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The map label for this gene is tyrR [H]

Identifier: 66044352

GI number: 66044352

Start: 1246586

End: 1248094

Strand: Reverse

Name: tyrR [H]

Synonym: Psyr_1101

Alternate gene names: 66044352

Gene position: 1248094-1246586 (Counterclockwise)

Preceding gene: 66044353

Following gene: 66044351

Centisome position: 20.48

GC content: 61.56

Gene sequence:

>1509_bases
ATGCGCATCCATGTCAGCTTCATCGACCGCGTCGGTATCACCCAGGAAGTGCTGGCGATTCTGGGTGGACGCAATCTGAA
TCTGGACGCGGTGGAGATGGTACCGCCCAACGTGTACATCGATGCGCCGACGCTCAGCCATCAAATGCTCGAAGAGCTCA
AGGACGCGCTGTTTCGGGTCCGTGGTGTGGAAGCGATCACCGTGGTCGACATCCTTCCGGGTCAGCGTCGCCACTTGCAG
CTGGACGCGTTGCTCGCCGCCATGACCGATCCGGTGCTGGCTCTGGATAGCGCCGGGCACGTGCTGCTGGCCAACCCGGC
ACTCATTGCACTGATCGGCAGGGAGCCGGCGGGCGAATCGATCGGTGAGCTGTTCAGCGACCCCAGTCTGCACGTCGCGT
TGCTGGAAAACGGCTTTCGCCTGCCGCTGCGCGAGATCACCCTCAATGGTGAAGCACTGCTGCTGGATGCCACGCCGATC
ACCGAGGCCGGCGCGCTGATTACCCTGTACCTGCCCAGCCGAATCGGCGAACGCCTGTCGGCATTGCACCATGATCACGC
CGAAGGTTTCGACGCTCTGCTCGGCGACTCGGCCGCCATCCGCACTCTCAAGGCACGCGCGCAACGGGTGGCGGCGCTGG
ACGCACCGCTGCTGATTCAGGGCGAAACCGGCACCGGCAAAGAGTTGGTCGCCCGCGCCTGTCACGCCAGCAGCGCGCGC
CACGGCGAACCGTTTCTGGCCCTCAACTGCGCGGCTTTGCCGGAGAACCTCGCCGAAAGCGAACTGTTCGGCTATGCCCC
GGGAGCGTTTACCGGGGCACAGCGTGGCGGCAAACCGGGATTGATGGAGCTGGCCAACCAAGGCAGCGTATTTCTCGATG
AAATCGGCGAAATGTCACCCTATCTGCAGGCCAAACTGCTGCGTTTTCTCAACGATGGCAGCTTCCGGCGCGTCGGTGGC
GATCGCGAAGTACGGGTCAATGTGCGCATTCTCAGCGCCACCCACCGCGATCTGGAAAAGATGGTCAGCGAAGGCACCTT
CCGTGAAGACCTGTTCTACCGCCTTAATGTCCTCAATCTTGAGGTTCCACCGTTGCGCGAGCGCGGTCAGGACATTCTGC
TGCTGGCCCGATACTTCATGGAGCAGGCATGCGCACAGATTCAGCGCCCGGTCTGCAGACTTGCACCCGGCACCTACCCT
GCACTGCTCGGCAACCGCTGGCCAGGCAATGTGCGGCAATTACAGAATGTGATTTTTCGCGCAGCTGCCATCTGCGAACA
CACTCAAGTGGATATAGGCGACCTGGATATCGCCGGCACCGCAGTGGCGCGCCAGAACGACAGCCCGATCGACAGCCTCG
AAAATGCCGTCGAAGCCTTCGAGCGGAATCTGCTGGAAAAGCTTTACGCGGATTACCCTTCCACCCGCCAACTGGCCAAT
CGCCTGCATACTTCGCACACCGCCATCGCTCATCGCCTGCGAAAATATGGAATTCCTGGCAAGCGTTAG

Upstream 100 bases:

>100_bases
GAAGAGTGACAGGTGTCTGCAAGGACACCAGCGGATTTCACCAAACCTGCCGCCACAAGGCATACTTGCCGCCTTCTCAT
TCGCGAACCGTCAACGCCTC

Downstream 100 bases:

>100_bases
TCGATTGAAGTCGCTCATCGAAAATATATTCCGAAAGGATTCATTTAATAACTAGTTTGCCGATAACGATCTGGTATCGT
CCATGAACCTCTTATCATCC

Product: helix-turn-helix, Fis-type

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 502; Mature: 502

Protein sequence:

>502_residues
MRIHVSFIDRVGITQEVLAILGGRNLNLDAVEMVPPNVYIDAPTLSHQMLEELKDALFRVRGVEAITVVDILPGQRRHLQ
LDALLAAMTDPVLALDSAGHVLLANPALIALIGREPAGESIGELFSDPSLHVALLENGFRLPLREITLNGEALLLDATPI
TEAGALITLYLPSRIGERLSALHHDHAEGFDALLGDSAAIRTLKARAQRVAALDAPLLIQGETGTGKELVARACHASSAR
HGEPFLALNCAALPENLAESELFGYAPGAFTGAQRGGKPGLMELANQGSVFLDEIGEMSPYLQAKLLRFLNDGSFRRVGG
DREVRVNVRILSATHRDLEKMVSEGTFREDLFYRLNVLNLEVPPLRERGQDILLLARYFMEQACAQIQRPVCRLAPGTYP
ALLGNRWPGNVRQLQNVIFRAAAICEHTQVDIGDLDIAGTAVARQNDSPIDSLENAVEAFERNLLEKLYADYPSTRQLAN
RLHTSHTAIAHRLRKYGIPGKR

Sequences:

>Translated_502_residues
MRIHVSFIDRVGITQEVLAILGGRNLNLDAVEMVPPNVYIDAPTLSHQMLEELKDALFRVRGVEAITVVDILPGQRRHLQ
LDALLAAMTDPVLALDSAGHVLLANPALIALIGREPAGESIGELFSDPSLHVALLENGFRLPLREITLNGEALLLDATPI
TEAGALITLYLPSRIGERLSALHHDHAEGFDALLGDSAAIRTLKARAQRVAALDAPLLIQGETGTGKELVARACHASSAR
HGEPFLALNCAALPENLAESELFGYAPGAFTGAQRGGKPGLMELANQGSVFLDEIGEMSPYLQAKLLRFLNDGSFRRVGG
DREVRVNVRILSATHRDLEKMVSEGTFREDLFYRLNVLNLEVPPLRERGQDILLLARYFMEQACAQIQRPVCRLAPGTYP
ALLGNRWPGNVRQLQNVIFRAAAICEHTQVDIGDLDIAGTAVARQNDSPIDSLENAVEAFERNLLEKLYADYPSTRQLAN
RLHTSHTAIAHRLRKYGIPGKR
>Mature_502_residues
MRIHVSFIDRVGITQEVLAILGGRNLNLDAVEMVPPNVYIDAPTLSHQMLEELKDALFRVRGVEAITVVDILPGQRRHLQ
LDALLAAMTDPVLALDSAGHVLLANPALIALIGREPAGESIGELFSDPSLHVALLENGFRLPLREITLNGEALLLDATPI
TEAGALITLYLPSRIGERLSALHHDHAEGFDALLGDSAAIRTLKARAQRVAALDAPLLIQGETGTGKELVARACHASSAR
HGEPFLALNCAALPENLAESELFGYAPGAFTGAQRGGKPGLMELANQGSVFLDEIGEMSPYLQAKLLRFLNDGSFRRVGG
DREVRVNVRILSATHRDLEKMVSEGTFREDLFYRLNVLNLEVPPLRERGQDILLLARYFMEQACAQIQRPVCRLAPGTYP
ALLGNRWPGNVRQLQNVIFRAAAICEHTQVDIGDLDIAGTAVARQNDSPIDSLENAVEAFERNLLEKLYADYPSTRQLAN
RLHTSHTAIAHRLRKYGIPGKR

Specific function: Involved in transcriptional regulation of aromatic amino acid biosynthesis and transport. Modulates the expression of at least 8 unlinked operons. Seven of these operons are regulated in response to changes in the concentration of the three aromatic amino

COG id: COG3283

COG function: function code KE; Transcriptional regulator of aromatic amino acids metabolism

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 sigma-54 factor interaction domain [H]

Homologues:

Organism=Escherichia coli, GI1787583, Length=527, Percent_Identity=41.1764705882353, Blast_Score=354, Evalue=8e-99,
Organism=Escherichia coli, GI1788550, Length=319, Percent_Identity=42.3197492163009, Blast_Score=243, Evalue=2e-65,
Organism=Escherichia coli, GI1789233, Length=340, Percent_Identity=37.6470588235294, Blast_Score=232, Evalue=3e-62,
Organism=Escherichia coli, GI87082152, Length=319, Percent_Identity=44.2006269592476, Blast_Score=230, Evalue=1e-61,
Organism=Escherichia coli, GI1788905, Length=279, Percent_Identity=44.0860215053763, Blast_Score=217, Evalue=1e-57,
Organism=Escherichia coli, GI1790437, Length=232, Percent_Identity=46.9827586206897, Blast_Score=214, Evalue=7e-57,
Organism=Escherichia coli, GI87082117, Length=233, Percent_Identity=47.6394849785408, Blast_Score=214, Evalue=1e-56,
Organism=Escherichia coli, GI1790299, Length=317, Percent_Identity=42.2712933753943, Blast_Score=213, Evalue=3e-56,
Organism=Escherichia coli, GI1789087, Length=233, Percent_Identity=46.3519313304721, Blast_Score=210, Evalue=2e-55,
Organism=Escherichia coli, GI87081872, Length=240, Percent_Identity=48.3333333333333, Blast_Score=209, Evalue=4e-55,
Organism=Escherichia coli, GI1786524, Length=457, Percent_Identity=35.2297592997812, Blast_Score=206, Evalue=3e-54,
Organism=Escherichia coli, GI1789828, Length=313, Percent_Identity=33.2268370607029, Blast_Score=134, Evalue=1e-32,
Organism=Escherichia coli, GI87081858, Length=382, Percent_Identity=26.9633507853403, Blast_Score=119, Evalue=4e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR003593
- InterPro:   IPR009057
- InterPro:   IPR012287
- InterPro:   IPR000014
- InterPro:   IPR002078 [H]

