Click here to switch to the map view.

The map label for this gene is yngE [H]

Identifier: 66044784

GI number: 66044784

Start: 1728915

End: 1730282

Strand: Direct

Name: yngE [H]

Synonym: Psyr_1538

Alternate gene names: 66044784

Gene position: 1728915-1730282 (Clockwise)

Preceding gene: 66044783

Following gene: 66044785

Centisome position: 28.37

GC content: 50.58

Gene sequence:

>1368_bases
ATGAGCGTTTCCGAAAGACGCGTCTCTAGGTTGTTTGATCCAGGTAGTTTCAAGGAGGACCTCGAGGGCCAGAACACCCA
TTTCATCTGCGGGGCAGGAACGATCCACTCAATCAAGACCTATGTTGCGATGAGTCGCGGTCGTGACTGCGAGTTTCAAA
GCAGTCGGCAATGGAGTACGGCTCAGCAAATTATAAAAACGGTAGGTTTGGCACGAGCTGCTGAAGCCCCGCTTATCTAT
ATTCAAGATAAAATCGGGGGTAATAATGATACTGAAGGCTTTGATACAGCCAGAGTTTTTTCTTCAGATATGTCAAGTTT
GCTTCTTTCCCCGTCCGGGATGGGCAGCGTCAGCGCATCGCTGGCAGAGTTGGCAAAACTCAATTTGCTGATGTCCGTGA
TTTTAGGGCCGACATCAGGGCCTTTGGCGTTACCTGTGATGCTCGCCGATCTGGTGCTGATGACTCGTCGAGGAGCTCTG
TGTATGGGACGACCTGACATGGTCAAGGCGATGCTCGCTCAACAGACCGATCTTTATTCCCTCGGCGGGTCCGATATCCA
CAGTACCGCGTCTGGGTCCGTGCACTTGGTTTTTGACGACGAGGCTGATCTGTTCGCCGATCTGAGAAAACTGCTCTTAT
ATCTGATTGCTGGAAAAAGCTCGACGTACGGTGAGTTTTCAACCCCACTTGAAGTGGATTTCAACCGCCTGCTGCCCCCG
TCTCATAATATTCCTTTTGATGTGCAGCATCTGGTACGTTCATTTGTCGATAGCGACAGCCTGATCGAAATCGGTGCCTC
TCATGCGCCTGAGGTTTTAGTCGGGCTGGCCAGCCTGCAAGGGCAGGTTTTTGCCGTGGTTGCCAACAACTCCGCGCATG
GCGGCGGCGTCATCTACAAAAGGACCGCCCGTAAAATGATTCATGTCATTGACCTAGCTGGGAAAATGAGCTTGCCCATT
TTGTTTATCGCAGATATTCCTGGGATCATGATTGGGGAAGAGGCTGAACGCGATGGGATTTTTGCCGCTGTGGCAGATTT
ATTCAGAGCACATACCCGATGCAAGGTAAAAAAATTATTGTTGGTTGCTCGGAAGGCGTACACCGGTGGTGTTTATGCCA
TGAGCGGGCCAGGCTTTGAACCTGTCGCCGTGCTGGCCTATCCTGACGCCAATATAGGCGTTTTCAGTACCCTTACCATG
GAAAAGATCATCAAGTCCTCAAGCATGACCGATGCGCAGAGAGCTGTGGTGTCCGCATTGGATGAAGAAATCAGATCGCC
GTTATTGCTCAAAGACAAGGGCTTGATTACCGATGTCATCAGTGTGCGAGATACACGGCAGGCAGTGTTCAAGTATCTGT
TTCATTAG

Upstream 100 bases:

>100_bases
AGAGAAAGTATTAAAGGGTTGAGGTTTCAGTTGCCGACGCTTGTTGACGGGGTGTCGCGGTGTCGGCGTTTATCTACGCA
AACCGACGTCAGGAGTTTCG

Downstream 100 bases:

>100_bases
GAGTGTTCAGCTCCGTACCTGACGGCGTCCCAGTGGTGGGCACCAGCAATTACTGCCCTGGGTTGCGTGCCCCTTCGCAA
TTGCAAAACTTGATGAGGGA

Product: propionyl-CoA carboxylase

Products: ADP; phosphate; (S)-methylmalonyl-CoA

Alternate protein names: NA

Number of amino acids: Translated: 455; Mature: 454

Protein sequence:

>455_residues
MSVSERRVSRLFDPGSFKEDLEGQNTHFICGAGTIHSIKTYVAMSRGRDCEFQSSRQWSTAQQIIKTVGLARAAEAPLIY
IQDKIGGNNDTEGFDTARVFSSDMSSLLLSPSGMGSVSASLAELAKLNLLMSVILGPTSGPLALPVMLADLVLMTRRGAL
CMGRPDMVKAMLAQQTDLYSLGGSDIHSTASGSVHLVFDDEADLFADLRKLLLYLIAGKSSTYGEFSTPLEVDFNRLLPP
SHNIPFDVQHLVRSFVDSDSLIEIGASHAPEVLVGLASLQGQVFAVVANNSAHGGGVIYKRTARKMIHVIDLAGKMSLPI
LFIADIPGIMIGEEAERDGIFAAVADLFRAHTRCKVKKLLLVARKAYTGGVYAMSGPGFEPVAVLAYPDANIGVFSTLTM
EKIIKSSSMTDAQRAVVSALDEEIRSPLLLKDKGLITDVISVRDTRQAVFKYLFH

Sequences:

>Translated_455_residues
MSVSERRVSRLFDPGSFKEDLEGQNTHFICGAGTIHSIKTYVAMSRGRDCEFQSSRQWSTAQQIIKTVGLARAAEAPLIY
IQDKIGGNNDTEGFDTARVFSSDMSSLLLSPSGMGSVSASLAELAKLNLLMSVILGPTSGPLALPVMLADLVLMTRRGAL
CMGRPDMVKAMLAQQTDLYSLGGSDIHSTASGSVHLVFDDEADLFADLRKLLLYLIAGKSSTYGEFSTPLEVDFNRLLPP
SHNIPFDVQHLVRSFVDSDSLIEIGASHAPEVLVGLASLQGQVFAVVANNSAHGGGVIYKRTARKMIHVIDLAGKMSLPI
LFIADIPGIMIGEEAERDGIFAAVADLFRAHTRCKVKKLLLVARKAYTGGVYAMSGPGFEPVAVLAYPDANIGVFSTLTM
EKIIKSSSMTDAQRAVVSALDEEIRSPLLLKDKGLITDVISVRDTRQAVFKYLFH
>Mature_454_residues
SVSERRVSRLFDPGSFKEDLEGQNTHFICGAGTIHSIKTYVAMSRGRDCEFQSSRQWSTAQQIIKTVGLARAAEAPLIYI
QDKIGGNNDTEGFDTARVFSSDMSSLLLSPSGMGSVSASLAELAKLNLLMSVILGPTSGPLALPVMLADLVLMTRRGALC
MGRPDMVKAMLAQQTDLYSLGGSDIHSTASGSVHLVFDDEADLFADLRKLLLYLIAGKSSTYGEFSTPLEVDFNRLLPPS
HNIPFDVQHLVRSFVDSDSLIEIGASHAPEVLVGLASLQGQVFAVVANNSAHGGGVIYKRTARKMIHVIDLAGKMSLPIL
FIADIPGIMIGEEAERDGIFAAVADLFRAHTRCKVKKLLLVARKAYTGGVYAMSGPGFEPVAVLAYPDANIGVFSTLTME
KIIKSSSMTDAQRAVVSALDEEIRSPLLLKDKGLITDVISVRDTRQAVFKYLFH

Specific function: Unknown

COG id: COG4799

COG function: function code I; Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta)

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 carboxyltransferase domain [H]

Homologues:

Organism=Homo sapiens, GI119943100, Length=469, Percent_Identity=24.7334754797441, Blast_Score=123, Evalue=3e-28,
Organism=Homo sapiens, GI295821216, Length=489, Percent_Identity=24.1308793456033, Blast_Score=120, Evalue=3e-27,
Organism=Homo sapiens, GI11545863, Length=317, Percent_Identity=26.4984227129338, Blast_Score=111, Evalue=1e-24,
Organism=Caenorhabditis elegans, GI25147359, Length=407, Percent_Identity=24.8157248157248, Blast_Score=119, Evalue=4e-27,
Organism=Caenorhabditis elegans, GI17552936, Length=419, Percent_Identity=26.491646778043, Blast_Score=119, Evalue=4e-27,
Organism=Caenorhabditis elegans, GI25147362, Length=407, Percent_Identity=24.8157248157248, Blast_Score=119, Evalue=4e-27,
Organism=Drosophila melanogaster, GI24586065, Length=463, Percent_Identity=23.110151187905, Blast_Score=119, Evalue=5e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000022
- InterPro:   IPR011763
- InterPro:   IPR011762 [H]

