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The map label for this gene is algA [H]

Identifier: 66044305

GI number: 66044305

Start: 1189612

End: 1191063

Strand: Reverse

Name: algA [H]

Synonym: Psyr_1052

Alternate gene names: 66044305

Gene position: 1191063-1189612 (Counterclockwise)

Preceding gene: 66044306

Following gene: 66044303

Centisome position: 19.55

GC content: 59.85

Gene sequence:

>1452_bases
ATGATTCCAGTTATCTTGTCAGGCGGTAGTGGTTCACGACTCTGGCCGCTTTCGCGTAAACAATTCCCTAAACAGTTCCT
GGCGTTGACCGGCGAGCACACCCTGTTCCAGCAAACCCTGGAGCGTCTGGTGTTCGAGGGCATGCAGGAGCCTATCGTGG
TCTGCAACAAGGACCACCGTTTCATCGTCAACGAGCAGCTCGCTGCATTGAACCTGGAAACCCAGGCGATCCTCATGGAA
CCGTTCGGCCGCAACACGGCACCCGCCGTTGCACTGACCGCCATGAAGCTGGTCAATGAAGGCAATGACGGCCTGATGCT
GGTGCTGCCAGCCGACCACGTCATCGAAGACCAGAAAGCCCTGCAACGTGCACTGGCACTGGCAACCGTCGCCGCAGAAC
GCGGCGAAATGGTGCTGTTCGGCGTACCGGCCAACAAGCCTGAAACCGGCTACGGCTACATCAAGTCCACCGCCGATGCC
CTGCTGCCGGAAGGCGTCAGCCGCGTGTCGCAGTTCGTCGAAAAACCTGACGAAAAACGCGCCAAGGAGTTCGTTGAAGC
CGGTGGTTACTACTGGAACAGCGGCATGTTCCTGTTCCGCGCCAGCCGCTTCCTCGAAGAGCTGAAAAAGCATGATCCGG
ACATCTACGACACCTGCCTGCTGACCCTCGAGCGCAGCGTGCAGGACGGCGACGCGCTTGAAATCGACTCCTCGACCTTC
GCCTGCTGCCCGGACAACTCCATCGACTACGCGGTCATGGAAAAAACCCAGCGCGCCTGCGTTGTACCGCTGTCGGCCGG
CTGGAGCGATGTCGGCTGCTGGTCGTCGCTGTGGGAAGTCAACGCCAAGGACGCCAACGGCAACGTCACCAAGGGCGACG
TCGTCATCCAGGACAGCCGCAACTGCATGATCCACGGCAACGGTAAACTGGTGTCGGTGATCGGTCTGGACAACATCGTG
GTCGTCGAAACCAAGGACGCGATGATGATTGCCCACAAGGACAAGGTCCAGGGCGTCAAGCAGATGGTCGCCACCCTGAA
CGAACAGGGCCGCACCGAGACCCAGAACCACCTCGAAGTGTACCGTCCGTGGGGCTCCTACGATTCGGTGGACATGGGCG
GTCGTTTCCAGGTCAAGCGTATCTCCGTCAAGCCGGGCGCCTGCCTGTCGCTGCAGATGCACCACCACCGCGCCGAACAC
TGGATCGTGGTATCCGGTACTGCGCAGGTCACCTGTGACGAGAACGTGTTCCTGCTCACTGAAAACCAGTCCACCTACAT
CCCGATCGCCTCGGTCCATCGCCTGCGCAACCCGGGCAAGATCCCGTTGGAAATCATCGAAGTGCAATCGGGCAGCTACC
TGGGCGAAGACGACATCGAGCGTTTCGAAGACATCTACGGTCGCTCGAACGCGCTTGAAGCGGGTGTGAAAACACAGACA
ATCGCTCGCTGA

Upstream 100 bases:

>100_bases
TTCAGGGCATCAGCACTGAACCGGCCCGCGCGGAACAAGAACAAGACAGAAACGACAGACACCTCGTACAGCCCTAATTG
AATGCTTTTGGAGAAACAAA

Downstream 100 bases:

>100_bases
CAGACGCTTTTAGCTGCAAGTGAGACAGCCCTCGGCAACACGTTGCGTAGCCTTACCCGCAACGTGTTGTCGAGGGCTTT
TTATCGTGAGATCCAGACCA

Product: mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase

Products: NA

Alternate protein names: Mannose-6-phosphate isomerase; Phosphohexomutase; Phosphomannose isomerase; PMI; Mannose-1-phosphate guanylyltransferase; GDP-mannose pyrophosphorylase; GMP; GMPP; GTP--mannose-1-phosphate guanylyltransferase [H]

Number of amino acids: Translated: 483; Mature: 483

Protein sequence:

>483_residues
MIPVILSGGSGSRLWPLSRKQFPKQFLALTGEHTLFQQTLERLVFEGMQEPIVVCNKDHRFIVNEQLAALNLETQAILME
PFGRNTAPAVALTAMKLVNEGNDGLMLVLPADHVIEDQKALQRALALATVAAERGEMVLFGVPANKPETGYGYIKSTADA
LLPEGVSRVSQFVEKPDEKRAKEFVEAGGYYWNSGMFLFRASRFLEELKKHDPDIYDTCLLTLERSVQDGDALEIDSSTF
ACCPDNSIDYAVMEKTQRACVVPLSAGWSDVGCWSSLWEVNAKDANGNVTKGDVVIQDSRNCMIHGNGKLVSVIGLDNIV
VVETKDAMMIAHKDKVQGVKQMVATLNEQGRTETQNHLEVYRPWGSYDSVDMGGRFQVKRISVKPGACLSLQMHHHRAEH
WIVVSGTAQVTCDENVFLLTENQSTYIPIASVHRLRNPGKIPLEIIEVQSGSYLGEDDIERFEDIYGRSNALEAGVKTQT
IAR

Sequences:

>Translated_483_residues
MIPVILSGGSGSRLWPLSRKQFPKQFLALTGEHTLFQQTLERLVFEGMQEPIVVCNKDHRFIVNEQLAALNLETQAILME
PFGRNTAPAVALTAMKLVNEGNDGLMLVLPADHVIEDQKALQRALALATVAAERGEMVLFGVPANKPETGYGYIKSTADA
LLPEGVSRVSQFVEKPDEKRAKEFVEAGGYYWNSGMFLFRASRFLEELKKHDPDIYDTCLLTLERSVQDGDALEIDSSTF
ACCPDNSIDYAVMEKTQRACVVPLSAGWSDVGCWSSLWEVNAKDANGNVTKGDVVIQDSRNCMIHGNGKLVSVIGLDNIV
VVETKDAMMIAHKDKVQGVKQMVATLNEQGRTETQNHLEVYRPWGSYDSVDMGGRFQVKRISVKPGACLSLQMHHHRAEH
WIVVSGTAQVTCDENVFLLTENQSTYIPIASVHRLRNPGKIPLEIIEVQSGSYLGEDDIERFEDIYGRSNALEAGVKTQT
IAR
>Mature_483_residues
MIPVILSGGSGSRLWPLSRKQFPKQFLALTGEHTLFQQTLERLVFEGMQEPIVVCNKDHRFIVNEQLAALNLETQAILME
PFGRNTAPAVALTAMKLVNEGNDGLMLVLPADHVIEDQKALQRALALATVAAERGEMVLFGVPANKPETGYGYIKSTADA
LLPEGVSRVSQFVEKPDEKRAKEFVEAGGYYWNSGMFLFRASRFLEELKKHDPDIYDTCLLTLERSVQDGDALEIDSSTF
ACCPDNSIDYAVMEKTQRACVVPLSAGWSDVGCWSSLWEVNAKDANGNVTKGDVVIQDSRNCMIHGNGKLVSVIGLDNIV
VVETKDAMMIAHKDKVQGVKQMVATLNEQGRTETQNHLEVYRPWGSYDSVDMGGRFQVKRISVKPGACLSLQMHHHRAEH
WIVVSGTAQVTCDENVFLLTENQSTYIPIASVHRLRNPGKIPLEIIEVQSGSYLGEDDIERFEDIYGRSNALEAGVKTQT
IAR

Specific function: Produces a precursor for alginate polymerization. The alginate layer provides a protective barrier against host immune defenses and antibiotics [H]

COG id: COG0836

COG function: function code M; Mannose-1-phosphate guanylyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the mannose-6-phosphate isomerase type 2 family [H]

Homologues:

Organism=Escherichia coli, GI1788362, Length=472, Percent_Identity=53.8135593220339, Blast_Score=509, Evalue=1e-145,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011051
- InterPro:   IPR006375
- InterPro:   IPR001538
- InterPro:   IPR005835
- InterPro:   IPR014710 [H]

Pfam domain/function: PF01050 MannoseP_isomer; PF00483 NTP_transferase [H]

EC number: =5.3.1.8; =2.7.7.13 [H]

Molecular weight: Translated: 53528; Mature: 53528

Theoretical pI: Translated: 5.24; Mature: 5.24

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIPVILSGGSGSRLWPLSRKQFPKQFLALTGEHTLFQQTLERLVFEGMQEPIVVCNKDHR
CCEEEEECCCCCEECCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCEEEECCCCE
FIVNEQLAALNLETQAILMEPFGRNTAPAVALTAMKLVNEGNDGLMLVLPADHVIEDQKA
EEEECCEEEEECCCEEEEECCCCCCCCCHHHHHHHHHHHCCCCCEEEEECCHHHHHHHHH
LQRALALATVAAERGEMVLFGVPANKPETGYGYIKSTADALLPEGVSRVSQFVEKPDEKR
HHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHH
AKEFVEAGGYYWNSGMFLFRASRFLEELKKHDPDIYDTCLLTLERSVQDGDALEIDSSTF
HHHHHHCCCEEECCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCEEEECCCEE
ACCPDNSIDYAVMEKTQRACVVPLSAGWSDVGCWSSLWEVNAKDANGNVTKGDVVIQDSR
EECCCCCCCHHHHHCCCCEEEEEECCCCCCCCHHHHHHCCCCCCCCCCEEECCEEEECCC
NCMIHGNGKLVSVIGLDNIVVVETKDAMMIAHKDKVQGVKQMVATLNEQGRTETQNHLEV
CEEEECCCCEEEEEECCCEEEEEECCEEEEEEHHHHHHHHHHHHHHHHCCCCCCCCCEEE
YRPWGSYDSVDMGGRFQVKRISVKPGACLSLQMHHHRAEHWIVVSGTAQVTCDENVFLLT
EECCCCCCCCCCCCEEEEEEEEECCCCEEEEEECCCCCCEEEEEECCEEEEECCCEEEEE
ENQSTYIPIASVHRLRNPGKIPLEIIEVQSGSYLGEDDIERFEDIYGRSNALEAGVKTQT
CCCCCEEEHHHHHHHCCCCCCCEEEEEECCCCCCCHHHHHHHHHHHCCCCHHHCCCCHHH
IAR
CCC
>Mature Secondary Structure
MIPVILSGGSGSRLWPLSRKQFPKQFLALTGEHTLFQQTLERLVFEGMQEPIVVCNKDHR
CCEEEEECCCCCEECCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCEEEECCCCE
FIVNEQLAALNLETQAILMEPFGRNTAPAVALTAMKLVNEGNDGLMLVLPADHVIEDQKA
EEEECCEEEEECCCEEEEECCCCCCCCCHHHHHHHHHHHCCCCCEEEEECCHHHHHHHHH
LQRALALATVAAERGEMVLFGVPANKPETGYGYIKSTADALLPEGVSRVSQFVEKPDEKR
HHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHH
AKEFVEAGGYYWNSGMFLFRASRFLEELKKHDPDIYDTCLLTLERSVQDGDALEIDSSTF
HHHHHHCCCEEECCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCEEEECCCEE
ACCPDNSIDYAVMEKTQRACVVPLSAGWSDVGCWSSLWEVNAKDANGNVTKGDVVIQDSR
EECCCCCCCHHHHHCCCCEEEEEECCCCCCCCHHHHHHCCCCCCCCCCEEECCEEEECCC
NCMIHGNGKLVSVIGLDNIVVVETKDAMMIAHKDKVQGVKQMVATLNEQGRTETQNHLEV
CEEEECCCCEEEEEECCCEEEEEECCEEEEEEHHHHHHHHHHHHHHHHCCCCCCCCCEEE
YRPWGSYDSVDMGGRFQVKRISVKPGACLSLQMHHHRAEHWIVVSGTAQVTCDENVFLLT
EECCCCCCCCCCCCEEEEEEEEECCCCEEEEEECCCCCCEEEEEECCEEEEECCCEEEEE
ENQSTYIPIASVHRLRNPGKIPLEIIEVQSGSYLGEDDIERFEDIYGRSNALEAGVKTQT
CCCCCEEEHHHHHHHCCCCCCCEEEEEECCCCCCCHHHHHHHHHHHCCCCHHHCCCCHHH
IAR
CCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12928499 [H]