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The map label for this gene is tlpA [H]

Identifier: 66044785

GI number: 66044785

Start: 1732352

End: 1734232

Strand: Direct

Name: tlpA [H]

Synonym: Psyr_1539

Alternate gene names: 66044785

Gene position: 1732352-1734232 (Clockwise)

Preceding gene: 66044784

Following gene: 66044786

Centisome position: 28.43

GC content: 54.07

Gene sequence:

>1881_bases
ATGACGGTTCGGGCGAAGCTACTGGTGGGGTTCGGACTGTTGATTTTAATGATTTTGTTAATGGCTTATACGGGAAAGGA
TGCCACCGATACGTTGAAGCGTCGGGCTGAACTGTCTGGGGATATTGCTCAATTCAGCTCGATCGCCCGAGACATGCGTA
TCGAGCGTTTGGTTTATTTTTTAAAAGCGGATGATGCACAGGCTTCAAAGTGGTTGGAGGCACTCGAGCGGACGGAGCGT
CAGCTGGTGAGCATCTCGCCCCGTTTCAAAACAGCCAATAACATCGCGCTGCTCAAAGAAGCCCAAACGACGATGCAGCT
TTACCGTGGGTTCTATACTCGATCAGTCGAGGCTACTCGAGAGCGTGAGCAACTGCGGACCCTTGCCGGCGCTTCGGGCG
AAACGATTAACGGTTTGTTGCTGAAGATCGCAGAAGCCGCCAACGACGAGAGCGGGAATGCCGCGGATCGTCAGAAACTC
CCTGCACTGTTTATCTCTGTCCAGAAGATGCGAACCGCGTTTCGCTCTTATACGGCATCCCCGAGTAAAAGCGGGGAAGA
CACTGTCCGTCAGGCAATAGCGCAGGTGGTGGCCAGTATCGACACGCTCAAAGATACCAGTTTGCCCCGTGCTGACGTTC
AAGCGTTGGCGGCAGGAATGGCCACCTATAGCGGGCAACTGGAAACATTAGTTGCCGCTCAGGCCAAAGTTGATGAGGCT
CAAGGCGGTATCACAACGTCGATCGCCACCATTCTTGGCATTACGGACAAGATGACGGCTATCCAGAATGAGTTTCGTGC
CTCCGATGCAGAGAAAGCACAGGAGAAGATTTTGCTCTGGCTGGGCCTTTCTGCTCTCTTGGGTGTTCTTGCGGCCTGGT
TGATTACTCGATCAATTGTTCATCCACTCAAAGAGACTGTTGAAATCGTTGAAGTCGTTGCAGAAGGGGATTTTACGTAC
AAAACGCAAGTGACTCGAAATGATGAGTTGGGCGCGTTGCAGGGCAGCATGCTGCGCATGACGTCCGGGCTCCGAAGCCT
GATCGGGGAAATGAAAGACGGAATCGTGCAGGTGGCAAGCGCGGCAGAGCAGCTTTCAGCAGTAACCGAGCAGACCAGTG
CGGGCGTGAACGCGCAGAAGCTGGAGACTGAGCAGATTGCCACTGCGATGCAGCAGATGACAGCCACTACTCATGAGGTA
TCTCGTAATGCAGCCCAAGCCGTAAATACTGCGCAAATCGCCAGTCAGTTGGCCCAGAAAGGTGGGCAAGTCGTTGACAG
GACTCGTTCCCAGATAGAGACCCTGGCGCGTGAGATGAACATGACCAGAACAGCGATGGCGGCGCTTAGAGGGAATACTC
AGAGCATCGGTGGCGTGCTGGATGTGATAAAAACGGTGGCTGATCAGACAAACCTTCTGGCGTTGAACGCGGCCATTGAA
GCTGCGCGTGCCGGGGAGGCAGGACGTGGTTTCGCTGTCGTCGCGGACGAGGTGAGAGGCCTGGCGGTGCGCACCCGCAC
GTCAACAGACGAGATCGCTCTGCTTATAAACGAACTGCAAACCAGTACCGATCATATGGGGCAGGTTCTAGAGCAAAATC
TGGCACTGACGGACAGCAGTGTCGAACTGTCTACGCAAGCCAGCGAAGTGCTGCAGAGTATTACCGCATCTGTTCATGAG
ATTGAGGTGATGAACGAACAGATCGCCGTTGCTACTGAGCAGCAAAGTAACGTCGGTGAAGAAATAGGCAGGGGCGTCAC
GAATGTCAGGGACATTTCAGACCAAACAGCCGCCGCCAGTGAAGAGACAGCGACATCGAGTGTTGAATTGGCCAGAGTCA
GCGCCAGACTGCAGGAGATGACCAACCGGTTTAAAGTCTAG

Upstream 100 bases:

>100_bases
TCGGACTCTATGTTCCGCTACCTGTCCGGCGGACTTTTATTTTCAAAAAATCAATGAGTAAAGATATATGTCCAGCGCAA
CATCTGGTGTGTTAAGTAAT

Downstream 100 bases:

>100_bases
CCTGAAGGTCTGGCCCAATGCGTTTGTGGCTTGGGTCAGGCCTCAACAAGACCAGATCGAGTTCATACCGCGTTGCGGCA
CTCAGCCGCCATGCATGGGC

Product: histidine kinase, HAMP region: chemotaxis sensory transducer

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 626; Mature: 625

Protein sequence:

>626_residues
MTVRAKLLVGFGLLILMILLMAYTGKDATDTLKRRAELSGDIAQFSSIARDMRIERLVYFLKADDAQASKWLEALERTER
QLVSISPRFKTANNIALLKEAQTTMQLYRGFYTRSVEATREREQLRTLAGASGETINGLLLKIAEAANDESGNAADRQKL
PALFISVQKMRTAFRSYTASPSKSGEDTVRQAIAQVVASIDTLKDTSLPRADVQALAAGMATYSGQLETLVAAQAKVDEA
QGGITTSIATILGITDKMTAIQNEFRASDAEKAQEKILLWLGLSALLGVLAAWLITRSIVHPLKETVEIVEVVAEGDFTY
KTQVTRNDELGALQGSMLRMTSGLRSLIGEMKDGIVQVASAAEQLSAVTEQTSAGVNAQKLETEQIATAMQQMTATTHEV
SRNAAQAVNTAQIASQLAQKGGQVVDRTRSQIETLAREMNMTRTAMAALRGNTQSIGGVLDVIKTVADQTNLLALNAAIE
AARAGEAGRGFAVVADEVRGLAVRTRTSTDEIALLINELQTSTDHMGQVLEQNLALTDSSVELSTQASEVLQSITASVHE
IEVMNEQIAVATEQQSNVGEEIGRGVTNVRDISDQTAAASEETATSSVELARVSARLQEMTNRFKV

Sequences:

>Translated_626_residues
MTVRAKLLVGFGLLILMILLMAYTGKDATDTLKRRAELSGDIAQFSSIARDMRIERLVYFLKADDAQASKWLEALERTER
QLVSISPRFKTANNIALLKEAQTTMQLYRGFYTRSVEATREREQLRTLAGASGETINGLLLKIAEAANDESGNAADRQKL
PALFISVQKMRTAFRSYTASPSKSGEDTVRQAIAQVVASIDTLKDTSLPRADVQALAAGMATYSGQLETLVAAQAKVDEA
QGGITTSIATILGITDKMTAIQNEFRASDAEKAQEKILLWLGLSALLGVLAAWLITRSIVHPLKETVEIVEVVAEGDFTY
KTQVTRNDELGALQGSMLRMTSGLRSLIGEMKDGIVQVASAAEQLSAVTEQTSAGVNAQKLETEQIATAMQQMTATTHEV
SRNAAQAVNTAQIASQLAQKGGQVVDRTRSQIETLAREMNMTRTAMAALRGNTQSIGGVLDVIKTVADQTNLLALNAAIE
AARAGEAGRGFAVVADEVRGLAVRTRTSTDEIALLINELQTSTDHMGQVLEQNLALTDSSVELSTQASEVLQSITASVHE
IEVMNEQIAVATEQQSNVGEEIGRGVTNVRDISDQTAAASEETATSSVELARVSARLQEMTNRFKV
>Mature_625_residues
TVRAKLLVGFGLLILMILLMAYTGKDATDTLKRRAELSGDIAQFSSIARDMRIERLVYFLKADDAQASKWLEALERTERQ
LVSISPRFKTANNIALLKEAQTTMQLYRGFYTRSVEATREREQLRTLAGASGETINGLLLKIAEAANDESGNAADRQKLP
ALFISVQKMRTAFRSYTASPSKSGEDTVRQAIAQVVASIDTLKDTSLPRADVQALAAGMATYSGQLETLVAAQAKVDEAQ
GGITTSIATILGITDKMTAIQNEFRASDAEKAQEKILLWLGLSALLGVLAAWLITRSIVHPLKETVEIVEVVAEGDFTYK
TQVTRNDELGALQGSMLRMTSGLRSLIGEMKDGIVQVASAAEQLSAVTEQTSAGVNAQKLETEQIATAMQQMTATTHEVS
RNAAQAVNTAQIASQLAQKGGQVVDRTRSQIETLAREMNMTRTAMAALRGNTQSIGGVLDVIKTVADQTNLLALNAAIEA
ARAGEAGRGFAVVADEVRGLAVRTRTSTDEIALLINELQTSTDHMGQVLEQNLALTDSSVELSTQASEVLQSITASVHEI
EVMNEQIAVATEQQSNVGEEIGRGVTNVRDISDQTAAASEETATSSVELARVSARLQEMTNRFKV

Specific function: Chemotactic-signal transducers respond to changes in the concentration of attractants and repellents in the environment, transduce a signal from the outside to the inside of the cell, and facilitate sensory adaptation through the variation of the level of

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 methyl-accepting transducer domain [H]

Homologues:

Organism=Escherichia coli, GI2367378, Length=353, Percent_Identity=32.5779036827195, Blast_Score=140, Evalue=2e-34,
Organism=Escherichia coli, GI1787690, Length=343, Percent_Identity=31.1953352769679, Blast_Score=139, Evalue=8e-34,
Organism=Escherichia coli, GI1788194, Length=328, Percent_Identity=33.5365853658537, Blast_Score=127, Evalue=3e-30,
Organism=Escherichia coli, GI1788195, Length=307, Percent_Identity=30.6188925081433, Blast_Score=120, Evalue=3e-28,
Organism=Escherichia coli, GI1789453, Length=337, Percent_Identity=29.080118694362, Blast_Score=102, Evalue=1e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004010
- InterPro:   IPR003122
- InterPro:   IPR004089
- InterPro:   IPR003660
- InterPro:   IPR022094 [H]

Pfam domain/function: PF02743 Cache_1; PF00672 HAMP; PF12332 McpA_N; PF00015 MCPsignal; PF02203 TarH [H]

EC number: NA

Molecular weight: Translated: 67412; Mature: 67281

Theoretical pI: Translated: 4.91; Mature: 4.91

Prosite motif: PS50885 HAMP ; PS50111 CHEMOTAXIS_TRANSDUC_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTVRAKLLVGFGLLILMILLMAYTGKDATDTLKRRAELSGDIAQFSSIARDMRIERLVYF
CCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHH
LKADDAQASKWLEALERTERQLVSISPRFKTANNIALLKEAQTTMQLYRGFYTRSVEATR
HHCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
EREQLRTLAGASGETINGLLLKIAEAANDESGNAADRQKLPALFISVQKMRTAFRSYTAS
HHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCC
PSKSGEDTVRQAIAQVVASIDTLKDTSLPRADVQALAAGMATYSGQLETLVAAQAKVDEA
CCCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHH
QGGITTSIATILGITDKMTAIQNEFRASDAEKAQEKILLWLGLSALLGVLAAWLITRSIV
CCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
HPLKETVEIVEVVAEGDFTYKTQVTRNDELGALQGSMLRMTSGLRSLIGEMKDGIVQVAS
HHHHHHHHHHHHHHCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AAEQLSAVTEQTSAGVNAQKLETEQIATAMQQMTATTHEVSRNAAQAVNTAQIASQLAQK
HHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
GGQVVDRTRSQIETLAREMNMTRTAMAALRGNTQSIGGVLDVIKTVADQTNLLALNAAIE
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCEEEHHHHHH
AARAGEAGRGFAVVADEVRGLAVRTRTSTDEIALLINELQTSTDHMGQVLEQNLALTDSS
HHHCCCCCCCCEEEHHHHCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
VELSTQASEVLQSITASVHEIEVMNEQIAVATEQQSNVGEEIGRGVTNVRDISDQTAAAS
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCHHHHHHHHHCCCHHHHHHCCHHHHCCC
EETATSSVELARVSARLQEMTNRFKV
HHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
TVRAKLLVGFGLLILMILLMAYTGKDATDTLKRRAELSGDIAQFSSIARDMRIERLVYF
CCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHH
LKADDAQASKWLEALERTERQLVSISPRFKTANNIALLKEAQTTMQLYRGFYTRSVEATR
HHCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
EREQLRTLAGASGETINGLLLKIAEAANDESGNAADRQKLPALFISVQKMRTAFRSYTAS
HHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCC
PSKSGEDTVRQAIAQVVASIDTLKDTSLPRADVQALAAGMATYSGQLETLVAAQAKVDEA
CCCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHH
QGGITTSIATILGITDKMTAIQNEFRASDAEKAQEKILLWLGLSALLGVLAAWLITRSIV
CCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
HPLKETVEIVEVVAEGDFTYKTQVTRNDELGALQGSMLRMTSGLRSLIGEMKDGIVQVAS
HHHHHHHHHHHHHHCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AAEQLSAVTEQTSAGVNAQKLETEQIATAMQQMTATTHEVSRNAAQAVNTAQIASQLAQK
HHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
GGQVVDRTRSQIETLAREMNMTRTAMAALRGNTQSIGGVLDVIKTVADQTNLLALNAAIE
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCEEEHHHHHH
AARAGEAGRGFAVVADEVRGLAVRTRTSTDEIALLINELQTSTDHMGQVLEQNLALTDSS
HHHCCCCCCCCEEEHHHHCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
VELSTQASEVLQSITASVHEIEVMNEQIAVATEQQSNVGEEIGRGVTNVRDISDQTAAAS
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCHHHHHHHHHCCCHHHHHHCCHHHHCCC
EETATSSVELARVSARLQEMTNRFKV
HHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8188684; 9384377 [H]