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The map label for this gene is kdsA [H]

Identifier: 66044610

GI number: 66044610

Start: 1546000

End: 1546845

Strand: Direct

Name: kdsA [H]

Synonym: Psyr_1362

Alternate gene names: 66044610

Gene position: 1546000-1546845 (Clockwise)

Preceding gene: 66044609

Following gene: 66044611

Centisome position: 25.37

GC content: 57.21

Gene sequence:

>846_bases
ATGGCTCAGAAAATCATCCGCGTAGGTTCGATCGAGGTCGCCAACGACAAGCCAATGGTGCTGTTCGGCGGCATGAACGT
ACTCGAATCCCGGGATATGGCCATGCAGGTCTGTGAAGAATACGTAAAGGTCACCGAAAAGCTCGGTATCCCTTACGTGT
TCAAGGCCAGCTTCGACAAGGCCAACCGCTCTTCGGTGAACTCCTACCGCGGGCCGGGCCTTGAAGAAGGCATGCGTATT
TTCGAAGAGATCAAGCGCACCTTCAACGTGCCGCTGATCACCGATGTTCACGAGCCTCATCAGGCTGCCGTGGTGGCCGA
AGTCTGCGACATCATTCAGCTGCCGGCTTTCCTGTCGCGGCAGACCGATCTGGTTGTGGCGATGGCGAAAACCGGCGCGA
TCATCAACATCAAGAAAGCCCAGTTCCTTGCACCCCAGGAAATGAAACACATCCTGACCAAGTGCGAAGAGGCCGGTAAC
GATCAGTTGATTCTCTGTGAGCGGGGTTCCAGCTTCGGTTACAACAACCTGGTCGTGGACATGCTTGGCTTCGGCATCAT
GAAACAGTTCGAGTACCCGATCCTGTTCGACGTGACCCACGCCCTGCAGATGCCGGGCGGTCGTTCCGATTCTGCCGGCG
GCCGCCGCGCCCAGGTGCTGGACCTGGCCAAGGCCGGCATCAGTCAGAATCTGGCCGGTTTGTTCCTTGAAGCCCATCCG
GACCCTGACAACGCCAAATGCGACGGGCCATGTGCCCTGCGTCTGGACAAACTGGAGCCGTTCCTGGCCCAGCTCAAGTC
ACTGGATGAACTTGTCAAAAGTTTTCCGATCGTAGAGACCGCTTGA

Upstream 100 bases:

>100_bases
AATTCACCTCCACGCCCCGTGACGGTCATCCGCTGTTCAGCGGCTTCGTCAAGGCGGCACTGGCTCAACATCAGAAAAAT
TCCTGACAGGGACTGCAGAC

Downstream 100 bases:

>100_bases
GCAGGGTTCTCCGGTAAAGTGCCGTTCCCCGTCATTCGTGACGGGGTTGTCACATTCAGGGCTGCCGGTTTTTGCGCCTG
ACTGTGAACATCGTTTTCCC

Product: 2-dehydro-3-deoxyphosphooctonate aldolase

Products: NA

Alternate protein names: 3-deoxy-D-manno-octulosonic acid 8-phosphate synthase; KDO-8-phosphate synthase; KDO 8-P synthase; KDOPS; Phospho-2-dehydro-3-deoxyoctonate aldolase [H]

Number of amino acids: Translated: 281; Mature: 280

Protein sequence:

>281_residues
MAQKIIRVGSIEVANDKPMVLFGGMNVLESRDMAMQVCEEYVKVTEKLGIPYVFKASFDKANRSSVNSYRGPGLEEGMRI
FEEIKRTFNVPLITDVHEPHQAAVVAEVCDIIQLPAFLSRQTDLVVAMAKTGAIINIKKAQFLAPQEMKHILTKCEEAGN
DQLILCERGSSFGYNNLVVDMLGFGIMKQFEYPILFDVTHALQMPGGRSDSAGGRRAQVLDLAKAGISQNLAGLFLEAHP
DPDNAKCDGPCALRLDKLEPFLAQLKSLDELVKSFPIVETA

Sequences:

>Translated_281_residues
MAQKIIRVGSIEVANDKPMVLFGGMNVLESRDMAMQVCEEYVKVTEKLGIPYVFKASFDKANRSSVNSYRGPGLEEGMRI
FEEIKRTFNVPLITDVHEPHQAAVVAEVCDIIQLPAFLSRQTDLVVAMAKTGAIINIKKAQFLAPQEMKHILTKCEEAGN
DQLILCERGSSFGYNNLVVDMLGFGIMKQFEYPILFDVTHALQMPGGRSDSAGGRRAQVLDLAKAGISQNLAGLFLEAHP
DPDNAKCDGPCALRLDKLEPFLAQLKSLDELVKSFPIVETA
>Mature_280_residues
AQKIIRVGSIEVANDKPMVLFGGMNVLESRDMAMQVCEEYVKVTEKLGIPYVFKASFDKANRSSVNSYRGPGLEEGMRIF
EEIKRTFNVPLITDVHEPHQAAVVAEVCDIIQLPAFLSRQTDLVVAMAKTGAIINIKKAQFLAPQEMKHILTKCEEAGND
QLILCERGSSFGYNNLVVDMLGFGIMKQFEYPILFDVTHALQMPGGRSDSAGGRRAQVLDLAKAGISQNLAGLFLEAHPD
PDNAKCDGPCALRLDKLEPFLAQLKSLDELVKSFPIVETA

Specific function: Synthesis Of Kdo 8-P Which Is Required For Lipid A Maturation And Cellular Growth. [C]

COG id: COG2877

COG function: function code M; 3-deoxy-D-manno-octulosonic acid (KDO) 8-phosphate synthase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the kdsA family [H]

Homologues:

Organism=Escherichia coli, GI1787466, Length=283, Percent_Identity=66.4310954063604, Blast_Score=399, Evalue=1e-112,

Paralogues:

None

Copy number: 200 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR006218
- InterPro:   IPR006269 [H]

Pfam domain/function: PF00793 DAHP_synth_1 [H]

EC number: =2.5.1.55 [H]

Molecular weight: Translated: 30931; Mature: 30800

Theoretical pI: Translated: 5.42; Mature: 5.42

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
6.0 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
5.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAQKIIRVGSIEVANDKPMVLFGGMNVLESRDMAMQVCEEYVKVTEKLGIPYVFKASFDK
CCCCEEEECCEEECCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCC
ANRSSVNSYRGPGLEEGMRIFEEIKRTFNVPLITDVHEPHQAAVVAEVCDIIQLPAFLSR
CCHHCCHHCCCCCHHHHHHHHHHHHHHCCCCEEECCCCCHHHHHHHHHHHHHHHHHHHCC
QTDLVVAMAKTGAIINIKKAQFLAPQEMKHILTKCEEAGNDQLILCERGSSFGYNNLVVD
CCCEEEEEECCCCEEEECHHHHCCHHHHHHHHHHHHHCCCCCEEEEECCCCCCCHHHHHH
MLGFGIMKQFEYPILFDVTHALQMPGGRSDSAGGRRAQVLDLAKAGISQNLAGLFLEAHP
HHHHHHHHHCCCCEEEEHHHHHHCCCCCCCCCCCCHHHHHHHHHHCHHCCCCEEEEEECC
DPDNAKCDGPCALRLDKLEPFLAQLKSLDELVKSFPIVETA
CCCCCCCCCCCEEEHHHHHHHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure 
AQKIIRVGSIEVANDKPMVLFGGMNVLESRDMAMQVCEEYVKVTEKLGIPYVFKASFDK
CCCEEEECCEEECCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCC
ANRSSVNSYRGPGLEEGMRIFEEIKRTFNVPLITDVHEPHQAAVVAEVCDIIQLPAFLSR
CCHHCCHHCCCCCHHHHHHHHHHHHHHCCCCEEECCCCCHHHHHHHHHHHHHHHHHHHCC
QTDLVVAMAKTGAIINIKKAQFLAPQEMKHILTKCEEAGNDQLILCERGSSFGYNNLVVD
CCCEEEEEECCCCEEEECHHHHCCHHHHHHHHHHHHHCCCCCEEEEECCCCCCCHHHHHH
MLGFGIMKQFEYPILFDVTHALQMPGGRSDSAGGRRAQVLDLAKAGISQNLAGLFLEAHP
HHHHHHHHHCCCCEEEEHHHHHHCCCCCCCCCCCCHHHHHHHHHHCHHCCCCEEEEEECC
DPDNAKCDGPCALRLDKLEPFLAQLKSLDELVKSFPIVETA
CCCCCCCCCCCEEEHHHHHHHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA