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The map label for this gene is algD [H]

Identifier: 66044316

GI number: 66044316

Start: 1204724

End: 1206040

Strand: Reverse

Name: algD [H]

Synonym: Psyr_1063

Alternate gene names: 66044316

Gene position: 1206040-1204724 (Counterclockwise)

Preceding gene: 66044317

Following gene: 66044315

Centisome position: 19.79

GC content: 57.33

Gene sequence:

>1317_bases
ATGCGTATCAGCATATTTGGTTTGGGTTATGTCGGTGCAGTCTGTGCCGGTTGCCTGTCTGCCCGCGGTCACGAAGTAGT
GGGTGTGGATATTTCCAGCACCAAGATCGACCTGATCAACAACGGCAAATCACCTATCGTTGAACCGGGTCTGGAAGAGC
TGTTGCAGAAAGGTATCACTACCGGAAAACTGCGCGGCACTACAGACTTCGCCGAAGCCATTCGCGCCACCGATCTGTCG
ATGATCTGCGTCGGTACGCCGAGCAAGAAGAACGGCGATCTGGAACTGGATTACATTGAGTCGGTGTGCCGCGAAATCGG
TTATGTCCTGCGTGACAAAGCCACCCGCCACACTATCGTGGTTCGCAGTACCGTACTGCCGGGCACTGTTGCCAACGTCG
TTATCCCGATTCTGGAAGACTGCTCCGGCAAGAAAGCCGGTGTTGACTTCGGTGTCGCCGTCAACCCTGAGTTCCTGCGC
GAAAGTACTGCGATCAAGGACTACGACCTGCCGCCAATGACCGTCATCGGCGAGTTCGACAAAGCGTCGGGCGACGTTCT
GCAATCGCTGTACGAAGAACTCGATGCACCGATCATCCGCAAGGACATCGCCGTTGCCGAGATGATCAAGTACACCTGCA
ACGTGTGGCACGCCACCAAGGTTACTTTCGCCAACGAAATCGGCAACATTGCCAAGGCTGTCGGCGTCGATGGCCGTGAA
GTGATGGACGTGGTCTGCCAGGACAAGGCGCTGAACCTGTCCCAGTACTACATGCGCCCTGGCTTCGCATTCGGCGGCTC
GTGCCTGCCGAAAGACGTTCGCGCCCTGACCTACCGCGCCAGCAGCCTGGACGTTGAAGCCCCCCTGCTCAACTCGCTGA
TGCGCAGTAACACCTCGCAAGTGCAGAACGCGTTCGACATGGTTGCCAGCTACGACACCCGCAAGGTTGCACTGCTGGGT
CTGAGCTTCAAGGCCGGCACTGACGATCTGCGTGAAAGCCCGCTGGTAGAGCTGGCCGAAATGCTGATCGGCAAGGGCTT
CGAACTGAGCATCTTCGACAGCAACGTTGAATATGCACGCGTTCACGGTGCCAACAAGGACTACATCGAATCCAAGATTC
CGCACGTTTCCTCGCTGCTGAACTCGGACTTCGAGCAAGTCATCAATGACTCCGACGTCATCATCCTCGGCAACCGCGAT
GAGCGTTTCCGCGCCCTCGCCAACAAGACCCCTGAAGGCAAGCGCGTCATCGATCTGGTGGGCTTCATGGCCAACGCCAC
CAGCGAAGACGGTCGTGCCGAAGGTATCTGCTGGTAA

Upstream 100 bases:

>100_bases
AGTTCTACGGCGTTGTTAGCCGTAAGGGATAGCGCGTGACATCTGCTGGCCAAAATTAATATCCAGCCAATCTATGGCGT
GAAAAATCGAGGAGAATACG

Downstream 100 bases:

>100_bases
ATCAGCCGCAAGCCACAAGCGCCAGGCTCCAGGCCACAGGCTCAAGCAATGTGCTTGCAGCCTGGGGCTTGAGGCTCGCA
ACTGACTTAGGGATACGATT

Product: GDP-mannose 6-dehydrogenase

Products: NA

Alternate protein names: GMD [H]

Number of amino acids: Translated: 438; Mature: 438

Protein sequence:

>438_residues
MRISIFGLGYVGAVCAGCLSARGHEVVGVDISSTKIDLINNGKSPIVEPGLEELLQKGITTGKLRGTTDFAEAIRATDLS
MICVGTPSKKNGDLELDYIESVCREIGYVLRDKATRHTIVVRSTVLPGTVANVVIPILEDCSGKKAGVDFGVAVNPEFLR
ESTAIKDYDLPPMTVIGEFDKASGDVLQSLYEELDAPIIRKDIAVAEMIKYTCNVWHATKVTFANEIGNIAKAVGVDGRE
VMDVVCQDKALNLSQYYMRPGFAFGGSCLPKDVRALTYRASSLDVEAPLLNSLMRSNTSQVQNAFDMVASYDTRKVALLG
LSFKAGTDDLRESPLVELAEMLIGKGFELSIFDSNVEYARVHGANKDYIESKIPHVSSLLNSDFEQVINDSDVIILGNRD
ERFRALANKTPEGKRVIDLVGFMANATSEDGRAEGICW

Sequences:

>Translated_438_residues
MRISIFGLGYVGAVCAGCLSARGHEVVGVDISSTKIDLINNGKSPIVEPGLEELLQKGITTGKLRGTTDFAEAIRATDLS
MICVGTPSKKNGDLELDYIESVCREIGYVLRDKATRHTIVVRSTVLPGTVANVVIPILEDCSGKKAGVDFGVAVNPEFLR
ESTAIKDYDLPPMTVIGEFDKASGDVLQSLYEELDAPIIRKDIAVAEMIKYTCNVWHATKVTFANEIGNIAKAVGVDGRE
VMDVVCQDKALNLSQYYMRPGFAFGGSCLPKDVRALTYRASSLDVEAPLLNSLMRSNTSQVQNAFDMVASYDTRKVALLG
LSFKAGTDDLRESPLVELAEMLIGKGFELSIFDSNVEYARVHGANKDYIESKIPHVSSLLNSDFEQVINDSDVIILGNRD
ERFRALANKTPEGKRVIDLVGFMANATSEDGRAEGICW
>Mature_438_residues
MRISIFGLGYVGAVCAGCLSARGHEVVGVDISSTKIDLINNGKSPIVEPGLEELLQKGITTGKLRGTTDFAEAIRATDLS
MICVGTPSKKNGDLELDYIESVCREIGYVLRDKATRHTIVVRSTVLPGTVANVVIPILEDCSGKKAGVDFGVAVNPEFLR
ESTAIKDYDLPPMTVIGEFDKASGDVLQSLYEELDAPIIRKDIAVAEMIKYTCNVWHATKVTFANEIGNIAKAVGVDGRE
VMDVVCQDKALNLSQYYMRPGFAFGGSCLPKDVRALTYRASSLDVEAPLLNSLMRSNTSQVQNAFDMVASYDTRKVALLG
LSFKAGTDDLRESPLVELAEMLIGKGFELSIFDSNVEYARVHGANKDYIESKIPHVSSLLNSDFEQVINDSDVIILGNRD
ERFRALANKTPEGKRVIDLVGFMANATSEDGRAEGICW

Specific function: Catalyzes the oxidation of guanosine diphospho-D-mannose (GDP-D-mannose) to GDP-D-mannuronic acid, a precursor for alginate polymerization. The alginate layer causes a mucoid phenotype and provides a protective barrier against host immune defenses and ant

COG id: COG1004

COG function: function code M; Predicted UDP-glucose 6-dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UDP-glucose/GDP-mannose dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI4507813, Length=384, Percent_Identity=28.6458333333333, Blast_Score=133, Evalue=3e-31,
Organism=Homo sapiens, GI296040438, Length=283, Percent_Identity=27.208480565371, Blast_Score=97, Evalue=4e-20,
Organism=Homo sapiens, GI296040443, Length=235, Percent_Identity=28.936170212766, Blast_Score=88, Evalue=2e-17,
Organism=Escherichia coli, GI1788340, Length=415, Percent_Identity=27.4698795180723, Blast_Score=139, Evalue=3e-34,
Organism=Escherichia coli, GI48994968, Length=445, Percent_Identity=26.2921348314607, Blast_Score=122, Evalue=4e-29,
Organism=Caenorhabditis elegans, GI17560350, Length=382, Percent_Identity=30.3664921465969, Blast_Score=136, Evalue=2e-32,
Organism=Drosophila melanogaster, GI17136908, Length=384, Percent_Identity=28.90625, Blast_Score=144, Evalue=1e-34,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR021157
- InterPro:   IPR016040
- InterPro:   IPR017476
- InterPro:   IPR014027
- InterPro:   IPR014026
- InterPro:   IPR014028
- InterPro:   IPR001732 [H]

Pfam domain/function: PF00984 UDPG_MGDP_dh; PF03720 UDPG_MGDP_dh_C; PF03721 UDPG_MGDP_dh_N [H]

EC number: =1.1.1.132 [H]

Molecular weight: Translated: 47622; Mature: 47622

Theoretical pI: Translated: 4.76; Mature: 4.76

Prosite motif: PS00290 IG_MHC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRISIFGLGYVGAVCAGCLSARGHEVVGVDISSTKIDLINNGKSPIVEPGLEELLQKGIT
CEEEEEECHHHHHHHHHHHHCCCCEEEEEECCCCEEEEEECCCCCCCCCCHHHHHHCCCC
TGKLRGTTDFAEAIRATDLSMICVGTPSKKNGDLELDYIESVCREIGYVLRDKATRHTIV
CCCCCCCHHHHHHHHHCCCEEEEEECCCCCCCCEEHHHHHHHHHHHHHHHHCCCCCEEEE
VRSTVLPGTVANVVIPILEDCSGKKAGVDFGVAVNPEFLRESTAIKDYDLPPMTVIGEFD
EEECCCCCHHHHHHHHHHHCCCCCCCCCCEEEECCHHHHHHCCCCCCCCCCCEEEEECCC
KASGDVLQSLYEELDAPIIRKDIAVAEMIKYTCNVWHATKVTFANEIGNIAKAVGVDGRE
CCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHCCCHHH
VMDVVCQDKALNLSQYYMRPGFAFGGSCLPKDVRALTYRASSLDVEAPLLNSLMRSNTSQ
HHHHHHCCCCCCHHHHHHCCCCCCCCCCCCHHHHHHHEECCCCCCCHHHHHHHHHCCHHH
VQNAFDMVASYDTRKVALLGLSFKAGTDDLRESPLVELAEMLIGKGFELSIFDSNVEYAR
HHHHHHHHHCCCCCEEEEEEEECCCCCCHHHCCHHHHHHHHHHCCCCEEEEECCCCCEEE
VHGANKDYIESKIPHVSSLLNSDFEQVINDSDVIILGNRDERFRALANKTPEGKRVIDLV
ECCCCHHHHHHHCHHHHHHHHHHHHHHCCCCCEEEECCCCHHHHHHHCCCCCCHHHHHHH
GFMANATSEDGRAEGICW
HHHHCCCCCCCCCCCCCC
>Mature Secondary Structure
MRISIFGLGYVGAVCAGCLSARGHEVVGVDISSTKIDLINNGKSPIVEPGLEELLQKGIT
CEEEEEECHHHHHHHHHHHHCCCCEEEEEECCCCEEEEEECCCCCCCCCCHHHHHHCCCC
TGKLRGTTDFAEAIRATDLSMICVGTPSKKNGDLELDYIESVCREIGYVLRDKATRHTIV
CCCCCCCHHHHHHHHHCCCEEEEEECCCCCCCCEEHHHHHHHHHHHHHHHHCCCCCEEEE
VRSTVLPGTVANVVIPILEDCSGKKAGVDFGVAVNPEFLRESTAIKDYDLPPMTVIGEFD
EEECCCCCHHHHHHHHHHHCCCCCCCCCCEEEECCHHHHHHCCCCCCCCCCCEEEEECCC
KASGDVLQSLYEELDAPIIRKDIAVAEMIKYTCNVWHATKVTFANEIGNIAKAVGVDGRE
CCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHCCCHHH
VMDVVCQDKALNLSQYYMRPGFAFGGSCLPKDVRALTYRASSLDVEAPLLNSLMRSNTSQ
HHHHHHCCCCCCHHHHHHCCCCCCCCCCCCHHHHHHHEECCCCCCCHHHHHHHHHCCHHH
VQNAFDMVASYDTRKVALLGLSFKAGTDDLRESPLVELAEMLIGKGFELSIFDSNVEYAR
HHHHHHHHHCCCCCEEEEEEEECCCCCCHHHCCHHHHHHHHHHCCCCEEEEECCCCCEEE
VHGANKDYIESKIPHVSSLLNSDFEQVINDSDVIILGNRDERFRALANKTPEGKRVIDLV
ECCCCHHHHHHHCHHHHHHHHHHHHHHCCCCCEEEECCCCHHHHHHHCCCCCCHHHHHHH
GFMANATSEDGRAEGICW
HHHHCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA