHHHHHHHHCCCCCCCCCHHHHHH
RHFFEVDRYFVAVAALKALADDGKVERKVVAQAIERYKIDPGKQNPVLV
HHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8021225 [H]