Pfam domain/function: PF01842 ACT; PF00158 Sigma54_activat [H]

EC number: NA

Molecular weight: Translated: 54910; Mature: 54910

Theoretical pI: Translated: 6.24; Mature: 6.24

Prosite motif: PS50112 PAS ; PS00675 SIGMA54_INTERACT_1 ; PS00688 SIGMA54_INTERACT_3 ; PS50045 SIGMA54_INTERACT_4

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRIHVSFIDRVGITQEVLAILGGRNLNLDAVEMVPPNVYIDAPTLSHQMLEELKDALFRV
CEEEEEEHHHCCCHHHHHHHHCCCCCCCCEEEECCCCEEEECCCHHHHHHHHHHHHHHHH
RGVEAITVVDILPGQRRHLQLDALLAAMTDPVLALDSAGHVLLANPALIALIGREPAGES
CCCCEEEEEECCCCCCHHHHHHHHHHHHCCCCEEECCCCCEEEECCEEEEEECCCCCCHH
IGELFSDPSLHVALLENGFRLPLREITLNGEALLLDATPITEAGALITLYLPSRIGERLS
HHHHHCCCCEEEEEECCCCCCCHHEEEECCCEEEEECCCCCCCCCEEEEECHHHHHHHHH
ALHHDHAEGFDALLGDSAAIRTLKARAQRVAALDAPLLIQGETGTGKELVARACHASSAR
HHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCEEEECCCCCCHHHHHHHHHCCCCC
HGEPFLALNCAALPENLAESELFGYAPGAFTGAQRGGKPGLMELANQGSVFLDEIGEMSP
CCCCEEEEEHHHCCCHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHCCCCCHHHHHHCCCH
YLQAKLLRFLNDGSFRRVGGDREVRVNVRILSATHRDLEKMVSEGTFREDLFYRLNVLNL
HHHHHHHHHHCCCCEEECCCCCEEEEEEEEEEHHHHHHHHHHHCCCHHHHHHHEEEEEEE
EVPPLRERGQDILLLARYFMEQACAQIQRPVCRLAPGTYPALLGNRWPGNVRQLQNVIFR
CCCCHHHCCCHHHHHHHHHHHHHHHHHHCCHHHCCCCCCHHHHCCCCCCHHHHHHHHHHH
AAAICEHTQVDIGDLDIAGTAVARQNDSPIDSLENAVEAFERNLLEKLYADYPSTRQLAN
HHHHHHCCCCCCCCCCCCCCEEECCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHH
RLHTSHTAIAHRLRKYGIPGKR
HHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MRIHVSFIDRVGITQEVLAILGGRNLNLDAVEMVPPNVYIDAPTLSHQMLEELKDALFRV
CEEEEEEHHHCCCHHHHHHHHCCCCCCCCEEEECCCCEEEECCCHHHHHHHHHHHHHHHH
RGVEAITVVDILPGQRRHLQLDALLAAMTDPVLALDSAGHVLLANPALIALIGREPAGES
CCCCEEEEEECCCCCCHHHHHHHHHHHHCCCCEEECCCCCEEEECCEEEEEECCCCCCHH
IGELFSDPSLHVALLENGFRLPLREITLNGEALLLDATPITEAGALITLYLPSRIGERLS
HHHHHCCCCEEEEEECCCCCCCHHEEEECCCEEEEECCCCCCCCCEEEEECHHHHHHHHH
ALHHDHAEGFDALLGDSAAIRTLKARAQRVAALDAPLLIQGETGTGKELVARACHASSAR
HHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCEEEECCCCCCHHHHHHHHHCCCCC
HGEPFLALNCAALPENLAESELFGYAPGAFTGAQRGGKPGLMELANQGSVFLDEIGEMSP
CCCCEEEEEHHHCCCHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHCCCCCHHHHHHCCCH
YLQAKLLRFLNDGSFRRVGGDREVRVNVRILSATHRDLEKMVSEGTFREDLFYRLNVLNL
HHHHHHHHHHCCCCEEECCCCCEEEEEEEEEEHHHHHHHHHHHCCCHHHHHHHEEEEEEE
EVPPLRERGQDILLLARYFMEQACAQIQRPVCRLAPGTYPALLGNRWPGNVRQLQNVIFR
CCCCHHHCCCHHHHHHHHHHHHHHHHHHCCHHHCCCCCCHHHHCCCCCCHHHHHHHHHHH
AAAICEHTQVDIGDLDIAGTAVARQNDSPIDSLENAVEAFERNLLEKLYADYPSTRQLAN
HHHHHHCCCCCCCCCCCCCCEEECCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHH
RLHTSHTAIAHRLRKYGIPGKR
HHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11055921 [H]