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The map label for this gene is zwf [H]

Identifier: 66044371

GI number: 66044371

Start: 1269242

End: 1270711

Strand: Direct

Name: zwf [H]

Synonym: Psyr_1120

Alternate gene names: 66044371

Gene position: 1269242-1270711 (Clockwise)

Preceding gene: 66044369

Following gene: 66044372

Centisome position: 20.83

GC content: 58.91

Gene sequence:

>1470_bases
ATGCCCTTGATTACGGTTGAACCGTGCACATTTGCCCTGTTTGGTGCCTTGGGGGACCTTGCGGTACGCAAGCTGTTCCC
GGCTCTTTATCAGCTTGATCGCGCTGGACTGCTGCATGAAGACACAAAAATTCTTGCCCTGGCGCGTGAACCAGGCGACG
AAGAGTCGCATCTGGCGTACATCGAAAAATCCATGCGCCGCTTCATTCCCGAGACGGAGCTGGAGCCGGACAACCTGAGC
CGCTTTCTGGCGCGTCTCAGCTATCTGCATGTCGACTTTCTCAAGGCCGAGGATTACGTTGCGCTCGCCGAGCGTGTCGG
CAATGCCGAAACCCTGATCGCCTATTTCGCCACACCGGCCTCGGTCTATGGCGCCATCTGCGAGAACCTCGCGTCGGTCA
ATCTCGCCGAACGCACGCGTGCCGTACTGGAAAAACCCATCGGCCACGACCTGGCCTCTTCGCGCCGGGTCAATGACGCC
GTCGCGCAGTTTTTCCCGGAAAACCGCGTCTATCGCATCGACCACTATCTGGGCAAGGACACGGTACAGAACCTCATCGC
TCTGCGCTTCGCCAACAGCCTGTTCGAAACCCAGTGGAACCAGAACCATATTTCGCACGTAGAGATCACGGTGGCCGAGA
AGGTCGGCATCGAAGGCCGTTGGGGCTACTTCGATCAGGCCGGCCAGCTGCGTGACATGATTCAGAACCACCTGCTGCAG
CTGCTCTGCCTGATTGCCATGGACCCGCCAAGCGACCTGTCGGCCGACAGTATCCGTGACGAGAAGGTCAAGGTGCTCAA
GGCACTCGCACCTTTCACCCCGGAGCGTCTGGCGACCCAGGTGGTGCGTGGCCAGTACACCTCTGGCTACAGCGAAGGCA
AGGCGGTGCCTGGCTATCTGGAAGAGGAAAACTCCAATACCCAGAGCGATACCGAAACCTTCGTCGCGTTGCGTGCCGAT
ATCCGCAACTGGCGCTGGTCGGGTACGCCGTTCTATTTGCGCACCGGCAAACGCATGCCGCAGAAGCTGTCGCAGATCGT
GATCCATTTCAAAGAGCCGCCGCACTACATCTTCGCGCCTGAACAGCGTTTGCAGATCAGCAACCGCCTGATCATCCGCC
TGCAGCCTGACGAAGGCATCTCCTTGCAGGTGATGACCAAGGATCAGGGCCTTGACAAGGGCATGCAGCTGCGCAGCGGT
CCCTTGCAACTGAATTTTTCCGACACCTACCGCAGCGCTCGTGTCCCCGACGCTTATGAGCGGTTGTTGCTGGAAGTCAT
GCGTGGCAATCAGAACCTGTTTGTCCGCAAAGATGAGATCGAGTACGCCTGGCAATGGTGCGATCAATTGATCGCTGGCT
GGAAGAAGGCGGGCGATGCGCCCAAGCCTTACCCGGCCGGAACCTGGGGGCCGATGAGCTCCATTGCCCTGATTACTCGC
GACGGGAGATCCTGGTATGGCGACATGTGA

Upstream 100 bases:

>100_bases
ATGCTTTCAGGCAGAATGTTGTGGTTATTACTACATATGGCCTTGAGTAACGCCTTTAAAAAAGGTATTTGTAGCCTAAC
TTGATAAAAGAACCAACATT

Downstream 100 bases:

>100_bases
CCTCAAGCTGCCAGCAGGGCTGGTAGCACACGATTTCGACACGGCGCAGCAACTGGCCGATGCACTGGCCGAAAAGGTCG
CCGAGCGCCTGAAGCAGGCG

Product: glucose-6-phosphate 1-dehydrogenase

Products: NA

Alternate protein names: G6PD [H]

Number of amino acids: Translated: 489; Mature: 488

Protein sequence:

>489_residues
MPLITVEPCTFALFGALGDLAVRKLFPALYQLDRAGLLHEDTKILALAREPGDEESHLAYIEKSMRRFIPETELEPDNLS
RFLARLSYLHVDFLKAEDYVALAERVGNAETLIAYFATPASVYGAICENLASVNLAERTRAVLEKPIGHDLASSRRVNDA
VAQFFPENRVYRIDHYLGKDTVQNLIALRFANSLFETQWNQNHISHVEITVAEKVGIEGRWGYFDQAGQLRDMIQNHLLQ
LLCLIAMDPPSDLSADSIRDEKVKVLKALAPFTPERLATQVVRGQYTSGYSEGKAVPGYLEEENSNTQSDTETFVALRAD
IRNWRWSGTPFYLRTGKRMPQKLSQIVIHFKEPPHYIFAPEQRLQISNRLIIRLQPDEGISLQVMTKDQGLDKGMQLRSG
PLQLNFSDTYRSARVPDAYERLLLEVMRGNQNLFVRKDEIEYAWQWCDQLIAGWKKAGDAPKPYPAGTWGPMSSIALITR
DGRSWYGDM

Sequences:

>Translated_489_residues
MPLITVEPCTFALFGALGDLAVRKLFPALYQLDRAGLLHEDTKILALAREPGDEESHLAYIEKSMRRFIPETELEPDNLS
RFLARLSYLHVDFLKAEDYVALAERVGNAETLIAYFATPASVYGAICENLASVNLAERTRAVLEKPIGHDLASSRRVNDA
VAQFFPENRVYRIDHYLGKDTVQNLIALRFANSLFETQWNQNHISHVEITVAEKVGIEGRWGYFDQAGQLRDMIQNHLLQ
LLCLIAMDPPSDLSADSIRDEKVKVLKALAPFTPERLATQVVRGQYTSGYSEGKAVPGYLEEENSNTQSDTETFVALRAD
IRNWRWSGTPFYLRTGKRMPQKLSQIVIHFKEPPHYIFAPEQRLQISNRLIIRLQPDEGISLQVMTKDQGLDKGMQLRSG
PLQLNFSDTYRSARVPDAYERLLLEVMRGNQNLFVRKDEIEYAWQWCDQLIAGWKKAGDAPKPYPAGTWGPMSSIALITR
DGRSWYGDM
>Mature_488_residues
PLITVEPCTFALFGALGDLAVRKLFPALYQLDRAGLLHEDTKILALAREPGDEESHLAYIEKSMRRFIPETELEPDNLSR
FLARLSYLHVDFLKAEDYVALAERVGNAETLIAYFATPASVYGAICENLASVNLAERTRAVLEKPIGHDLASSRRVNDAV
AQFFPENRVYRIDHYLGKDTVQNLIALRFANSLFETQWNQNHISHVEITVAEKVGIEGRWGYFDQAGQLRDMIQNHLLQL
LCLIAMDPPSDLSADSIRDEKVKVLKALAPFTPERLATQVVRGQYTSGYSEGKAVPGYLEEENSNTQSDTETFVALRADI
RNWRWSGTPFYLRTGKRMPQKLSQIVIHFKEPPHYIFAPEQRLQISNRLIIRLQPDEGISLQVMTKDQGLDKGMQLRSGP
LQLNFSDTYRSARVPDAYERLLLEVMRGNQNLFVRKDEIEYAWQWCDQLIAGWKKAGDAPKPYPAGTWGPMSSIALITRD
GRSWYGDM

Specific function: Pentose phosphate pathway; first step. [C]

COG id: COG0364

COG function: function code G; Glucose-6-phosphate 1-dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glucose-6-phosphate dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI109389365, Length=485, Percent_Identity=38.5567010309278, Blast_Score=323, Evalue=3e-88,
Organism=Homo sapiens, GI108773793, Length=485, Percent_Identity=38.5567010309278, Blast_Score=322, Evalue=4e-88,
Organism=Homo sapiens, GI52145310, Length=496, Percent_Identity=29.8387096774194, Blast_Score=171, Evalue=1e-42,
Organism=Escherichia coli, GI1788158, Length=485, Percent_Identity=54.4329896907216, Blast_Score=545, Evalue=1e-156,
Organism=Caenorhabditis elegans, GI17538218, Length=494, Percent_Identity=36.6396761133603, Blast_Score=311, Evalue=4e-85,
Organism=Saccharomyces cerevisiae, GI6324088, Length=475, Percent_Identity=35.5789473684211, Blast_Score=293, Evalue=6e-80,
Organism=Drosophila melanogaster, GI24643350, Length=477, Percent_Identity=35.6394129979036, Blast_Score=286, Evalue=3e-77,
Organism=Drosophila melanogaster, GI24643352, Length=477, Percent_Identity=35.6394129979036, Blast_Score=285, Evalue=4e-77,
Organism=Drosophila melanogaster, GI221513548, Length=502, Percent_Identity=30.6772908366534, Blast_Score=206, Evalue=3e-53,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001282
- InterPro:   IPR019796
- InterPro:   IPR022675
- InterPro:   IPR022674
- InterPro:   IPR016040 [H]

