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The map label for this gene is prs [H]

Identifier: 66044197

GI number: 66044197

Start: 1079101

End: 1080042

Strand: Reverse

Name: prs [H]

Synonym: Psyr_0944

Alternate gene names: 66044197

Gene position: 1080042-1079101 (Counterclockwise)

Preceding gene: 66044198

Following gene: 66044196

Centisome position: 17.72

GC content: 55.73

Gene sequence:

>942_bases
GTGTCCAAGATGATGGTCTTTACGGGGAATGCCAACCCCGATCTCGCTCGGCGTGTAGTACGTCAGCTGCATATCCCACT
GGGTGATGTTTCTGTTGGAAAATTCTCCGACGGCGAAATCAGCACTGAGATTAATGAAAACGTCCGCGGTAAAGACGTCT
TTATCATTCAGCCGACCTGCGCACCCACGAACGACAACCTGATGGAACTCGTCGTGATGGCTGATGCCTTCCGTCGCTCC
TCAGCGTCCCGAATCACTGCTGTGATTCCCTACTTTGGTTATGCCCGCCAGGATCGCCGTCCGCGCTCCGCACGTGTTGC
CATCAGCGCAAAAGTTGTCGCTGACATGCTGACCGTAGTGGGAATCGACCGTGTGCTCACGGTTGATCTGCATGCTGACC
AGATTCAGGGCTTCTTCGACATTCCGGTAGATAACATCTACGGCTCCCCCGTTCTGGTGGATGACATCGAAGATCAGCGC
TTTGAAAACCTGATGATCGTTTCCCCGGACATCGGTGGTGTCGTGCGTGCACGTGCTGTCGCCAAATCCTTGGGCGTCGA
TCTCGGTATCATCGACAAACGCCGTGAGAAAGCCAATCACTCCGAAGTGATGCATATCATTGGTGATGTCGAAGGGCGTA
CCTGCATTCTGGTCGATGACATGGTCGATACCGCCGGCACGCTGTGCCACGCGGCCAAGGCCCTGAAAGAGCATGGTGCT
GCCAAGGTCTTCGCCTACTGCACACACCCTGTGCTGTCGGGTCGGGCGATCGAAAACATTGAAAATTCCGTGCTGGACGA
ACTGGTGGTGACCAACACCATCCCGTTGTCCGCCGCCGCTCAAGCCTGTGGCCGTATCCGTCAACTGGATATTGCCCCGG
TAGTCGCCGAAGCGGTTCGCCGCATCAGCAACGAAGAATCGATCAGCGCGATGTTCCGTTAA

Upstream 100 bases:

>100_bases
AGGCAGCAGGTTTTGATCCTGCCATGCGTTGGTTCGAATCCAGCCGCCCCTGCCATTTTCTATACTCATCCAGGTTACCC
TCAGCCTCTAGGTACTGCGC

Downstream 100 bases:

>100_bases
CTGACATCACGCAGACGAAAAGCGCCCCGCCCTGACATCCGGTCAGGGCGGGGCTTTTTTGCCCATACCATCCGAGCGCT
GGTCGCAAACGCAACGGTGG

Product: ribose-phosphate pyrophosphokinase

Products: NA

Alternate protein names: RPPK; Phosphoribosyl pyrophosphate synthase; P-Rib-PP synthase; PRPP synthase [H]

Number of amino acids: Translated: 313; Mature: 312

Protein sequence:

>313_residues
MSKMMVFTGNANPDLARRVVRQLHIPLGDVSVGKFSDGEISTEINENVRGKDVFIIQPTCAPTNDNLMELVVMADAFRRS
SASRITAVIPYFGYARQDRRPRSARVAISAKVVADMLTVVGIDRVLTVDLHADQIQGFFDIPVDNIYGSPVLVDDIEDQR
FENLMIVSPDIGGVVRARAVAKSLGVDLGIIDKRREKANHSEVMHIIGDVEGRTCILVDDMVDTAGTLCHAAKALKEHGA
AKVFAYCTHPVLSGRAIENIENSVLDELVVTNTIPLSAAAQACGRIRQLDIAPVVAEAVRRISNEESISAMFR

Sequences:

>Translated_313_residues
MSKMMVFTGNANPDLARRVVRQLHIPLGDVSVGKFSDGEISTEINENVRGKDVFIIQPTCAPTNDNLMELVVMADAFRRS
SASRITAVIPYFGYARQDRRPRSARVAISAKVVADMLTVVGIDRVLTVDLHADQIQGFFDIPVDNIYGSPVLVDDIEDQR
FENLMIVSPDIGGVVRARAVAKSLGVDLGIIDKRREKANHSEVMHIIGDVEGRTCILVDDMVDTAGTLCHAAKALKEHGA
AKVFAYCTHPVLSGRAIENIENSVLDELVVTNTIPLSAAAQACGRIRQLDIAPVVAEAVRRISNEESISAMFR
>Mature_312_residues
SKMMVFTGNANPDLARRVVRQLHIPLGDVSVGKFSDGEISTEINENVRGKDVFIIQPTCAPTNDNLMELVVMADAFRRSS
ASRITAVIPYFGYARQDRRPRSARVAISAKVVADMLTVVGIDRVLTVDLHADQIQGFFDIPVDNIYGSPVLVDDIEDQRF
ENLMIVSPDIGGVVRARAVAKSLGVDLGIIDKRREKANHSEVMHIIGDVEGRTCILVDDMVDTAGTLCHAAKALKEHGAA
KVFAYCTHPVLSGRAIENIENSVLDELVVTNTIPLSAAAQACGRIRQLDIAPVVAEAVRRISNEESISAMFR

Specific function: Utilized by both the de novo and the salvage pathways by which endogenously formed or exogenously added pyrimidine, purine, or pyridine bases are converted to the corresponding ribonucleoside monophosphates. [C]

COG id: COG0462

COG function: function code FE; Phosphoribosylpyrophosphate synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ribose-phosphate pyrophosphokinase family [H]

Homologues:

Organism=Homo sapiens, GI4506129, Length=314, Percent_Identity=49.6815286624204, Blast_Score=313, Evalue=1e-85,
Organism=Homo sapiens, GI84875539, Length=316, Percent_Identity=49.0506329113924, Blast_Score=312, Evalue=3e-85,
Organism=Homo sapiens, GI4506127, Length=314, Percent_Identity=48.7261146496815, Blast_Score=309, Evalue=2e-84,
Organism=Homo sapiens, GI28557709, Length=314, Percent_Identity=47.1337579617834, Blast_Score=299, Evalue=2e-81,
Organism=Homo sapiens, GI4506133, Length=346, Percent_Identity=35.8381502890173, Blast_Score=201, Evalue=9e-52,
Organism=Homo sapiens, GI194018537, Length=343, Percent_Identity=36.1516034985423, Blast_Score=196, Evalue=2e-50,
Organism=Homo sapiens, GI310128524, Length=149, Percent_Identity=34.8993288590604, Blast_Score=93, Evalue=3e-19,
Organism=Homo sapiens, GI310115209, Length=149, Percent_Identity=34.8993288590604, Blast_Score=93, Evalue=3e-19,
Organism=Homo sapiens, GI310118259, Length=149, Percent_Identity=34.8993288590604, Blast_Score=93, Evalue=3e-19,
Organism=Homo sapiens, GI310119946, Length=149, Percent_Identity=34.8993288590604, Blast_Score=93, Evalue=3e-19,
Organism=Escherichia coli, GI1787458, Length=313, Percent_Identity=67.4121405750799, Blast_Score=439, Evalue=1e-124,
Organism=Caenorhabditis elegans, GI25149168, Length=314, Percent_Identity=47.1337579617834, Blast_Score=304, Evalue=3e-83,
Organism=Caenorhabditis elegans, GI17554702, Length=314, Percent_Identity=47.1337579617834, Blast_Score=304, Evalue=5e-83,
Organism=Caenorhabditis elegans, GI17554704, Length=309, Percent_Identity=47.5728155339806, Blast_Score=303, Evalue=9e-83,
Organism=Caenorhabditis elegans, GI71989924, Length=314, Percent_Identity=47.1337579617834, Blast_Score=302, Evalue=1e-82,
Organism=Caenorhabditis elegans, GI17570245, Length=341, Percent_Identity=34.0175953079179, Blast_Score=202, Evalue=2e-52,
Organism=Saccharomyces cerevisiae, GI6319403, Length=316, Percent_Identity=44.9367088607595, Blast_Score=272, Evalue=5e-74,
Organism=Saccharomyces cerevisiae, GI6321776, Length=301, Percent_Identity=47.8405315614618, Blast_Score=270, Evalue=2e-73,
Organism=Saccharomyces cerevisiae, GI6320946, Length=314, Percent_Identity=44.2675159235669, Blast_Score=270, Evalue=3e-73,
Organism=Saccharomyces cerevisiae, GI6322667, Length=206, Percent_Identity=40.7766990291262, Blast_Score=160, Evalue=3e-40,
Organism=Saccharomyces cerevisiae, GI6324511, Length=114, Percent_Identity=43.859649122807, Blast_Score=104, Evalue=2e-23,
Organism=Drosophila melanogaster, GI21355239, Length=314, Percent_Identity=50, Blast_Score=305, Evalue=2e-83,
Organism=Drosophila melanogaster, GI45551540, Length=336, Percent_Identity=46.7261904761905, Blast_Score=296, Evalue=1e-80,
Organism=Drosophila melanogaster, GI24651458, Length=357, Percent_Identity=35.8543417366947, Blast_Score=221, Evalue=5e-58,
Organism=Drosophila melanogaster, GI24651456, Length=357, Percent_Identity=35.8543417366947, Blast_Score=221, Evalue=5e-58,
Organism=Drosophila melanogaster, GI281362873, Length=357, Percent_Identity=35.8543417366947, Blast_Score=221, Evalue=6e-58,
Organism=Drosophila melanogaster, GI24651454, Length=357, Percent_Identity=35.8543417366947, Blast_Score=221, Evalue=6e-58,
Organism=Drosophila melanogaster, GI24651462, Length=204, Percent_Identity=38.2352941176471, Blast_Score=142, Evalue=3e-34,
Organism=Drosophila melanogaster, GI24651464, Length=204, Percent_Identity=38.2352941176471, Blast_Score=142, Evalue=3e-34,
Organism=Drosophila melanogaster, GI45552010, Length=204, Percent_Identity=38.2352941176471, Blast_Score=142, Evalue=3e-34,

Paralogues:

None

Copy number: 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000842
- InterPro:   IPR005946
- InterPro:   IPR000836 [H]

Pfam domain/function: PF00156 Pribosyltran [H]

EC number: =2.7.6.1 [H]

Molecular weight: Translated: 34119; Mature: 33987

Theoretical pI: Translated: 5.92; Mature: 5.92

Prosite motif: PS00103 PUR_PYR_PR_TRANSFER ; PS00114 PRPP_SYNTHETASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKMMVFTGNANPDLARRVVRQLHIPLGDVSVGKFSDGEISTEINENVRGKDVFIIQPTC
CCCEEEEECCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHCCCCCCCEEEEECCCC
APTNDNLMELVVMADAFRRSSASRITAVIPYFGYARQDRRPRSARVAISAKVVADMLTVV
CCCCCCHHHHHHHHHHHHCCCCCCEEEEECCCCCHHCCCCCCHHEEEEHHHHHHHHHHHH
GIDRVLTVDLHADQIQGFFDIPVDNIYGSPVLVDDIEDQRFENLMIVSPDIGGVVRARAV
CCCEEEEEEEEHHHCCCEEECCHHHCCCCCEEEECCCCHHHCCEEEECCCCCHHHHHHHH
AKSLGVDLGIIDKRREKANHSEVMHIIGDVEGRTCILVDDMVDTAGTLCHAAKALKEHGA
HHHHCCCEEECCHHHHHCCHHHHHHHHCCCCCCEEEEEECHHHHHHHHHHHHHHHHHCCC
AKVFAYCTHPVLSGRAIENIENSVLDELVVTNTIPLSAAAQACGRIRQLDIAPVVAEAVR
CEEEEEECCCHHCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCHHHHHHHHHH
RISNEESISAMFR
HHCCHHHHHHHCC
>Mature Secondary Structure 
SKMMVFTGNANPDLARRVVRQLHIPLGDVSVGKFSDGEISTEINENVRGKDVFIIQPTC
CCEEEEECCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHCCCCCCCEEEEECCCC
APTNDNLMELVVMADAFRRSSASRITAVIPYFGYARQDRRPRSARVAISAKVVADMLTVV
CCCCCCHHHHHHHHHHHHCCCCCCEEEEECCCCCHHCCCCCCHHEEEEHHHHHHHHHHHH
GIDRVLTVDLHADQIQGFFDIPVDNIYGSPVLVDDIEDQRFENLMIVSPDIGGVVRARAV
CCCEEEEEEEEHHHCCCEEECCHHHCCCCCEEEECCCCHHHCCEEEECCCCCHHHHHHHH
AKSLGVDLGIIDKRREKANHSEVMHIIGDVEGRTCILVDDMVDTAGTLCHAAKALKEHGA
HHHHCCCEEECCHHHHHCCHHHHHHHHCCCCCCEEEEEECHHHHHHHHHHHHHHHHHCCC
AKVFAYCTHPVLSGRAIENIENSVLDELVVTNTIPLSAAAQACGRIRQLDIAPVVAEAVR
CEEEEEECCCHHCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCHHHHHHHHHH
RISNEESISAMFR
HHCCHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10984043 [H]