Pfam domain/function: PF01039 Carboxyl_trans [H]

EC number: 6.4.1.3

Molecular weight: Translated: 49115; Mature: 48984

Theoretical pI: Translated: 6.74; Mature: 6.74

Prosite motif: PS00624 GMC_OXRED_2 ; PS50980 COA_CT_NTER ; PS50989 COA_CT_CTER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSVSERRVSRLFDPGSFKEDLEGQNTHFICGAGTIHSIKTYVAMSRGRDCEFQSSRQWST
CCCCHHHHHHHCCCCCCHHHCCCCCCEEEECCCHHHHHHHHHHHHCCCCCCCCCCCCHHH
AQQIIKTVGLARAAEAPLIYIQDKIGGNNDTEGFDTARVFSSDMSSLLLSPSGMGSVSAS
HHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCHHHHH
LAELAKLNLLMSVILGPTSGPLALPVMLADLVLMTRRGALCMGRPDMVKAMLAQQTDLYS
HHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCEECCCHHHHHHHHHHCCCHHC
LGGSDIHSTASGSVHLVFDDEADLFADLRKLLLYLIAGKSSTYGEFSTPLEVDFNRLLPP
CCCCCCCCCCCCEEEEEECCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHCCCC
SHNIPFDVQHLVRSFVDSDSLIEIGASHAPEVLVGLASLQGQVFAVVANNSAHGGGVIYK
CCCCCHHHHHHHHHHCCCCCCEECCCCCCHHHHHHHHHCCCEEEEEEECCCCCCCCEEEH
RTARKMIHVIDLAGKMSLPILFIADIPGIMIGEEAERDGIFAAVADLFRAHTRCKVKKLL
HHHHHHHHHHHHCCCCCCCEEEEECCCCEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHH
LVARKAYTGGVYAMSGPGFEPVAVLAYPDANIGVFSTLTMEKIIKSSSMTDAQRAVVSAL
HHHHHHHCCCEEEECCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHH
DEEIRSPLLLKDKGLITDVISVRDTRQAVFKYLFH
HHHHCCCEEEECCCHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
SVSERRVSRLFDPGSFKEDLEGQNTHFICGAGTIHSIKTYVAMSRGRDCEFQSSRQWST
CCCHHHHHHHCCCCCCHHHCCCCCCEEEECCCHHHHHHHHHHHHCCCCCCCCCCCCHHH
AQQIIKTVGLARAAEAPLIYIQDKIGGNNDTEGFDTARVFSSDMSSLLLSPSGMGSVSAS
HHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCHHHHH
LAELAKLNLLMSVILGPTSGPLALPVMLADLVLMTRRGALCMGRPDMVKAMLAQQTDLYS
HHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCEECCCHHHHHHHHHHCCCHHC
LGGSDIHSTASGSVHLVFDDEADLFADLRKLLLYLIAGKSSTYGEFSTPLEVDFNRLLPP
CCCCCCCCCCCCEEEEEECCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHCCCC
SHNIPFDVQHLVRSFVDSDSLIEIGASHAPEVLVGLASLQGQVFAVVANNSAHGGGVIYK
CCCCCHHHHHHHHHHCCCCCCEECCCCCCHHHHHHHHHCCCEEEEEEECCCCCCCCEEEH
RTARKMIHVIDLAGKMSLPILFIADIPGIMIGEEAERDGIFAAVADLFRAHTRCKVKKLL
HHHHHHHHHHHHCCCCCCCEEEEECCCCEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHH
LVARKAYTGGVYAMSGPGFEPVAVLAYPDANIGVFSTLTMEKIIKSSSMTDAQRAVVSAL
HHHHHHHCCCEEEECCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHH
DEEIRSPLLLKDKGLITDVISVRDTRQAVFKYLFH
HHHHCCCEEEECCCHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; propanoyl-CoA; HCO3-

Specific reaction: ATP + propanoyl-CoA + HCO3- = ADP + phosphate + (S)-methylmalonyl-CoA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377; 9387222 [H]