Pfam domain/function: PF02781 G6PD_C; PF00479 G6PD_N [H]

EC number: =1.1.1.49 [H]

Molecular weight: Translated: 55582; Mature: 55451

Theoretical pI: Translated: 6.21; Mature: 6.21

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPLITVEPCTFALFGALGDLAVRKLFPALYQLDRAGLLHEDTKILALAREPGDEESHLAY
CCEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEECCCCCCHHHHHH
IEKSMRRFIPETELEPDNLSRFLARLSYLHVDFLKAEDYVALAERVGNAETLIAYFATPA
HHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCHHEEEEECCCHH
SVYGAICENLASVNLAERTRAVLEKPIGHDLASSRRVNDAVAQFFPENRVYRIDHYLGKD
HHHHHHHHHHHHCCHHHHHHHHHHCCCCCHHHHCCHHHHHHHHHCCCCCEEEEHHHCCHH
TVQNLIALRFANSLFETQWNQNHISHVEITVAEKVGIEGRWGYFDQAGQLRDMIQNHLLQ
HHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEEHHCCCCCCCCCCCCHHHHHHHHHHHHHH
LLCLIAMDPPSDLSADSIRDEKVKVLKALAPFTPERLATQVVRGQYTSGYSEGKAVPGYL
HHHHHHCCCCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCC
EEENSNTQSDTETFVALRADIRNWRWSGTPFYLRTGKRMPQKLSQIVIHFKEPPHYIFAP
CCCCCCCCCHHHHHHHHHHHHHCCCCCCCCEEEECCCHHHHHHHHHHEEECCCCCEEECC
EQRLQISNRLIIRLQPDEGISLQVMTKDQGLDKGMQLRSGPLQLNFSDTYRSARVPDAYE
HHHHCCCCEEEEEECCCCCCEEEEEECCCCCCCCCCCCCCCEEEEEHHHHCCCCCCHHHH
RLLLEVMRGNQNLFVRKDEIEYAWQWCDQLIAGWKKAGDAPKPYPAGTWGPMSSIALITR
HHHHHHHHCCCCEEEEEHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEEEE
DGRSWYGDM
CCCCCCCCC
>Mature Secondary Structure 
PLITVEPCTFALFGALGDLAVRKLFPALYQLDRAGLLHEDTKILALAREPGDEESHLAY
CEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEECCCCCCHHHHHH
IEKSMRRFIPETELEPDNLSRFLARLSYLHVDFLKAEDYVALAERVGNAETLIAYFATPA
HHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCHHEEEEECCCHH
SVYGAICENLASVNLAERTRAVLEKPIGHDLASSRRVNDAVAQFFPENRVYRIDHYLGKD
HHHHHHHHHHHHCCHHHHHHHHHHCCCCCHHHHCCHHHHHHHHHCCCCCEEEEHHHCCHH
TVQNLIALRFANSLFETQWNQNHISHVEITVAEKVGIEGRWGYFDQAGQLRDMIQNHLLQ
HHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEEHHCCCCCCCCCCCCHHHHHHHHHHHHHH
LLCLIAMDPPSDLSADSIRDEKVKVLKALAPFTPERLATQVVRGQYTSGYSEGKAVPGYL
HHHHHHCCCCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCC
EEENSNTQSDTETFVALRADIRNWRWSGTPFYLRTGKRMPQKLSQIVIHFKEPPHYIFAP
CCCCCCCCCHHHHHHHHHHHHHCCCCCCCCEEEECCCHHHHHHHHHHEEECCCCCEEECC
EQRLQISNRLIIRLQPDEGISLQVMTKDQGLDKGMQLRSGPLQLNFSDTYRSARVPDAYE
HHHHCCCCEEEEEECCCCCCEEEEEECCCCCCCCCCCCCCCEEEEEHHHHCCCCCCHHHH
RLLLEVMRGNQNLFVRKDEIEYAWQWCDQLIAGWKKAGDAPKPYPAGTWGPMSSIALITR
HHHHHHHHCCCCEEEEEHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEEEE
DGRSWYGDM
CCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9537370; 10984043 [H]